In order to investigate modulating effect of total tomato saponin(TTS) on uric acid, we used hypoxanthine, oxonic acid potassium salt, and uric acid and potassium oxyzincate to establish hyperuric acid model mice, and investigated the effects of TTS on uric acid excretion, blood uric acid, urea nitrogen, creatinine, xanthine oxidase and organ index in normal mice and hyperuricemic mice. The experimental results were as follows: TTS did not affect the blood uric acid level in normal mice, and the blood uric acid values in the normal group and the low, medium and high dose groups of TTS were(170.4±36.7),(178.3±69.7),(175.5±42.1),(185.3±72.6) μmol·L-1, respectively. TTS could reduce blood uric acid level and xanthine oxidase activity in hypoxanthine and oxonic acid potassium salt combination-induced hyperuricemia mice, and the blood uric acid values in normal group, model group and TTS high dose group were(140.4±36.7),(378.3±69.7),(278.3±62.6) μmol·L-1, respectively. The xanthine oxidase values in the normal, model and TTS low, medium and high dose groups were(1.2±0.3),(1.8±0.2),(1.6±0.2),(1.5±0.3),(1.3±0.4) U·g-1 liver, respectively. TTS reduced blood uric acid levels and decreased xanthine oxidase activity in mice with hyperuricemia induced by the combination of uric acid and oxonic acid potassium salt, and the blood uric acid values in normal group, model group and TTS high dose group were(98.8±21.8),(455.6±78.8),(333.7±68.7) μmol·L-1, respectively. The xanthine oxidase values in the normal, model and TTS high dose groups were(2.1±0.3),(2.5±0.2),(2.3±0.2) U·g-1 liver, respectively. The above results suggest that TTS does not affect blood uric acid levels in normal mice, but can reduce blood uric acid levels in mice in a hyperuricemia acid model, and the mechanism may be related to the reduction of xanthine oxidase activity. [ABSTRACT FROM AUTHOR]