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Leye County was identified as a pilot for integrating green development and reform in Guangxi in 2021. The government aims to systematically explore and implement green development while advancing the development of the county. In this study, comprehensive research at a grassroots level was conducted. First, this study analyzed problems faced during the delivery of green reform in Leye County. Then, solutions that foster comprehensive green economic and social development in Leye County were summarized. The proposed solutions promote a system that integrates green development and reform in Leye County with systematic optimization and integrated thinking approaches, which will support the effective implementation of reform measures and maximize its overall effect. Specifically, these solutions take ecological advantages as a starting point and create a modern green industrial system with advanced technology, high economic benefits, low resource consumption, and low environmental pollution to promote green development. In terms of developmental policy, this study also puts forward some suggestions for strengthening the management functions of a green government, including optimizing the management of innovative green talent, boosting returns on investments, advancing green reform, initiating green industrial projects, developing clean energy, and broadening green infrastructure. This study provides suggestions for establishing a model in which government, society, enterprises, and citizens participate jointly, and proposes principles and a vision for the future green development of the county. [ABSTRACT FROM AUTHOR]

Hepatic fibrosis is the common pathological basis of various chronic liver diseases. Liver biopsy remains the gold standard for the assessment and diagnosis of liver fibrosis, but its invasiveness and high requirements for operation limit its clinical application. This article introduces the development of noninvasive diagnosis of hepatic fibrosis, such as serological and imaging techniques. However, these methods cannot completely replace liver biopsy. Therefore, a comprehensive noninvasive diagnosis model for hepatic fibrosis has become a research hotspot. [ABSTRACT FROM AUTHOR]

Objective To investigate the effects of berberine on intestinal glucose absorption and the underlying mechanisms. Methods Eight-ten weeks old male Sprague-Dawley rats were divided into control group and berberine group. Blood glucose, serum insulin and glucagon-like peptide-1 (GLP-1) were tested in oral glucose tolerance test (OGTT) and intraperitoneal glucose tolerance test (IPGTT) after berberine gavage. Glucose transport test in vitro was applied to determine the specific target glucose transporter of berberine. Jejunum segments were treated with glucose (100 mmol/L), berberine (25, 50, 100, 200 μmol/L), glucose transporter 2 (GLUT2) inhibitor phloretin and sodium/glucose co-transporter 1 (SGLT-1) inhibitor phloridzin, 2-(N-(7-nitrobenz-2-oxa-1, 3-diazol-4-yl) amino)-2-deoxyglucose (2-NBDG) was used to test the intestinal glucose transport ability. The expression and localization of GLUT2 and SGLT1 on intestinal epithelial cells membrane was tested by using Western blotting. Dunnett-t test was used to evaluate the statistical significance of difference between groups. Results Compared with control group, blood glucose was significantly decreased at 15, 30, and 60 min in berberine group in OGTT (t=2.812, 2.648, 3.044, all P<0.05), however, there was no significant difference between two groups in IPGTT results. Compared with control group, serum insulin was significantly decreased at 15, 30, 60, and 120 min in berberine group (t=3.981, 3.583, 2.658, 2.707, all P<0.05), and serum GLP-1 level showed no significant difference between the two groups. Compared with glucose group (1.00±0.03), berberine (25, 50, 100, 200 μmol/L) treatment reduced glucose transport significantly (0.84±0.05, 0.62±0.04, 0.47±0.04, 0.46±0.04 respectively, q=2.847, 7.067, 9.712, 9.786, all P<0.05). Furthermore, there was no significant difference in glucose transport between the phloretin group and berberine+phloretin group (0.60±0.02 vs 0.58±0.02, q= 0.68, P>0.05), but glucose transport decreased significantly in berberine+phloridzin group when compared with that in phloridzin group (0.42±0.02 vs 0.68±0.03, q=7.436,P<0.05). Western blotting showed that intestinal epithelial cells membrane GLUT2 localization decreased significantly in berberine group than that in control group (0.57±0.04 vs 1.00±0.00, t=9.808, P<0.05). Conclusion Berberine decreases intestinal glucose absorption through inhibiting intestinal epithelial cells membrane GLUT2 translocation. [ABSTRACT FROM AUTHOR]

In recent years, new changes have occurred in the treatment of chronic hepatitis C. Direct - acting antiviral agents have shown powerful efficacy in the treatment of active hepatitis C, and even refractory hepatitis C shows a high continuous virologic response. Among these direct-acting antiviral agents, sofosbuvir (SOF) has the advantages of short course of antiviral treatment and high response rate, and some patients with certain hepatitis C genotypes have no need to receive interferon therapy. This article introduces the mechanism of action, current status of clinical application, and major adverse effects of SOF, and points out its promising future in patients with refractory hepatitis C. [ABSTRACT FROM AUTHOR]

Bee pollen is collected by honeybees from the pollen of flowers, with the addition of the nectar and their own secretions to form grains. Approximately 70% of the substances in bee pollen have biological activities, such as antioxidant, liver protection, anti-inflammatory, antibacterial and anti-cancer. However, the outer wall of pollen spores has the characteristics of acid resistance, alkali resistance, and anti-microbial decomposition. Without breaking the wall of spores, phenolic compounds can only be released from the germination pores, and thus the digestibility of bee pollen is only 52%-59% in vivo, meaning that most of them cannot be digested by human. Therefore, the wall breaking of spores has become necessary to improve the bioavailability of bee pollen. In this study, taking six kinds of bee pollen as research objects, including lotus, jujube, camellia, rape, rose, and schisandra, a wall breaking method of enzymatic hydrolysis combined with high-shear technology was used to reveal the effect of wall breaking on the phenolic compounds and antioxidant activities of bee pollen. An attempt was made to explore the protective effect of bee pollen, with or without wall breaking, on the OH-mediated oxidative damage of plasmid DNA for bee-pollen functional foods. An investigation was also made to find the effects of cellulase enzymatic hydrolysis on the wall breaking rates of different kinds of bee pollen. Different kinds of bee pollen exhibited different degrees of tolerance to the cellulase. The wall breaking rate of bee pollen increased with the increase of cellulase concentration. After six kinds of bee pollen enzymatically hydrolyzed, the wall breaking rate was significantly improved with high shear at 10 000-15 000 r/min for 30 s. More than 90% of wall breaking rate was achieved with less cellulase in the combined methods. The release of phenolic compounds from rape bee pollen was the most significant after the wall was broken (P<0.05). The total flavonoid content increased by 6.4 times, and the total phenol content increased from 8.6 mg/g to 21.6 mg/g, as well as the total phenol content of camellia bee pollen was 15.7 mg/g, an increase of 11.3% after the wall was broken. The phenolic compounds in six kinds of bee pollen were analyzed using high-performance liquid chromatography method with diode array detection (HPLC-DAD). The results showed that the types and content of phenolic compounds in bee pollen increased after the wall was broken. The concentration of jujube bee pollen to scavenge 50% DPPH free radicals is reduced by about 95%, and rape bee pollen is reduced by about 92%, the Fe2+ complex ability of jujube bee pollen increased from 0.36 mg/g to 1.16 mg/g, increased by about 2.2 times. The Fe3+ reducing power in the six types of bee pollen increased after the walls were broken. The Fe3+ reducing power of rape bee pollen increased from 6.2 mg/g to 55.8 mg/g, increased 8 times. After walls breaking, the protective abilities against DNA oxidative damage increased by 60.5%, 12.4%, 287.7%, 82.5%, 442.7% and4.8% in the six kinds of bee pollen( lotus, jujube, camellia, rape, rose and schisandra), respectively, indicating that the wall breaking made phenolic compounds of bee pollen fully be released, which can effectively improve the protective ability of OH-induced pBR322 plasmid DNA oxidative damage. This findings can provide a theoretical basis and strategy for the development of bee-pollen functional foods. [ABSTRACT FROM AUTHOR]

Objective: To investigate the relationship between serum myeloperoxidase (MPO) level and contrast-induced acute kidney injury (CI-AKI) and prognosis in patients undergoing emergency percutaneous coronary intervention (PCI) and its predictive value.Methods: 381 patients with acute myocardial infarction who underwent emergency PCI in The Second Affiliated Hospital of Anhui Medical University from March 2020 to February 2021 were selected. The clinical data were collected and the serum MPO level was detected within 12 hours before operation. According to the occurrence of CI-AKI after operation, they were divided into CI-AKI group (n=34)and non CI-AKI group (n=347). Multivariate Logistic regression was used to analyze the influencing factors of the incidence of CI-AKI in patients undergoing emergency PCI, and receiver operating characteristic (ROC) curve was used to evaluate the effectiveness of MPO in predicting CI-AKI. According to the best cutoff value, the patients were divided into high MPO group and low MPO group, and the patients were followed up for 12 months. The cumulative incidence of major adverse cardiovascular events (MACE) in high MPO group and low MPO group were analyzed by Kaplan-Meier survival curve. Results: The proportion of combined hypertension, diabetes mellitus, hyperlipidemia and smoking history proportion in CI-AKI group were higher than those in non CI-AKI group, and MPO level, creatinine level, contrast agent dosage were higher than those in non CI-AKI group (P＜0.05). Multivariate Logistic regression analysis showed that diabetes mellitus, high MPO and creatinine level were the risk factors influencing the occurrence of CI-AKI after emergency PCI (P＜0.05). ROC curve analysis showed that the area under the curve (AUC) of preoperative serum MPO level in predicting CI-AKI after emergency PCI was 0.726, and the optimal cut-off value was 491.12 μg/L, with a sensitivity of 58.80%, and specificity of 76.50%. A total of95 cases of MACE occurred one year after operation, with an incidence of 24.93%. Kaplan-Meier survival curve showed that the incidence of MACE in high MPO group was 27.37% higher than that in low MPO group 22.77% (P＜0.05). Conclusion: The serum MPO level of patients with CI-AKI after emergency PCI significantly increased, which is associated with the prognosis of patients, and it is a risk factor for CI-AKI, with high specificity, which can be an effective auxiliary indicator for predicting the occurrence of CI-AKI after emergency PCI. [ABSTRACT FROM AUTHOR]

目的 探讨臀部皮瓣修复骶尾部、臀部、坐骨结节部压疮的临床效果。方法 自 2016 年 7 月至 2022 年 7 月，芜湖 市第二人民医院整复烧伤科收治的压疮患者 20 例（骶尾部 9 例，臀部 5 例，坐骨结节部 6 例）；分别采用臀上动脉穿支皮瓣修复 5 例，压疮创面大小为 3 cm×4 cm~8 cm×13 cm，皮瓣切取面积为 4 cm×8 cm~9 cm×18 cm；臀下动脉穿支皮瓣修复 7 例，压疮创面 大小为 2 cm×4 cm~8 cm×12 cm，皮瓣切取面积为 5 cm×10 cm~12 cm×20 cm；臀大肌肌皮瓣修复 8 例，压疮创面大小为 4 cm× 4 cm~11 cm×15 cm，皮瓣切取面积为 8 cm×12 cm~12 cm×20 cm。结果 20 例患者皮瓣全部成活，18 例患者供瓣区直接拉拢 缝合，均一期愈合，2 例患者皮瓣术后裂开，经 2 期手术修复愈合，其中 1 例患者缩小供瓣区后行全厚皮片移植术，术后全厚皮 片成活良好；1 例患者缩小供瓣区后行中厚皮片移植术，术后皮片部分成活，残留少许肉芽创面经后期换药治愈。结论 臀部皮 瓣血供丰富，外形美观，不臃肿，弹性佳，耐磨性较好，抗感染能力较强，是目前修复骶尾部、臀部、坐骨结节部压疮的较好选择。 [ABSTRACT FROM AUTHOR]

高原低氧环境中颅脑损伤患者的病情加重，出现继发脑损伤，其机制主要有低氧血症、凝血功能障碍、脑 血管自身调节功能失常、脑组织氧化应激反应增强及脑细胞结构和功能障碍。高原低氧环境中颅脑损伤患者出现 低氧血症，低氧血症可加重颅脑损伤，颅脑损伤又会影响肺功能，加重低氧血症；凝血纤溶系统激活，最终促使DIC 的发生，影响血液向脑组织提供营养，血小板被激活，释放5-羟色胺等生物活性因子，破坏血管基底膜，产生微循环 障碍，导致继发脑损伤；脑血管的自动调节功能失常，引起脑静脉压增高和脑血管通透性增加，引发创伤性颅脑损伤 患者出现继发脑损伤；脑组织严重受损，机体通过自身的调节作用对外源性损伤做出应对，表现为神经递质过度释 放和聚集、具有组织损伤活性的蛋白分泌增加和炎性因子释放增加，从而引发继发脑损伤；脑细胞结构和功能障碍， 出现细胞毒性脑水肿和线粒体自噬，最终导致继发脑损伤。 [ABSTRACT FROM AUTHOR]

Most of the main oilfields in China have entered the middle and late stage of exploitation, and its exploitation difficulty has further increased. Microbial oil recovery technology has the advantages of low cost, high efficiency, green and environmental protection, and has a wide application prospect in further enhancing oil recovery of remaining oil. Due to the lack of understanding of reservoir microbial community structure and the long selection cycle of activator formula, the field popularization and application of microbial oil displacement technology is limited. By analyzing the difference of community structure in the reservoir and the interaction between environmental factors and dominant bacteria, basic data and theoretical guidance were provided for directional activation of reservoir microorganisms. The reservoir high-throughput sequencing data were analyzed by species composition analysis, species diversity analysis, principal coordinate analysis (PCoA) analysis and redundancy analysis. The results show that the species composition difference between water injection wells and production wells in Oilfield A is large, and the species composition difference between water injection wells and production wells in Oilfield L is not obvious; In terms of species abundance, species average and species diversity, there is no obvious difference between a oilfield and l oilfield; However, in terms of species similarity between water injection wells and production wells based on genus level, oilfield a shows low similarity, while oilfield L shows high similarity. In the analysis of environmental factors, the microbial community in L oilfield is significantly correlated with salt content, while the microbial community composition in a oilfield is significantly correlated with temperature, pH and SO2- 4 concentration [ABSTRACT FROM AUTHOR]

Target detection algorithms under big data often have the problem of missed target detection and repeated detection. To solve this problem, Mask RCNNAT-NMS algorithm based on AT-NMS is proposed. Firstly, a deformable convolution module is added on the basis of ResNet to enhance the ability to extract multi-layer convolution features of the target. Secondly, the AT-NMS algorithm is used to extract the in-depth information of the candidate target area in the RPN (Regional Candidate Network) stage. Thirdly, the positioning of the target is more accurate through two quantitative processing of ROI Align. Finally, three branches are used to achieve target instance segmentation, target classification and target border regression. The experimental results on the PASCAL-VOC2012 and Indoor CVPR_09 data sets show that, compared with the mask RCNN algorithm, the Mask RCNNAT-NMS algorithm reduces the repeated detection rate and the target missed detection rate, and improves the recognition accuracy. It can be seen that Mask RCNNAT-NMS algorithm can alleviate the problem of target missing and repeated detection caused by fixed threshold, and improve the detection accuracy on this basis. [ABSTRACT FROM AUTHOR]

Soil erosion and sediment transport in Losses Plateau region are crucial for sustainable development of the local region and downstream of Yellow river due to the harmful sedimentation in the plain area. This study was to investigate the sediment transport capacity and flow-sediment relationship in different topographical units of different scales in loess region to explore the countermeasures for solving the sediment-related environmental issues. The Peijiamao watershed in losses region was selected as prototype for observation, including the embedded whole slope runoff plot (0.25 hm2) and 3 hydrological stations that were first branch of Qiaogou (subwatershed of Qiaogou watershed), Qiaogou watershed (subwatershed of Peijiamao watershed), and Peijiamao watershed (3930 hm2) with increasing scales, acting as 4 different topographical units. The rainfall, runoff and sediment contents data at these sites were recorded and collected from 1986 to 2008. Results showed that during the observation period the runoff depth and the sediment transport modulus at the annual timescales of the slope scale were more than that of the watershed scale, probably due to the well-known gravitational erosion occurring on the steeper slopes at slope scale in this region. When the spatial scale was up to the watershed scale, at the annual timescale the runoff depth increased with the spatial scale, but the sediment transport modulus decreased with spatial scale. However, at the inter-event timescale the maximum value of the runoff depth and the sediment transport modulus may occur at the different topographical units influenced by the rainfall process, rainfall duration, rainfall spatial distribution, the antecedent soil moisture content and other factors. Totally, 67.74% of the runoff peaks occurred at whole slope runoff plot and 29.03% at entire Peijiamao watershed. However, 38.71% of sediment transport modulus occurred at whole slope runoff plot and 48.39% occurred at entire Peijiamao watershed. With the increasing in spatial scale, the sediment transport capacity decreased dramatically. The sediment concentration carried by unit flow power of the whole slope runoff plot, the first-branch of Qiaogou and the Qiaogou was 186, 77 and 58 times that of entire Peijiamao watershed, respectively. It was further confirmed that slope scale triggered tremendous intensity of soil erosion, and the probability of hyper-concentration flow decreased when spatial scale increased. The gentler slope in the larger watersheds from first branch of Qiaogou to the whole Peijiamao watershed and more interception by the flattened terraces might lower sediment transport capacity in this region. Furthermore, the probability of hyper-concentrated flow was closely related to the ratios of width to depth of the different gully. Result showed that the smaller the ratio of width to depth the bigger the probability of hyper-concentrated flow. In this study, the ratios of width to depth of the watershed gullies were 8.15, 15.86 and 38.09, respectively at the 3 watershed scales from first branch of Qiaogou to the whole Peijiamao watershed and the gully gradient decreased with spatial scales from 4.97% at subwatershed of Qiaogou watershed to 1.51% at Peijiamao wathershed. The runoff-sediment transport modulus relationship of different topographical units was in linear function, suggesting that runoff volume was the controlling factor of sediment transport. And with the increase in spatial scale, the runoff-sediment transport modulus relationship was more significant from 0.71 at whole slope runoff plot to 0.99 (for the decisive factor) at entire Peijiamao watershed scale. It also showed that curve slope decreased with increase in watershed area, with highest slope of 1.10×106 at whole slope runoff plot and 1210 at entire Peijiamao watershed indicating that the relationship between runoff and sediment was more complex in the slope scale. The results can provide valuble inforamtion for exploring the spatial scale effects and scale transformation of soil erosion in Losses Plateau region. [ABSTRACT FROM AUTHOR]