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Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Substance dependence mainly refers to the behavior of an individual who is strongly or repeatedlycraving a drug abuse．Though psychologically aware that often or repeated doses of the substance lead to adverseconsequences，but one still cannot control his own behavior．Often used substances are wine，heroin，ecstasy，Kpowder， methamphetamine and marijuana， etc．Regulation and control of substance addiction is by interwovenconstitute of the society， environment, biology and other factors．The biological factors mainly work through theaction of a drug on the central nervous system，resulting in a strong reward effect．The OPRM1 gene encoding muopioid receptors plays a bridge role Regulation and control mode of substance addiction is by interwoven constitute ofthe society， environment, biology and other factors．Researches have shown that methylation of OPRM1 promotercan increase the risk of alcohol dependence syndrome and other drug dependence．This paper makes a review on thecorrelation between DNA methylation of OPRM1 gene and substance dependence． [ABSTRACT FROM AUTHOR]