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目的探讨治疗前炎性指标在卵巢癌患者预后中的作用，建立卵巢癌患者的便捷、准确的生存预测模型。方法回顾性分析2013年1月至2018年12月在广州市第一人民医院就诊的145例卵巢癌患者及同期60例卵巢良性肿瘤患者的临床、病理及随访资料。根据随访截止日期时患者的生存情况，将患者分成生存组（48例）和死亡组（97例），比较两组患者治疗前外周血中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）、单核细胞与淋巴细胞计数比值（MLR）、单核细胞与淋巴细胞计数比值（NAR）水平，采用Cox回归分析明确影响卵巢癌患者生存的因素，用R软件建立列线图生存预测模型，并进行内部验证。结果NLR、PLR、MLR、NAR在卵巢癌患者中的中位数（四分位数间距）分别为2.98 （1.85， 5.55）、156.17 （110.38， 194.66）、0.28 （0.21， 0.42）、0.17 （0.13， 0.28）；四个指标在卵巢良性肿瘤患者中的中位数（四分位数间距）分别为1.94 （1.49， 3.65）、125.00 （109.38， 180.66）、0.09 （0.04， 0.19）、0.14 （0.11， 0.17）。卵巢癌患者四个指标均高于卵巢良性肿瘤患者，差异具有统计学差异（P ＜0.05）；卵巢癌生存亚组在年龄、FIGO分期、治疗前血清白蛋白水平（37.22±4.86）、NLR （3.12±2.00）、PLR （143.61±54.18）、MLR （0.30±0.17）、NAR ［0.14 （0.11， 0.18）］与死亡亚组的年龄、FIGO分期、治疗前血清白蛋白水平 （34.33±3.73）、NLR （5.38±2.29）、PLR （185.76±64.04）、MLR （0.41±0.19）、NAR ［0.56 （0.19， 0.61）］存在统计学差异（P ＜0.05）；多因素分析显示病理分型、腹水、淋巴结转移、NLR、PLR、NAR是卵巢癌患者5年生存的独立预测因素。列线图预测术后生存模型的C-index为 0.865（0.792，0.921），校准预测曲线和理想曲线拟合良好。结论病理分型、腹水、淋巴结转移、治疗前外周血的NLR、PLR、NAR值是卵巢癌患者预后的独立预测因素，以此为基础构建的列线图模型对卵巢癌患者术后生存情况有良好的预测价值。

【目的】探讨信号转导与转录激活因子4（STAT4）基因rs10181656及rs16833431位点多态性与子痫前期相关性 的关系。【方法】应用聚合酶链反应-限制性片段长度多态性法检测228名子痫前期患者（病例组）和179名健康孕妇（对照 组）的STAT4基因rs10181656 C/G及rs16833431 C/T位点的基因型频率。【结果】①rs10181656位点在病例组中C/C、C/G及G/ G基因型频率分别是35.96％、47.81％及16.23％，而对照组中的三种基因型的频率分别是46.37％、44.69％及8.94％，C/C、C/ G及G/G基因型频率在病例组和对照组中分布具有统计学差异（P = 0.031），C、G等位基因频率在病例组和对照组中分布具 有统计学差异（P = 0.009）；②rs16833431位点：三种基因型和C、T等位基因频率在病例组和对照组的分布无统计学意义 （P = 0.508，0.461）。【结论】STAT4基因rs10181656位点多态性与子痫前期相关，而rs16833431位点多态性与子痫前期发病 无关。

【目的】研究IGF1、IGF2和IGF1R、IGF2R的表达及与胃肠道间质瘤(GISTs)临床病理学特征的关系及其相互间的相关性。【方法】应用免疫组化SABC法检测55例胃肠道间质瘤中IGF1、IGF2和IGF1R、IGF2R的表达情况,结合临床病理学资料(性别、组织学分型、肿瘤直径、组织学分级及部位)分组比较并进行统计学分析。【结果】55例GISTs中IGF1、IGF2和IGF1R、IGF2R阳性表达率分别为61.8%(34/55)、49.1%(28/55)和10.9%(6/55)、18.2%(10/55)。不同肿瘤直径及组织学分级之间IGF1和IGF2的阳性率有显著性差异(P0.05)。IGF1和IGF2、IGF1R和IGF1、IGF1R和IGF2、IGF1R和IGF2R、IGF2R和IGF2的表达均呈正相关(P

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目的 探讨心理干预联合肺康复训练干预在慢性阻塞性肺疾病 (COPD) 患者中的应用价值. 方法 按照随 机数字表法将 2021 年 1 月至 2022 年 12 月就诊于肇庆市第一人民医院的 160 例 COPD 患者分为 2 组 (对照组和观 察组), 并进行前瞻性研究. 对照组的 80 例患者予以常规护理模式干预, 在此基础上, 观察组的 80 例患者予以心理 干预联合肺康复训练干预. 比较 2 组患者在干预前后的心理状态, 肺功能, 运动耐力及生活质量. 结果 干预 7 周 及 12 周后, 2 组的焦虑自评量表, 抑郁自评量表和生活质量评估问卷评分均较同组干预前更低,肺功能各项指标均 较同组干预前更高, 6 分钟步行试验距离均较同组干预前更长 (P 均 < 0. 05); 观察组的上述评分和指标均优于同期 对照组,均有统计学差异 (P 均 < 0. 05) . 结论 将心理干预联合肺康复训练应用于 COPD 患者,有助于其心理状态 和肺功能的改善,以及运动耐力和生活质量的提高。 [ABSTRACT FROM AUTHOR]

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Objective: To investigate the effects of memory training combined with electroacupuncture therapy on cognitive function, health-related quality of life and brain magnetic resonance perfusion imaging parameters in patients with whole brain radiotherapy. Methods: 94 patients with whole brain radiotherapy who were treated in Affiliated Hospital of Jiangnan University from March 2020 to January 2022 were selected, and they were randomly divided into the study group (routine intervention, memory training combined with electroacupuncture therapy) and the control group (routine intervention), 47 cases each. The changes of cognitive function, health-related quality of life and brain magnetic resonance perfusion imaging parameters were compared between the two groups. Results: 1 week, 2 weeks, 3 week and 4 weeks after treatment, the scores of Montreal Cognitive Function Scale (MoCA) and Mini-Mental State Examination (MMSE) in two groups decreased gradually compared with those before treatment, but the scores of MoCA and MMSE in the study group at each time point were higher than those in the control group (P<0.05). 4 weeks after treatment, the scores and total scores of all dimensions of the health-related quality of life scale (HRQoL) in two groups were higher than those before treatment, and the above scores in the study group were higher than those in the control group (P<0.05). 4 weeks after treatment, mean cerebral blood volume (CBV) and mean cerebral blood flow (CBF) in two groups were decreased compared with those before treatment, but those in the study group were higher than those in the control group (P<0.05). Conclusion: Memory training combined with electroacupuncture therapy can alleviate the cognitive impairment caused by whole brain radiotherapy and improve the health-related quality of life of patients, which may be related to the regulation of cerebral blood volume and cerebral blood flow. [ABSTRACT FROM AUTHOR]

本病例报道1例以短暂性脑缺血发作为初发表现的 Stanford A 型急性主动脉夹层患者的临床诊疗情况. 纳 入男性患者, 46岁, 有高血压病史, 表现为“突发左上肢麻木无力3小时”收入院. 患者在入院前3小时突发左上肢麻 木无力, 有头晕、胸闷、大汗淋漓, 伴双眼视物模糊, 无胸痛. 入院神经系统查体未见异常. 结合病史、体征及头颅 CT检查, 初步诊断为短暂性脑缺血发作. 入院再发左上肢麻木、伴轻微胸闷、头晕等, 血压下降, 完善全主动脉CTA 提示主动脉夹层（Stanford A 型）, 经抢救治疗无效而死亡. 本文强调了以神经系统低灌注为主要表现的主动脉夹层的 临床特点, 为非胸痛来诊的主动脉夹层类似病例的诊治提供临床资料, 减少误诊、漏诊率. [ABSTRACT FROM AUTHOR]