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Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

分析磁共振（MRI）腰部成像参数与腰椎间盘突出症（LDH）患者椎间孔镜术后疗效的关系。 方法 选取LDH患者114例作为观察组，另选同期有腰痛症状无腰椎间盘突出患者110例作为对照1组，无腰痛症 状及腰椎间盘突出的健康体检人群110例作为对照2组.三组行腰部MRI检查，测量并计算两侧腰大肌、多裂肌横 截面面积差值. 观察组均行椎间孔镜手术治疗，于术后6个月采用改良MacNab评估疗效，比较不同疗效患者术前、 术后6个月腰部疼痛评分（VAS）、腰椎功能（JOA）评分及两侧腰大肌、多裂肌横截面面积差值，分析两侧腰大肌、多 裂肌横截面面积差值与疗效、VAS、JOA评分相关性.结果 观察组、对照1组男性、女性累及侧/疼痛侧腰大肌、多 裂肌横截面面积小于非累及侧/非疼痛侧（P均<0. 05），对照 2组男性、女性左右两侧腰大肌、多裂肌横截面面积无 明显差异；观察组两侧腰大肌、多裂肌横截面面积差值均高于对照1组、对照2组（P均<0. 05）.术后6个月，观察组 优良率92. 11%（105/114）；观察组疗效优良者术前、术后6个月两侧腰大肌、多裂肌横截面面积差值、VAS低于非优 良者，JOA评分高于非优良者（P均<0. 05）；Pearson相关性分析，术前、术后6个月两侧腰大肌、多裂肌横截面面积差 值与 VAS呈正相关，与 JOA评分呈负相关（P均<0. 05）；多元线性逐步回归分析，将 VAS、JOA评分等其他因素控制 后，两侧腰大肌、多裂肌横截面面积差值与疗效相关（P均<0. 05）.结论 LDH患者MRI两侧腰大肌、多裂肌横截面 面积经椎间孔镜术治疗后明显恢复，且与腰部疼痛、腰椎功能改善及疗效密切相关，在疗效评估中具有良好价值. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 分析三维CT导航辅助椎间孔镜手术治疗腰椎间盘突出症 (LDH) 的疗效及安全性。方法 将 106 例 LDH 患者随机分为两组各 53 例, 对照组行常规 C 臂机透视导航辅助椎间孔镜手术, 观察组行三维 CT 导航辅助椎间孔镜手术。记录两组手术情况(手术时间、术中失血量、穿刺次数、工作通道建立时间)、术后恢复情况(术后卧床时间、术后引流量、住院时间), 分别于术前及术后 3、7 d 检测血清应激反应指标[血管紧张素 Ⅱ(AngⅡ)、白细胞介素 6(IL-6)、超敏 C 反应蛋白 (hs-CRP)], 分别于术前及术后 7 d、3 个月、1年评价腰腿部疼痛 (VAS) 及腰椎功能(JOA 评分), 随访1年评价预后情况, 记录并发症发生情况。结果 与对照组比较, 观察组工作通道建立时间、手术时间、术后卧床时间、住院时间缩短, 穿刺次数、术中失血量、术后引流量减少, 术后 3、7 d血 清 AngⅡ、IL-6、hs-CRP 水平降低, 术后 7 d 腰腿部 VAS 降低而 JOA 评分增高, 并发症发生率降低 (P均<0.05); 两组术后 3 个月、1年腰部腿部 VAS、JOA 评分及术后 1 年预后优良率比较差异均无统计学意义。结论 三维 CT 导航辅助椎间孔镜手术治疗 LDH 能有效减少穿刺次数, 降低术中出血量, 缩短工作通道建立时间、手术时间及术后恢复时间, 减轻应激反应, 降低腰腿部疼痛程度及并发症发生风险, 且安全性较高。 [ABSTRACT FROM AUTHOR]

BACKGROUND: In the treatment of bone defect or bone injury by tissue engineering, biomaterials affect the survival rate, proliferation and differentiation of bone marrow mesenchymal stem cells. OBJECTIVE: To review the research progress regarding how biomaterials affect the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells, and to guide the rational application of biomaterials. METHODS: A computer-based online search of CNKI, PubMed, Web of Science, and Wanfang database with the search terms "Bone marrow mesenchymal stem cells, Osteogenic differentiation, Biological materials, The microstructure". The eligible literatures regarding the effects of different biomaterials on the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells were included. RESULTS AND CONCLUSION:(1) Metallic materials have the advantages of good biocompatibility, bone conductivity, and mechanical performance. Non-metallic materials exhibit good biocompatibility, bone conductivity, reabsorption, and three-dimensional shaping.(2) There are many factors that affect the surface microstructure of the biomaterial. As for the same biomaterial, greater surface energy/wettability leads to better proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells; greater roughness better promotes the proliferation, adhesion, and differentiation of bone marrow mesenchymal stem cells; larger pore diameter and lower pore diameter rate are more prone to promote the osteogenic differentiation of bone marrow mesenchymal stem cells; greater substrate rigidity and elastic modulus better facilitate the osteogenic differentiation of bone marrow mesenchymal stem cells. The abovementioned factors of the biomaterials affect the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells. These findings help promote the application of biomaterials seeded with bone marrow mesenchymal stem cells in the clinic. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Neurosurgery / Linchuang Shenjingwaike Zazhi is the property of Editorial Board of Journal of Clinical Neurosurgery and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Angiotensin II（Ang II）as the key effect factor of renin-angiotensin system（RAS）, binds with angiotensin II type 1 receptor（AT1R）to maintain fluid and electrolyte balance, constrict blood vessels、regulate blood pressure, promote myocardium, renal proximal tubule and vascular smooth muscle cell proliferation, participate in the development、angiogenesis and metastasis of tumor, as well as other important roles. New studies have found that, AT1 receptor-associated protein binding with C-terminal region of AT1R specially, control its expression by adjusting receptor internalization, cell membrane recycling and sensitivity of the receptor. This article briefly summarized the research progresses of several AT1R-associated proteins. Therefore it may provide new basis for further research of RAS in the furture. [ABSTRACT FROM AUTHOR]

ASPH is a highly conserved deoxidizing enzyme of mammalian embryonic period is found in cells. In recent years, it is found in most normal tissues relatively low expression or no expression and high expression in placental trophoblast cells and adrenal cells. And ASPH is over expressed in a variety of malignant tumors, the catalytic domain can be hydroxylated EGF- like domain of certain proteins of aspartic acid or asparagine residues, which mediates cell movement and differentiation, and participate in the regulation of invasion and metastasis of malignant tumor cells, and can induce antitumor immune response in immune regulation. Progress in recent years in the field of cancer and other ASPH research paper briefly reviewed. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)