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通过13个Q460C、Q550D和Q690D钢中长柱的双向偏压试验，研究了高强钢焊接薄壁箱形截面双向压弯构件的局部-整体相关屈曲性能和极限承载力；将极限承载力与美国、欧洲规范以及新提出的计算公式的计算结果相比较，以验证它们对高强钢焊接薄壁箱形截面双向压弯构件局部-整体相关屈曲计算的适用性。结果表明，在钢材名义屈服强度fy=460~690 MPa，板件宽厚比b/t=40~70，构件长细比λ=45~79，偏心距ex=ey=20~45 mm范围内，美国规范ANSI/AISC 360-16对较大长细比（λ=79）和Q690D钢较小宽厚比（b/t=40）试件的计算结果偏于保守；欧洲规范BS EN 1993-1-1对较小板件宽厚比（b/t=40）试件的计算结果偏于保守，对其余试件是安全的；使用新提出的有效屈服强度法所得到的计算结果和试验结果吻合良好；新提出的有效截面法对大部分试件的计算结果偏于保守。

目的: 探讨小儿寰枢椎脱位的病因、诊断与治疗方法。方法: 分析 42 例患儿的临床资料,以病史、体征与影象学检查结合的方 法作为诊断依据,采用非手术或手术方法进行治疗。结果: 大部分( 29/42)患儿起因于上呼吸道感染与急性扁桃腺炎,所有病例颈椎正侧位及 寰枢椎张口位 X 线照片所见均有异常,绝大部分( 38/42)患儿用牵引疗法取得良好效果。结论: 小儿头颈部炎症与上呼吸道感染是本症最主 要的发病原因; 加强对本症的认识,及时进行影象学检查可提高诊断率,避免误诊; 颌枕带牵引或颅骨牵引是主要的治疗方法。 主题词 寰枢关节/外科学;脱位/病因;脱位/诊断;脱位/治疗 中图号

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目的　探讨临床罕见的 Ael亚型血型检测鉴定方法, 并观察其编码蛋白结构变化。方法 ABO正、反定 型不符的送检者样本1例, 采用经典试管法进行ABO血型正定型、反定型实验和吸收放散试验, 根据血清学特征判 定其血型。提取献血者外周血基因组 DNA进行基因测序和单倍型测序, 鉴定其 ABO血型基因型。以人类 GTA蛋 白的晶体结构为分子模型, 使用 AlphaFold 2. 2. 0 软件绘制野生型 GTA 蛋白和突变型 GTA 蛋白的 3D 结构模型, 用 PyMOL 2. 5. 4软件分析基因突变对编码蛋白结构的影响。结果　正定型结果显示, 送检者红细胞与抗-A、抗-B及 抗-AB抗原均不发生凝集；反定型结果显示, 送检者血清中有抗-A1抗体；吸收放散试验结果显示, 送检者红细胞上 存在较弱的 A 抗原。综合以上血清学特征, 判定送检者血型为 A 型 Ael 亚型。送检者血型基因型为 Ael 亚型, 其 ABO基因第 7外显子存在 c. 797dupT、c. 467C>T突变, 且 c. 797dupT突变不存在于 ISBT血型等位基因表中, 为新发 现的突变。突变型GTA蛋白肽链上的第267号氨基酸产生新的开放阅读框, 比野生型GTA蛋白在C端多了38个氨 基酸；突变型GTA蛋白第274～294位氨基酸组成的α螺旋消失了, 同时在C端第343～390位出现无规则卷曲, 表明 基因突变对编码蛋白三维结构造成了较大的改变。结论　发现1例临床罕见的Ael亚型血型, 其ABO基因第7外显 子存在 c. 797dupT、c. 467C>T突变, 其中 c. 797dupT突变为新发现的突变, 且基因突变对编码蛋白三维结构造成了 较大的改变。 [ABSTRACT FROM AUTHOR]

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Bioavailability of selenium is a key factor in determining the transport and accumulation of selenium in soil-plant system. However, systematic summary data and discussion of research progress are scant. Based on the results of our previous investigation of selenium-rich navel orange in Gannan, this study systematically summarizes and discusses the oxidation-reduction, absorption, and transport processes of selenium in soil-plant system. Furthermore, this study discussed the effects of soil physical and chemical properties, microorganisms, fertilization, agronomic management, and plant growth stages on the bioavailability and transport of selenium. Future hot spots of selenium research are proposed and discussed. These include：the coupled relationship between soil microbial activity and selenium in biogeochemical cycles; molecular mechanisms related to plant growth, fruit quality, and selenium metabolism; combined isotope tracing technique and thin film diffusion gradient technique in situ to explore the attribution of selenium in biogeochemistry. This study provides a theoretical reference for investigating the regulations of soil selenium bioavailability, effective accumulation of selenium in plant systems, and agronomic bio-enrichment measures for selenium enrichment. [ABSTRACT FROM AUTHOR]

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急性上消化道出血(UGIB)是指屈氏韧带以上的食管、胃、十二指肠和胰管、胆管病变引起的急性出血，是 临床常见的急症之一。输血的阈值应根据患者的临床症状、生命体征以及组织灌注状态进行综合判断，不同输血策 略也是影响输血阈值的重要因素。根据输血理念以及输血措施和阈值分类主要有限制性输血策略和开放性输血策 略两种，研究普遍认为限制性输血策略治疗UGIB无论是在患者结局还是经济负担均具有显著优势；但同时也有研 究发现，对于存在严重心血管疾病或其他合并症的患者，限制性输血策略可能存在一定的风险。关注个体化输血策 略、探寻新的输血治疗方法是未来提高UGIB患者输血治疗效果及改善预后的关键。 [ABSTRACT FROM AUTHOR]

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Estrogen receptor (ER) is overexpressed in approximately 2/3 of breast cancer patients' lesions. Noninvasive detection of ER in vivo and dynamic monitoring of ER are crucial for individualized treatment decision-making. 16α-18F-17β-fluoroestradiol (18F-FES) positron emission tomography (PET) has been used in a variety of preclinical and clinical studies to detect ER expression. However, there is still a lack of technical specifications in China. This technical specification was jointly written by domestic experts who had experience of 18F-FES PET imaging and was formed through consultation based on their own experience and research progress in this field both domestically and internationally. This technical specification introduced the synthesis method and quality control requirements of 18F-FES, recommended its clinical application scenarios, and classified them. In addition, experts' suggestions were provided throughout the entire process systemically and detailly, including pre-imaging preparation, imaging process, image analysis (normal biological distribution, determination of ER positive and negative, lesion detection, influencing factors, false negative and false positive, report requirements), and the limitations of this imaging technique were proposed. The future application prospects were also discussed. This specification aimed to promote the standardized application of 18F-FES PET in China, achieve repeatability and comparability, and provide important molecular imaging technical support for accurate diagnosis and treatment of breast cancer. [ABSTRACT FROM AUTHOR]