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Objective To observe the immediate analgesic effect and mechanism of Three-Manipulation and Three-Acupoint tuina on rats with sciatic nerve injury. Methods Twenty-seven Sprague-Dawley (SD) rats were randomly divided into the sham operation group, model group, and tuina group, with nine rats in each group. In the model and tuina groups, we established the models of mild chronic constriction injury of sciatic nerve to simulate clinical neuropathic pain, while in the sham operation group, rats only underwent nerve exposure and suturing. On the 7th day after modeling, rats in the tuina group received Three-Manipulation and Three-Acupoint tuina therapy, with each acupoint treated for 1 minute using three techniques (9 minutes in total). Rats in the sham operation and model groups were only restrained without intervention for 9 minutes. Mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) were measured before modeling (T1), after modeling but before tuina (T2), and after tuina (T3) to evaluate the immediate analgesic effect. After evaluation, lumbar enlargement segment spinal dorsal horn tissues were collected. Western blotting was used to detect the expression of brain-derived neurotrophic factor (BDNF), tyrosine kinase receptor B (TrkB), and potassium-chloride cotransporter 2 (KCC2) proteins, and immunofluorescence was used to detect the ionized calcium-binding adapter molecule 1 (IBA-1), cluster of differentiation 68 (CD68), and cellular oncogene Fos (c-Fos) expression. Results Compared with the sham operation group, the model group showed significantly lower MWT and TWL at both T2 and T3 (both P<0. 05). However, the tuina group had significantly higher MWT and TWL at T3 as compared with the model group (both P<0. 05). The expression levels of BDNF and TrkB in the dorsal horn were higher, and KCC2 expression was lower in the model group than in the sham operation group (all P<0. 05). Compared with the model group, the tuina group exhibited lower BDNF and TrkB expression but higher KCC2 expression (all P<0. 05). No significant differences were found in the expression of BDNF, TrkB, or KCC2 between the sham operation and tuina groups (all P>0. 05). Additionally, the fluorescence intensity of IBA-1, CD68, and c-Fos was higher in the model group than in the sham operation group (all P<0. 05), while CD68 and c-Fos expression was lower in the Tuina group as compared with the model group (both P>0. 05). Conclusions Three-Manipulation and Three-Acupoint tuina demonstrates a good immediate analgesic effect in rats with sciatic nerve injury. The underlying mechanism may involve modulating microglia-neuron interactions and altering the activation state of microglia. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of trigonelline (TRG) on the proliferation, migration and invasion of non-small cell lung cancer (NSCLC) cells by regulating hypoxia inducible factor-la (HIF-1α)/vascular endothelial growth factor (VEGF) signaling pathway. Methods: (1) In vitro experiments: NSCLC cell lines (A549) were randomly divided into control group (Control group, normal culture), TRG low concentration group (TRG-Low group, 25 μΜ), TRG high concentration group (TRG-High group, 50 µM), TRG high concentration+HIF-la activator dimethyloxalylglycine group (TRG-High+DMOG group, 50 μ.Μ TRG+10 µM DMOG). The proliferation, migration and invasion abilities of cells in each group were detected by Cell Counting Kit-8 (CCK-8) method, cell scratch assay, and transfer the chamber (Transwell), respectively. (2) In vivo experiment: 60 SPF male Rowett nude mice were randomly divided into normal group (NC group), in situ NSCLC model group (Model group), TRG low dose group (TRG-Low group, 40 mg/kg TRG), TRG high dose group (TRG-High group, 80 mg/kg TRG) and TRG high dose+DMOG group (TRG-High+DMOG group, 80 mg/kg TRG+40 mg/kg DMOG), TRG and DMOG were injected intraperitoneally, with 12 mice in each group. The lung tissue in each group of rats was taken for lung weight index and total tumor load measurement at the end of the experiment. The pathological changes of lung in each group were observed by hematoxylin-cosin (HE) staining. The apoptosis rate in lung tissue was evaluated by in situ end labeling (TUNEL) assay. The expression of HIF-1α, VEGF, cyclin D1 (cyclinD1), E-cadherin (E-cadherin) and vimentin (Vimentin) in lung tissue of rats in each group were detected by immunoblot experiments (Western Blot). Results: (1) In vitro experiments: The survival rate, cell migration rate and cell invasion number of A549 cells in TRG-Low group and TRG-High group were significantly lower than those in control group (P<0.05). The survival rate, cell migration rate and cell invasion number of A549 cells in TRG-High+DMOG group were significantly higher than those in TRG-High group(P<0.05). (2) In vivo experiment: The lung weight index, total tumor load, HIF-1α, VEGF, CyclinD1 and Vimentin protein expression in Model group were significantly higher than those in NC group (P<0.05), and the apoptosis rate and E-cadherin protein expression were significantly decreased (P<0.05). The pathological damage of lung tissue was serious, and there were obvious NSCLC lesions. The lung weight index, total tumor load, HIF-1α, VEGF, CyclinD1 and Vimentin protein expression in TRG-High group were significantly lower than thoes in Model group(P<0.05), the apoptosis rate and E-cadherin protein expression level were significantly higher than those in Model group (P<0.05), the pathological damage of lung tissue was reduced, and the NSCLC lesions were reduced. DMOG alleviated the inhibitory effect of TRG on NSCLC (P<0.05). Conclusion: TRG may inhibit the proliferation, migration and invasion of NSCLC cells by inhibiting the HIF-1α/VEGF signaling pathway in vitro and in vivo to prevent progression of NSCLC. [ABSTRACT FROM AUTHOR]

Robotic harvesting had been constrained by the low positioning accuracy of strawberry stem picking points and the significant challenge of identifying occluded strawberries. In this study, we proposed an improved YOLO v8 model combined with Pose key-point detection for enhanced strawberry recognition and localization. The accuracy of picking point localization was also improved, especially for occluded strawberries in complex environments. To optimize the YOLO v8 model, we introduced the Bidirectional Feature Pyramid Network (BiFPN) and the Generalized Attention Module (GAM), which enhanced bidirectional information flow, dynamically allocated feature weights, and focused on extracting features of small targets and enhancing the features of occluded regions. As a result, the model's ability to accurately detect and localize strawberries in complex environments was significantly improved. Experimental results showed that the improved YOLO v8- pose model outperformed the original model in several metrics: the Precision (P) increased by 6. 01 percentage points, Recall (R) by 1. 98 percentage points, mean Average Precision (mAP) by 6. 67 percentage points, and mean Average Precision for key points (mAPkp) by 7. 85 percentage points. The positioning accuracy for strawberry stem picking points, based on key-point detection, achieved errors of just 1. 4 mm in both the X and Y directions and 2. 2 mm in the Z direction. Additionally, the occlusion level was classified according to the overlap area of occluded strawberries, and the model's performance under varying occlusion conditions was assessed. Under these conditions, the mAPkp of the improved YOLO v8-pose model increased by 9. 78 percentage points compared to the original model. Field trials further validated the model's effectiveness, with the strawberry-picking robot achieving a 95% success rate, picking each strawberry within 10 seconds. The high success rate and short picking time demonstrated the practicality of the model in real-world agricultural settings, indicating its high efficiency and accuracy. The improved YOLO v8 model with key-point detection accurately and robustly recognized strawberries, leveraged multi-scale features with the BiFPN architecture, and focused attention on relevant regions with the GAM, especially for occluded strawberries. These advancements significantly improved overall performance in precision, recall, and average precision, particularly under occlusion scenarios. In conclusion, these advanced techniques were integrated into a more capable strawberry-picking robot system. The enhanced accuracy and efficiency achieved in recognizing and localizing strawberries, even in challenging occlusion scenarios, highlighted the system's potential for practical agricultural applications. The findings contributed significantly to automated strawberry harvesting in agricultural robotics, paving the way for more efficient and cost-effective farming solutions in sustainable production. [ABSTRACT FROM AUTHOR]

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to explain the removal mechanism of abrasive cutting materials under ultrasonic action, the single grain grinding process was analyzed, and the mathematical model of undeformed cutting thickness and the fixed velocity ratio (vs/vw) of abrasive and workpiece was established. The single grain tests of conventional grinding (CG), tangential ultrasonic vibration assisted grinding (TUVAG) and radial ultrasonic vibration assisted grinding (RUVAG) with a fixed speed ratio were carried out on AISI 304 specimens. The results showed that the specimens are removed by plastic deformation under the action of CG and TUVAG at the fixed speed ratio, but the ultrasound significantly improves the material removal rate. The material removal method of the specimen under RUVAG was closely related to the value of the maximum undeformed cutting thickness agmax. When agmax is less than 0. 8 μm, the specimen was removed in the form of brittle fracture. After that, with the increase of agmax, the specimen was removed in the form of plastic deformation. [ABSTRACT FROM AUTHOR]

Objective To observe the immediate analgesic effects of Three-Manipulation and Three-Acupoint Tuina on rats with sciatic nerve injury and to explore its mechanisms. Methods Sprague-Dawley (SD) rats were randomly divided into the sham surgery group, model group, and Tuina group, with six in each group. Rats in the model and Tuina groups were subjected to the mild chronic constriction injury of the sciatic nerve to simulate clinical neuropathic pain, while rats in the sham surgery group only had nerve exposure followed by suturing. Seven days after modeling, rats in the Tuina group received Three-Manipulation and Three-Acupoint Tuina intervention using a massage simulator, whereas rats in the sham surgery and model groups underwent equal duration of grip restraint. Mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) were measured before modeling (T1), before Tuina (T2), and after Tuina (T3) to evaluate the immediate analgesic effects of Three-Manipulation and Three-Acupoint Tuina. Subsequently, spinal dorsal horn tissues in intumescentia lumbalis were collected for detection of P2Y12 purinergic receptor (P2RY12), phosphorylat⁃ ed p38 mitogen-activated protein kinase (p-p38 MAPK), and tumor necrosis factor-α（TNF-α) proteins via Western blot⁃ ting. Results Compared with the sham surgery group at the same time points, MWT and TWL in the model and Tuina groups decreased at T2 and T3 (all P<0. 05); compared with the model group at the same time points, MWT and TWL in the Tuina group increased at T3（P<0. 05). The expression levels of P2RY12, p-p38 MAPK, and TNF-α proteins in the model group were higher than those in the sham surgery and Tuina groups (all P<0. 05), with no significant difference be⁃ tween the sham surgery and Tuina groups (all P>0. 05). Conclusion Three-Manipulation and Three-Acupoint Tuina exhibits significant immediate analgesic effects in rats with sciatic nerve injury, potentially through inhibiting the microglial P2RY12/p38 MAPK/TNF-α pathway, thereby alleviating neuropathic pain. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Harbin Institute of Technology. Social Sciences Edition / Haerbin Gongye Daxue Xuebao. Shehui Kexue Ban is the property of Harbin Institute of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Industrial Water Treatment is the property of CNOOC Tianjin Chemical Research & Design Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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A high-precision semi numerical and semi analytical method for interfacial fracture problem of piezo- electric quasicrystals (PQCs)/piezoelectric crystals (PZCs)/elastic material composites with notches was de- veloped. Firstly, the Hamiltonian system was introduced and the Hamiltonian dual equations for the 3-material composite were formulated. The higher order partial differential governing equations were transformed into a set of ordinary differential equations. Secondly, the symplectic eigenvalues and eigensolutions were obtained through separation of variables. The physical quantities were expressed with the expansion of symplectic series. Finally, a symplectic isogeometric analysis (IGA) coupling equation was derived through combination of the symplectic series and the IGA. The analytical expressions of the physical quantities near the notch tip and the intensity factors were derived. [ABSTRACT FROM AUTHOR]

Copyright of Bulletin of the Chinese Ceramic Society is the property of Bulletin of the Chinese Ceramic Society Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Hot air drying is required for the short duration, energy saving, and high quality of food products. In this study, an artificial perforation and alcohol (PAT) pretreatment was proposed to enhance the hot air drying of carrot slices. The carrot was first cut in the transverse and longitudinal sections. Various parameters were then evaluated, including the effective moisture diffusion coefficient, drying rate and time, color, volume shrinkage, rehydration potential, total content of carotenoids and ascorbic acid, antioxidant activity, and flavor. Control samples were selected without pretreatment or subjected to separate perforation (PT) and alcohol maceration (AT) pretreatments. The results demonstrated that the effective moisture diffusion coefficients of pretreated carrot slices ranged from 1.07 to 1.69 times higher in the AT, PT, and PAT pretreatments, compared with the unpretreated samples. The high drying rates enhanced the drying efficacy of carrot slices during hot air drying in the PT, AT, and PAT pretreatments. The drying duration was reduced by 10.61%~50.00%, compared with the unpretreated samples, when the moisture content fell to 0.1 (g water/g dry basis). There was a positive correlation between the drying duration and energy savings. Terefore, at constant drying temperature, air velocigy, and loading, reducing the drying duration implies saving a certain amount of energy. Among them, the PAT pretreated samples exhibited the highest effective moisture diffusion coefficient and drying rate, with the shortest drying duration, followed by the AT, PT, and unpretreated samples. Additionally, a triple enhancement was proposed for the carrot slices drying in the PAT pretreatment: 1) The dehydration load was reduced at the initial dehydration stage in the pretreatment during hot air drying; 2) Capillary water flow was induced by the porous structure that created by artificial perforation; 3) Cell permeability increased to reduce the water flow resistance. Three factors improved the hot air drying of carrot slices. Importantly, the longitudinally-cut carrot slices shared a higher effective moisture diffusion coefficient and drying rate, but a shorter drying time in all pretreatments, compared with the transversely-cut slices. This was attributed to the severe volume shrinkage in the transverse cuts during drying, leading to the less microchannels and impeded moisture diffusion. In physicochemical quality, the hot air drying negatively impacted the quality of fresh carrots. However, the PT, AT, and PAT pretreatments improved the quality of dried carrot slices, in terms of color, volume shrinkage, rehydration, total content of carotenoids and ascorbic acid, antioxidant activity, and flavor. Specifically, PAT pretreatment significantly mitigated the volume shrinkage of longitudinally-cut carrot slices during drying, leading to the least color alteration, the highest saturation and rehydration capacity, as well as the highest content of volatile components. Furthermore, there was the strongest antioxidant activity, due to a relatively high concentration of total carotenoids and ascorbic acid. In conclusion, PAT pretreatment on longitudinal slicing can be an efficient strategy to produce dehydrated carrot slices with superior quality. This research offers practical and effective implications to enhance the hot air drying of fruits or vegetables at an industrial scale. [ABSTRACT FROM AUTHOR]

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Objective: To explore the effects of high-frequency repetitive transcranial magnetic stimulation(r TMS) on cognitive function, cold executive function, and suicidal ideation in first-episode adolescent depression patients. Methods: According to the double color ball method, 114 first-episode adolescent depression patients admitted to the Brain Hospital affiliated to Nanjing Medical University from October 2020 to November 2022 were divided into the control group(treated with Quetiapine Fumarate Extended-Release Tablets and Lithium Carbonate Sustained-release Tablets, n=57) and the observation group(treated with high-frequency r TMS on the basis of the control group, n=57). Control group received quetiapine fumarate combined with lithium carbonate treatment, and observation group received high-frequency r TMS treatment on the basis of control group. The clinical efficacy,depression symptoms, cognitive function, cold executive function, suicidal ideation, and incidence of adverse reactions were compared between two groups. Results: The clinical total effective rate in observation group was higher than that in control group(P＜0.05). The Hamilton depression scale-17(HAMD-17) scores decreased in two groups 2 weeks after treatment and 4 weeks after treatment, and observation group was lower than that in control group at the same time point(P＜0.05). The scores of Montreal cognitive assessment(MoCA), auditory quotient, attention quotient and visual quotient increased 4 weeks after treatment in two groups, and observation group were lower than those in control group at the same time point(P＜0.05). The Chinese version of the Beck suicide intention scale(BSI-CV)scores decreased, and observation group was lower than that in control group(P＜0.05). There was no significant difference in the total incidence of adverse reactions between two groups(P＞0.05). Conclusion: High-frequency r TMS treatment in first-episode adolescent depression patients, which can effectively improve patients’ cognitive function, cold executive function, and reduce suicidal ideation,further alleviate clinical symptoms, and good safety. [ABSTRACT FROM AUTHOR]

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At present, the existing feature selection methods based on ant colony algorithm optimization mostly use attribute dependence and information entropy attribute importance as the heuristic search factor on the path. However, this kind of search method has premature convergence in some decision tables or the searched feature subset contains redundant features, which leads to a significant decrease in selection accuracy. Aiming at such problems, this paper proposed an attribute importance measurement method based on the proportion of conditional attributes in the discernibility matrix. Taking the importance of the discernibility matrix as the heuristic factor on the path, this article designed a feature subset search method based on the discernibility matrix and ant colony algorithm optimization. The algorithm started from the feature core, and the ant colony selected features with high probability in turn to add to the feature core set, until the ant found the smallest feature subset. Validation of examples and experimental results of UCI data set show that compared with the feature selection method based on attribute dependence and information entropy attribute importance, under normal circumstances, this algorithm can find the smallest feature subset at a lower cost. [ABSTRACT FROM AUTHOR]

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在1.55μm和1.3μm上使用稀土金属掺杂氟化物光纤（ZBLAN）的光放大最近已取得令人振奋的实验室结果。靠使用一段长度为1.4m的Er掺杂氟化物光纤（[Er3+]=5000ppm）,由1.48μm双向泵激的已封装放大器能够在1.55μm上对微小信号取得27dB的增益。与硅基EDFA（掺铒光纤放大器）相比,这种新型放大器主要的好处在于:即使微小信号的领域内,在30nm的频宽上,也有频谱增益的平坦性。

Modified titanium dioxide (TiO2-GOTS-POSS. TGP) was prepared by reaction of nano titanium dioxide (TiO2) with 7-glycidyl trimethoxysilane (GOTS) and aminopropyl isobutyl polypolysiloxane (POSS), Nano TGP was mixed with waterborne epoxy resin (WEP) to prepare nanocomposite coating (TGP/WEP). The structure and properties of modified TiO2 and TGP/WEP coatings were characterized by FTIR. XRD. water contact an gle water absorption.UV radiation resistance. electrochemical impedance and salt water cor rosion resistance. The results show that the modified nano-TiO2 becomes nano-TGP. which has obtained super-hydrophobicity and thermal stability. Nano-scale convex and concave hy. drophobic structure was formed on the surface of TGP/WEP composite coating, and its static. water contact angle reached 153.6. The conting has the features of low water absorption. strong adhesion, anti ultraviolet radiation. large electrochemical impedance and salt water corrosion resistance, TGP/WEP composite coating can be used as metal anticorrosive coating with excellent physical and electrochemical anticorrosive effect. [ABSTRACT FROM AUTHOR]

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