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In order to explore the effective measures to improve the reclaimed land in the loess area, this study set four additives, namely, cow dung, chicken manure, green manure and microbial inoculum, and 10 treatments with water-retaining agent. Field experiments were conducted to study the characteristics of plant growth and soil nutrients under different treatments, in order to find out whether the addition of water-retaining agent can cooperate with exogenous additives to have a positive impact on the reclamation in the mining area. The results showed that: Most exogenous additives combined with water-retaining agent can promote the growth of Astragalus mongholicus in different degrees, and water-retaining agent combined with cow dung and chicken manure can promote the increase of plant height and biomass of A. membranaceus, but the opposite is true under the application of microbial agents; Water-retaining agent combined with chicken manure and green manure can increase the root diameter of two-level roots. Water-retaining agent combined with organic fertilizer can increase soil organic matter and nitrogen content, while microbial agent treatment is not conducive to increase soil organic matter and nitrogen content; The application of water-retaining agent combined with cow manure and chicken manure decreased the total phosphorus content in soil, and the water-retaining agent combined with green manure and microbial inoculants could increase the total phosphorus content in soil, which had the opposite effect on available phosphorus. Comprehensive evaluation and analysis showed that water-retaining agent cooperated with green manure and microbial inoculum can promote the growth of A. membranaceus, and water-retaining agent cooperated with microbial inoculum can also improve soil nutrients. Without water-retaining agent, most growth indexes of A. membranaceus were negatively correlated with soil total phosphorus and available phosphorus; Under the treatment of adding water-retaining agent, most growth indexes of A. membranaceus were only negatively correlated with soil total phosphorus. To sum up, water-retaining agent and microbial inoculum can promote the growth of A. membranaceus and improve soil nutrients, but the soil fertility level after improvement is still low, so it is suggested that the amount of exogenous additives should be increased in actual production. [ABSTRACT FROM AUTHOR]

[Objective] This study aimes to accurately evaluate the soil improvement benefits and to reveal the nutrient limitations under different vegetation types in the open-pit dump in the sandy loess area, so as to provide a theoretical basis to construct an efficient vegetation restoration model for ecological reconstruction and environmental improvement in this area. [Methods] The soils from ten kinds of vegetation restoration modes, belonging to three vegetation types of forest, shrub, and grass were selected as study samples, while the soil from the newly dumped land was selected as control. The ecological stoichiometric characteristics of soil organic carbon, total nitrogen and total phosphorus and their relationships were studied. [Results] The values of soil organic carbon, total nitrogen, and total phosphorus for soil under different vegetation types of dump in sandy loess region varied between 0.62～18.60 g/kg, 0.09～0.36 g/kg and 0.04～0.21 g/kg, respectively. The values of soil organic carbon and total nitrogen in the forest land and shrub land were significantly greater than those in the newly dumped land(p≤0.05), and the values of total phosphorus in the arboreal land were significantly lower than those in the other three plots(p≤0.05). In the vertical section of soil layer, the soil nutrients of three types of planting cover enriched in the surface layer. The soil total nitrogen amount of shrub land was the highest in different soil layers, the mean soil organic carbon amount of arbor land was the highest, and the mean soil total phosphorus amount of grass land was the highest. There was no significant difference in soil C/N among different vegetation types(p＞0.05). Soil C/P and soil N/P were greatly affected by vegetation types, and all of them showed the order: new soil dumping of arbor land＞shrub land＞grass land＞new dump. In the vertical section of soil layer, soil C/N showed the increasing trend overall, and soil N/P firstly decreased and then increased with the increase of soil layer depth. Soil organic carbon was significantly positively correlated with soil C/N, C/P and N/P(p≤0.01). Soil total nitrogen was significantly positively correlated with soil C/P and N/P(p≤0.01), while soil total phosphorus was on the contrary. Soil N/P in arbor land was high, and vegetation growth was limited by the phosphorus amount. Soil N/P in grass land and shrub land was low, and vegetation growth was limited by the nitrogen amount. [Conclusion] It is suggested that grass and shrub should be planted at the early stage of vegetation restoration to improve soil surface nutrients; furthermore, nitrogen fertilizer should be applied appropriately. With the improvement of soil fertility, trees should be gradually planted and phosphorus fertilizer should be applied to enhance the reclamation effect. [ABSTRACT FROM AUTHOR]

The incidence of cancer has remained high in recent years, and anti-tumor treatment methods are emerging. Cancer treatment has undergone significant changes, and the survival rate of patients with cancer has significantly improved. Various types of new anti-tumor treatments may not only treat and control tumor growth but also place patients in critical situations that require treatment by intensive care medical personnel. Patients with cancer are in critical condition mainly due to three reasons: severe cases caused by cancer diseases themselves, complications during the perioperative period, and accompanying diseases and hospital acquired diseases. In the new situation, we should consider patient characteristics, such as abnormal metabolism, abnormal coagulation system, and abnormal immune mechanism, to save them from serious illness. We need to comprehensively evaluate patients with cancer, emphasize the role of the Intensive Care Unit (ICU) treatment platform, and promote the treatment concept of planned transfer to ICU, to improve the success rate and efficiency of treatment. After transferring the patient out of the ICU, the planned follow-up anti-tumor treatment can still be continued as the endpoint of ICU treatment for critically ill patients with cancer. In the future, efforts will be devoted to establishing a discipline and talent echelon with distinctive characteristics of oncology critical care medicine and treating “the critical illness of cancer and the cancer of critical illness”. [ABSTRACT FROM AUTHOR]

This paper proposes a multi-scale structure that integrates deep neural networks and Transformer features, aiming to address the issue of performance degradation in salient object detection networks when objects of different sizes appear in the same scene. When dealing with objects of different scales, the performance of existing methods often fluctuates due to the contradiction between sampling depth and receptive field size. To tackle this challenge, three different sampling rates were adopted to sample the feature maps,and the Transformer module was used to learn global context information.This method enables the effective fusion of the characteristics of Convolutional Neural Networks (CNNs) and Transformer networks,thereby innovatively proposing a salient object detection strategy for multi-scale objects.Experimental results on three public datasets,UHRSD-TE,DUT-OMRON,and DUTS-TE,demonstrate that this method performs excellently in the task of salient object detection for objects of different sizes in the same scene. [ABSTRACT FROM AUTHOR]

MicroRNA395 is a conserved miRNA family in higher plants, which mainly responses to sulfur starvation by targeting low affinity sulfate transporter(AST) and ATP sulfonylases(APS). Sulfur starvation significantly affects the process of nodulation and symbiotic nitrogen fixation of nitrogen fixing plants. To elucidate the role of miR395 in nodulation and symbiotic nitrogen fixation in leguminous plants, in this study, bioinformatics prediction was performed on the member of pvu-miR395 family members in red kidney bean, and differential expression analysis of pvu-miR395 in different tissues and at different periods of rhizobium infection was conducted. The results showed that eight members of miR395 family were identified in whole genome level, located on chromosomes 2 and 3. The mature and star sequences of miR395 family members in red kidney bean were highly conserved, and their precursor could generate stable secondary structures. Further phylogenetic analysis of miR395 family members in Phaseolus vulgaris, Glycine max, Medicago truncatula, Arabidopsis thaliana, and Oryza sativa were conducted to divide the members into four subfamilies(Group Ⅰ - Ⅳ). cis-acting element analysis revealed that the family members might be involved in plant hormones response, stress response, plant growth, and development. qRT-PCR differential expression analysis showed that pvu-miR395 family members had the highest expression levels in nodules with tissue specificity. The expression of pvu-miR395 increased first and then decreased with the treatment time of rhizobium, significantly inhibiting rhizobium infection. Target gene prediction showed that sulfate transporter and adenylyl sulfate transferase might be the target genes of pvu-miR395. [ABSTRACT FROM AUTHOR]

目的 探讨混合式教学模式在《介入放射学》教学中的应用。方法 前瞻性选取2020-2021 学年授课的齐齐哈尔医学院2017级医学影像学专业学生184人为研究对象均采取混合式教学模式,分析考核 成绩、与学生对教学模式评价。结果 184名学生考核成绩:常规理论成绩(41.07±2.47)分、技能操作成绩 (45.89±2.75)分与总分(89.39±5.54)分,其中总分优秀101例,良好77例,中等6例,差0例。优良率为 96.74%(178/184)。184名学生对教学模式评价:知识记忆理解提高率为79.89%(147/184)、操作能力提高率 为75.00%(138/184)、介入治疗设计能力提高率为76.63%(141/184)、分析解决问题能力提高率为71.74% (132/184)、学习热情增加率为83.15%(153/184)。结论 混合教学法应用于《介入放射学》教学中可有效提高 带教质量与教学效果,提高学生学习热情,从而有效提高学生对于课程内容的理解和掌握,鼓励学生更积极地 参与学习和练习,还能提高学生的学习兴趣和自主学习能力,使学生能够更好地应用所学知识。 [ABSTRACT FROM AUTHOR]

[Objective ] To optimize the fertilizer application method, improve soil fertility and land production capacity in wind sandy land. [Method] Five treatments were set, including CK,T,(1.0kg/m² organic fertilizer),T(5.0kg/m² bentonite),T(5.0kg/m² bentonite+ 1.5 kg/m² organic fertilizer),T(5.0kg/m² bentonite+1.0 kg/m² organic fertilizer). The physiological characteristics of Elymus dahuricus in different growth stages were monitored, and the effects of different application methods of bentonite and organic fertilizer on the physiological characteristics of Elymus dahuricus in different growth stages were discussed, and the improvement effect of different application methods of bentonite and organic fertilizer on sandy land were analyzed.[ Result] The application of bentonite and organic fertilizer promoted the physiologial characteristics of alkali grass, including SOD activity, POD activity, CAT activity, MDA content, proline content and chlorophyll content. Among them, the T treatment significantly improved the SOD activity, POD activity, CAT activity, proline content and chlorophyll content, and by 33.51%,27.57%,65.37%,39.58% and 43.30% compared with CK, respectively, and the MDA content decreased by 25.95%.[Conlusion] The application of bentonite and organic fertilizer in wind sandland can promote the change of physiological characteristics of alkali grass and improve the improvement effect of wind sandland. [ABSTRACT FROM AUTHOR]

背景：过度的酒精摄入会导致诸多的肝脏疾病, 然而目前尚无有效的防治药物。前期研究发现鹿茸干细胞能够显著改善肝纤维化, 推测其 治疗作用可能是通过旁分泌效应产生的。目的：研究鹿茸干细胞的主要旁分泌物质——外泌体对小鼠急性肝损伤的预防作用及其机制。方法：40只C57BL6小鼠随机分为对照组、模型组、骨髓间充质干细胞外泌体预防组、鹿茸干细胞外泌体预防组, 每组10只。2个外泌体 预防组连续7 d给予相应外泌体进行干预, 模型组给予PBS干预, 然后给予体积分数为50%的酒精(15 mL/kg)灌胃1次建立急性酒精性肝损伤 模型。灌胃后24 h, 计算肝指数、检测肝损伤及氧化还原指标、评价肝组织病理病变、检测炎症因子和NF-κB信号通路相关基因的表达水 平。结果与结论：①鹿茸干细胞来源外泌体显著减轻了肝损伤的程度, 包括改善体质量、降低血清中谷丙转氨酶和谷草转氨酶水平、改善肝组 织病理病变、促进肝实质细胞增殖分裂以及提高抗氧化水平(谷胱甘肽过氧化物酶和超氧化物歧化酶水平升高, 丙二醛水平降低), 且效果 强于骨髓间充质干细胞来源外泌体；②进一步研究发现, 鹿茸干细胞来源外泌体显著降低了肝组织中白细胞介素1β、白细胞介素6和肿瘤 坏死因子α的mRNA表达水平, 以及NF-κB信号通路相关基因(p65、p-p65、IKB和p-IKB)的蛋白表达水平；③这说明鹿茸干细胞来源外泌体能 够起到保护肝脏的作用, 减轻酒精所造成的肝损伤, 其作用的发挥可能是通过靶向抑制NF-κB信号通路实现的。 [ABSTRACT FROM AUTHOR]

Scarring after glaucoma surgery is the primary complication of glaucoma filtration surgery and it can lead to high postoperative intraocular pressure. Although there are many drugs for inhibiting filtration bleb scarring, the action time is generally short. The application of drug delivery technology has the advantages of prolonging the action time of drugs in inhibiting scarring after glaucoma filtering operation, reducing the dosage and frequency of drugs, and reducing the side effects of drugs. The use of this technique has important significance for controlling intraocular pressure to proptect the usual function of glaucoma patients. [ABSTRACT FROM AUTHOR]

The operational safety of pipeline projects crossing mountainous areas is threatened by landslides, which have caused a large number of casualties and economic losses. Taking the two landslide and pipe breakage accidents of the Guizhou Qinglong section of the China-Myanmar natural gas pipeline in 2017 and 2018 as examples, combined with geological environmental conditions and onsite accident investigation data, based on a finite element entity contact model, the process of the two accidents was inverted. The stress and deformation characteristics of pipelines under landslide action was analyzed to determine the cause of the accident. The results show that the deflection deformation of the pipeline presents nearly normal distribution under the action of landslide, and the stress at the middle and boundary of the pipeline is relatively the largest and is easy to be destroyed. The accumulation of soil above the slope where the pipeline is located causes the pipeline to produce large axial tensile stress, which is easy to produce brittle crack damage at the pipe body or girth weld defects, and then cause gas leakage and explosion. Therefore, the pipeline should be avoided engineering disturbance during the later maintenance of the pipeline, especially a large amount of soil piled above the slope. It would prevent threats to the operation safety of the pipeline. [ABSTRACT FROM AUTHOR]

In late March 2022, an aerial survey of moose (Alces alces) in the Nanwenghe National Nature Reserve was conducted using fixed-wing drones to estimate and analyze the relationship between the population, distribution density and habitat variables of moose in the reserve. Results show that 17, 818 unmanned aerial vehicle (UAV) images were obtained, and the splicing area of UAV transect was 206. 9 km² . The moose was identified by visual interpretation and the moose UAV image interpretation symbol library was established accordingly. According to the interpretation results of UAV transect, the density of moose transect was (0. 174±0. 038) individuals/km², and the population of moose in the reserve was estimated to be 310-484 individuals. The distribution of moose and the analysis of ecological factors in habitat selection showed that moose were mainly distributed in temperate deciduous broad-leaved forests with an altitude of 400-500 m. Moose preferred flat areas with a slope of 0°-6°, and areas within 1-3 km from water sources and 5 km away from roads. This paper proposes a method based on UAV remote sensing to investigate the size and distribution of large wild animal populations in a large area. This method uses UAV platform to obtain wild animal images and to estimate the number of wild animal populations. Combining remote sensing, geographic information system and wild animal survey, it provides effective visual data for dynamic monitoring and protection of wild animals, and can provide reference for accurately obtaining the active area and habitat environmental parameters of wild animals. [ABSTRACT FROM AUTHOR]

目的：探究重症胰腺炎消化内科的临床治疗效果。方法：选取于2021年1月-2023年1月本院收治的150 例重症胰腺炎患者，随机分为观察组（消化内科综合治疗）、对照组（常规治疗）各75人。结果：观察组治疗效果 高，且生活质量、炎性反应改善明显（P < 0.05）。结论：重症胰腺炎应用消化内科综合治疗可以获得更为理想的治 疗效果。 [ABSTRACT FROM AUTHOR]

Probiotics preparations is a green feed additive, which can improve the gastrointestinal health by regulating the gastrointestinal barrier, metabolites and flora of calves. Probiotics preparations can regulate cellular and humoral immunity, increase immunoglobulin, reduce the number of inflammatory factors, improve the immune function of calves and reduce the diarrhea rate of calves. The article mainly reviews the mechanism and research progress of probiotics preparations on calf gastrointestinal health and immune function, so as to provide reference for selecting or developing corresponding probiotics preparations of calf breeding production. [ABSTRACT FROM AUTHOR]

BACKGROUND: In the field of pancreatic tissue engineering, constructing biomimetic microenvironment to promote the survival and functional exertion of insulin-secreting cells remains difficult point and hot problem. OBJECTIVE: To construct a biomimetic microenvironment based on gelatin methacrylamide/platelet-rich plasma hydrogel to promote the survival and cellular functional of MIN6. METHODS: 10%, 30% and 50% platelet-rich plasmas were mixed with 50 g/L final concentration of gelatin methacrylamide, gelation by the activation of Ca2+/ thrombin and ultraviolet irradiation (abbreviated as G+10P, G+30P, G+50P). Simultaneously, pure gelatin methacrylamide hydrogel was prepared (denoted as G). The porosity, Young’s modulus, swelling properties and rheological behavior of hydrogels of the four groups were tested. MIN6 cells were seeded on the gel surface, and cell morphology and proliferation were detected, followed by qRT-PCR, immunofluorescence and release assays of insulin. RESULTS AND CONCLUSION: (1) The porosity of the composite-component hydrogel was smaller than that of the single-component hydrogel, and the Young's modulus was higher than that of the single-component hydrogel. Furthermore, the porosity and Young's modulus of the composite hydrogel decreased with the increase of the platelet-rich plasma concentration. The swelling rate of the G+30P and G+50P groups was lower than that of the G and G+10P groups (P < 0.05). The storage modulus and dissipation modulus of the composite hydrogels were higher than those of the single-component hydrogels (P < 0.05). (2) Under the light microscope, the cells on the surface of the monocomponent hydrogel were clumpy and scattered; the cells on the surface of the compositecomponent hydrogel were clumps, but grew faster and the cell clusters were tightly connected. Live-dead staining showed that the hydrogels in each group could promote cell survival; the number of dead cells in G+30P and G+50P groups was significantly less than that in G+10P and G groups. The CCK-8 assay displayed that the composite-component hydrogel had a stronger promoting effect on cell proliferation than the monocomponent hydrogel. Moreover, with the increase of platelet-rich plasma concentration, the promoting effect on proliferation was more obvious. (3) qRT-PCR demonstrated that compared with the monocomponent hydrogel, the composite-component hydrogel could significantly up-regulate the mRNA expression levels of islet-duodenum homeobox 1, insulin, and glucokinase; among them, the G+30P group was the most obvious. Immunofluorescence and insulin release assays exhibited that compared with monocomponent hydrogels, composite-component hydrogels could promote insulin protein expression and insulin release. (4) The results confirm that the gelatin methacrylamide/platelet-rich plasma hydrogel can be used to simulate the microenvironment of insulin-secreting cells and can significantly improve their survivals and functions. [ABSTRACT FROM AUTHOR]

Based on the daily precipitation data from national meteorological stations, ERA5 reanalysis data and the CMA Tropical Cyclone Best Track Dataset during 1979-2019, this paper sets out to conduct statistical analysis and synoptic classification of 51 large-scale persistent severe rainfall (LPSR) events during the rainy season in Guangxi Autonomous Region, and study the key circulation characteristics and differences in frontogenetic structure. The main conclusions are as follows: There are six synoptic types of the LPSR events, namely North China Trough (NCT), South Branch Trough (SBT), Low Vortex&Shear (LVS), Subtropical High Edge (SHE), Tropical Cyclone (TC) and Monsoon Depression (MD), all of which are characterized by a background of stable synoptic circulation. The NCT has the highest frequency, and the SBT has the longest average duration and the widest average influence range. The precipitation intensity of NCT, SBT and LVS is almost the same, and their precipitation areas overlap in northeast Guangxi. The frontogenesis is caused by the special terrain of this area and its interaction with cold and warm air. The initial height of strong frontogenesis is higher and shallow. There are some intrusions of dry and cold air in the middle and low layers, especially in the NCT, and such intrusions increase atmospheric instability and induce frontogenesis development. Moreover, SBT is accompanied by warm rain belt along the coast. The precipitation intensity of SHE, TC and MD is more intense, and their main precipitation area is in southern Guangxi. In these cases, the frontogenesis is mostly caused by the warm air lifted by the terrain, the narrow tube effect, and the friction convergence, which triggers and maintains efficient warm cloud precipitation. The initial height of strong frontogenesis of the latter two are lower and deeper, and their efficiency of warm cloud precipitation is higher, while the strong frontogenesis of the SBT's coastal frontogenesis area and SHE are relatively shallower. [ABSTRACT FROM AUTHOR]

In order to test the accuracy of the weapon hitting the target, it is very important to locate and measure the spatial coordinates of the falling point target. Aiming at the needs of space coordinate positioning and measurement of targets falling into the sea/ground plane, this paper studies a positioning method of UAV camera combined with target, and uses the principle of homography transformation to calculate the space coordinates of targets. The influence of pixel error on the positioning method is simulated by Monte Carlo method, and the shooting attitude range meeting the measurement requirements is determined by simulation. The results show that the positioning method of UAV camera combined with target has high accuracy, which can meet the needs of landing target positioning and measurement. [ABSTRACT FROM AUTHOR]

Aiming at the problem of shape optimization of boundary slope in open-pit coal mine, taking the north slope of open-pit mine in block II of Tar Coalfield as the engineering background, considering the three factors of safety, technology and economy, on the basis of analyzing the shape effect of slope section, a bottom-up subsection optimization method of slope in near-horizontal open-pit coal mine is proposed based on limit equilibrium method. This method is used to optimize the shape of the north slope of the open-pit mine in block II of Tar coalfield. The comparison before and after optimization shows that the overall slope angle is increased by 3° and 6.332 4×106 t coal is recovered. The results show that the rational use of slope section shape effect and three-dimensional effect can maximize the recovery of slope coal under the premise of safety. The research conclusions can provide reference for similar slope shape optimization. [ABSTRACT FROM AUTHOR]

[Purpose/Significance] In order to solve the core problems in the digitization process of cultural and creative works in China, taking cultural and creative works as the research object, this paper constructs a metadata hierarchy model of cultural and creative works based on their internal and external information characteristics. This model is standardized, accurately described, easy to operate and adapted to the needs of management and research, and is useful in preservation, transmission, knowledge transformation and innovation of cultural and creative works. This paper aims to provide possible solutions for the digitization process of cultural and creative works and make the maintenance of artistic information resources feasible, which is conducive to the standardized management of the data of literary and creative works and meets the needs of the research, appreciation and dissemination of literary and creative works. [Method/Process] The CDWA data standard is designed to describe artistic works, including the physical form, digital images and the relationship between time and space, characters, history and culture, etc. At the same time, it also has a unique description of elements for the preservation and management, which lays the foundation for data exchange and sharing. The completeness and comprehensiveness of information description of CDWA is quite consistent with the purpose of systematically and comprehensively describing cultural and creative works. Different from AACR2R and RDA to describe paper literature, electronic resources, music works and micro literature, the main purpose of CCO is to promote the standardization of cultural relics such as artworks and their image description. It is the first set of data content standards in the field of cultural assets. The data content standards of CCO focus on descriptive metadata and normative control of artistic works. Based on the above, this paper builds the meta framework of digital resource construction of cultural and creative works, then based on the data content standard CCO, it catalogues and describes the cultural and creative works designed by teachers and students of School of Art and Design of Wuxi Institute of Technology, China, and then promotes the practice of digital construction. [Results/Conclusions] Based on the discussion and analysis of existing metadata models of art and intangible cultural heritage, a metadata model was formed to describe cultural and creative works from three aspects: basic metadata, management metadata and associated metadata. As an indispensable part of revealing, transforming and innovating the cultural and artistic value of artistic works, this paper constructed a modular and extensible metadata standard and model which is much more suitable for cultural and creative works, and provided solutions for the digitization process of cultural and creative works. What's more, this study plays an important role in preservation and inheritance of characteristic resources. It also promoted the formation of new formats and new models of digital cultural and creative industries and provided data support for the vigorous development of China's cultural and creative industries. [ABSTRACT FROM AUTHOR]

Majorization theory is a new mathematical subject，Schur convex function is its core concept，and Schur geometrically convex function is the generalization of Schur convex function. The conditional inequalities in which the product of variables is constant are a common class of inequalities. In this paper，ten such inequalities are proved by Schur geometrically convex function. The method is different，concise and interesting，and some strengthened results are obtained. [ABSTRACT FROM AUTHOR]

目的：探究肿瘤内科治疗常见并发症和对应的治疗方法。方法：选取2020年5月~2022年6月于我院接受 治疗的176例肿瘤内科患者为研究对象, 按照数字随机法进行分组, 其中对照组和实验组各有患者88例, 对照组采取 常规的辅助治疗方法进行处理, 实验组采取综合治疗的方法进行处理, 对两组患者并发症发生率和治疗满意度进行 比较。结果：两组患者出现感染、脱发、肠胃功能紊乱、骨髓抑制以及药物外渗等并发症, 对照组并发症发生率为 96.6%, 实验组并发症发生率为86.4%, 实验组并发症发生率低于对照组, 对比结果差异有统计学意义 (P < 0.05)。结论：感染、脱发、肠胃功能紊乱、骨髓抑制以及药物外渗等是肿瘤内科治疗过程中发生概率较高的并发症, 但是通 过科学的和针对性的治疗能够减少这些并发症的发生。 [ABSTRACT FROM AUTHOR]

Due to the high hardness and wear resistance of difficult-to-machine materials, the grinding wheel wears faster in the grinding process. At present, the dressing and replacement cycle of the grinding wheel is mainly judged by experience, which may lead to untimely dressing. Accordingly, the wear state of grinding wheel was accurately monitored by combining acoustic emission signals and grinding force signals. By analyzing the characteristic parameters of acoustic emission signals, the changes of grinding force and grinding force ratio during the grinding of grinding wheels with different wear states, the wear state of grinding wheels during the experimental process was comprehensively judged. The results showed that the acoustic emission signals are all correlated with the grinding wheels’ wear state, and the grinding force ratio is the most correlated with the grinding wheels’ wear degree, which proves the effectiveness of the acoustic emission monitoring technology in grinding wheel dressing and provides theoretical guidance for the actual production process. [ABSTRACT FROM AUTHOR]

Defects are inevitable in the synthesis of monolayer transition metal dichalcogenides（ TMDs） and will impose important influence on the physical and chemical properties of monolayer TMDs. In order to study the influence on the piezoelectric effect of monolayer TMDs with grain boundaries （GBs），the piezoelectric coefficients of 36 kinds of monolayer TMDs with GBs and 36 kinds of perfect monolayer TMDs are calculated based on density functional theory （DFT）. The results show that the GBs enhance the piezoelectric effect of monolayer TMDs. This is owing to that GBs lead to strain gradients and the flexoelectricity is triggered. The change in piezoelectric coefficients shows an obvious periodic trend. The piezoelectric coefficient increases gradually with the relative atomic mass of chalcogenide elements increase. The maximum piezoelectric coefficient of monolayer MoTe2 with GBs is 11.17 pm/V， which is enhanced about 27.8% compared with that of the perfect MoTe2（8.74 pm/V）. These results provide a theoretical guidance for the development of high‑sensitivity sensors and high‑precision controllers in aircraft. [ABSTRACT FROM AUTHOR]

In order to maximize the safe and efficient recovery of coal buried on the east slope, the FLAC3D numerical model was established. This numerical model was used to study the three-dimensional stability of the horizontal mining at the east slope. The effects of tracking distance and deep slope angle has been discussed. The effects of weak layer internal friction angle on mode of slope failure and the stability of the slope are also investigated. The research shows that when the tracking distance is small, the deep slope angle and the internal friction angle of the weak layer have little effect on the failure mode and stability of the slope. In the process of increasing the tracking distance, the deformation amount and deformation range of the deep rock mass in the east side gradually increase. The result shows that the landslide mode is the tangential-bedding sliding with the weak layer of the second aquifer floor as the bottom interface, and successively transitioning to the tangential layer with the weak floor of the 2-7 coal seam and the weak layer of the 2-8 coal floor as the bottom interface-sliding along the bed, resulting in a downward trend in the overall slope stability. When the horizontal mining and inner row tracking and pressing mining method is used for leaning, the reasonable control of the tracking distance is conducive to the realization of deep and steep mining, and significantly reduce the risk of landslide caused by the uncertainty of mechanical properties of weak layers. [ABSTRACT FROM AUTHOR]

In order to solve the problem of the railway surrounding soil deformation caused by the load of the open pit soft substrate dump, the dump is simplified to the trapezoidal distribution load acting on the ground. Mechanical model of semi-infinite elastic plane foundation is setted up. The method of plane elasticity and the two-dimensional surface subsidence formula are calculated by planar elastic mechanics method and integral superposition principle. The surface deformation pattern around the soil dump is analyzed. The results show that when other parameters are the same, the surface inclination and horizontal deformation are inversely proportional to the distance from slope foot, the elastic modulus of foundation soil, Poisson's ratio, slope angle, and directly proportional to the height of slope. When the slope toe distance is small and the abandon height is increased, the horizontal deformation is significantly increased. The accuracy of the elastic analysis method is verified by the field monitoring data. The height and angle of the waste dump are proportional to the amount of waste material. The theoretical basis for ensuring the safety of railway, buildings and engineering facilities are provided by the obtained deformation law of soil around the soft substrate soil dump. [ABSTRACT FROM AUTHOR]

To further understand the basic characteristics of the tropical cyclones over the South China Sea (SCSTC), this paper uses the best track dataset of tropical cyclones compiled by the Shanghai Typhoon Institute of China Meteorological Administration (CMA-ATI) to analyze the frequency, origin and intensity changes of SCSTC with different moving paths from 1949 to 2019 by wavelet analysis and synthetic analysis. The results show that: (1) The frequency of SCSTC shows a decreasing trend year by year. The overall frequency of SCSTC in the northeast direction is relatively low, and the peak months are mainly in May and June. The overall frequency of SCSTC in the west/ northwest direction is relatively high, accounting for about 76 % of the total, and the peak months are mainly in August and September. The change in the frequency of SCSTC in the west/ northwest direction is consistent with the movement of the ridgeline of the western Pacific subtropical high. When the ridgeline of the subtropical high gradually moves north (south), the frequency of SCSTC gradually increases (decreases). (2) The average intensity of the SCSTC in the northeast direction is stronger than that in the west/ northwest direction, and the life cycle is longer. Secondary strengthening of typhoons and strong typhoons is more significant in northeastward SCSTC. (3) The oirigin points of SCSTC with different paths have undergone northward uplift and then southward withdrawal with the change of seasons, which is consistent with the movement of subtropical high ridgeline. The oirigin point of SCSTC in the northeast direction is 2～3 latitudes norther than that of SCSTC in the west/ northwest direction. [ABSTRACT FROM AUTHOR]

Objective To investigate the value of triglyceride-glucose index (TyG) and body mass index (BMI) in predicting nonalcoholic fatty liver disease (NAFLD) in type 2 diabetes mellitus (T2DM). Methods A retrospective analysis was performed for the clinical data of 349 patients with T2DM who were treated in Shengjing Hospital of China Medical University from May 2020 to July 2021, and according to the presence or absence of NAFLD, they were divided into T2DM+NAFLD group with 213 patients and simple T2DM group with 136 patients. The t-test or the Mann Whitney U test was used for comparison of continuous data between two groups, and the chi-square test was used for comparison of categorical data between two groups. A logistic regression analysis was used to investigate the association of TyG and BMI with T2DM+NAFLD, and the receiver operating characteristic (ROC) curve was plotted to evaluate the prediction efficiency of TyG alone, BMI alone, and TYG combined with BMI for NAFLD in T2DM. The Kappa coefficient was used to analyze the consistency of prediction results. Results Compared with the simple T2DM group, the T2DM+NAFLD group had significantly higher BMI, diastolic pressure, fasting blood glucose, HbA1c, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transpeptidase, triglyceride, total cholesterol, low-density lipoprotein cholesterol, and TyG (all P < 0.05) and a significantly lower high-density lipoprotein cholesterol (P < 0.05), while there were no significant differences between the two groups in systolic pressure, total bilirubin, direct bilirubin, and indirect bilirubin (all P > 0.05). The logistic regression analysis showed that TyG (odds ratio [OR]=6.513, 95% confidence interval [CI]: 1.884-22.517, P < 0.001) and BMI (OR=1.369, 95% CI: 1.191-1.575, P < 0.001) were independent risk factors for NAFLD in T2DM. The ROC curve analysis showed that TyG had an area under the ROC curve (AUC) of 0.875 in predicting NAFLD in T2DM, with a sensitivity of 80.3%, a specificity of 80.1%, a positive predictive value of 86.36%, and a negative predictive value of 72.19% at the optimal cut-off value of 9.41; BMI had an AUC of 0.787, with a sensitivity of 78.9%, a specificity of 64.0%, a positive predictive value of 77.36%, and a negative predictive value of 64.23% at the optimal cut-off value of 24.22; TyG combined with BMI had an AUC of 0.910, a sensitivity of 81.2%, a specificity of 88.2%, a positive predictive value of 91.53%, and a negative predictive value of 75.00% in predicting NAFLD in T2DM. TyG alone, BMI alone, and TyG combined with BMI had a Kappa coefficient of 0.592, 0.416, and 0.673, respectively, in predicting NAFLD in T2DM. Conclusion TyG and BMI can be used to predict the onset of NAFLD in T2DM, and the combination of TyG and BMI can improve the predictive value. [ABSTRACT FROM AUTHOR]

BACKGROUND: The anti-osteoporotic mechanism of salvianolic acid B is different from traditional anti-bone resorption drugs. It has a multi-target pharmacological effect, which has not yet been fully elucidated. OBJECTIVE: To study the effect of salvianolic acid B on bone density of femur and lumbar vertebra in rats with osteoporosis, and to explore its anti-osteoporotic mechanism. METHODS: Totally 36 SPF SD rats aged 6 months were randomly divided into three groups: sham operation group, osteoporosis group, and salvianolic acid B group. Bilateral ovaries were removed and the osteoporosis model was replicated in the osteoporosis group and salvianolic acid B group. In the sham operation group, intact ovaries were kept and part of adipose tissue was removed. At 4 weeks after surgery, 50% salvianolic acid B 25 mg/kg was given by gavage for 6 days per week for 12 consecutive weeks in the salvianolic acid B group. In the other two groups, the same amount of normal saline was given for the same time. At 16 weeks postoperatively, all the rats were sacrificed after anesthesia. The bone density of the right posterior femur and lumbar vertebra was scanned by dual-energy X-ray absorptiometry. The levels of osteoprotegerin and receptor activator of nuclear factor-kB ligand in serum were detected by enzyme-linked immunosorbent assay. The protocols were approved by the Animal Management Committee of Bengbu Medical College (approval No. [2021]255). RESULTS AND CONCLUSION: (1) The bone mineral density of femur in the osteoporosis group was lower than that in the sham group (P < 0.05). The femoral bone mineral density of salvianolic acid B group was significantly higher than that of osteoporosis group (P > 0.05). The bone mineral density of lumbar vertebrae in osteoporosis group was not significantly different from that in sham operation group (P > 0.05). The lumbar vertebrae bone density of salvianic acid B group was higher than that of osteoporosis group, but the difference was not significant (P > 0.05). (2) Osteoprotegerin level of osteoporosis group was lower than that of sham operation group (P < 0.05). Osteoprotegerin level of salvianolic acid B group was higher than that of osteoporosis group, but the difference was not significant (P > 0.05). The level of receptor activator of nuclear factor-kB ligand of osteoporosis group was significantly higher than that of sham operation group (P < 0.05). The level of receptor activator of nuclear factor-kB ligand of salvianolic acid B group was lower than that of osteoporosis group, but the difference was not significant (P > 0.05). (3) These findings suggest that in the early stage of postmenopausal osteoporosis, bone mineral density of femur decreased significantly, but there was no significant change in bone mineral density of the lumbar spine. At present, it is not believed that salvianolic acid B alone can effectively treat osteoporosis in the short term. [ABSTRACT FROM AUTHOR]

Objective: To observe the relationship between serum secretory curl associated protein 1 (SFRP1), secretory curl associated protein 5 (SFRP5), sphingosine 1-phosphate (S1P), T cell immunoglobulin domain and mucin domain protein 4 (TIM4) and lung function, airway inflammation and acute recurrence after treatment in adult patients with acute attack stage of bronchial asthma. Methods: 120 patients with bronchial asthma who were treated in Rocket army characteristic medical center from July 2016 to August 2020 were selected, of which 47 patients in remission stage were included in the remission group, 73 patients with acute attack stage were included in the attack group. The serum S1P, SFRP1, TIM4 and SFRP5 levels, lung function [forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), FEV1/FVC], airway inflammation [serum total immunoglobulin E (IgE), sputum eosinophils, exhaled nitric oxide (FeNO), blood eosinophils] in the attack group and remission group were compared. After treatment, the patients were followed up for 1 year in the form of outpatient review or telephone. According to whether there was another acute recurrence within 1 year, they were divided into recurrence group and non recurrence group. The serum S1P, SFRP1, TIM4 and SFRP5 levels in recurrence group and non recurrence group were compared. Results: S1P, SFRP1 and TIM4 in the attack group were higher than those in the remission group, and SFRP5 was lower than that in the remission group (P<0.05). FEV1, FVC and FEV1/FVC in the attack group were lower than those in the remission group (P<0.05). The total serum IgE, eosinophils, FeNO and blood eosinophils in the attack group were higher than those in the remission group (P<0.05). Pearson correlation analysis showed that S1P, SFRP1 and TIM4 were negatively correlated with FEV1, FVC and FEV1/FVC (P<0.05), but positively correlated with serum total IgE, eosinophils, FeNO and blood eosinophils (P<0.05). SFRP5 was positively correlated with FEV1, FVC and FEV1/FVC(P<0.05), but negatively correlated with serum total IgE, eosinophils, FeNO and blood eosinophils (P<0.05). S1P, SFRP1 and TIM4 in the recurrence group were higher than those in the non recurrence group, and SFRP5 was lower than that in the non recurrence group (P<0.05 ). Conclusions: The S1P, SFRP1 and TIM4 levels are abnormally increased, and SFRP5 is abnormally decreased in adult patients with acute attack stage of bronchial asthma, which is related to lung function, airway inflammation and acute recurrence again. [ABSTRACT FROM AUTHOR]

Objective: To examine validity and reliability of the simplified version of the Community Assessment of Psychic Experiences（CAPE-P8） in college students. Methods: Totally 1451 college students completed the CAPE-P8. The 16-Item Version of the Prodromal Questionnaire（PQ-16） was used as criterion validity instruments. Two hundred and seventeen college students completed the CAPE-P8 retest in 7-14 days, and 90 college students completed telephone interviews within one month. Results: The CAPE-P8 had good internal consistency（α=0.82-0.84), retest reliability（α=0.80-0.83） and self-evaluation-interview consistency（α=0.64-0.78). The confirmatory factor analysis showed the good fit of the two-factor（delusional experiences and hallucinatory experiences） in CAPE-P8. The frequency scores of CAPE-P8 were strongly correlated with the distress scores（r=0.72-0.89,P <0.001), and there was a significant positive correlation between scores of CAPE-P8 and PQ-16（r=0.50-0.67, P <0.001). The prevalence of lifetime PLEs and current PLEs among college students were 83.5% and 58.6%, respectively, and the distress of lifetime PLEs and current PLEs were 15.9% and 9.9%, respectively. Conclusion: It indicates that the simplified version of the Community Assessment of Psychic Experiences has good validity and reliability and could effectively measure PLEs among college students. [ABSTRACT FROM AUTHOR]

Based on the Global Ensemble Forecast System data, the present study uses the WRF model and the GEFS dynamic downscaling method to obtain the regional ensemble forecast initial states. Moreover, the assimilated analysis field is integrated to achieve the reginal ensemble forecast for a precipitation event during annually first rainy season in South China. Four tests, namely Hybrid, 3DVar, EnKF, and Ctrl, are carried out for a torrential rain process on June 10, 2019 in South China. We also explore the evolution characteristics of the ensemble disturbance and ensemble spread for the assimilation schemes with difference background error covariance matrices and evaluate the precipitation simulation performance of different tests. The results show that: (1) Hybrid can improve the initial field of the model, while 3DVar and EnKF failed. (2) For wind, temperature, and relative humidity, the forecast error of Hybrid in the early forecast is less than that of 3DVar and EnKF. In the middle and late forecast, the forecast error of 3DVar and EnKF is reduced and is smaller than that of Hybrid. As for the ensemble disturbance energy, Hybrid and Ctrl are better than 3DVar and EnKF in the early forecast, and 3DVar and EnKF are better than Hybrid and Ctrl in the middle and late forecasts. (3) According to the 24-hour cumulative precipitation scores, the assimilation test is better than Ctrl, 3DVar and EnKF are better than Hybrid; 3DVar scores the best in heavy and moderate rainfall and EnKF scores the best in torrential rain and above. (4) For 24-hour cumulative precipitation ensemble statistical analysis, the area under the curve value of the assimilation test is greater than that of Ctrl; 3DVar performs the best in the 10mm~100mm cumulative precipitation threshold and EnKF performs the best in the 125mm cumulative precipitation threshold. [ABSTRACT FROM AUTHOR]

Reducing the resistance of soil-engaging components can greatly contribute to the energy saving for a higher performance of agricultural machinery in modern agriculture. In this study, a motion theoretical model was constructed to investigate the mechanical properties of the soil-engaging components that interacted with the ultrasonic high-frequency vibration in agricultural machinery. A novel device with ultrasonic vibration was also developed to excite the key soil-engaging components, thereby reducing the operating resistance, high-power supporting power, and the impact on soil compaction. Specifically, the device was composed of the ultrasonic generator, transducer, horn, and soil blade. A systematic analysis was made on the contact separation and impact fragmentation in the interaction between the soil-engaging component with high-frequency vibration and soil. A blade with high-frequency vibration was utilized to produce the vibration impact with the small amplitude, but there was a great acceleration to the soil. Once the vibration speed was greater than the forward speed, the contact time between the blade and the soil was reduced significantly in this case. A theoretic analysis was then implemented to explore the specific mechanism for the soil crushing and resistance reduction of the soil-engaging component with ultrasonic vibration. A soil tank test system was designed to evaluate the performance of soil-engaging components with ultrasonic vibration. Some parameters were also optimized for the operating resistance and soil crushing characteristics of soil contacting parts with ultrasonic high-frequency vibration. The test results showed that the operating resistance of the soil-engaging component under the excitation of ultrasonic vibration was significantly lower than that under the non-vibration state. Furthermore, the greater the soil hardness was, the higher the operating resistance reduction rate was. The reduction rate of operating resistance increased from 22% to 43%, when the soil hardness increased from 1 to 4 MPa. Alternatively, the reduction rate of resistance was greater than before, as the moisture content decreased in the range of soil moisture content of 15%-30%. Once the soil moisture content exceeded 30%, the reduction rate of operating resistance increased slightly, with the increase of soil moisture content. Correspondingly, the fluctuation stability of instantaneous operating resistance was improved for a stronger soil crushing, due to the impact fragmentation and energy transfer of the soil-engaging component under the excitation of ultrasonic high-frequency vibration to the soil. In addition, the resistance fluctuation was averaged by the standard deviation of operating resistance, where the soil fragmentation was calculated by the soil particle size. Once the soil hardness was 1 MPa, the fluctuation stability of working resistance was not significantly improved in the soil-engaging component. The reduction rate of operating resistance increased significantly in the fluctuation, with the increase of soil hardness. The standard deviations for the reduction rate of operating resistance were 37.1% and 54.3%, respectively, when the values of soil hardness were 2.5 and 4 MPa. More importantly, the distribution of soil particles was tended to the direction of small size after the action of ultrasonic vibrating on the soil-engaging component, compared with that without vibration. This finding can provide strong technical support to the potential application of soil-engaging components under ultrasonic vibration with high frequency and low amplitude in agricultural machinery. [ABSTRACT FROM AUTHOR]

Based on the 156 destructive earthquakes occurred in Chinese mainland in the past 1993—2012 years, the representative death prediction models for earthquake victims and the main parameters adopted are analyzed and compared. From the angle of the two parameters of the parameters accessibility and prediction accuracy, the model is optimized and combined by the way of dividing the geographical area. A death prediction model based on building damage area, collapse rate, epicenter intensity and the number of victims is proposed. On this basis, the national building seismic capacity index is used as the correction parameter to modify the model, and the actual earthquake cases from 2013 to 2019 are compared to verify the reliability of the earthquake death model proposed in this paper. [ABSTRACT FROM AUTHOR]

Osteoporosis is a chronic systemic bone disease characterized by loss of bone mass and degeneration of bone microstructure, which eventually leads to increased fragility of the bone and an increased risk of fracture. At present, the aging population in China is gradually increasing and we have entered an aging society. The incidence of osteoporosis and brittle fractures caused by osteoporosis are increasing year by year, which greatly affect the safety and quality of life of patients and have become an urgent problem to be solved. Before the emergence of the concept of bone immunology, bone was believed to be vital to the immune system because of the formation of immune cells in bone marrow. However, the role of the immune system in bone regulation is not well understood. In 2000,Arron proposed the concept of bone immunology in the Nature and pointed out the complex interaction between the bone and immune system. Since then, bone immunology has gradually become the research hot spot of metabolic osteoarthropathy. Bone immunology plays an important regulatory role in the process of bone reconstruction. Its main research content is to elucidate the close and complex mutual regulatory mechanism between the immune system and the bone. During the occurrence and development of osteoporosis, OPG/RANK/RANKL signaling system, immune cells, and cytokines produced by them play a decisive role. Bone immunology has laid the theoretical foundation for the research and development of novel antiosteoporosis drugs. [ABSTRACT FROM AUTHOR]

Objective: To investigate the protective effect of miR-29a on synovial injury in rats with knee osteoarthritis (KOA). A KOA rat model was established by anterior cruciate ligament transection (ACLT). Rats were injected with microRNA- negative control and miR-29a. miR-29a expression in synovial tissue and synovial cells of KOA was detected by real-time quantitative polymerase chain reaction (RT-qPCR). Toll-like receptor 4/ myeloid differentiation protein 88/ nuclear factor κB (TLR4/MyD88/NF-κB) signaling pathway related protein expression was detected by RT-qPCR and Western blot assay. The expression levels of inflammatory cytokines in KOA synovial tissue and synovial cells were detected. Results: miR-29a expression was down-regulated in KOA synovial tissue and synovial cells. Up-regulation of Mir-29a inhibits the inflammatory response of synoviocytes in KOA rats, and inactivates the TLR4/Myd88/NF-κB signaling pathway in KOA rats. Conclusion: The up-regulation of miR-29a inhibited the inflammatory response of synovial cells in KOA rats through the inactivation of TLR4/MyD88/NF-κB signaling pathway, thereby protecting the synovial injury. [ABSTRACT FROM AUTHOR]

Polycystic ovary syndrome (PCOS) manifests as a series of disorders in reproductive system, endocrine, and metabolism, and there is a significant increase in the prevalence rate of nonalcoholic fatty liver disease (NAFLD) in the population with PCOS. At present, the risk factors for PCOS with NAFLD have not been fully clarified. This article introduces the research advances in PCOS with NAFLD from the aspects of hyperandrogenism, insulin resistance, obesity, dyslipidemia, chronic low-grade inflammation, and intestinal flora imbalance, so as to provide ideas and methods for improving the awareness and management of PCOS with NAFLD. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of transumbilical single port and conventional laparoscopic cholecystectomy (LC) on gastrointestinal function, liver function and immunological indexes in patients with calculous cholecystitis. Methods:157 patients with calculous cholecystitis who were treated in our hospital from March 2016 to December 2019 were selected, and they were divided into three hole group (n=85, treated with conventional three hole LC) and single hole group (n=72, treated with single hole LC) according to the operation mode. The perioperative indexes, gastrointestinal function, liver function and immunological index of the two groups were compared, and the incidence of complications in the two groups was recorded. Results: The length of stay in the single hole group was shorter than that in the three hole group, the visual analogue scale (VAS) score was lower than that in the three hole group (P<0.05), and the operation time in the single hole group was longer than that in the three hole group(P<0.05). There was no difference in intraoperative blood loss between the two groups(P>0.05). The recovery time of bowel sounds, anal exhaust time, defecation time and eating time in the single hole group were shorter than those in the three hole group (P<0.05). The levels of glutamyl transferase (GGT), aspartate aminotransferase (AST) and total bilirubin (TBIL) in the two groups increased 1 day after operation, but the levels in the single well group were lower than those in the three hole group(P<0.05). The levels of immunoglobulin M (IgM), immunoglobulin A (IGA), CD3+, CD4+ /CD8+ in the two groups were significantly lower than those in the three well group (P<0.05). There was no significant difference in the incidence of postoperative complications between the two groups (P>0.05). Conclusion: Compared with the conventional three port LC, transumbilical single port LC in the treatment of calculous cholecystitis can effectively reduce the impact on liver function and immunology, promote the improvement of gastrointestinal function, reduce postoperative pain and shorten hospital stay. [ABSTRACT FROM AUTHOR]

目的 观察胃癌组织 Rap1 GTP 酶激活蛋白（Rap1GAP）、人内源性逆转录病毒-H 长末端重复关联蛋白 2 （HHLA2）mRNA 表达变化，并探讨其表达与患者临床病理特征和预后的关系。方法 选择胃癌患者 97 例，取手术 切除的胃癌组织及其配对的癌旁正常组织，采用 RT-qPCR 法检测 Rap1GAP、HHLA2 mRNA 表达。比较胃癌组织与 癌旁正常组织 Rap1GAP、HHLA2 mRNA 表达差异，分析二者表达与胃癌患者临床病理特征的关系。以 Rap1GAP、 HHLA2 mRNA 表达的中位数为截断值，将患者分为 Rap1GAP、HHLA2 mRNA 高表达者与低表达者，比较不同 Rap1GAP、HHLA2 mRNA 表达者 5 年生存率差异。采用 Cox 风险比例回归模型分析影响胃癌患者预后的危险因素。 结果 胃癌组织 Rap1GAP mRNA 相对表达量低于癌旁正常组织，HHLA2 mRNA 相对表达量高于癌旁正常组织（P 均<0. 05）。Rap1GAP、HHLA2A mRNA 表达与肿瘤浸润深度、 TNM 分期和淋巴结转移有关（P 均<0. 05），与性别、年 龄、肿瘤直径、组织分化程度无关（P 均>0. 05）。Rap1GAP mRNA 低表达者 5 年生存率低于 Rap1GAP mRNA 高表达者， HHLA2 mRNA 高表达者5年生存率低于 HHLA2 mRNA 低表达者（P 均<0. 05）。Cox 风险比例回归分析显示，有淋巴结 转移、Rap1GAP mRNA 低表达、HHLA2 mRNA 高表达是胃癌患者预后不良的危险因素（P 均<0. 05）。结论 胃癌组织 Rap1GAP 低表达、HHLA2 高表达，二者异常表达与胃癌恶性生物学行为和患者预后不良有关。Rap1GAP、HHLA2 有可能成为胃癌预后评估的生物标志物和潜在的治疗靶点。 [ABSTRACT FROM AUTHOR]

This study aims to meet the application requirements of unmanned driving and autonomous operation in agricultural machinery, particularly for better adaptability of quadrilateral farmland. A path planning was also designed to implement the farmland operation using unmanned agricultural machinery. AB line operation mode was selected to generate executable paths with speed and implement state instructions. Two parts were composed of farmland information processing and path planning. The farmland information processing module was used to process the surveying point data in land contour and obstacles. Among them, one data processing was for land contour surveying and mapping points, and another for obstacle surveying and mapping points. The former was used to extract the longitude and latitude fields of original position data, and then convert them into Universal Transverse Mercator (UTM) coordinates. The latter was utilized to convert the point and line obstacles generated by surveying and mapping into the unified obstacle polygonal contour data for the subsequent path planning. Next, the operating parameters were defined by the user in the path planning module, including the operating direction, operating width, turning radius, and starting position. The sub-modules were also constructed, such as unmanned operation trapezoidal area generation, turning and operation area division, operation strip segmentation, obstacle strip processing, strip routing planning, turning, and final path generation. The result showed that: (1) In the sub-module of Unmanned operation trapezoidal area generation, the operation direction was taken as the parallel side to construct a trapezoidal area suitable for unmanned operation in the quadrilateral land. (2) In the sub-module of turning and operation area division, the width of the turning area was set, according to the operating width and turning radius. Then, 2 parallelogram turning and 1 operation area were generated inside the unmanned operation trapezoidal areas. (3) In the sub-module of operation strip segmentation, the operating direction was taken as the strip direction, while, the operating width as the strip width, in order to complete the strip dividing of the entire operation areas. (4) In the sub-module of obstacle strip processing, the operation line was cut to intersect with the obstacle polygon back and forth, and thereby to construct a detour path composed of arcs and line segments. (5) In the sub-module of strip routing planning, the operation strips were sorted in order. All the strips were divided into the blocks with constructing units, while, the strip selection was designed for different operating sequences to achieve better orderly operation strips. (6) In the sub-module of turning path generation, a U-shaped turning path was generated in the form of "arc-line-arc" using the adjacent sequence of operation strips and turning radius. (7) In the sub-module of final path generation, the final path was realized by adding speed instructions and implement state instructions at the path points. The final path was thus executed in the unmanned agricultural machine. Simulation tests show that the proposed method was suitable for different quadrilateral farmland and obstacles. The operation area ratio and distance ratio increased by 10.0% and 8.8%, respectively, compared with the adjacent. Field tests show that the mean value and standard deviation for the lateral deviations of agricultural unmanned driving and autonomous operation were 0.002 m to the left and 0.027 m, respectively. Consequently, the generated path can meet the requirements of unmanned and autonomous operation in agricultural machinery. The finding can provide a complete path planning for unmanned agricultural machinery with the high adaptability of farmland and operating parameters for higher production efficiency. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of transumbilical single port and conventional laparoscopic cholecystectomy(LC) on gastrointestinal function, liver function and immunological indexes in patients with calculous cholecystitis. Methods: 157 patients with calculous cholecystitis who were treated in our hospital from March 2016 to December 2019 were selected, and they were divided into three hole group(n=85, treated with conventional three hole LC) and single hole group(n=72, treated with single hole LC) according to the operation mode. The perioperative indexes, gastrointestinal function, liver function and immunological index of the two groups were compared, and the incidence of complications in the two groups was recorded. Results: The length of stay in the single hole group was shorter than that in the three hole group, the visual analogue scale(VAS) score was lower than that in the three hole group(P<0.05), and the operation time in the single hole group was longer than that in the three hole group(P<0.05). There was no difference in intraoperative blood loss between the two groups(P>0.05). The recovery time of bowel sounds, anal exhaust time, defecation time and eating time in the single hole group were shorter than those in the three hole group(P<0.05). The levels of glutamyl transferase(GGT), aspartate aminotransferase(AST) and total bilirubin(TBIL) in the two groups increased 1 day after operation, but the levels in the single well group were lower than those in the three hole group(P<0.05). The levels of immunoglobulin M(Ig M), immunoglobulin A(IGA), CD3+, CD4+/CD8+ in the two groups were significantly lower than those in the three well group(P<0.05). There was no significant difference in the incidence of postoperative complications between the two groups(P>0.05). Conclusion: Compared with the conventional three port LC, transumbilical single port LC in the treatment of calculous cholecystitis can effectively reduce the impact on liver function and immunology, promote the improvement of gastrointestinal function, reduce postoperative pain and shorten hospital stay. [ABSTRACT FROM AUTHOR]

In order to respond to the requirements of oil and gas pipeline design specifications and ensure the safety of the pipeline in the landslide area, the use of EPS block flexible materials as the trench backfill instead of backfill soil to relieve the strain of the pipeline is proposed for the stress characteristics of the pipeline suffering from landslide displacement. By establishing the oil and gas pipeline interaction model in the landslide area, the EPS block has a significant effect on alleviating the pipeline strain under the action of the landslide displacement load, and can reduce the pipeline strain by 28%-32% under the same landslide displacement condition. Through further research, the following conclusions are obtained: (1) When EPS blocks are used to replace pipe trench backfills, the curvature radius of the pipeline can be larger, the strain value is smaller, and the additional strain value of the pipeline is lower; (2) With the EPS block As the initial density increases, the ability and effect of alleviating the strain of the pipeline is decreasing. In actual engineering, it is recommended to choose a block with a lower initial density. The selection of the thickness of the EPS block is related to the pipe diameter. Selecting a thickness similar to the pipe diameter has the best strain relief effect; (3) Before using the EPS block, a numerical calculation method should be used to evaluate its effectiveness. Obviously appeared near the edge of the landslide perimeter, and the effect of setting EPS blocks at the intersection of the landslide edge and the pipeline was more obvious. [ABSTRACT FROM AUTHOR]

In order to improve the comprehensive practical ability of students majoring in robot engineering, a teaching robot experimental platform which integrates machinary, electricity, control and image processing is designed and developed in this paper. As a platform integrates robot mechanical structure design, kinematics analysis, motion control and image processing, it is able of joint assembly and demonstration experiments, which avails students to understand robot’s mechanical structure and working principle, and more importantly, it is developed as an open control experimental platform that can complete complex experiments such as robot kinematics analysis, drive control, trajectory planning, image processing, and object recognition & grasp under vision guidance.Strong in integration and manipulability, the designed experimental platform can stimulate students’ learning interest and improve their engineering practical and innovative ability effectively. [ABSTRACT FROM AUTHOR]

Dolomite mineral deposits are abundant and widely distributed in our country. Calcium carbonate whiskers were prepared by gas-liquid contact method using dolomite refining solution and carbon dioxide as experimental raw materials. The effects of impurity ions Mg2+, NH4+ and NO3- on the aspect ratio and morphology of calcium carbonate whiskers were studied. Morphology and phase structure of the products were characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD). The results show that the morphology and aspect ratio of calcium carbonate whiskers are the best when the concentration of NH4+ is 0.3 mol/L, the concentration of Mg2+ is 0.05 mol/L, and the concentration of NO3- is 0.2 mol/L, the aspect ratio reaches above 25 at the highest. Finally, the crystallization process and growth mechanism of calcium carbonate whiskers are explained by combining with crystal growth theory. [ABSTRACT FROM AUTHOR]

Preventing and dissolving the risk of earthquake disasters is an important measure to implement the reduction of earthquake disasters and ensure the sustainable development of society. The earthquake disaster risk prevention and control business platform can provide strong support for improving the comprehensive prevention and control level of earthquake disaster risks. This paper analyzes the current research status of earthquake disaster risk and loss assessment system platforms at home and abroad, combined with the current situation of my country's earthquake disaster risk prevention and control business, combs the functional requirements of earthquake disaster risk prevention and control business, and proposes earthquake disaster risk investigation, assessment, governance and service As the core chain of the national earthquake disaster risk prevention and control business platform design concept, the overall architecture and business functions of the platform are designed, and the platform functions are prospected. The construction of this platform will promote the effective integration of earthquake disaster risk data resources, promote the construction of earthquake disaster risk prevention and control business systems, and further improve the level of social services for earthquake risk prevention and control. [ABSTRACT FROM AUTHOR]

Objective: To examine validity and reliability of the Chinese version of the 15-item Positive Subscale of the Community Assessment of Psychic Experiences ( CAPE-PI5) in high school students. Methods: A total of 2054 high school students completed the Chinese version of the CAPE-PI5. Besides, the 16-item version of the Prodromal Questionnaire (PQ-16) was conducted in 800 of them, and the retest of the CAPE-PI5 was conducted in 121 of them within two weeks (7 - 14 days). Results: The exploratory factor analysis showed the best fit of the three-factor (persecutory ideation, bizarre experiences and perceptual abnmmalities) model (X² = 257. 79, df = 63, TLI = 0. 973, CFI = 0. 955, SRMR = 0. 023, RMSEA = 0. 050), which was also confirmed through the confirmatory factor analysis (X²= 229. 58, df = 87, TLI = 0. 949, CFI = 0. 938, SRMR = 0. 038, RMSEA = 0. 045). The CAPE-P15 also showed strict measurement invariance across sex( ΔCFI < 0. 01, ΔTLI < 0. 01). The correlation between frequency and distress score was significant for total CAPE-P15 score and three factors ( r = 0. 88 - 0. 92, Ps < 0. 001) . The total CAPE-P15 frequency score were significantly positively correlated with the item score and distress score of the PQ-16 ( r = 0. 62, 0. 68, Ps < 0. 001) . Both the whole scale and three factors all showed acceptable internal consistency ( Cronbach α = 0. 73 - 0. 91), as well as satisfactory retest reliability ( ICC = 0. 71 - 0. 84). Conclusion: The Chinese version of the 15-item Positive Subscale of the Community Assessment of Psychic Experiences ( CAPE-P15) shows good validity and reliability in high school students, and could be used to assess psychotic-like experiences in high school students. [ABSTRACT FROM AUTHOR]

[Objective] To determine the indoor inhibitory effect of the tested microbial fertilizers on the four soil-borne disease pathogens of potato (Streptomyces galilaeus, Verticillium dahliae, Fusarium oxysporum and Rhizoctonia solani). [Methods] By the method of mycelial growth rate, the inhibitory effect of four soil-borne disease pathogens of potato treated with different concentrations of microbial fertilizer (50, 100, 1 000 mg/L) was determined, and the effect of microbial fertilizer on the 4 pathogens toxicity was determined. [Results] The inhibition ratio of same pathogen was improved with the increase of concentration of microbial fertilizer;the greatest inhibitory effect showed when four pathogens treated with 1 000 mg/L microbial fertilizer, and the inhibition ratio of Streptomyces galilaeus and Verticillium dahliae were 97.44% and 85.01%, the inhibition ratio of Fusarium oxysporum and Rhizoctonia solani were 76.62% and 32.07%. The microbial fertilizer showed different toxicity effects on 4 pathogens, EC50 of Verticillium dahliae and Streptomyces galilaeus were smaller and were 18.251 mg/L and 41.461 mg/L;EC50 of Fusarium oxysporum was 140.939 mg/L, while EC50 of Rhizoctonia solani was the biggest (18 632.649 mg/L). [Conclusion] The tested microbial fertilizer had a strong inhibitory effect and toxicity against Verticillium dahliae and Streptomyces galilaeus, and has a certain inhibitory effect and toxicity against Fusarium oxysporum, but it has a lesser inhibitory effect and toxicity against Rhizoctonia solani. [ABSTRACT FROM AUTHOR]

This study aims to investigate the impact of circulation injection quantity on the cold start and emission performance of small agricultural diesel engines. The optimal quantity of circulation injection was also determined at critical temperatures. The study focuses on an inline twin-bar high-pressure common rail diesel engine. Using the environment simulation cabin whole engine test platform, several pre-tests were conducted. The results showed that the diesel engine started successfully without opening the preheating device at an altitude of 2 000 m and a critical temperature of -5 ℃. Three types of injections were used in this case. Specifically, the injection time of pre-injection 2, pre-injection 1 and main injection was -22, -14.4 and - 7.7 °CA ATDC (crank angle after top dead center), respectively, and the injection duration of pre-injection 2 was 2.5 °CA, and the circulation injection quantity was fixed at 2.5 mg. The pre-injection 1 injection duration was 3 °CA, and the pre-injection amount was fixed at 3 mg. The circulation injection quantity was varied in the main injection volume, with the values of 8, 15, 17, 20, 25, 30, 34, and 40 mg. The target speed was set as 1 050 r/min. The cold start time and emissions of HC, CO, and NOx were measured at various circulation injection quantities during the test. The results indicate that the cold start time of the diesel engine increased or even resulted in the start failure with the larger or smaller amount of circulation fuel injection. As the circulation injection quantity increased, the cold start time initially decreased and then increased again. The shortest start time was 266 s at the 20 mg of circulation injection quantity. The longest start time was 365 s at the 15 mg of circulation injection quantity, with a difference of nearly 100 s. Additionally, the lowest peaks of HC and CO emissions were also observed as 12 984 and 3 008 mg/L, respectively, at 20 mg. The variation in the circulation injection quantity also resulted in an increase in the peak of HC and CO emissions. Furthermore, the peak value of CO emission increased significantly with the larger circulation injection quantity, where the peak value appeared earlier. The circulation injection quantity had a greater effect on the NOx emission peak. The lowest peak of NOx emission was 368 mg/L at the circulation injection quantity of 30 mg. Therefore, there was a significant impact of circulation injection quantity on the cold start and emission performance of diesel engines. The optimal quantity of circulation injection was also beneficial to reducing the start time and emissions for higher generating efficiency and a friendly environment. Furthermore, 20 mg was the optimal circulation injection quantity for the cold start in this small diesel engine at an altitude of 2 000 m and an ambient temperature of -5 ℃. These findings can also provide experimental data to optimize the cold start and emissions of engines. The circulation injection quantity with after-treatment devices can further reduce the cold start emissions. [ABSTRACT FROM AUTHOR]

Following pseudo-periodic time series, the 11 cycles 11 of hog price repeats differently in length and shape, which causes difficulties in prediction. To solve the problem, a hog price prediction method was proposed based on long short term memory ( LSTM ) network model. The prediction factors were preprocessed and selected by PCA model, and the key parameters of LSTM model were optimized by firefly algorithm (FA) . According to the parameters, the networks were trained to establish 3 prediction models, and the models were used to predict hog prices of the following 1, 2 and 8 weeks. The results show that according to the proposed method, the mean absolute error, the root mean squared error and the decision coefficient are respective 1. 455 8, 4. 910 2 and 92. 57%, which illuminates that compared with conventional shallow prediction models and unoptimized LSTM model, the proposed method exhibits superior performance. The proposed method can deal with the changes of the cycles of hog price and is suitable for the prediction of hog price and other price series with the same characteristics. [ABSTRACT FROM AUTHOR]

Crop diseases have posed a major threat to food production and the agricultural ecosystem worldwide. Automatic detection and classification of crop diseases are highly urgent to facilitate targeted and timely disease control in modern agriculture. The complex crop disease is ever-deepening the difficulty of feature extraction in traditional machine learning, where the human selection of features requires lots of experiments and experience. Alternatively, the convolutional neural network (CNN) can automatically extract relevant features from the input images, thereby imitating the human visual process. The learned features are also the key to the success of deep learning. However, the CNN identification model is difficult to deal with the complex planting structure in the actual production, if only a single species is identified. In this study, a feasible classification of crop disease was proposed using the improved deep residual network (SE-ResNeXt-101) and transfer learning (TL-SE-ResNeXt-101) for the detection task without specifying crop species. The dataset of crop disease was used from the AI Challenger 2018 competition, containing 27 types of diseases on 10 plant species: apple, cherry, corn, grape, citrus, peach, pepper, potato, strawberry, and tomato. In the reconstructed dataset, the "species-disease" approach was utilized to extract 33 categories of crop diseases with a total of 35 332 leaves images of different sizes. The training set, validation set, and test set were divided at the ratio of 8:1:1. In the test, the dataset was first preprocessed to uniformly transform the images of different sizes into 224×224×3, and then the image pixels were de-averaged and normalized to reduce the computational effort, in order to prevent the gradient explosion in the training of deep learning models for the convergence. Data enhancement techniques were used to increase the diversity of samples, including color enhancement, random angle, random crop, and horizontal random flip. The color enhancement was utilized to adjust the brightness, contrast, saturation, and chromaticity. The random angle was to rotate the image randomly between -15°and 15°. The random crop was to obtain a portion of the image arbitrarily between the scales of 0.1 to 1, and then convert it to 224×224 image size. The horizontal random flip was to randomly flip the image into a mirror image. The randomization probability of all data enhancement was 50%. The proposed model was compared with the VGG-16, GoogLeNet, ResNet-50, and DenseNet-121 models under the same experimental conditions. The experimental results show that the transfer learning significantly improved the convergence speed and classification performance of the model, thereby training a better model in a shorter period. Data enhancement techniques reduced the dependence of the model on certain attributes without overfitting for better performance and generalization. The average accuracy and weighted F1 value reached 98% in the TL-SE-ResNeXt-101 model, better than other models. The TL-SE-ResNeXt-101 model also had an excellent classification effect on the image samples in real agricultural production. The average accuracy of the TL-SE-ResNext-101 model reached 47.37% on the PlantDoc test set, indicating strong robustness to serve as a promising technology for crop disease identification. [ABSTRACT FROM AUTHOR]

Using the panel data of 30 provincial-level administrative units in China from 2006 to 2017, an empirical analysis of the relationship between fiscal decentralization and environmental pollution was carried out by means of a spatial measurement model, and the direct effect, space spillover effect and total effect of fiscal revenue decentralization and fiscal expenditure decentralization on environmental pollution were calculated respectively by means of effect decomposition. The results of the model estimation showed that: ① The decentralization of fiscal revenue and that of fiscal expenditure had a significant impact on environmental pollution through direct effects and space spillover effects, but the decentralization of fiscal revenue and fiscal expenditure demonstrated heterogeneity in the spatial effect on environmental pollution,② The decentralization of fiscal revenue had a significant negative direct effect and negative spatial spillover effect on environmental pollution. The impact coefficients were -5.429 and - 17.572, respectively. Increasing fiscal revenue decentralization not only helped reduce the environmental pollution in a province per se, but also had a restraining effect on the environmental pollution of neighboring provinces; decentralization of fiscal expenditure had a significant negative direct effect and positive spatial spillover effect on environmental pollution, the impact degrees were -3.345 and 1. 173, respectively. Increasing fiscal decentralization was beneficial to the reduction of provincial pollution emissions, but to a certain extent, could cause inter-provincial pollution spillover effects and increase the pollution level of neighboring provinces.③ In terms of total effect, the decentralization of fiscal revenue and decentralization of fiscal expenditure had a significant negative correlation to environmental pollution, with the impact levels of -23,001 and - 2. 172, respectively. Increasing fiscal decentralization could reduce the level of environmental pollution and help to improve environmental quality.④ The robustness of the model was tested by constructing different spatial weight matrices. The results showed that the model estimation was robust and reliable. According to the conclusions of the analysis, this study puts forward the following suggestions:① Fiscal authority and expenditure responsibility should be rationally divided between the central government and the local governments, the decentralization of fiscal expenditure and the decentralization of local government fiscal revenue should be increased, and the enthusiasm and initiative of the local governments in environmental governance should be brought into full play. ② It is necessary to continue to increase the intensity of ecological environmental protection, improve the green economy assessment mechanism, and guide local governments to increase their expenditure levels and efficiency on pollution control and environmental improvement. [ABSTRACT FROM AUTHOR]