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Objective: To explore the correlation between serum Klotho protein, fibroblast growth factor-23 (FGF-23), retinol binding protein 4 (RBP4), tumor necrosis factor like weak apoptosis inducing factor (TWEAK) levels and renal function in patients with chronic kidney disease at different stages(CKD). Methods: 80 cases of patients with CKD who were diagnosed and treated in our hospital from February 2018 to February 2020 were selected as the CKD group, and 80 healthy patients who underwent physical examination in our hospital during the same period were selected as the control group. Serum levels of Klotho protein, FGF-23, RBP4, TWEAK and the renal function indexes in the control group, CKD group and patients with different CKD stages were measured and compared, the correlation between serum levels of Klotho protein, FGF-23, RBP4, TWEAK and renal function indexes were analyzed by Pearson correlation. Results: Compared with the control group, the serum levels of Klotho protein, TWEAK and glomerular filtration rate (GFR) were significantly reduced in the CKD group, while the levels of serum FGF-23, RBP4, serum creatinine, 24 urine protein and serum urea nitrogen were significantly increased (P<0.05). Serum levels of Klotho protein, TWEAK and glomerular filtration rate in the Ⅰ~Ⅱ stage patients was highest, followed by Ⅲ ~ Ⅳ period patients, Ⅴ period in patients were the lowest (P<0.05). And the Serum level of FGF-23, RBP4 24 urinary protein, serum creatinine, serum urea nitrogen in the stage Ⅰ~Ⅱ patients were the lowest, followed by Ⅲ ~ Ⅳ period patients, patients with Ⅴ period were the highest(P<0.05). The levels of serum Klotho protein and TWEAK were negatively correlated with the levels of serum creatinine, 24 urine protein quantification and serum urea nitrogen, and positively correlated with glomerular filtration rate (P<0.05). The levels of FGF-23 and RBP4 were positively correlated with the levels of serum creatinine, 24 urine protein quantification and serum urea nitrogen, and negatively correlated with glomerular filtration rate (P<0.05). Conclusion: In CKD patients, the levels of serum Klotho protein, TWEAK and renal function decreased, the levels of FGF-23 and RBP4 increased significantly, and the levels of serum Klotho protein, TWEAK, FGF-23 and RBP4 are related to the renal function and the CKD stage. [ABSTRACT FROM AUTHOR]

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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)