1. Expression of manganese superoxide dismutase in patients with breast cancer
- Author
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Shih-Meng Tsai, Ming-Feng Hou, Szu-Hsien Wu, Bao-Wen Hu, Sheau-Fang Yang, Wan-Tzu Chen, Chee-Yin Chai, Hsu Ma, Li-Yu Tsai, 蔡世盟, 侯明鋒, 吳思賢, 胡寶文, 楊曉芳, 陳婉姿, 蔡志仁, 馬旭, and 蔡麗玉
- Subjects
Breast cancer ,Ductal carcinoma in situ ,Invasive ductal carcinoma ,Manganese superoxide dismutase ,Immunohistochemical stain ,Medicine (General) ,R5-920 - Abstract
Breast cancer has become the second leading cancer among females in Taiwan. Even though the etiology of breast cancer is multifactorial, oxidative stress plays an important role in the carcinogenesis. The purpose of this study was to investigate the expression of manganese superoxide dismutase (MnSOD), one of the major antioxidant enzymes that is involved against oxidative stress, in adjacent cancer-free breast tissues and neoplasm tissues within the same patient. Sixty-five breast cancer patients’ formalin-fixed tissue blocks, including ductal carcinoma in situ (DCIS) tissues, invasive ductal carcinoma (IDC) tissues, and adjacent cancer-free tissues, were evaluated by immunohistochemical stain. Meanwhile, their demographic and clinical information was also collected. The combined scores of MnSOD-positive cell proportion and MnSOD staining intensity were compared for different tissues within the same patient. The results showed that the mean combined scores of MnSOD expression in adjacent cancer-free tissues (6.33), IDC (5.30), and DCIS (3.78) were significantly different when assessed by repeated-measurement analysis of variance (F=14.17, p
- Published
- 2011
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