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目的探究雌性大鼠性早熟对糖代谢和脂代谢的影响。方法将60只两天龄的雌性大鼠随机分为性早熟组和正常组两组，分别在5天龄时给予达那唑（300 μg/只）或溶剂大豆油进行皮下注射，从21天龄起每天观察大鼠的阴道开口状况。建模成功的两组按照阴道开口顺序分别于阴道开口后3 d、7周龄和12周龄进行处死，处死前空腹12 h。方法测量麻醉后的体重和鼻肛长，通过酶联免疫吸附试验测量葡萄糖、胰岛素、血脂、雌二醇、瘦素和脂联素的浓度，病理切片观察肾周脂肪、子宫和卵巢的变化。结果通过正常组和早熟组两组3个时间点对比，早熟组在阴道开口3 d时体质量和鼻肛长小于正常组，但是不影响后续生长发育，7周龄和12周龄时两组体质量和鼻肛长差异无统计学意义。两组的胰岛素浓度对比在阴道开口后3天内有统计学意义（P = 0.001），早熟组存在高胰岛素血症，且早熟组此时的肾周脂肪细胞增多，在7和12周龄差异无统计学意义，两组3个时间点的雌二醇、瘦素和脂联素浓度差异均无统计学意义，两组卵巢和子宫与体质量的比重差异无统计学意义。结论通过两组大鼠的对比，性早熟使机体提前跨越发育的时间窗，不能适应内环境的骤变，产生的一系列变化只是暂时性且可逆性，至成年期会恢复。

目的总结以黄色瘤为首发表现的谷固醇血症（STSL）患儿临床特点，以期为临床早识别、早诊断提供线索。方法总结和比较儿童STSL的临床特征及以黄色瘤为首发临床表现的STSL和纯合子FH（HoFH）患儿的胆固醇（Chol）、低密度脂蛋白胆固醇（LDL-c）、平均血小板体积（MPV）水平、贫血比例，探讨其在两病的鉴别诊断的价值。结果来自两个三甲医院儿科内分泌专科的10例STSL儿童纳入研究，男女孩各5例。儿童STSL的黄色瘤表现多样。有5例（50%）合并轻度贫血。2例（20%）有血管并发症。Chol和LDL-c水平显著高于父亲和母亲。ABCG5纯合或者复合杂合变异9例，ABCG8复合杂合变异1例。纳入10例黄色瘤为首发表现FH为对照组，均为HoFH，男孩4例，女孩6例。黄色瘤表现与STSL组类似。FH组无贫血患儿，有更高的Chol和LDL-c水平（P分别为0.001、0.003），STSL组有更高的MPV（P=0.006）和贫血比例（P=0.033）。Chol、LDL-c、MPV、贫血诊断STSL的AUC值分别为0.910、0.890、0.869、0.750，均具有较好的鉴别诊断价值。在约登指数最大时，取各个值的诊断界值，当Chol≤15.41mmol/L、LDL-c≤13.22 mmol/L、MPV≥9.05fl、贫血，为诊断STSL最佳界值。结论STSL的黄色瘤表现多样，与FH类似，而易误诊。以黄色瘤为首发表现，若患儿Chol≤15.41mmol/L、LDL-c≤13.22 mmol/L、MPV≥9.05 fl、贫血，提示临床诊断为STSL可能性大。

Copyright of Modern Preventive Medicine is the property of Modern Preventive Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Diabetes Mellitus is the property of Chinese Journal of Diabetes Mellitus and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

【目的】对比不同剂量聚乙二醇重组人生长激素（PEG-rhGH）注射液治疗青春期前生长激素缺乏症（GHD）儿童促生长的疗效、安全性和不良事件，为临床用药提供参考。【方法】2015 年6 月至2016 年10 月在中山大学附属第一医院儿童生长发育中心确诊青春期前GHD 儿童 37 例，按PEG-rhGH 剂量随机分为两组：低剂量组（0.12 mg/kg，每周皮下注射 1 次）19 例和高剂量组（0.20 mg/kg，每周皮下注射 1 次）18 例，疗程 26 周。治疗过程监测身高、体质量、身高增长速度（HV）、身高标准差分值（HtSDS）、体质量指数（BMI）、骨龄（BA）和血清IGF-1 水平，收集不良反应信息。【结果】两组儿童治疗后的HV、HtSDS 及IGF-1 均较治疗前显著提高（P < 0.001），高剂量组 HV、HtSDS 增加值和血清 IGF-1 水平均高于低剂量组，但差异无显著性（P 值分别为 0.055、0.052 和 0.054）； HtSDS 和骨龄增长两组差异无统计学意义（P > 0.05）。治疗过程中出现不同程度局部脂肪萎缩6 例（16.2%）（高剂量组3 例16.7%，低剂量组3 例15.8%），与家长相对固定注射部位相关，经指导变换注射部位后3~6 月脂肪萎缩好转。低皮 质醇血症6 例（16.2%）（高剂量组4 例22.2%，低剂量组2 例10.5%）；亚临床甲状腺功能减退2 例（高剂量组1 例， 低剂量组1 例，为高TSH，T3、T4 正常）。两组的不良反应发生率无统计学差异（P > 0.05），未见明显严重不良反应。【结论】PEG-rhGH 能有效促进GHD 患儿的线性生长，高剂量组疗效似优于低剂量组。两组不良事件差异无统计学意义。聚乙二醇重组人生长激素治疗过程中有相当比例发生一定程度的局部脂肪萎缩，临床应用中必须注意注射部位轮换，可防范和降低不良反应的发生，提高治疗依从性。

Copyright of Chinese Mental Health Journal / Zhongguo Xinli Weisheng Zazhi is the property of Chinese Mental Health Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Modern Preventive Medicine is the property of Modern Preventive Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Rural Water & Hydropower is the property of China Rural Water & Hydropower Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的】分析中国儿童青少年特纳综合征患者的血脂水平及其相关因素。【方法】将未经任何药物治 疗的特纳综合征（TS）患者按年龄（

： 【目的】探讨芳香化酶抑制剂来曲唑对青春早中期男童生殖功能和线性生长的影响。【方法】来曲唑 组为43例预测成年身高受损的青春早中期男孩，口服来曲唑1.5 mg/平方米/天，每天不大于2.5 mg。48例青春 早中期、未治疗的健康男孩作为对照。比较两组生殖功能和线性生长的各项指标、血清性激素、IGF-1、AMH和 Inhibin B水平干预前后的变化。【结果】干预前对照组与来曲唑组年龄、骨龄、观察时间、年龄别身高及骨龄别身 高标准差分值（HtSDSCA、HtSDSBA）等生长参数差异均无统计学意义。干预治疗后，来曲唑组与对照组相比，骨 龄抑制明显，预测成年身高增加，睾丸容积增大明显，且 BMI 增加，差异均有显著性（P 值分别是 0.001、0.018、 0.002、0.027）。来曲唑组 FSH、△FSH 、LH、△LH、T、△T、水平显著高于对照组（P 值均

【目的】探讨早初潮女孩及应用过促性腺激素释放激素类似物（GnRHa）治疗的女孩代谢和性腺轴的改变。 【方法】选取我院因早初潮就诊 39 例，曾应用 GnRHa 治疗并已呈现初潮女孩 58 例作为研究对象，并以正常初潮 19 例作 为对照。测量身高、体重，B 超测量子宫、卵巢大小，抽血查性激素及胰岛素、血糖、血脂、leptin、adiponectin 等代谢指标。 【结果】早初潮女孩年龄别和骨龄别体质指数标准差分值（BMISDS）均较正常初潮女孩显著增高（P < 0.05），发生胰岛素抵 抗的比例（20.5%）亦较正常初潮女孩（0%）显著升高，而脂代谢和性腺轴各项指标均无差异。GnRHa治疗者初潮后BMISDS 和胰岛素、HOMA-IR及发生胰岛素的比例（20.7%）均较正常初潮组显著升高（P < 0.05）；同时，DHEAS、雄烯二酮和睾酮均 较早初潮组高，子宫体积较正常和早初潮组显著增大。【结论】早初潮及GnRHa治疗有可能对BMI和糖代谢产生负面影响， GnRHa治疗者还伴雄激素分泌功能相对稍亢进。因此，建议早初潮女孩应监测胰岛素、血糖等糖代谢指标，GnRHa治疗的 患儿应从治疗开始一直监测糖代谢指标至初潮后，从而早期发现、早期治疗可能存在的高胰岛素血症。

【目的】观察二甲双胍对于肥胖儿童非酒精性脂肪性肝病（NAFLD）的治疗效果。【方法】回顾性分析2013年 7月10日至2016年8月23日中山大学附属第一医院儿科内分泌门诊诊断为NAFLD，伴ALT、AST升高，单纯使用二甲双 胍进行治疗的患儿，共10例。比较二甲双胍治疗前后患儿的肝酶学、肝脏彩超表现、血脂、血糖、胰岛素、稳态模型胰岛素 抵抗指数（HOMA-IR），BMI 及腰围身高比（WHtR）的变化。【结果】脂肪性肝炎（NASH）患儿 10 例，其中男孩 5 例，女孩 5 例。二甲双胍短期治疗后血ALT、AST、HOMA-IR、空腹胰岛素及WHtR均较治疗前降低（P < 0.05），其中ALT、AST、HOMA- IR降低显著（P < 0.01），下降率为100%（10/10），并随疗程延长呈逐渐下降趋势，而BMI、TG、血糖在治疗前后无统计学差异 （P > 0.05）。其中3例有复查肝脏彩超的患儿均显示脂肪肝程度有所改善。【结论】二甲双胍治疗短期内即可有效的改善 NASH患儿肝酶学的异常和胰岛素敏感性，而短期内对于血脂和BMI无明显改善。

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Mental Health Journal / Zhongguo Xinli Weisheng Zazhi is the property of Chinese Mental Health Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Transactions of the Chinese Society of Agricultural Engineering is the property of Chinese Society of Agricultural Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To systematically evaluate the efficacy of metadoxine in the treatment of alcoholic liver disease (ALD). Methods The databases of PubMed，Cochrane Library，MEDLINE，EMBASE，Web of Science，Chinese Journal Net Database(CNKI)，Wanfang database were retrieved to search the Chinese/English articles about the randomized controlled clinical trials(RCTs)in the application of metadoxine for treating ALD from their establishment to June 2017. The RevMan5.3 software was adopted to conduct the analysis. Results A total of 10 atticles were included. The meta analysis results showed that the total effective rate，ALT decreasing amount，AST decreasing amount，GGT decreasing amount，cholesterol decreasing amount and triglyceride decreasing amount had statistical difference between the metadoxine single use group and combined medication group(P<0.05). The combined medication group had statistical significance in the outcome indicator of total bilirubin decreasing amount(P<0.05)，while the metadoxine single use group had no statistical significance(P>0.05). Using metadoxine combined with other positive drugs in the patients with severe alcoholic hepatitis could significantly reduce the occurrence of recent death event. Conclusion Metadoxine can improve the liver function，total bilirubin and blood lipids in ALD patients，reduces the recent death event of the patients with severe alcoholic hepatitis，and has a certain clinical value in the treatment of ALD. [ABSTRACT FROM AUTHOR]

Copyright of Foreign Literature Studies is the property of Foreign Literature Studies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)