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Copyright of Journal of International Reproductive Health/Family Planning is the property of Editorial Board of the Journal of International Reproductive Health/Family Planning and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Immunology is the property of Medical Periodical Society of Jilin and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the effect of intrauterine infusion of danhong injection on the outcome of freeze)thawing embryo transfer (FET) in patients with thin endometrium caused by blood stagnation. Methods Sixty-six patients with infertility caused by thin endometrium and treated with FET were enrolled and randomly divided into the treatment group and the control group by random number table method, with 33 cases in each group. In the treatment group, follicular development was monitored from the day 8 to 10 of menstrual cycle, and danhong injection was used for intrauterine infusion every other day when the follicle diameter reached 14 mm to 18 mm. A total of 2-3 times of treatment were performed, while no intervention was given to the control group. After treatment, the endometrial thickness, endometrial blood flow type, live birth rate, positive rate of β-HCG, clinical pregnancy rate, ongoing pregnancy rate, early abortion rate, cycle cancellation rate and embryo implantation rate on human chorionic gonadotropin (HCG) injection day were compared between the two groups. Results The live birth rate, positive rate of β-HCG and persistent pregnancy rate were significantly better in the treatment group than those in the control group, and the endometrial thickness and endometrial blood flow type on ovulation day were significantly better in the treatment group than those in the control group (P＜0.05). There were no significant differences in cycle cancellation rate, embryo implantation rate, early abortion rate and clinical pregnancy rate between the two groups (P＞0.05). Conclusion Intrauterine infusion of danhong injection can improve pregnancy outcome in patients with thin endometrium with good safety. [ABSTRACT FROM AUTHOR]

BACKGROUND: Previous studies have shown that Miao medicine fumigation therapy has a definite effect on the treatment of osteoarthritis; however, its mechanism is unclear. Because excessive angiogenesis in synovial tissue and subchondral bone tissue is an important cause of the occurrence and development of osteoarthritis, vascular endothelial growth factor is an important pro-angiogenesis factor in the body, and the stromal cell-derived factor 1/CXCR4 signaling pathway is closely related to the overexpression of vascular endothelial growth factor. OBJECTIVE: To explore the role of stromal cell-derived factor 1/CXCR4 signaling pathway in the osteoarthritic occurrence and development and the therapeutic mechanism of Miao medicine fumigation on knee osteoarthritis. METHODS: Fifty healthy New Zealand white rabbit were randomized into normal, model, positive control (voltaren ointment for external use), early intervention, and Miao medicine fumigation groups. The knee osteoarthritis model was established in the latter four groups by injecting sodium iodoacetate into the knee joint cavity of rabbits. Hematoxylin-eosin staining was used to observe the pathological changes of synovium and cartilage. Immunohistochemical method was used to detect the levels of interleukin-1β and tumor necrosis factor-α in synovial tissue. ELISA method was used to detect the level of stromal cell-derived factor 1 in synovial fluid and the level of vascular endothelial growth factor in serum. Real-time fluorescence quantitative PCR was used to detect vascular endothelial growth factor mRNA expression in articular cartilage tissue. Western blot assay was used to detect the expression of type II collagen and aggrecan protein in cartilage tissue. RESULTS AND CONCLUSION: Compared with the model group, Miao medicine fumigation treatment significantly inhibited the inflammation in synovium and cartilage tissue and reduced its pathological changes. Compared with the model group, the integral absorbance values of interleukin-1β and tumor necrosis factor-α in synovium and the levels of vascular endothelial growth factor in serum and stromal cell-derived factor in joint fluid were significantly reduced in the Miao medicine fumigation group (P < 0.05). Compared with the model group, the serum vascular endothelial growth factor mRNA was reduced in the Miao medicine fumigation group, while type II collagen and aggrecan expressions were increased (P < 0.05). The above experimental results indicated no significant differences among Miao medicine fumigation group, positive control group and early intervention group (P > 0.05). To conclude, the Miao medicine fumigation therapy maybe by reducing the binding of stromal cell-derived factor 1 to its receptor CXCR4 inhibits the expression of interleukin-1β, tumor necrosis factor-α, and vascular endothelial growth factor, delays the destruction of extracellular matrix, and plays a therapeutic role. [ABSTRACT FROM AUTHOR]

Human papilloma virus (HPV) is one of the most common viruses in reproductive tract infections. The recurrent infection of HPV virus, especially high-risk type HPV, can be turned into cervical epithelial endothelial tumor, and may even induce malignant tumors in the cervix, anus and mouth cavity. Men and women of childbearing age are the most common group of HPV infections, and it has been reported that HPV infection may have adverse effects on reproductive health and pregnancy. In the light of the domestic and international literature published in recent years, the issues related to HPV infection and pregnancy outcome are reviewed. This paper expounds the susceptibility of HPV infection during pregnancy, the effect of HPV infection on abnormal pregnancy, the way of HPV infection and delivery and neonatal outcome, the effect of HPV on success rate of assisted reproductive technology and pregnancy outcome, and the effect of HPV vaccine on pregnancy. [ABSTRACT FROM AUTHOR]

Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease for women of childbearing age. Ovulation stimulation is the main treatment of PCOS, and clomiphene citrate (CC) is the firstline medicine of ovulation stimulant. However, some patients are not sensitive to CC, so -called clomiphene resistant PCOS (CCR-PCOS). Clinically, pre-treatments should be done in the early stage of ovulation induction in order to achieve a good therapeutic effect, including lifestyle management, improvement of insulin resistance, reduction of androgens and lipid levels, etc., the single or combined stimulation therapy was then selected among letrozole, gonadotropin and laparoscopic ovarian drilling. It is worth noting that IVF can be used to facilitate pregnancy in those CCR-PCOS patients with the first- and second-line ovulation induction failure or with other IVF indications (such as advanced age, fallopian tube factors or male factors leading to infertility). The pregnancypromoting strategies of CCR-PCOS patients were reviewed in this paper. [ABSTRACT FROM AUTHOR]

The fertility decline caused by oocyte aging and the decreased ovarian reservation is a bottleneck problem in the field of reproduction，Improving ovarian reserve function is an important factor to improve the natural pregnancy rate and ART success rate of infertile women. It has been found that sirtuin 1 (SIRT1) is an important player in regulating the key processes of oogenesis and cellular stress response. SIRT1 can inhibit oocyte senescence by regulating oocyte number, improving oocyte quality, inhibiting oxidative stress and regulating mitochondrial function. Therefore, SIRT1 can improve the ovarian reserve function and prolong ovarian life. SIRT1 can also increase the number of eggs, embryo formation rate and clinical pregnancy rate during assisted reproductive technology (ART). This paper reviews the research progress on SIRT1 in improving ovarian reserve function by inhibiting oocyte senescence. [ABSTRACT FROM AUTHOR]