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Copyright of Journal of Computer Engineering & Applications is the property of Beijing Journal of Computer Engineering & Applications Journal Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Jinan University (Social Science Edition) is the property of Jinan University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Science Technology & Engineering is the property of Chinese Society of Technology Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Practical Medicine / Shiyong Yixue Zazhi is the property of Journal of Practical Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective·To investigate the expression and clinical significance of geranylgeranyl diphosphate synthase1 (GGPS1) in lung squamous cell carcinoma (LUSC) by bioinformatics and immunohistochemistry. Methods·Firstly, the transcriptome data of LUSC tissues and paired normal tissues were downloaded from UCSC Xena platform. The data were standardized and differentially expressed by R language, and verified by UALCAN database. UALCAN and LinkedOmics databases were used to analyze the relationship between GGPS1 expression and clinicopathological features in LUSC patients. The Kaplan-Meier Plotter database was used to explore the effect of GGPS1 expression on prognosis in LUSC patients. The least absolute shrinkage and selection operator (LASSO) regression analyses were applied to screen gene correlation coefficients and risk scores. The diagnostic value of GGPS1 for LUSC was evaluated by nomogram and calibration curve. The protein-protein interaction (PPI) network of GGPS1 was constructed by using STRING and GeneMANIA databases. R language was used to select the differential genes related to GGPS1, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were performed. The expression of GGPS1 in LUSC patients was detected by immunohistochemistry, and its correlation with clinicopathological features and prognosis was analyzed. Results·Through the TIMER2.0 database, it was found that GGPS1 expression was increased in most tumors and was highly expressed in LUSC. The expression of GGPS1 in LUSC was higher than that in adjacent tissues in UCSC Xena and UALCAN databases (both P<0.05). It was found that the expression level of GGPS1 was higher in patients with late stage in UALCAN and LinkedOmics databases, and the overall survival (OS) of LUSC patients with high expression of GGPS1 was shorter (P<0.05) in the Kaplan-Meier Plotter database. Assessment of LUSC patients based on LASSO regression had good risk prediction efficacy. Constructing an individualised prediction model for LUSC patients has the best prediction accuracy. The results of GO and KEGG showed that GGPS1-related genes were mainly related to protein metabolism, regulation of lipid and cholesterol metabolism, nicotine addiction, phosphatidylinositol3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR), peroxisome proliferator-activated receptors (PPAR) signaling pathway and so on. The metabolic function of GGPS1 may promote tumorigenesis. The results of immunohistochemistry showed that GGPS1 was mainly located in the cytoplasm, and the expression of GGPS1 in LUSC tissues was higher than that in adjacent tissues (P<0.05). The high expression of GGPS1 was related to tumor size, lymph node metastasis and TNM stage of LUSC patients (all P<0.05), and the OS of patients with high expression of GGPS1 was significantly shorter than that of patients with low expression (P=0.000). Multivariate Cox regression analysis suggested that GGPS 1 could be used as an independent prognostic factor for LUSC. Conclusion·Compared with normal lung tissue, the expression of GGPS1 in LUSC is significantly increased, especially in patients with large tumor volume, positive lymph node metastasis and advanced stage. GGPS1 overexpression is an independent predictor of poor prognosis in LUSC patients. GGPS1 is expected to become a new molecular target for the diagnosis, treatment and prevention of LUSC. [ABSTRACT FROM AUTHOR]

Copyright of Water Conservancy & Electric Power Technology & Application is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Applied Ecology / Yingyong Shengtai Xuebao is the property of Chinese Journal of Applied Ecology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Aeronautical Materials is the property of Editorial Board of Journal of Aeronautical Materials and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore the correlation between depression and comorbidity of cerebral small vessel disease (CSVD) in patients with depression, so as to provide evidence for early prevention and treatment. Methods: Totally 80 patients with stable depressive episode and recurrent depressive disorder according to the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10), as well as 97 normal controls were included. Medical historywas collected, and cognitive function and mental status were assessedusing Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), Hamilton Depression Scale and Hamilton Anxiety Scale. Positive rate of CSVD diagnosis and the relevant magnetic resonance imaging (MRI) diagnostic features were evaluated by cranial MRI. Logistic regression analysis was used to analyze the correlation between depression and CSVD. Results: The age of depression group and normal control group were (59±9) years and (58±8) years, respectively (P＞0.05). Higher proportion of hypertension and lower MoCA total scores were seen in the depression group than in the normal control group (Ps ＜0.05). The proportion of CSVD was higher in the depression group than in the normal control group (83.8% vs. 64.9%, P ＜0.01). Logistic regression analysis showed that lacunar cerebral infarction (OR=4.4, 95% CI: 1.07-18.23), frontal lobe demyelination (OR = 2.4, 95% CI: 1.05-5.42) and MoCA ＜26 (OR=2.3, 95% CI: 1.16-4.47) were the risk factors of depression. Conclusion: Comorbid CSVD is common in the middle-aged and elderly patients with depression, for whom lacunar cerebral infarction and frontal lobe demyelination maybe the risk factors. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Xi'an Jiaotong University (Medical Sciences) is the property of Xian Jiaotong University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Practical Pharmacy & Clinical Remedies is the property of Editorial Department of Practical Pharmacy & Clinical Remedies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Earth Sciences & Environment is the property of Journal of Earth Sciences & Environment and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Economic Science / Jingji Kexue is the property of Economic Science Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Diabetes Mellitus is the property of Chinese Journal of Diabetes Mellitus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective We conducted a network meta-analysis to compare the efficacy of acetyl-levo-carnitine (ALC) with other commonly used oral medications in patients with diabetic peripheral neuropathy (DPN). Methods We searched the Chinese and English electronic databases up to February 2020 to identify randomized controlled trial (RCT) that evaluated one or more of the following oral monotherapy interventions in the treatment of DPN in adults: ALC, α-lipoic acid (ALA), epalrestat, methylcobalamin (MC), and pancreatic kininogenase. The primary outcome was nerve conduction velocity (NCV). The secondary outcomes were amplitude, neurological symptoms, neurological signs, and pain. A random-effect network meta-analysis within a Bayesian framework was performed. We estimated the ranking probabilities for each intervention by use of surface under the cumulative ranking curve (SUCRA). Results Fifty-five RCT with 6 473 participants were included in this network meta-analysis. All trials were two-arm studies, involving four treatments (ALC, ALA, eparlrestat, MC). Three trials related to ALC (two studies compared ALC versus placebo, and the other one versus MC) were included. Compared with MC, ALC had more improvement in NCV of median sensory nerve (MD=4.0 m/s, 95%CI 0.1--7.9 m/s). According to the ranking results, ALC might be better in improving median sensation nerve (SUCRA, 91.6%), ulnar motor nerve (SUCRA, 69.3%) and ulnar sensation nerve (SUCRA, 77.8%) compared with other commonly used oral drugs. However, the results of relative-effect network meta-analysis showed no significant difference between ALC and other drugs in NCV improvement of other nerves. Conclusions The findings of this network meta-analysis showed ALC might have beneficial effects on improving the sensory nerve function and pain intensity, and have similar performance with other commonly used oral medications on other outcomes. [ABSTRACT FROM AUTHOR]

Desmoglein-2 (DSG2) is a member of the cadherin family. As an important part of desmoglein, DSG2 mainly plays a role in maintaining intercellular adhesion. Studies have found that DSG2 can also regulate cell proliferation, differentiation and apoptosis through signal transduction, and plays a key role in regulating intestinal epithelial barrier. With the deepening of research, more and more evidence shows that DSG2 is abnormally expressed in a variety of digestive system tumors, and the expression levels are different. The expression level is closely related to the prognosis of tumors. It is speculated that DSG2 plays different roles in the occurrence and development of different digestive system tumors. This article reviews the biological function of DSG2 and its role in digestive system tumors. [ABSTRACT FROM AUTHOR]

Copyright of Environmental Science & Technology (10036504) is the property of Editorial Board of Environmental Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Ecology & Rural Environment is the property of Journal of Ecology & Rural Environment Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shanghai University / Shanghai Daxue Xuebao is the property of Journal of Shanghai University (Natural Sciences) Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore the clinical effect of Linggui Shugan Decoction combined with electroacupuncture at Fengchi Xuegui on the treatment of vertebrobasilar arterial insufficiency (VBI) vertigo. Methods: A total of 145 patients with VBI vertigo admitted to our hospital from November 2017 to August 2019 were selected as the research objects, and they were divided into a combination group (75 cases) and a control group (70 cases) using a random number table method. Under the premise of basic treatment, the combined group was treated with Lingguizhugan Decoction combined with electroacupuncture at Fengchi's blood supply points, and the control group was treated with Sibelin. The clinical efficacy, dizziness improvement, cerebral arterial blood flow velocity index, arteriosclerosis index (AI) and blood rheology index were compared between the two groups. Results: After treatment, the total effective rate of the combined group was 89.33%, which was higher than 75.71% of the control group (P<0.05); after treatment, the combined group's vertigo symptom score, European Vertigo Rating Scale (EEV) score and vertigo disorder scale (DHI) ) Score was lower than that of the control group (P<0.05); the left artery, basilar artery peak velocity (Vp), left and right lateral arteries, and basilar artery average blood flow velocity (Vm) after treatment in the combined group were all higher than those of the control group., Basilar artery pulsatility index (PI), right arterial resistance index (RI), AI, high-cut whole blood viscosity, mid-cut whole blood viscosity, low-cut whole blood viscosity, plasma viscosity, and hematocrit are all lower than the control Group (P<0.05). Conclusion: Linggui Zhugan Decoction combined with electro-acupuncture at Fengchi supplying blood points in the treatment of VBI vertigo can alleviate the patient's vertigo, with definite curative effect, improving cerebral arterial blood flow velocity and cerebral arteriosclerosis, and reducing blood viscosity. [ABSTRACT FROM AUTHOR]

Copyright of Modern Food Science & Technology is the property of Editorial Office of Modern Food Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Telecommunications Science is the property of Beijing Xintong Media Co., Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Traumatic brain injury (TBI) is a surgical disease with high mortality and disability rates. China is still in a weak stage in the judgment and treatment of TBI. It is necessary to understand the differentially expressed gene and miRNA after TBI at the molecular level，so as to provide basis for better treatment. This paper aims to investigate the differentially expressed gene and miRNA after TBI in rats， and provide a new way for clinical treatment of TBI. GEO2R was used to screen genes，and mirwalk software was adopted to predict the target genes of the screened miRNA， Then， David was used to conduct gene ontology function enrichment analysis， and finally cytoscape was applied to carry out network analysis. Results show that 247 differentially expressed genes were found， including 150 up-regulated genes and 97 down-regulated genes， and 7 differentially expressed miRNAs were found， including 2 up-regulated miRNAs and 5 down-regulated miRNAs. These differentially expressed genes play a role in both intracellular and extracellular processes， as well as in biological processes such as inflammatory response and drug response. By comparing the difference gene and the target gene， 48 overlapped genes were obtained， and it was found that these overlapped genes had a certain relations with the differentially expressed miRNA. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Pharmaceutical Practice & Service is the property of Journal of Pharmaceutical Practice Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Forest Research is the property of Forest Research Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore the effects of chewing gum on anxiety and depression symptoms in patients with primary hepatocellular carcinoma after laparotomy. Methods: Sixty-four patients with hepatocellular carcinoma after laparotomy in the department of hepatobiliary surgery were randomly divided into the chewing group (n = 32) and the control group (n = 32). A total of 60 patients (each group of 30 cases) completed the study. On the basis of routine postoperative care, the chewing group was given sugar-free xylitol and cold mint-flavored chewing gum for 15 min every day from 8:00 and 14:00 on the first day to the fifth day after surgery, while the control group was given routine postoperative care. The state anxiety inventory (SAI) and self-rating depression scale (SDS) were used to evaluate the anxiety and depression of the two groups before intervention, after intervention (5 days after surgery) and follow-up (1 week after intervention). Results: After the intervention, the SAI [ (37.8 ±3.3) vs. (49.4 ±8.3)] and SDS [ (38.9 ±6.8) vs. (48. 9 ±6.3)) scores were lower in the chewing group than in the control group (P <0.05), while the differences in follow-up SAI and SDS scores between the two groups were not sta-tistically significant (P> 0.05). Conclusion: It suggests that chewing gum could be used as a method to improve anxiety and depression in patients with hepatocellular carcinoma after laparotomy. [ABSTRACT FROM AUTHOR]