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Copyright of Technology of Water Treatment is the property of Technology of Water Treatment Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

AIM: To investigate the therapeutic effects of syringin (SY) on vascular cognitive impairment (VCI) in rats and its possible mechanisms. METHODS: The rats were allocated into three groups: sham group(n=15); model group (n=21); and SY treatment group (n=19). The VCI rat model was induced via a modified bilateral ligation of the common carotid artery. Three days after the model induction, the SY treatment group received intraperitoneal injections of 50 mg/kg SY once daily for 28 d. In total, 15 rats in the sham operation group, 17 rats in the model group, and 17 rats in the SY treatment group were included for further investigation. The cognitive and learning functions of the rats were assessed using the Morris water maze test, Y-maze test, and novel object recognition experiment. Cerebral blood flow was monitored through laser speckle imaging, while Evans blue staining was used to assess damage to the blood-brain barrier. Nissl staining, microtubule-associated protein-2(MAP-2), and neuronal nuclear antigen(NeuN) co-localization immunofluorescence staining demonstrated the extent of hippocampal damage. ELISA was employed to measure the levels of interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) in the brain tissue. Microglial activation was observed viaionized calcium-binding adapter molecule 1 (IBA1) immunofluorescence staining, and Western blot analysis detected the expression of Toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88) and phosphorylated (p)-P65 proteins in the brain tissue. RESULTS: Compared with the sham group, rats in the model group exhibited reduced cognitive function and cerebral blood flow (P<0. 01), increased blood-brain barrier permeability and degree of hippocampal tissue damage (P<0. 01), upregulation of TLR4, MyD88, and p-P65 protein expression in the brain tissue (P<0. 01), elevated levels of IL-1β, IL-6 and TNF-α (P<0. 01), as well as microglia activation (P<0. 01). In contrast to the model group, rats in the SY group demonstrated enhanced cognitive function and cerebral blood flow (P<0. 01), decreased blood-brain barrier permeability and degree of hippocampal tissue damage (P<0. 01), downregulation of TLR4, MyD88 and p-P65 protein expression in the brain tissue(P<0. 01), reduced levels of IL-1β, IL-6 and TNF-α, and reduced microglia density (P<0. 01). CONCLUSION: SY enhances cognitive function in VCI rats by improving cerebral blood flow, safeguarding the integrity of the blood-brain barrier, attenuating neuroinflammation, mitigating neuronal damage within the hippocampus, and inhibiting TLR4/MyD88/NF-κB signaling pathways. [ABSTRACT FROM AUTHOR]

Copyright of Modern Food Science & Technology is the property of Editorial Office of Modern Food Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 探讨急性非ST段抬高型心肌梗死（NSTEMI）患者血清B型脑利钠肽（BNP）水平与病情及预后的关系。方法选择92例NSTEMI患者，根据入院时血清BNP水平均值为界值，将患者分为低BNP组33例（BNP≤142．19 ng／L），高BNP组59例（BNP＞142．19 ng／L）。两组均行经皮冠状动脉介入治疗（PCI），出院后随访2年。分析血清BNP水平与梗死冠状动脉位置、病变冠状动脉支数、Gensini积分、PCI效果、随访期间主要心血管不良事件（MACE）发生情况的关系。结果低BNP组和高BNP组梗死冠状动脉位置、病变冠状动脉支数比较差异均无统计学意义（P均＞0．05），低BNP组Gensini 积分低于高BNP组、PCI成功率高于高BNP组（P均＜0．05）。随访期间，低BNP组MACE发生率低于高BNP组（P＜0．05）。结论血清BNP水平有助于判断NSTEMI患者病情及预后。 [ABSTRACT FROM AUTHOR]