Search

旨在为全氢化硬脂在塑性脂肪、油凝胶等的应用提供一定的开发依据和理论基础，全面分析硬脂组成对其晶体性质的影响。测定了全氢化棕榈仁油（HPKO）、全氢化棕榈油（HPO）、全氢化棉籽油（HCSO）、全氢化大豆油（HSO）、全氢化低芥酸菜籽油（HCO）、全氢化高芥酸菜籽油（HRO）、精炼漆蜡（LW）、可可脂（CCB）的脂肪酸与甘三酯组成、热性质、微观结构及形态，研究硬脂的组成对其热性质、微观结构及形态的影响。结果表明：HPO、HCSO、HSO、HCO均以棕榈酸和硬脂酸为主，HPKO以月桂酸和豆蔻酸为主，HRO以硬脂酸和山嵛酸为主，LW以棕榈酸和油酸为主，CCB以硬脂酸、油酸、棕榈酸为主；硬脂的甘三酯组成对其熔点有很大影响，CCB、HPKO的熔化温度较低，HSO、HCO、HRO的熔化温度较高；HRO虽然含有大量的山嵛酸，但其熔化温度低于HSO和HCO，这可能与甘三酯间的相互作用有关；油脂中高熔点甘三酯含量影响油脂的固体脂肪含量曲线，相同温度下高熔点甘三酯含量高的油脂具有更高的固体脂肪含量，甘三酯间的相互作用也会影响油脂的固体脂肪含量曲线；CCB晶型为β型，HPKO、HPO、HCSO为β′型，HCO、HSO、HRO则为α型，LW为β和β′混合晶型；油脂的甘三酯组成会影响结晶聚集体的形态，高熔点甘三酯含量越高，结晶聚集体越致密有序；测定条件下（25 ℃）油脂的固体脂肪含量也会影响结晶聚集体形态。 In order to provide certain development basis and theoretical basis for the application of full hydrogenated stearin in plastic fats and oleogels, the influence of stearin composition on its crystal properties was analyzed, the fatty acid and triacylglycerols (TAGs) compositions, thermal properties, microstructure and morphology of hard fats, including fully hydrogenated palm kernel oil (HPKO), fully hydrogenated palm oil (HPO), fully hydrogenated cottonseed oil (HCSO), fully hydrogenated soybean oil (HSO), and fully hydrogenated canola oil (HCO), fully hydrogenated rapeseed oil (HRO), refined lacquer wax (LW) and cocoa butter (CCB) were determined, and the effects of composition of these stearin on their thermal properties, microstructure and morphology were investigated. The results showed that the major fatty acids of HPO, HCSO, HSO and HCO were palmitic acid and stearic acid. Lauric acid and myristic acid were the major fatty acids of HPKO. HRO was mainly composed of stearic acid and behenic acids. LW contained large amount of palmitic acid and oleic acid. The major fatty acids of CCB were stearic acid, oleic acid and palmitic acid. The melting points of these stearin were influenced greatly by their TAGs composition. The melting points of CCB and HPKO were lower relatively, and the melting points of HSO, HCO and HRO were higher. Although HRO contained a lot of behenic acid, its melting point was lower than that of HSO and HCO, which was related to the interaction of TAGs. The content of TAGs with high melting point affected the solid fat content (SFC) profile of the stearin. At the desired temperature, the higher the content of TAGs with high melting points in stearin, the higher the SFC of stearin. SFC profile of stearin was also affected by the interaction of TAGs in them. The crystals in CCB was β form,HPKO, HPO and HCSO were β′ form,HCO, HSO and HRO were α form, LW was a mixture of β and β′ form. The morphology of the crystalline aggregates was affected by TAGs composition in stearin, the higher the content of high melting point TAGs, the denser and more orderly the crystalline aggregates. The SFC of stearin under the determination condition （25 ℃） also influenced the morphology of the crystalline aggregates.

毛漆蜡酸值高、色泽深，需要通过精炼提高其品质。对毛漆蜡进行脱酸、脱色和脱臭处理，对精炼前后漆蜡的酸值、过氧化值、色泽、甘油酯和脂肪酸组成进行了分析，采用X-射线衍射技术对漆蜡晶型进行测定，通过固体脂肪含量的测定和差示扫描量热法分析了漆蜡的热性质。结果表明：脱酸后漆蜡的酸值（KOH）由（35.06±0.05）mg/g降至（0.12±0.01）mg/g；精炼后，漆蜡色泽由深褐色变为乳白色，过氧化值为（0.28±0.04）mmol/kg。精炼过程中漆蜡的甘油酯和脂肪酸组成没有发生改变，但脱酸漆蜡的甘三酯含量显著增加，甘一酯和甘二酯含量显著降低，棕榈酸含量显著增加，油酸和亚油酸含量显著降低;脱色、脱臭对漆蜡的甘油酯和脂肪酸含量没有显著影响。固体脂肪含量分析表明，毛漆蜡的熔化范围为20~55 ℃，脱酸、脱色和脱臭漆蜡熔化范围为30~60 ℃；X-射线衍射数据显示，毛漆蜡以β晶型为主，并存在少量α晶型，精炼后α晶型消失；差示扫描量热分析表明，脱酸、脱色和脱臭漆蜡熔点有所升高。这些变化可能是精炼过程中毛漆蜡中的绝大部分游离脂肪酸、部分甘二酯和一些挥发性物质被除去所致。The crude lacquer wax should be refined to improve its quality because of its high acid value and dark color. The crude lacquer wax was deacidified, bleached and deodorized,and the acid value, peroxide value, color, glycerides and fatty acid composition of lacquer wax before and after refining were analyzed. The crystalline shape of lacquer wax was determined by X-ray diffraction technique, and the thermal properties of lacquer wax were analyzed by solid fat content determination and differential scanning calorimetry. The results showed that after deacidification, the acid value of lacquer wax decreased from (35.06±0.05)mgKOH/g to (0.12±0.01)mgKOH/g; after refining, the color changed from brown to milky white, and the peroxide value was (0.28±0.04) mmol/kg. The glycerides and fatty acid compositions of lacquer wax did not change in the refining process, but in deacidification process, the contents of triglycerides increased significantly, the contents of monoglyceride and diglyceride decreased significantly, and the palmitic acid content increased obviously, while the oleic acid and linoleic acid contents decreased obviously. There was no significant effect of bleaching and deodorization processes on the glycerides and fatty acid contents of lacquer wax. The solid fat content analysis showed that the melting range of crude lacquer wax was 20-55 ℃, and the melting range of deacidified, bleached and deodorized lacquer wax was 30-60 ℃. The X-ray diffraction data showed that the crude lacquer wax was dominated by β-type crystals, and a small amount of α-type crystals existed, while the α-type crystals disappeared after refining. The differential scanning calorimetric analysis showed that the melting points of deacidified, bleached and deodorized lacquer waxes increased. These changes might be due to the removal of most of the free fatty acids, some diglycerides and some volatile substances from the crude lacquer wax during refining.

目的为了研究β-淀粉样蛋白（Aβ）产生神经毒性的机制，本研究探讨了Aβ对凋亡相关核转录因子叉头蛋白O3a （FoxO3a）和突触后致密蛋白95 （PSD95）的作用及可能的机制。方法采用梯度浓度（5、10、20 μmol/L）寡聚化的Aβ25-35处理PC12细胞和神经元24 h，采用Western blot法检测FoxO3a和PSD95的变化。免疫荧光法检测PC12细胞中PSD95表达量的变化和FoxO3a在细胞内的定位。在Aβ25-35海马注射的大鼠和APP/PS1转基因鼠中，考察脑组织中PSD95和FoxO3a的变化。采用Western Blot法检测体外环境和在体环境中，Aβ对FoxO3a和蛋白激酶B（AKT）磷酸化的影响。结果与正常对照组相比，20 μmol/L的Aβ25-35处理组PSD95蛋白水平下调至（45.09±1.61）% （F=7.487， P=0.0540）。与之对应，20 μmol/L的Aβ25-35上调FoxO3a的蛋白水平为对照组的（228.7±20.44）% （F=17.48， P=0.021 0）。在原代培养的神经元中，获得了相似的结果。另外，免疫荧光的结果显示Aβ25-35可以促进FoxO3a进入细胞核。大鼠海马注射Aβ25-35后，水迷宫实验中目标区域的平均停留时间为（24.35 ±1.29） s （F=2.843， P=0.098），平均穿越次数为（2.53±0.49）次 （F=3.459， P=0.014 9），与对照组相比都显著降低。RT-PCR结果显示Aβ25-35组大鼠海马组织中PSD95的mRNA水平下降为对照组的（58.40±8.28） % （F=1.193， P=0.010 1），同时FoxO3a的mRNA的表达量上调（140.90±7.45）% （F=2.378， P=0.049 6）。在7月龄的APP/PS1转基因小鼠的大脑组织中，PSD95的mRNA和蛋白水平分别下调为野生型小鼠的（60.89±1.53）% （F=20.05， P=0.008 8）和（59.63±13.55）% （F=8.496， P=0.044 5），而FoxO3a的mRNA和蛋白水平则分别上调为对照组的（172.4±4.87）% （F=2.351， P=0.0004） 和（235.00±39.03）% （F=2.754， P=0.032 0）。20 μmol/L的Aβ25-35处理PC12细胞不同时间后（5、10、20和40 min），FoxO3a和AKT的磷酸化水平随着时间增长而降低，APP/PS1转基因小鼠脑组织中的AKT和FoxO3a的磷酸化水平与对照组相比也显著下降至（65.75±3.51）% （F=6.362， P=0.023 6）和（46.62±9.64）% （F=8.562， P=0.007 9）。结论Aβ在体外细胞模型和体内动物模型中都可以上调核转录因子FoxO3a的表达，下调PSD95的水平，可能的机制是通过去磷酸化AKT从而减少了PSD95的合成，同时降低了FoxO3a的磷酸化水平并增加FoxO3a的表达量。

Copyright of e-Education Research is the property of Northwest Normal University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chemical Engineering (China) / Huaxue Gongcheng is the property of Hualu Engineering Science & Technology Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of High Pressure Physics is the property of Chinese Journal of High Pressure Physics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Irrigation & Drainage is the property of Journal of Irrigation & Drainage Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Social Work (1672-4828) is the property of Journal of Social Work Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Petroleum Refinery Engineering is the property of Petroleum Refinery Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The purpose of this study is to investigate the species diversity of Malmidea in China and further identify its species composition and distribution. The lichen specimens collected from Yunnan Province were classified based on the investigation of lichen resources in the field and the collection of lichen specimens, and combined with the methods of morphology, anatomy and chemistry. Three new records of Malmidea were reported from China, M. indica (D. D. Awasthi & M. R. Agarwal) Hafellner & T. Sprib, M. reunionis Kalb and M. hechicerae Kalb. In this paper, detailed descriptions, morphology and anatomical pictures of the recorded species were provided, and comparison and discussion were made with similar species. A key to all known Chinese Malmidea species was also provided. This study enriches the diversity of Malmidea in China, and has some significance for conservation and study of lichen diversity of China. [ABSTRACT FROM AUTHOR]

Copyright of China Rural Water & Hydropower is the property of China Rural Water & Hydropower Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of China Medical University is the property of Journal of China Medical University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To investigate the protective effect and mechanism of magnesium isoglycyrrhizinate (MgIG) on cisplatin (CDDP) -induced myocardial injury in rats. Methods Twenty-four Wistar rats were randomly divided into the normal control group, the cisplatin model group (CDDP group), the cisplatin + magnesium isoglycyrrhizinate low-dose group (MgIG-L group) and the cisplatin + magnesium isoglycyrrhizinate high-dose group (MgIG-H group), with 6 rats in each group. Changes of body mass of rats were monitored daily. At the end of drug administration, cardiac function indexes including left ventricular ejection fraction (LVEF), left ventricular short-axis narrowing rate (LVFS), left ventricular endsystolic internal diameter (LVESD) and left ventricular end-diastolic internal diameter (LVEDD) were detected by echocardiography. The morphology of myocardial tissue was observed by HE staining. Enzyme-linked immunosorbent assay (ELISA) was used to detect serum levels of creatine kinase isoenzyme MB (CK-MB) and troponin I (cTnI). Levels of superoxide dismutase (SOD), malondialdehyde (MDA), glutathione synthase (GSH), reactive oxygen species (ROS) and ferrous ion (Fe2+ ) in homogenates of myocardial tissue were measured biochemically. The protein expressions of nuclear factor E2-associated factor 2 (Nrf2), long-chain fatty acyl coenzyme A synthase 4 (ACSL4), glutathione peroxidase 4 (GPX4) and ferritin heavy chain 1 (FTH1) protein were detected by Western blot assay. Results The body mass of rats in the control group showed an increasing trend during feeding, and the body mass of rats in the CDDP group showed a decreasing trend. Compared with the CDDP group, the body mass of rats in the MgIG-L group and the MgIG-H group increased after 5 d, 9 d and 13 d of treatment (P＜0.05). Compared with the control group, the CDDP group showed decreased LVEF and LVFS, increased LVESD and LVEDD, disturbed myocardial fiber alignment, myocardial fiber degeneration and fracture, increased serum CK-MB and cTnI levels, increased levels of MDA, Fe2+ and ROS in myocardial tissue, decreased levels of SOD and GSH, and decreased levels of Nrf2, GPX4, and decreased FTH1 protein expression levels and increased ACSL4 protein expression levels in myocardial tissue (P＜0.05). Compared with the CDDP group, the above indicators and myocardial histopathological changes were significantly improved in the MgIG-L group and the MgIG-H group. Conclusion Magnesium isoglycyrrhizinate can ameliorate cisplatin-induced myocardial injury by regulating myocardial oxidative stress and inhibiting cardiomyocyte iron death in rats. [ABSTRACT FROM AUTHOR]

Copyright of Acta Agronomica Sinica is the property of Crop Science Society of China and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Guangdong Architecture Civil Engineering is the property of Guangdong Architecture Civil Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Nanchang University (Natural Science) is the property of Journal of Nanchang University (Natural Science) Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Stroke is the property of Chinese Journal of Stroke Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Application Research of Computers / Jisuanji Yingyong Yanjiu is the property of Application Research of Computers Edition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Continue Education Research is the property of Harbin Normal University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Refrigeration is the property of Journal of Refrigeration Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Forest Products Industry is the property of China Forest Products Industry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of New Media Research is the property of New Media Research Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Summary Building a new development pattern is a strategic choice made in the light of China's own development stage and conditions, taking full account of economic globalization and changes in the external environment. It is an inevitable choice for China to rebuild its competitive advantage after entering a new development stage. In-depth exploration of the industrial policy system's evolution and main trends that adapt to the new development pattern is not only the need for actively responding to the actions of developed countries to suppress China with the stick of industrial policy. but also the need for promoting China's high-quality development. For more than 40 years since the reform and opening up, the main goal of industrial policy system has been to promote China's economic growth. The selective industrial policy committed to catching up with developed countries has promoted economic growth, but also caused great damage to the market environment of fair competition. Under the new development pattern, stimulating internal competition and strengthening external security have become the new main goals of industrial policy system. To build a new development pattern, industrial policy is still an indispensable tool for promoting domestic and international double circulation and promoting high-quality economic development due to great changes in internal and external environment and factors such as the development environment of the times and industrial policy objectives. However, the previous industrial policy objectives and pattern should be adjusted and upgraded. The narrow industrial policy which is represented by industrial structure policy and industrial development policy with selective characteristics, scientific and technological innovation policy and competition policy and some other polices together constitute the broad industrial policy system closely related to economic development, but the implications of above policies overlap. Based on the perspective of economic development stage, this paper clarifies the integration. coordination withdrawal and reconstruction of industrial policy, scientific and technological innovation policy and competition policy. And we clarify the evolution of the three types of policies in the four stages of economic development, and try to explore the basic role of various policies in the construction of new development pattern. The new development pattern that makes the national economy supply and demand to achieve a virtuous cycle is a dynamic process. It requires that industrial policy and competition policy, special science and technology innovation policy dedicated to overcome the"stuck neck" difficulties and conventional science and technology innovation policy are balanced and coordinated with each other. Based on the above analysis, this paper proposes that under the diversified policy goals of the new development pattern. the relationship between the three types of economic policies is not the opposite but the complementary and coordinated. And China's policy system should be structured as follows: competition policy should be the basis of all policies: industrial policy and competition policy coordinate with each other; selective industrial policy gradually gives way to functional industrial policy; science and technology policy pay more attention to the front of the innovation chain than the back and the new nationwide system keeps the selective character. Finally, this paper further puts forward some suggestions to improve the industrial policy system under the new development pattern. such as establishing anti-monopoly law enforcement agencies. establishing a multi-level policy coordination mechanism. improving the whole-process governance mechanism of industrial policy. The conclusion in this paper is of great significance for exploring what kind of industrial policy system is needed in the new development pattern and what is the evolution trend of China's industrial policy system in the future. It also provides institutional innovation impetus and important policy tools for China to build a new development pattern. [ABSTRACT FROM AUTHOR]

[Objective] The diversity and composition of rhizosphere fungal communities of two typical plants (Dacrydium pectinatum and Vatica mangachapoi) in tropical rain forest were studied, which provided scientific basis for biodiversity protection of rare and endangered species in tropical rain forest ecosystem. [Method] The composition, diversity and function of fungal communities in the rhizosphere of D. pectinatum and V. mangachapoi in Hainan tropical rain forest were analyzed by Illumina Miseq high-throughput sequencing. [Result] Basidiomycota and Ascomycota were the dominant phyla among different niches in the rhizosphere. PCoA results showed that compared with niche, species had more influence on the fungal community structure of D. pectinatum and V. mangachapoi and had different effects on different niches in the rhizosphere (rhizosphere: R=0. 1983, P=0.007; rhizoplane: R=0. 2622, P=0.004; endosphere: R=0.7342, P = 0.001). At the OTU level, there was no significant difference in fungal community a diversity between D. pectinatum and V. mangachapoi, but there were significant differences in rhizoplane and endosphere fungal community a diversity of the same tree species (P <0.05), and the a diversity of endosphere fungal community was the lowest compared with other niches. The results of CCA analysis showed that pH and ammonia nitrogen (AN) were important environmental factors affecting the fungal community structure in the rhizosphere of the two tree species. The results of FUNGuild function prediction showed that Ectomycorrhizal-Undefined Saprotroph, Ectomycorrhizal, Undefined Saprotroph and Fungal Parasite-Undefined Saprotroph were the main functional groups, and there were differences among different tree species. [Conclusion] Plant species significantly affect the composition of rhizosphere fungal communities, but niche is an important factor affecting fungal community diversity in small-scale regions. pH and AN are important environmental factors driving the difference of fungal community composition in rhizosphere between D. pectinatum and V. mangachapoi. [ABSTRACT FROM AUTHOR]

Copyright of Mycosystema is the property of Mycosystema Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Xi'an Jiaotong University (Medical Sciences) is the property of Xian Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Soochow University Law Edition is the property of Soochow University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Modern Economic Science is the property of Modern Economic Science Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Materials Engineering / Cailiao Gongcheng is the property of Journal of Materials Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the effects of curcumin on the in vitro proliferation and apoptosis of mouse liver cancer Hepa1-6 cells. Methods Hepa1-6 cells in the logarithmic growth phase were divided into the control group, 10 µmol/L group, 20 µmol/L group and 40 µmol/L group, respectively, which were treated with 0, 10, 20, and 40 µmol/L of curcumin. Cell proliferation was assessed by the MTT assay, and apoptosis level was detected by FACS. Real-time quantitative PCR (RT-qPCR) was employed to detect the levels of apoptosis-related molecules Bcl-2, Caspase-3, Toll-like receptor 2 (TLR2), IFN-α, and IFN-β in Hepa1-6 cells. The secretion levels of IFN-α and IFN-β in the cell culture supernatant were determined using ELISA. Hepa1-6 cells were incubated with CD4+ T cells, CD8+ T cells and NK cells in the control group and 40 µmol/L curcumin group, respectively. FACS was used to detect the expression levels of CD69 in CD4+ T cells, CD8+ T cells and NK cells. Results The proliferation inhibition rates of Hepa1-6 cells in the 10, 20 and 40 µmol/L groups increased in a dose-dependent manner, and the inhibition rates were (36. 45 ± 2. 11) %, （46. 40 ± 2. 08) % and (82. 16 ± 3. 32) %, respectively. There was statistically significant difference in comparison with that of the control group (P<0. 05) . The apoptotic proportions of Hepa1-6 cells in the 10 µmol/L, 20 µmol/L and 40 µmol/L groups were 10. 47%, 26. 66% and 49. 81%, respectively. And the difference was statistically significant in comparison with that of the control group (P<0. 01) . RT-qPCR results showed that the transcription levels of anti-apoptotic gene Bcl-2 in the 10 µmol/L, 20 µmol/L and 40 µmol/L groups were (0. 77 ± 0. 06) times, （0. 44 ± 0. 06) times and (0. 25 ± 0. 08) times that of the control group, respectively, with statistically significant difference (all P<0. 01) . At the same time, the expression of proapoptotic gene Caspase-3 significantly increased, and the transcription levels of pro-apoptotic gene Caspase-3 in the 10 µmol/L, 20 µmol/L and 40 µmol/L groups was (1. 73 ± 0. 31) times, （2. 52 ± 0. 45) times and (3. 25 ± 0. 20) times that of the control group, respectively, with statistically significant difference (all P<0. 01) . With the increase of curcumin concentrations, TLR2 transcription levels increased gradually. TLR2 transcription levels in the 10 µmol/L, 20 µmol/L and 40 µmol/L groups were (3. 56 ± 0. 59) times, （4. 93 ± 0. 04) times and (6. 60 ± 0. 47) times that of the control group, respectively, with statistically significant difference (all P<0. 05) . In addition, the transcription levels of IFN-α in the 10 µmol/L, 20 µmol/L and 40 µmol/L groups significantly increased, which were (4. 21 ± 0. 22), （5. 54 ± 0. 39) and (8. 05 ± 0. 93) times that of the control group, respectively, and there were statistically significant differences among these groups (all P<0. 05) . The transcription levels of IFN-β were (3. 08 ± 0. 51), （5. 31 ± 0. 55) and (8. 35 ± 0. 59) times that of the control group, and the difference was statistically significant (all P<0. 01) . For IFN-α, compared with the control group ［（36. 26 ± 6. 12) pg/mL］, the levels of IFN-α secreted by cells in the 10 µmol/L, 20 µmol/L and 40 µmol/L groups were (57. 00 ± 8. 8), （82. 47 ± 4. 42), and (100. 37 ± 8. 99) pg/mL, respectively； the levels of IFN-α secreted by cells in the 10, 20, and 40 µmol/L groups were higher that that of the control group (all P<0. 01) . The levels of IFN-β secreted by the cells in the 10, 20, and 40µmol/L groups were (60. 67 ± 6. 81), （91. 33 ± 5. 51), and (144. 00 ± 10. 15) pg/mL, respectively, while that in the control group was (44. 67 ± 1. 15) pg/mL. The levels of IFN-β secreted by the cells in the 10, 20, and 40 µmol/L groups were higher than that in the control group (all P<0. 01) . In the control group, CD69 expression levels of CD4+ T cells, CD8+ T cells and NK cells were (24. 53 ± 1. 39) %, （23. 40 ± 2. 32) %, （32. 33 ± 3. 08) %, respectively. The CD69 expression levels of CD4+ T cells, CD8+ T cells and NK cells in the 40 µmol/L group were (39. 90 ± 3. 51) %, (31. 47 ± 3. 88) %, （50. 83 ± 4. 74) %, respectively. There were significant differences in CD69 levels of CD4+ T cells, CD8+ T cells and NK cells between control group and 40 µmol/L group (all P<0. 05) . Conclusion Curcumin promotes the secretion of type Ⅰ interferon by regulating the expression of TLR2, thus inhibits the proliferation of hepatocellular carcinoma cells, induces the apoptosis of hepatocellular carcinoma cells, as well as promotes the activation of immune cells. [ABSTRACT FROM AUTHOR]

Copyright of Applied Mathematics & Mechanics (1000-0887) is the property of Applied Mathematics & Mechanics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Agro-Environment Science is the property of Journal of Agro-Environment Science Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Rehabilitation Medicine is the property of China Association of Rehabilitation Medicine, China-Japan Friendship Hospital and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Computational Mechanics / Jisuan Lixue Xuebao is the property of Chinese Journal of Computational Mechanics Editorial Office, Dalian University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Guihaia is the property of Guihaia Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Applied Chemical Industry is the property of Shaanxi Research Design Insitute of Petroleum & Chemical Industry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Modern Food Science & Technology is the property of Editorial Office of Modern Food Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Water Conservancy & Electric Power Technology & Application is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Science Technology & Engineering is the property of Chinese Society of Technology Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)