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Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To research the influence of rocuronium pharmacodynamics in patients with different degree of hepatosis.Methods: The 152 cases of patients with surgery were divided into three groups according to the Child-Pugh scores: group A(Child-Pugh A) with 62 cases, group B(Child-Pugh B) with 55 cases and group C(Child-Pugh C) with 35 cases. Meanwhile, 60 patients with normal liver function were included in this research as control group. Vecuronium bromide was injected with dynamic target control infusion procedure control, between 0.15~0.2 μg/m L, muscle relaxant T1/TC level maintained within 25%. General indexes including gender,age, weight and BMI, and the anesthesia onset time, maximum block anesthesia duration, T110% recovery time, T125% recovery time,T1 75 % recovery time, recovery index were analyzed and compared. Results: Anesthetic onset time extended gradually in A, B, C groups, and differences between them were statistically significant(P>0.05). The duration of block anesthesia in A, B, C groups gradually declined, and difference between them was statistically significant(P>0.05). Anesthesia recovery index in A, B, C groups increased gradually, and the difference between groups was statistically significant(P>0.05). T110 %, T125%, and T175 % % recovery time in group A, B, C, and the control group had no significant difference(P>0.05). In Child-Pugh class A group, the anesthesia onset time was obviously faster in women subgroup than in men subgroup, with statistically significant difference(P>0.05); and the block duration was longer in women subgroup than in men subgroup, also with statistically significant difference(P>0.05). In the Child-Pugh class B group, the anesthesia onset time was obviously faster in women subgroup than in men subgroup, and the difference was statistically significant(P>0.05). Yet, there were no statistical differences in onset time, maximum block anesthesia and recovery index between women and men in Child-Pugh C group(P>0.05). Conclusions: Hepatosis significantly affect the effect time of rocuronium. It could not consider the effect of gender when rocuronium is used for patients with severe liver disorders. [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: Methods: To compare the influence of cis atracurium and atracurium on the airway function in pediatric anesthesia. A total of 72 patients (42 male and 30 female) were divided into the observation group and control group randomly, 36 cases in each group. Anesthesia induction adopted propofol, fentanyl and midazolamin two groups. The cis atracurium (0.15 mg/kg) was used in observation group while atracurium (0.5 mg/kg) was used in control group. Then comparison of the PETCO2, P-PEAK, auscultation breath sounds, SPO2were conducted between two groups of children at 5, 10, 15, 20 min after intubation on the respiratory system. Results: The changing trend of ETCO2 and P-PEAK was not obvious in observation group at 5, 10, 15, 20 min after intubation, and the auscultation breath sounds and SPO2 also had no significant change (P>0.05). However, ETCO2, P-PEAK, auscultation breath sounds and SPO2 had great changes at 5, 10, 15, 20 min after intubation in control group (P<0.05). As time increasing, the ETCO2 and P-PEAK increased markedly, and SPO2 declined gradually in the control group (P <0.05). At each time point, the SPO2 in observation group was higher than in the control group; ETCO2, P-PEAK and the rale occurrence rate in observation group were significantly lower than in the control group, and the differences were statistically significant (P<0.05). Conclusion: The cis atracurium has less impact on the airway function and ideal muscle relaxant effect, so it could be widely used in clinical general anesthesia. [ABSTRACT FROM AUTHOR]