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Objective To explore the follow-up management mode of patients with prostate cancer during COVID-19 pandemic. Methods We sent questionnaires by internet and telephone to 76 patients with prostate cancer from May 2020 to April 2021 for follow-up management.The patients were divided into radical operation group (53 cases) and drug treatment group (23 cases).According to the severity of the disease classification management, they were divided into active monitoring and priority treatment. The quality of life was assessed with QLQ-C30, and the psychological status was assessed with SAS and SDS. Individualized treatment for each patient based on the evaluation results.The disease progress, quality of life and psychological status of the patients at the initial management, 3 months, 6 months and 12 months were comparatively analyzed. Results All patients successfully completed follow-up management of the new model.In the radical operation group, 1 case (1.89%) developed disease progression within 12 months.Except that the scores of role and cognitive function were not significantly different from those in the initial survey (P> 0.05),other life quality scores and psychological status after 3, 6 and 12 months new model follow-up management were stable and significantly better than those at the initial survey (P<0.05).In the drug treatment group, 5 patients (21.74%) developed disease progression within 12 months, the quality of life and psychological state of the patients were stable after 3, 6 and 12 months follow-up management, which was significantly better than those at the initial investigation (P<0.05). Conclusion During the COVID-19 pandemic, we applied a new follow-up management model (Internet and telephone) to regularly evaluate the condition,quality of life and psychological status of patients with prostate cancer. Evaluation data-based individualized treatment will be helpful to delay the progress of the disease and improve the quality of life and mental state of patients. [ABSTRACT FROM AUTHOR]

目的 探讨进阶式培训模式在泌尿外科规范化培训 (规培) 医师技能培训中的应用效果。 方法 选取 2018 年 8 月至 2021 年 7月在该院泌尿外科进行培训的 48 名规培医师 (学员), 随机分为试验组和 对照组,每组 24 名。试验组采用进阶式培训模式进行腹腔镜基本技能培训,对照组采用传统带教模式进行腹 腔镜基本技能培训,培训3个月后对两组学员进行基本技能考核,并通过调查问卷的形式了解学员对培训模式 的满意度。结果 试验组学员的最终技能考核成绩 [(90.5±3.4) 分] 明显高于对照组 [(81.3±4.9)分], 对培 训模式的满意度评分显著高于对照组,差异均有统计学意义 (P<0.05)。结论 在泌尿外科规培医师腹腔镜基 本技能培训中采用进阶式培训方式可取得良好教学效果,且可获得学员的积极认可,有利于提高整体培训质 量,实现均质化目标。 [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Water Conservancy & Electric Power Technology & Application is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Forest Engineering is the property of Forest Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: There are few studies, especially in China, addressing the correlation between exosome miRNAs and graft-versus-host disease (GVHD) following human hematopoietic stem cell transplantation. Exosome-derived nucleic acid molecules are expected to become new biomarkers for predicting the occurrence of acute GVHD (aGVHD). OBJECTIVE: To investigate the differential expression of candidate gene microRNAs in peripheral blood serum exosomes of aGVHD patients with after allogeneic hematopoietic stem cell transplantation. METHODS: A total of 30 patients with aGVHD and without aGVHD after allogeneic hematopoietic stem cell transplantation from August 2017 to May 2018 were enrolled, including 20 in aGVHD group and 10 in non-aGVHD group. Serum exosomes and miRNAs were extracted before and after transplantation. Image acquisition and data analysis were performed after gene chip hybridization. RESULTS AND CONCLUSION: After microarray hybridization microRNAs showed an over 10-fold upward or downward trend before and after transplantation. Compared with the control group, 11 microRNAs increased and 26 decreased in the aGVHD group. hsa-miR-3976, hsa-miR-122-5p, and hsa-miR-3125 were significantly up-regulated, while hsa-miR-941, hsa-miR-4687-5P and hsa-miR-4769-5p were significantly down-regulated. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the optimization method of administration of biapenem in patients with severe infection. METHODS: 70 patients with severe infection admitted into the First People’s Hospital of Changzhou from Mar. 2015 to Mar. 2016 were extracted to be divided into observation group(40 cases) and control group(30 cases) via the random number table. Monte Carlo method was used to fit different administration regimens to obtain two regimens with better pharmacodynamic target values. The control group was given biapenem of 0.3 g, administration was provided in once every 6 hours with intravenous drip for 30 min; while the observation group received biapenem of 0.3 g, administration was provided in once every 8 hours with micropump infusion for 3 h. The clinical efficacy, bacterial clearance, mean administration time, mean cost and incidence of adverse drug reactions of two groups were compared. RESULTS: The total effective rate of observation group and control group were respectively65. 0%(26/40) and 63. 3%(19/30), without any statistically significant difference(P > 0.05). The bacterial clearance of observation group and control group were respectively 27. 5%(11/40) and 20.0%(6/30), without any statistically significant difference(P > 0.05). The mean administration time of observation group was(6. 23 ± 2. 50) d, significantly shorter than that of control group [(8. 40 ± 3. 95) d], with statistically significant difference(P < 0.05).The mean cost of observation group was(3 762 ± 2 054) yuan, significantly lower than that of control group[(5 571 ± 2 938) yuan], with statistically significant difference(P < 0.05). There was no statistically significant difference between two groups in the incidence of adverse drug reactions(P > 0.05). CONCLUSIONS: The efficacy of3 h pumping administration of biapenem in patients with severe infection was better than that of routine intravenous drip for 30 min, with less dosage, shorter course of treatment and less cost. [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)