Search

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Lubrication Engineering (0254-0150) is the property of Editorial Office of LUBRICATION ENGINEERING and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food & Machinery is the property of Food & Machinery Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Environmental Science & Technology (10036504) is the property of Editorial Board of Environmental Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Technology Economics is the property of Chinese Society of Technology Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Bulletin of Botanical Research is the property of Bulletin of Botanical Research Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To observe the effects of exosomes derived from human umbilical cord mesenchymal stem cells on the proliferation and invasion of pancreatic cancer cells, and to analyze the contents of exosomes and explore the mechanisms affecting pancreatic cancer cells. Methods Exosomes extracted from human umbilical cord mesenchymal stem cells were added to pancreatic cancer cells BxPC3, Panc-1 and mouse models of pancreatic cancer, respectively. The proliferative activity and invasion abilities of BxPC3 and Panc-1 cells were measured by cell counting kit-8 ( CCK-8 ) and Transwell assays. The expressions of miRNAs in exosomes were detected by high-throughput sequencing. GO and KEGG were used to analyze the related functions and the main metabolic pathways of target genes with high expressions of miRNAs. Results The results of CCK-8 cell proliferation assay showed that the absorbance of BxPC3 and Panc-1 cells in the hucMSCs-exo group was significantly higher than that in the control group [ (4.68±0.09) vs. (3.68±0.01), P<0.05; (5.20±0.20) vs. (3.45±0.17), P< 0.05]. Transwell test results showed that the number of invasion cells of BxPC3 and Panc-1 in hucMSCs-exo group was significantly higher than that in the control group (129.40±6.02) vs. (89.40±4.39), P<0.05; (134.40±7.02) vs. (97.00±6.08), P<0.05. In vivo experimental results showed that the tumor volume and weight in the exosomes derived from human umbilical cord mesenchymal stem cells (hucMSCs-exo) group were significantly greater than that in the control group [ (884.57±59.70) mm3 vs. (695.09±57.81) mm3, P<0.05; (0.94±0.21) g vs. (0.60±0.13) g, P< 0.05]. High-throughput sequencing results showed that miR-148a-3p, miR-100-5p, miR-143-3p, miR-21- 5p and miR-92a-3p were highly expressed. GO and KEGG analysis showed that the target genes of these miRNAs were mainly involved in the regulation of glucosaldehylation, and the main metabolic pathways were ascorbic acid and aldehyde acid metabolism, which were closely related to the development of pancreatic cancer. Conclusion Exosomes derived from human umbilical cord mesenchymal stem cells can promote the growth of pancreatic cancer cells and the mechanism is related to miRNAs that are highly expressed in exosomes. [ABSTRACT FROM AUTHOR]

Copyright of Nankai Business Review is the property of Nankai Business Review Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of West China Journal of Stomatology is the property of Sichuan University, West China College of Stomatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Oncology is the property of Chinese Journal of Oncology / Zhonghua Zhongliu Zazhi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Jilin University (Science Edition) / Jilin Daxue Xuebao (Lixue Ban) is the property of Zhongguo Xue shu qi Kan (Guang Pan Ban) Dian zi Za zhi She and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the economic burden of inpatients with hepatitis B virus (HBV) infection-related diseases (including primary liver cancer, hepatitis B cirrhosis, and chronic hepatitis B) and its impact on family financial status in Qidong, Jiangsu Province, China. Methods Cluster random sampling was used to select consecutive cases of HBV infection-related diseases who were hospitalized in The People′s Hospital of Qidong and Qidong Hospital for Infectious Diseases from May 1, 2014 to March 31, 2015. A questionnaire survey was performed to collect their demographic data, clinical data, direct medical costs within the past three years, direct non-medical costs, loss of income due to missed work, and the impact of disease on family financial status. The Wilcoxon rank sum test or the Kruskal-Wallis H rank sum test was used to analyze the impact of various factors on economic burden, such as clinical stage, age, sex, educational level, occupation, type of medical insurance, and family income. The chi-square test or Fisher′s exact test was used to analyze the difference in family economic pressure caused by different disease types after HBV infection. Results The total costs of primary liver cancer, hepatitis B cirrhosis, and chronic hepatitis B within the past three years were 94001 yuan, 63421 yuan, and 39360 yuan, respectively, and direct medical costs accounted for 84.7%, 83.6%, and 89.9%, respectively. The self-paid costs within the past one year accounted for 996%, 59.4%, and 16.7%, respectively, of the annual family income. There was a significant difference in the proportion of patients with great economic pressure between the three groups (38.7% vs 43.1% vs 11.3%, χ2=30.066, P＜0.001). There were also significant differences in the number of missed working days and loss of income due to missed work (7903 yuan vs 6280 yuan vs 2600 yuan, χ2=68.601, P＜0.001). Conclusion HBV infection-related diseases bring considerable burden to inpatients and their families, and the economic burden increases with a longer course of disease and more serious conditions. With the progression of chronic hepatitis B to hepatitis B cirrhosis and primary liver cancer, diseases impose greater economic pressure on families, and patients themselves and their relatives may suffer from greater loss of income due to missed work. Prevention and control of HBV infection has great social and economic benefits. [ABSTRACT FROM AUTHOR]

Objective To quantify the medical expenditure per case of patients with hepatitis B virus-related diseases in Qidong, Jiangsu, China, and analyze its composition and related influencing factors. Methods Cluster sampling was used to select consecutive cases in The People′s Hospital of Qidong and Qidong Infectious Diseases Hospital. A total of 217 hospitalized patients of HBV related primary liver cancer, 234 hospitalized patients with HBV related B cirrhosis, and 136 hospitalized patients with chronic hepatitis B (CHB) were enrolled, and the total inpatient and outpatient costs (medical costs per case) from January 2010 to December 2012 and related clinical data were collected from the hospital records. Expert consultation was performed to investigate the costs per case of patients with acute hepatitis B, HBsAg asymptomatic carriers, and occult HBV infection. Costs in different years were converted based on the consumer price index for medical and health consumption in 2014. The independent samples t-test was used for comparison of continuous data between groups, an analysis of variance was used for comparison between multiple groups, and the SNK-q test was used for comparison within each group. Multiple linear regression analysis (stepwise regression) was used to investigate the influencing factors for medical costs per case. Results The medical costs per case of patients with HBV related primary liver cancer, patients with HBV related cirrhosis, and CHB patients from 2010 to 2012 were 30183 RMB, 22066 RMB, and 15703 RMB, respectively, and the inpatient costs were 29058 RMB, 21383 RMB, and 15394 RMB, respectively, which accounted for 96.3%, 96.9%, and 98.0% of the medical costs per case. Drug costs of these three groups accounted for 55.0%, 73.4%, and 78.2% of the medical costs per case, respectively. The number of times of hospitalization (F=89.1, 67.7, and 11.5, all P＜0.001), treatment regimen (F=21.8, t=-2.1, and t=-3.7, P＜0.001, P=0.039, and P＜0.001), and type of medical insurance (t=3.1, 2.6, and 2.7, P=0.002, 0.011, and 0.012) were influencing factors for medical costs per case, while clinical stage was an influencing factor for medical costs per case only in CHB patients (a multivariate analysis for patients mild, moderate, and severe CHB: β=1.238, F=5.9, P=0.021). The medical costs per case for patients with acute hepatitis B were 5950 RMB, and the annual medical costs for HBsAg asymptomatic carriers and patients with occult HBV infection ranged from 770 RMB to 1540 RMB. Conclusion The medical costs of HBV related is increasing as the illness progresses. Our results will provide baseline information for the following economic evaluation of vaccination or screening interrention. [ABSTRACT FROM AUTHOR]