Objective: To explore Chen's heart failure formula and its application β-Effect of receptor blockers on heart failure in ischemic cardiomyopathy and its effect on cardiac function and 6-minute walk test. Methods: A total of 70 patients with ischemic cardiomyopathy and heart failure treated in our hospital from April 2022 to May 2022 were selected as the research objects, and were randomly divided into heart failure formula group and control group, with 35 patients in each group. The patients in the control group were treated with routine treatment+ β-The patients in the heart failure formula group were treated with Chen's heart failure formula on the basis of the treatment of the control group. The effects of the two treatment schemes on cardiac function and 6-minute walking test were compared. Results: The treatment effective rate of the heart failure formula group(97.1 %) was significantly higher than that of the control group(82.9 %)(P<0.05); After treatment, the cardiac function in both groups was significantly improved, while compared with the control group, the LVEDD and LVESD in the Xinshuaifang group were significantly decreased, and the LVEF was significantly increased (P<0.05); There was no statistical difference in the results of walking test 6 minutes before treatment(P>0.05). After treatment, the results of 6-min walking test in the two groups were significantly longer than those before treatment, and the heart failure formula group was also significantly longer than the control group after treatment(P<0.05); Before treatment, there was no significant difference in BNP level, TCM syndrome score and quality of life score between the two groups(P>0.05). After treatment, the BNP levels, TCM syndrome scores, and quality of life scores in the two groups were significantly decreased, and the heart failure formula group was also significantly lower than the control group(P<0.05). Conclusion: Chen's heart failure formula and β-Receptor blockers are effective in the treatment of ischemic cardiomyopathy with heart failure. They can improve the cardiac function of patients, and the curative effect is better than that of single application β-Receptor blockers are more suitable for the treatment of ischemic cardiomyopathy and heart failure. Clinically, functional combination therapy is actively and widely used. [ABSTRACT FROM AUTHOR]