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2016年6月，福州动物园5只环尾狐猴（Lemur catta）相继发生食欲不振，高烧不退，呼吸困难，急性腹泻等临床症状，诊断结果疑似为不动杆菌（Acinetobacter）感染。诊断依据是：①提示性临床症状，精神萎靡、高热、呼吸障碍；②剖检及病理检查特征病变，出现肺组织出血性坏死性病变，肺气肿、肺水肿，肝炎及其他脏器出血性病变；③细菌分离及PCR检测，鉴定为不动杆菌。药敏试验结果显示，该菌对恩诺沙星、诺氟沙星、环丙沙星、氧氟沙星等喹诺酮类药物敏感。针对性用药后，环尾狐猴群的病症得以解除。该病的发生与福州高温高湿天气相关，夏季的防暑降温以及提高动物抵抗力是预防的关键。

Copyright of Chinese Journal of Clinical Healthcare is the property of Chinese Journal of Clinical Healthcare and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of CT Theory & Applications is the property of Editorial Department of CT Theory & Applications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Herein, we report a method for constructing protein models via 3D printing, and demonstrate it using a series of protein models with distinct structures. These models can be used in teaching to visualize hierarchical protein structures in real space and to help students understand topics such as protein folding and protein-protein interactions. They are also useful in scientific research as aesthetically appealing representations and pieces of art for the popularization of science. [ABSTRACT FROM AUTHOR]

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Objective To investigate the risk factors of hemorrhagic pituitary adenoma apoplexy. Methods The clinical date of 875 patients with non-functioning pituitary adenoma from January 2010 to January 2021 in the Department of Neurosurgery, Affiliated Hospital of Qingdao University were analyzed retrospectively. According to the occurrence of pituitary adenoma hemorrhagic stroke, the patients were divided into stroke group (88 cases) and non-stroke group (787 cases). The risk factors affecting the occurrence of pituitary adenoma hemorrhagic stroke were screened by univariate analysis and multivariate logistic regression analysis. Results The proportion of bromocriptine therapy, the history of taking antithrombotic drugs, recurrent or residual tumor, and the history of intervention operation in the patient with pituitary apoplexy were higher than those without pituitary apoplexy. The proportion of microadenoma in pituitary adenoma apoplexy group was lower than non-apoplexy group. The difference between the two groups has statistical significance (P＜0.05). Multivariate logistic regression analysis indicated that macroadenoma (OR=0.189, 95%CI:0.069-0.522, P=0.001), the history of taking antithrombotic drugs (OR=4.168, 95%CI:1.611-10.785, P=0.003), bromocriptine therapy (OR=2.912, 95%CI:1.156-7.34, P=0.023) and recurrent or residual tumor (OR=2.787, 95%CI:1.179-6.59, P=0.020) were independent risk factors of pituitary apoplexy. Conclusion The risk factors of hemorrhagic pituitary apoplexy are macroadenoma, the history of taking antithrombotic drugs, bromocriptine therapy and recurrent or residual tumor. Objective To investigate the risk factors of hemorrhagic pituitary adenoma apoplexy. Methods The clinical date of 875 patients with non-functioning pituitary adenoma from January 2010 to January 2021 in the Department of Neurosurgery, Affiliated Hospital of Qingdao University were analyzed retrospectively. According to the occurrence of pituitary adenoma hemorrhagic stroke, the patients were divided into stroke group (88 cases) and non-stroke group (787 cases). The risk factors affecting the occurrence of pituitary adenoma hemorrhagic stroke were screened by univariate analysis and multivariate logistic regression analysis. Results The proportion of bromocriptine therapy, the history of taking antithrombotic drugs, recurrent or residual tumor, and the history of intervention operation in the patient with pituitary apoplexy were higher than those without pituitary apoplexy. The proportion of microadenoma in pituitary adenoma apoplexy group was lower than non-apoplexy group. The difference between the two groups has statistical significance (P＜0.05). Multivariate logistic regression analysis indicated that macroadenoma (OR=0.189, 95%CI:0.069-0.522, P=0.001), the history of taking antithrombotic drugs (OR=4.168, 95%CI:1.611-10.785, P=0.003), bromocriptine therapy (OR=2.912, 95%CI:1.156-7.34, P=0.023) and recurrent or residual tumor (OR=2.787, 95%CI:1.179-6.59, P=0.020) were independent risk factors of pituitary apoplexy. Conclusion The risk factors of hemorrhagic pituitary apoplexy are macroadenoma, the history of taking antithrombotic drugs, bromocriptine therapy and recurrent or residual tumor. [ABSTRACT FROM AUTHOR]

Existing knowledge graph query methods ignore the geographic location information of entities themselves, so they do not support geographic location related queries. In view of this problem, on the basis of the hybrid knowledge graph integrating geographic location information, this study proposes a knowledge graph query method based on geographic location information. By extracting the triples from the query problem, the corresponding query graph is constructed to understand the natural language query problem. The query problems based on geographic location information are divided into six categories, and combined with the existing semantic query methods for fact-based problems, the corresponding knowledge graph query methods are studied according to the query graph or K-nearest neighbor search idea. Experimental results show that the accuracy rate of the proposed method can reach more than 77%, which can provide effective support for query based on geographic location information. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Clinical Neurosurgery / Linchuang Shenjingwaike Zazhi is the property of Editorial Board of Journal of Clinical Neurosurgery and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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报道了国内圈养羊驼（Vicugna pacos）住肉孢子虫病的确诊病例。诊断的依据是：（1）提示性临床症状，动物机体出现消瘦、贫血症状，临床出现肌肉震颤和神经症状。（2）尸体剖检特征性病变，心冠脂肪萎缩，呈胶冻样变；心包、胸腔有较多积液；食管平滑肌内有多个纺锤形的虫体包囊，呈乳白色，与肌纤维平行。（3）组织病理学特征，镜下食道平滑肌内可见住肉孢子虫包囊、小室及慢殖子；肌纤维出现不同程度的透明变性、萎缩、溶解，间质结缔组织增生。住肉孢子虫属专性异宿主性寄生虫，尚无特效药物，定期查虫驱虫、提高机体抵抗力和严控环境猫狗的流窜是预防本病的关键。

首次报道了国内圈养斑纹角马肝片吸虫病确诊病例。诊断依据:(1)提示性临床症状:贫血、消瘦、营养不良;(2)尸体剖检特征性病理变化:胆管显著扩张和胆管内挤排出大量肝片吸虫成虫的虫体;(3)肝片吸虫感染强度测定:运用麦克马斯特法测定了病死角马肝片吸虫感染强度为1 600个/g;(4)中间宿主调查:角马的饲养区内发现大量椎实螺,椎实螺体内含有大量的肝片吸虫尾蚴;(5)组织病理学检查:细支气管和肺泡腔内见有童虫的虫体结构。首次证实了角马肝片吸虫感染时,童虫在移行过程中可误移至肺,导致肺的病理变化。该病的发生与环境潮湿多水、环境中存在大量椎实螺而未被重视有关。肝片吸虫宿主范围广,应重视易感动物的生活环境,定期粪检确定感染率和感染强度,以及选择有效的药物防治,这是科学预防该病的关键。