The experiment was to study the effect of compound Chinese herbal medicine additive on growth performance and serum biochemical indexes of Suyou No. 2 meat ducks. A total of 240 20-day-old Suyou No. 2 meat ducks were randomly divided into four groups with three replicates in each group and 20 ducks (male and female in half) in each replicate. Ducks in group A were fed with basic diet, group B, C and D were fed with salinomycin, 0.1% and 0.2% compound Chinese herbal medicine preparations, respectively. The pre-test period was 7 d, and the test period was 35 d. The growth performance of ducks was measured on 1 d and 35 d of the experiment, and the serum biochemical indices of ducks were measured on the 7, 14, 21 and 35 d of the experiment. The results showed that compared with group A, the daily gain, daily feed intake and crude protein metabolic rate of group C and group D were significantly increased, and the feed to gain ratio of ducks was decreased (P<0.05). The contents of IL-2, IgA, IgG, IgM and TP in serum of group C and group D were significantly higher than those of group A (P<0.05). Complement C3 and AKP contents in group C and group D were significantly higher than those in groups A and B (P<0.05). Serum BUN in group B, C and D was significantly lower than that in group A (P<0.05). The experiment indicates that adding salinomycin, 0.1% and 0.2% compound Chinese herbal medicine additives to the diet can effectively improve the growth performance and immune function of Suyou No. 2 meat ducks, and the optimal supplemental level of compound Chinese herbal medicine additive in the diet of Suyou no.2 meat duck is 0.2% in order to reduce feed cost and feed waste. [ABSTRACT FROM AUTHOR]