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文章对由色散补偿光纤（DCF）、分布式拉曼放大的色散位移光纤（DSF）以及非线性光纤环镜（NOLM）构成的全光纤脉冲压缩器进行了理论分析和数值模拟。结果表明,光脉冲经DCF后可消除啁啾,为压缩提供有利条件;而经分布式拉曼放大的DSF后,脉冲得到了较大的压缩;最后再通过NOLM消基座。利用此压缩器可获得压缩率高且压缩效果好的光脉冲。

Objective To investigate the correlation between baseline data, early treatment response and prognosis in children with acute lymphoblastic leukemia (ALL). Methods Ninety-two children with ALL were divided into the endpoint event group (19 cases) and the event-free survival group (73 cases) according to whether there was an endpoint event (recurrence or death). The age and gender at initial diagnosis were recorded. Initial white blood cell count (WBC), platelet count (PLT), immunophenotype, chromosome karyotype, fusion gene, prednisone test, bone marrow remission status on the 15th day of induction chemotherapy and minimal residual disease (MRD) on the 15th, 33rd and 55th day of induction chemotherapy were detected. The correlation between the above baseline data and early treatment response and the occurrence of endpoint event in children with ALL was analyzed. Logistic regression was used to analyze influencing factors of endpoint events in children with ALL. Receiver operating characteristic (ROC) curve was plotted to evaluate the predictive value of baseline data and early treatment response to endpoint events in children with ALL. Results The proportion of WBC ≥100×109 /L at first diagnosis, prednisone poor reaction and positive MRD on the 33rd day of induction chemotherapy were higher in the endpoint event group than those in the event-free survival group (P < 0.05), and there were no significance differences in remaining indicators (P > 0.05). Logistic regression analysis showed that prednisone poor reaction and positive MRD on the 33rd day of induction chemotherapy were risk factors for endpoint event in children with ALL (P < 0.05), and the combined value of the two indicators was better than that of a single indicator in predicting endpoint events in children with ALL. Conclusion Prednisone poor reaction and positive MRD on the 33rd day of induction chemotherapy are associated with recurrence and death in children with ALL. [ABSTRACT FROM AUTHOR]

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目的: 探究针灸是否通过调节脑源性神经营养因子(BDNF)及其下游酪氨酸激酶受体B(TrkB)对肠易激综合 征(IBS)大鼠的肠道屏障和内脏疼痛产生影响, 探究BDNF/TrkB信号通路作为针灸治疗新靶点的可能性。方法: 将60只SD大 鼠随机分为健康组、IBS组、针灸组、阳性对照组、针灸+TrkB激活组, 每组12只。建立IBS大鼠模型, 腹部撤回反射(AWR)检测 各组大鼠内脏疼痛;检测各组大鼠结肠TNF-α、IL-1β水平;免疫组化检测结肠黏膜胞质紧密黏连蛋白1(ZO-1)、闭合蛋白(occludin)表达水平;荧光定量PCR及Western blot检测各组大鼠结肠BDNF、TrkB mRNA及蛋白表达水平。结果: 与健康组相比, IBS组大鼠结肠黏膜出现破损, ZO-1、occludin表达显著降低, 大鼠AWR评分、粪便含水量、TNF-α、IL-1β含量、结肠BDNF、 TrkB mRNA及BDNF蛋白表达量、TrkB磷酸化程度显著升高(P<0.05);与IBS组相比, 针灸组、阳性对照组大鼠结肠黏膜逐渐 恢复, ZO-1、occludin表达显著升高, 大鼠AWR评分、粪便含水量、TNF-α、IL-1β含量、结肠BDNF、TrkB mRNA及BDNF蛋白表 达量、TrkB磷酸化程度显著降低(P<0.05);与针灸组相比, 针灸+TrkB激活组大鼠结肠黏膜仍有病变, ZO-1、occludin表达显著 降低, 大鼠AWR评分、粪便含水量、TNF-α、IL-1β含量、结肠BDNF、TrkB mRNA及BDNF蛋白表达量、TrkB磷酸化程度显著升 高(P<0.05)。结论: 针灸可通过调控BDNF/TrkB通路, 抑制相关蛋白表达, 改善肠道屏障功能, 减轻内脏疼痛及炎症反应, 缓解 IBS. Objective: To explore whether acupuncture can affect intestinal barrier and visceral pain of rats with irritable bowel syndrome (IBS) by regulating brain-derived neurotrophic factor (BDNF) and its downstream tyrosine kinase receptor B (TrkB), and to explore the possibility of BDNF/TrkB signaling pathway as a new target for acupuncture treatment. Methods: Sixty SD rats were randomly grouped into healthy group, IBS group, acupuncture group, positive control group and acupuncture+TrkB activation group, with 12 rats in each group. An IBS rat model was established, abdominal withdrawal reflex (AWR) was used to detect visceral pain of rats in each group; levels of TNF-α and IL-1β in colon of rats in each group were measured; expression levels of colonic mucosal cytoplasmic Claudin 1 (ZO-1) and occludin were measured with immunohistochemistry; expression levels of BDNF and TrkB mRNA and protein in colon of rats in each group were measured with fluorescence quantitative PCR and Western blot. Results: Compared with healthy group, colonic mucosa of rats in IBS group was damaged, expressions of ZO-1 and occludin were significantly reduced, AWR score, fecal water content, TNF-α and IL-1β contents, colonic BDNF, TrkB mRNA and BDNF protein expressions, and TrkB phosphorylation were significantly increased (P<0.05); compared with IBS group, colon mucosa of acupuncture group and positive control group gradually recovered, expressions of ZO-1 and occludin were significantly increased, AWR score, fecal water content, TNF-α and IL-1β contents, colonic BDNF, TrkB mRNA and BDNF protein expressions, and TrkB phosphorylation were significantly reduced (P<0.05); compared with acupuncture group, colonic mucosa of rats in acupuncture+TrkB activation group still had lesions, expressions of ZO-1 and occludin were significantly reduced, AWR score, fecal water content, TNF-α and IL-1β contents, colonic BDNF, TrkB mRNA and BDNF protein expressions, and TrkB phosphorylation were significantly increased (P<0.05). Conclusion: Acupuncture can regulate BDNF/TrkB pathway, inhibit expression of related proteins, improve intestinal barrier function, reduce visceral pain, inflammation and relieve IBS. [ABSTRACT FROM AUTHOR]

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The extensive development of lead - zinc resources over the years has led to the gradual manifestation of geological and environmental issues in Xunyang Lead Zinc Belt, including geological environmental pollution caused by mining activities, damage to land resources in mining areas, and hidden geological hazards in mines. This paper provides a detailed analysis and summary of the current status of environmental issues in Xunyang Lead - Zinc Belt and proposes corresponding strategies for geological environmental remediation [ABSTRACT FROM AUTHOR]

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水利工程作为维持国家经济持续发展、保障人民生命财产安全的一项重要基础产业项目，建设发展相关 水利设施，对于抵抗洪涝灾害、改善解决国家水资源时空分布不均匀的现状，保障农业发展等都有极其重要的意义。 通过发展建设水利设施，合理有效地利用珍贵的水资源，对于更好地保障社会经济发展具有不可或缺的作用。因此， 本文将重点讨论水利工程建设施工过程当中的质量管理措施，希望提高管理水平，保障水利工程建设施工安全性与稳 定性。 [ABSTRACT FROM AUTHOR]

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This work is to clone the genes of glycosyltransferases UGTPg17 and UGTPg36 from Lonicera macranthoides, and analyze the correlation between their expression and saponin content at different flowering stages. According to the Unigene sequence of L. macranthoides transcriptome, specific primers were designed to clone UGTPg17 and UGTPg36. The physical and chemical properties, protein structure and evolutionary relationship of the cloned UGTPg17- and UGTPg36-encoding proteins were analyzed using the bioinformatics websites; quantitative reverse-transcription polymerase chain reaction(RT-qPCR)was used to analyze gene expressions at different flowering stages. The content of L. macranthoides saponin was determined by HPLC; and the correlation between gene expression and saponin content was analyzed by SPSS. The open reading frame length of UGTPg17 and UGTPg36 genes was 1 410 bp and 1 428 bp, respectively, encoding 469 and 475 amino acids, containing 4 and 7 glycosylation sites, respectively, which belonged to unstable and hydrophilic proteins without transmembrane region. UGTPg36 protein did not contain signal peptide sequence, and the average S value of UGTPg17 protein was >0.5, suggesting that it may contain signal peptide. The expressions of UGTPg17 and UGTPg36 in different flowering stages showed an upward trend, and the saponin content fluctuated in different flowering stages. The correlation analysis between the two showed that the two UGT genes were significantly negatively correlated with the saponin content. In this study, UGTPg17 and UGTPg36 genes were successfully cloned from L. macranthoides, and their expressions variedt at different flowering stages. Correlation analysis showed that UGTPg17 and UGTPg36 genes were related to saponin biosynthesis of L. macranthoides, which lays a foundation for further exploring their specific functions. [ABSTRACT FROM AUTHOR]

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The experiment was conducted to investigate the effect of different content of compound probiotics on growth performance, immune performance, intestinal microbiome and intestinal morphology of AA broilers. A total of 1 440 one-day-old broilers (half in male and female) with similar body weight were randomly divided into four groups with six replicates in each group and 60 broilers in each replicate. Broilers in control group were fed with basic diet (CON group), and the experimental groups were supplemented with 500 (CP1 group), 1 000 (CP2 group) and 2 000 g/t complex probiotics (CP3 group), respectively. The experiment lasted for 42 d. The results showed that during the whole experiment period, the average daily gain of broilers in CP2 group and CP3 group was extremely higher than that of CP1 group and CON group (P<0.01), and feed to gain ratio was extremely lower than that of CON group (P<0.01). The spleen index, thymus index and bursa of Fabricius index of broilers in CP3 group were extremely higher than those in CON group (P<0.01), and the serum IgA and IgM content of broilers in CP3 group were extremely higher than those in CON group (P<0.01). The number of E. coli in cecum in CP3 group was extremely lower than that in CON group (P<0.01), and the number of Lactobacillus in cecum was significantly higher than that in CON group (P<0.01). The villus height and pile to hide ratio of small intestine of broilers in CP3 group were significantly (P<0.05) or extremely (P<0.01) higher than those in CON group. The study indicates that dietary supplementation of complex probiotics can effectively improve the growth performance, immune performance, intestinal microbial abundance and intestinal villus height of broilers, and the better effect is when the supplemental level is 2 000 g/t. [ABSTRACT FROM AUTHOR]