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Copyright of China Tropical Medicine is the property of China Tropical Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Differentially expressed genes were systematically indentified by analyzing transcriptome data of dengue fever patients and healthy samples. Then a competing endogenous RNA (ceRNA) network was constrcuted and essential genes were indentified. The potential biological functions were revealed through enrichment analysis. This study can give an insight into the development of diagnostic markers for dengue disease. The differential expression gene and enrichment analysis were performed based on the microarray data from the GE0 database for dengue. Through integration of the StarBase dataset, hypergeometric and Pearson correlation methods, we identified ceRNA interactions for dengue disease. The visualization and the screening of ceRNA network modules were performed by Cytoscape software. We also performed enrichment analysis and verified the expression pattern of ceRNA in an external dataset and identified 251 differentially expressed (DE) genes, The DE genes were significantly enriched in several biological processes like cell cycle. The expression pattern of network module genes was verified in the external dataset, indicating the potential diagnostic efficacy of the ceRNA network module in dengue disease. This study can provide insights for identifying effective molecular markers for disease diagnosis. [ABSTRACT FROM AUTHOR]

Copyright of China Tropical Medicine is the property of China Tropical Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)