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Objective: To observe the effects of periodontal basic treatment on serum inflammatory factors, subgingival microflora, and autophagy factors in gingival crevicular fluid in patients with chronic periodontitis with coronary heart disease. Methods: 83 patients with chronic periodontitis with coronary heart disease who were admitted to the Stomatology Department of Chengdu Third People’s Hospital from March 2020 to February 2022 were selected. According to random number table method, patients were divided into control group (n=41) and study group (n=42). The control group received routine medical maintenance treatment, and the study group received periodontal basic treatment on the basis of the control group. The changes of periodontal clinical indicators, serum inflammatory factors, subgingival flora, serum inflammatory factors, autophagy factors in gingival crevicular fluid and periodontal clinical indicators between the two groups were compared. Results: 3 months after treatment, the gingival index (GI), periodontal attachment loss (AL) and periodontal pocket depth (PD) in the study group were lower than those in the control group (P＜0.05). 3 months after treatment, C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin (IL-1β), IL-6, IL-8, IL-17 and IL-18 in the study group were lower than those in the control group, and IL-10 was higher than that in the control group (P＜0.05). 3 months after treatment, relative content of porphyromonas gingivalis, Hemophilus actinomycetes, Prevotella intermediate, Tannerella forsythia and Treponema serrata in the study group were lower than those in the control group (P＜0.05). 3 months after treatment, microtubule-associated protein 1 light chain 3 (LC3) and Beclin-1 in the study group were lower than those in the control group (P＜0.05). Conclusion: Periodontal basic treatment can effectively regulate the level of serum inflammatory factors in patients with chronic periodontitis with coronary heart disease, regulate the content of subgingival microflora, and reduce the level of autophagy factors in gingival crevicular fluid. [ABSTRACT FROM AUTHOR]