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目的罕见的原发性腰椎间隙感染肺炎克雷伯菌合并阴沟肠杆菌的临床诊疗初探，为此类罕见脊柱感染诊疗提供临床经验。方法腰痛伴左下肢麻痛7月余、加重1周余的老年男性患者，经实验室、影像学检查，诊断为腰椎间盘突出症，入院后症状急性加重，复查腰椎增强MRI示L3/4椎间隙后部局部强化信号，VAS评分9分，腰部JOA评分6分。实施腰椎后路L3/4、L4/5椎间盘摘除＋cage植骨融合＋L3-L5椎弓根钉棒内固定术，并留取术中L3/4椎间盘标本备细菌培养。结果细菌培养结果回示肺炎克雷伯杆菌及阴沟肠杆菌感染，术后敏感抗生素治疗6周，患者在术后半年的随访中获得痊愈。结论对临床表现为急性剧烈腰痛或下肢疼痛的中老年患者，在常规实验室、影像学检查提示腰椎退行性疾病的同时应考虑脊柱感染可能。

针对硅光芯片在应用中由于其模场较小存在耦合损耗较大的问题，文章利用一款硅光调制器芯片对其与单模光纤的耦合效率进行了研究。首先对模场匹配理论进行了分析，随后对硅光芯片以及耦合用的单模光纤进行了模场测试，提出了一种提高耦合效率的低成本耦合方式。实验结果表明，该单模光纤与硅光芯片的耦合效率达到70%。利用该方案制作了光组件并进行了四阶脉冲幅度调制（PAM4）眼图测试，得到了较好的眼图。

首先总结了近些年单层网壳的节点刚度对结构静力力学性能和地震响应影响的研究概况。前人的研究中大多没有按照实际情况考虑焊接空心球的刚度,而强震下部分球节点的塑性变形可能会明显影响到结构整体的动力特性。在这方面开展了一些深入的研究,研究表明在建模时建立考虑球节点刚度的精细化模型是必要的,除此之外,要想真正实现精细化研究还需在几何精细化模型的基础上加入能够考虑损伤累积效应的本构模型,实现双重精细化。

文章采用自适应均衡技术对偏振模色散（PMD）进行补偿,给出了判决反馈均衡器（DFE）结构,通过对前向均衡器（FFE）部分的改进,得到了适用于高速光纤通信系统的行波滤波器（TWF）及折叠级联的TWF结构,最后通过ADS仿真软件,得到了系统S参数仿真结果。

【目的】 观察离子型谷氨酸受体AMPA受体和NMDA受体在leptin参与神经病理性痛机制中的作用.【方法】 用膜片钳全细胞模式记录leptin是否影响正常大鼠脊髓切片背角Ⅱ层神经元AMPA受体和NMDA受体介导的电流;大鼠鞘内注射leptin,持续14 d,在第1,3,7,14天检测热痛阈和机械痛阈,在第14天处死动物,用免疫组化法和western blot检测脊髓背角AMPA受体和NMDA受体的表达.【结果】 灌流液中加入leptin能增加NMDA受体介导的电流,并有剂量依赖性,100 nmol/L leptin的作用最显著,leptin对AMPA受体介导的电流无影响;大鼠鞘内注射leptin,在第14天明显降低热痛阈和机械痛阈;leptin增加了脊髓背角NMDA受体亚单位NR1的表达,但是对AMPA受体亚单位GluR1的表达无影响,NMDA受体拮抗剂MK-801可抑制并逆转leptin诱导的痛行为及抑制leptin诱导的NR1表达增多.【结论】 Leptin可能通过影响NMDA受体参与神经病理性痛的发生.

【目的】了解高龄孕妇的妊娠结局,为提高该高危人群的围产期预后提供指导。【方法】回顾性分析2006年2月11日至2006年10月7日在我院分娩的156例年龄介于35～48岁高龄孕妇的妊娠结局,并随机选择同期分娩的年龄介于21～34岁的孕妇156例作为对照。【结果】高龄组剖宫产率及辅助生育受孕率均显著高于对照组,妊娠期糖尿病及糖耐量异常、胎儿窘迫、早产的发生率高于对照组,而HSV及CMV感染显著低于对照组,两组新生儿畸形率及围产儿死亡率差异无显著性。【结论】高龄与早产、胎儿窘迫、妊娠期糖尿病、剖宫产率升高等不良妊娠结局密切相关。在妊娠期应加强对高龄孕妇糖尿病和早产等高危因素的筛查,分娩过程中密切监护,及早发现胎儿窘迫的征兆,改善妊娠结局。

【目的】探讨子宫内膜异位早期种植的相关基因,特别是与早期种植相关的血管生长基因。【方法】采用裸鼠人子宫内膜皮下种植的方法,建立裸鼠人子宫内膜异位症模型,在种植后14d,取出成模病灶与未种植内膜进行CSC-GE-80基因芯片筛查比较。【结果】在基因表达谱中最有显著性上调基因50个,最有显著性下调基因47个,包括生长因子和细胞因子及其受体的变化,其中生长因子受体结合蛋白10（growth factor receptor-bound protein10,Grb10）与丁酸盐反应因子1（butyrate response factor 1）中表皮生长因子（EGF-response factor 1）上调明显,下调明显胰岛素样生长因子结合蛋白7（insulin-like growth factor binding protein 7）。【结论】通过基因筛查我们初步考虑生长因子结合蛋白10（growth factor receptor-bound protein 10）有可能参与早期异位内膜的血管生长。

【目的】探讨腹腔镜手术对女性不孕患者的治疗效果, 了解术后怀孕时间分布特点, 以期指导患者进一步治疗。 【方法】收集自1997 年1 月至1998 年12 月在我院接受腹腔镜手术治疗的女性不孕患者共401 例, 分子宫内膜异位症、输卵 管伞端闭锁、多囊卵巢综合征、子宫肌瘤和盆腔粘连组, 追踪分析其手术后妊娠率及术后妊娠时间的分布特点。【结果】子宫 内膜异位症组术后妊娠率为50.0 %;输卵管伞端闭锁组32.9 %;多囊卵巢综合征组52.8%;子宫肌瘤组36.0%;盆腔粘连组 42.0%。绝大部分妊娠(93.0 %)在术后18 个月内发生。【结论】腹腔镜手术对不同盆腔病变引起的不孕均有一定疗效;手术 有效者多在术后18 个月内妊娠, 术后一定时间内不能妊娠者建议接受辅助生育治疗, 使患者及时获得妊娠。

【目的】探讨腹腔镜下保守性手术治疗输卵管妊娠的效果、安全性。【方法】选择我院腹腔镜下作输卵管修补术 的输卵管壶腹部妊娠 30 例,同时选择同期经剖腹输卵管修补术的输卵管壶腹部妊娠 27 例,比较两组术中及术后妊娠的情况。 【结果】腹腔镜组手术时间、术后住院时间均较剖腹组明显缩短,腹腔镜组比剖腹组术后妊娠率高、未增加重复异位妊娠率, 1 年内腹腔镜组受孕快。【结论】腹腔镜融诊断与治疗于一体,在输卵管妊娠方面, 对于希望保留生育功能的妇女, 有不可取代 的优势。

With the increasing complexity of aircraft landing gear retractable mechanism, the effect of multiple structural clearances coupling on the motion accuracy of the mechanism is more significant. The motion accuracy reliability of complex mechanism presents the characteristics of high nonlinear degree, many influencing parameters and small sample size, so it is very difficult to study. For this problem, this paper proposes a method for analyzing the motion accuracy reliability of the mechanism by combining theoretical analysis, dynamics joint simulation, and clearance wear. Firstly, a dynamic model of the retractable mechanism considering seven structural clearances is established to study the independent and coupled effects of structural clearances on the retracting accuracy. Then, the analysis model of the structural wear with the increase of retracting cycles is established to obtain the change rule of clearance, and then the reliability analysis model of retractable mechanism motion accuracy with the change of retracting cycles is established. Finally, based on the adaptive Kriging surrogate model, the reliability of the landing gear retractable mechanism is analyzed, and the variation law of reliability with retracting cycles is provided. The research results show that the structural clearances at different locations have varying degrees of impact on the motion accuracy of the mechanism, and the probability of mechanism failure shows a trend of initially stabilizing and then sharply increasing. The proposed analysis method provides an important analytical means for the motion reliability evaluation of complex landing gear mechanisms. [ABSTRACT FROM AUTHOR]

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Objective: To investigate whether the lung specific X protein (LUNX) gene can serve as a prognostic biomarker for non-small cell lung cancer related to immune cell infiltration. Methods: A total of 280 non-small cell lung cancer patients admitted to Hengshui People's Hospital from January 2020 to January 2023 were selected to detect the expression of LUNX gene in cancer tissue and adjacent tissues, and to analyze the relationship between LUNX gene and immune cell infiltration and prognosis survival status in the tumor microenvironment. Results: Compared with adjacent tissues, the expression level and positive rate of LUNX gene in nonsmall cell lung cancer tissue were increased, which were related to differentiation degree, lymph node metastasis and tumor staging (P<0.05). GEPIA database analysis showed that the LUNX gene was only slightly expressed or not expressed in other tissues, while its expression was elevated in LUAD and LUSC (P<0.05). The copy number of LUNX gene and LUNX gene were related to the level of immune cell infiltration( P<0.05). Survival analysis showed that high expression of the LUNX gene was associated with patient survival prognosis (P<0.05). Conclusion: The LUNX gene is specifically expressed in non-small cell lung cancer tissue, affecting the level of immune cell infiltration in non-small cell lung cancer, leading to an imbalance in the immune microenvironment, and is an important mechanism for causing patients prognostic death, which can be used as a prognostic biomarker for evaluating immune cell infiltration. [ABSTRACT FROM AUTHOR]