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Objective：To evaluate the clinical diagnostic value of rheumatoid arthritis （RA） related autoantibodies based on magnetic particle chemiluminescence examination. Methods：RA related autoantibodies （anti-RA33, anti-CCP, RF, RF-IgM and RFIgG） detected in People's Hospital of Chongqing Banan District from September 2021 to March 2022 were analyzed retrospectively, including 105 patients with RA and 71 disease control groups. All autoantibodies were detected by acridine ester magnetic particle che⁃ miluminescence method. ROC curve was used to analyze diagnostic value of each test index for RA, and Spearman correlation analysis was used to analyze correlation between the test variables. Results：Serum levels of anti-CCP, RF, RF-IgG and RF-IgM in RA group were significantly higher than those in control group （P<0.05）, while there was no significant difference in anti-RA33 between two groups （P>0.05）； anti-CCP had the highest negative predictive value, positive predictive value and Youden index as diagnosis of RA, and anti-RA33 had the lowest sensitivity but the highest specificity as diagnosis of RA； RF-IgG has the highest sensitivity in diagnosis of RA. ROC curve analysis showed that AUC of anti-RA33, anti CCP, RF, RF-IgG and RF-IgM were 0.520，0.870，0.816，0.853 and 0.848, respectively. Spearman correlation analysis showed that there was a significant correlation among anti-CCP, RF, RF-IgG and RF-IgM （P<0.05）, while there was no significant correlation between anti-RA33 and these four indexes （P>0.05）. Conclusion：Sensi⁃ tivity of ani-RA33 is too low, hence it is easy to escape diagnosis or be misdiagnosed as preliminary screening test. RF, RF-IgG and RF-IgM had important diagnostic value for RA and can be used for the preliminary screening test of RA diseases. Anti-CCP is still the autoantibody with the highest diagnostic accuracy in the five autoantibodies, which can be used for the preliminary screening and confirmatory of RA. [ABSTRACT FROM AUTHOR]