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Copyright of Science & Technology of Food Industry is the property of Science & Technology of Food Industry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Science & Technology of Food Industry is the property of Science & Technology of Food Industry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Dermatovenereology is the property of Xi'an Jiaotong University Periodicals Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Topologically nontrivial Fe-based superconductors attract extensive attentions due to their ability of hosting Majorana zero modes (MZMs) which could be used for topological quantum computation. Topological defects such as vortex lines are required to generate MZMs. Here, we observe the robust edge states along the surface steps of CaKFe4As4. Remarkably, the tunneling spectra show a sharp zero-bias peak (ZBP) with multiple integer-quantized states at the step edge under zero magnetic field. We propose that the increasing hole doping around step edges may drive the local superconductivity into a state with possible spontaneous time-reversal symmetry breaking. Consequently, the ZBP can be interpreted as an MZM in an effective vortex in the superconducting topological surface state by proximity to the center of a tri-junction with different superconducting order parameters. Our results provide new insights into the interplay between topology and unconventional superconductivity, and pave a new path to generate MZMs without magnetic field. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Natural Gas Industry is the property of Natural Gas Industry Journal Agency and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Poyang Lake is the property of Journal of Poyang Lake Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To analyse the changes of bone metabolic markers in type 2 diabetes patients with osteoporosis, and analyze the risk factors. Methods: Eighty patients with type 2 diabetes and osteoporosis admitted to our hospital from January 2022 to December 2022 were selected as the research objects, and they were divided into osteoporosis group. Eighty patients with type 2 diabetes and non osteoporosis admitted to our hospital in the same period were selected as the non osteoporosis group, and 80 healthy volunteers who came to our hospital for physical examination in the same period were selected as the control group. The expression level of bone metabolic markers in three groups of subjects was compared, and dual energy X-ray absorptiometry was used as the "gold standard" for the diagnosis of osteoporosis. The ROC curve of subjects was established, and the critical value of related bone metabolic markers for the diagnosis of type 2 diabetes with osteoporosis was analyzed. Finally, the disease risk factors were analyzed. Results: There was no significant difference in the levels of alkaline phosphatase (ALP), blood phosphorus (P), and calcium (Ca) among the three groups of subjects (P＞0.05). However, there were differences in the levels of urinary type 1 collagen C-terminal peptide (CTX-1), osteocalcin, and parathyroid hormone (PTH) among the three groups of subjects. There were also differences in the levels of CTX-1, osteocalcin, and parathyroid hormone (PTH) among the three groups of subjects PTH was higher than that of the non osteoporosis group and control group, while osteocalcin was lower than that of the non osteoporosis group and control group (P＜0.05); The critical value of CTX-1 for the diagnosis of type 2 diabetes with osteoporosis was 525.74 μg/mmoL Cr, the sensitivity was 83.35%, the specificity was 67.95%, the critical value of osteocalcin was 14.12ng/L, the sensitivity was 81.27%, the specificity was 79.46%, and the critical value of PTH was 45.75 pmol/L, the sensitivity was 74.84%, the specificity was 81.36%; There was no difference between the osteoporosis group and the non osteoporosis group in terms of gender, duration of diabetes, combined with other basic diseases, peripheral neuropathy, and fasting blood glucose (P＞0.05). There were differences between the osteoporosis group and the non osteoporosis group in terms of age, BMI, peripheral vascular disease, diabetes nephropathy, retinopathy, glycosylated hemoglobin, CTX-1, osteocalcin, and PTH levels (P＜0.05); Age, diabetes nephropathy, retinopathy, glycosylated hemoglobin, CTX-1, osteocalcin, PTH were independent risk factors for type 2 diabetes with osteoporosis (P＜0.05). Conclusion: The levels of CTX-1 and PTH in type 2 diabetes patients with osteoporosis increase and osteocalcin decreases. The three can provide important reference for the clinical diagnosis of type 2 diabetes patients with osteoporosis. Age, diabetes nephropathy, retinopathy, glycosylated hemoglobin, CTX-1, osteocalcin and PTH are independent risk factors for type 2 diabetes patients with osteoporosis. [ABSTRACT FROM AUTHOR]

Objective: To explore the correlation between the expression levels of Gremlin-1, Blood uric acid (SUA), and bone metabolism indicators with the severity of osteoporosis in patients and their combined diagnostic value. Methods: 80 patients with osteoporosis admitted to our hospital from January 2019 to December 2020 were selected. All patients were classified according to the severity of the double X-ray absorption (DXA) method diagnosis results. Patients with -2.5＜ T＜-1 were divided into a low bone mass group (n=23), and patients with T≤ -2.5 were divided into an osteoporosis group (n=37). Patients with T≤ -2.5 and Patients who have experienced osteoporotic fractures are divided into the severe osteoporosis group (n=20). Compare the expression levels of Gremlin-1, SUA, and bone metabolism indicators among three groups of patients, and use Spearman correlation analysis to examine the correlation between the expression levels of Gremlin-1, SUA, and bone metabolism indicators with the severity of osteoporosis in patients. Finally, the ROC curve was established to evaluate the diagnostic value of the combination of Gremlin-1, SUA, and bone metabolism indicators for osteoporosis. Results: There were differences in the comparison of Gremlin-1 and SUA levels among the three groups, with Gremlin-1 higher in the low bone mass group than in the osteoporosis group and severe osteoporosis group, and SUA lower than in the osteoporosis group and severe osteoporosis group (P<0.05); the levels of vitamin D3 [25-(OD)-D3], β-collagen special sequence (β-CTX), parathyroid hormone (PTH), N-terminal peptide of type I procollagen (PINP), and osteocalcin (OC)-related bone metabolism index levels were significantly different in comparison, and 25- (OD)-D3, PINP, and OC were higher in the low-bone group than in the osteoporosis group and the severe osteoporosis group, and β-CTX, PTH were lower than those in the osteoporosis and severe osteoporosis groups (P<0.05); the expression of SUA (r = -0.636), β-CTX (r = 00.626), and PTH (r = 0.625) was positively correlated with disease severity in osteoporosis patients, and Gremlin-1 (r = -0.452), 25-(OD)-D3 (r = - 0.462), PINP (r = -0.622), and OC (r=-0.426) expression of expression was negatively correlated with the disease severity of osteoporosis patients (P<0.05); the area under the curve of the combination of Gremlin-1, SUA, and bone metabolism indexes for the diagnosis of osteoporosis was 0.688, with a sensitivity of 92.53% and specificity of 87.49%, which was higher than that of single index diagnosis (P<0.05). Conclusion: Gremlin-1, SUA, and bone metabolism indicators are closely related to the severity of osteoporosis, and the combined diagnosis of osteoporosis has high sensitivity and specificity. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To explore medication laws of traditional Chinese medicine in the treatment of chronic atrophic gastritis complicated with intestinal metaplasia, and to analyze the potential mechanism of common drug pairs. METHODS: CNKI, Wanfang and VIP databases were retrieved (from database establishment to Jun. 30th, 2022). Excel, SPSS Modeler 18. 1 and SPSS Statistics 26 were used for frequency statistics, association rule analysis and cluster analysis of the included traditional Chinese medicine. Protein-protein interaction, Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were performed by using Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, GeneCards, STRING, Cytoscape and other tools to reveal the potential mechanisms. RESULTS: A total of 100 prescriptions were screened out, with 187 traditional Chinese medicines. The medicinal properties were mainly warm, calm and cold. The medicinal tastes were mainly bitter and sweet. The main meridians were spleen and stomach. There were 21 kinds of traditional Chinese medicine used more than 20 times. Atractylodes macrocephala koidz-Hedyotis diffusae herba was the most supported drug combination. The key components of Atractylodes macrocephala koidz-Hedyotis diffusae herba in the treatment of chronic atrophic gastritis complicated with intestinal metaplasia were quercetin, β-sitosterol and stigmasterol. The core targets were tumor protein p53, protein kinase B1 and transcription factor AP-1. The main pathways of action were tumor-associated pathways, hepatitis B virus and advanced glycosylation end (AGE) product-AGE receptor signaling pathways. Molecular docking results showed strong binding activity of 3 key components to 3 core targets. CONCLUSIONS: Traditional Chinese medicine in the treatment of chronic atrophic gastritis complicated with intestinal metaplasia mainly based on strengthening the spleen, regulating the Qi, clearing heat and promoting blood circulation. Atractylodes macrocephala koidz-Hedyotis diffusae herba exerts the therapeutic effects on chronic atrophic gastritis complicated with intestinal metaplasia from multiple components, multiple targets and multiple pathways, laying a theoretical foundation for further mechanism research. [ABSTRACT FROM AUTHOR]

Copyright of Bulletin of the Chinese Ceramic Society is the property of Bulletin of the Chinese Ceramic Society Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Urban Architecture & Development is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the relationship between serum osteopontin (OPN), high mobility group protein B1 (HMGB1) and T cell subsets and chemotherapy efficacy in patients with multidrug-resistant pulmonary tuberculosis (MDR-TB). Methods: 147 MDR-TB patients (MDR-TB group) admitted to Xuzhou Infectious Disease Hospital from March 2018 to September 2021 were selected, and 109 non-MDR-TB patients (control group) admitted to Xuzhou Infectious Disease Hospital during the same period were selected. The correlation between serum OPN, HMGB1 and peripheral blood T cell subsets in MDR-TB group was analyzed by Pearson correlation analysis. The factors of unsuccessful MDR-TB treatment were analyzed by multivariate Logistic regression analysis. Results: Serum OPN and HMGB1 in MDR-TB group were positively correlated with peripheral blood CD8+ count (P<0.05), and negatively correlated with peripheral blood CD3+ count, CD4+ count and CD4+ /CD8+ ratio (P<0.05). Multivariate Logistic regression analysis showed that cavity, high OPN and high HMGB1 were risk factors for unsuccessful MDR-TB treatment (P<0.05). Conclusion: The levels of serum OPN and HMGB1 in MDR-TB patients are significantly increase, which are relate to the abnormality of T cell subsets and the failure of chemotherapy. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Earthquake Sciences is the property of China Earthquake Administration, Institute of Geophysics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Science & Technology of Food Industry is the property of Science & Technology of Food Industry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Geodesy & Geodynamics (1671-5942) is the property of Editorial Board Journal of Geodesy & Geodynamics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Computer Engineering & Applications is the property of Beijing Journal of Computer Engineering & Applications Journal Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Transactions of the Chinese Society of Agricultural Engineering is the property of Chinese Society of Agricultural Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food & Fermentation Industries is the property of Food & Fermentation Industries and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Food Science & Biotechnology is the property of Journal of Food Science & Biotechnology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shanxi Agricultural Sciences is the property of Shanxi Academy of Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The physical and chemical repair technology of acid mining wastewater AMD commonly used at home and abroad has many shortcomings. The microbial method led by sulfate-reducing bacteria (SRB) has the advantages of low cost, good effect and environmental friendliness, and has become a research hotspot. The article briefly introduces the formation and harm of AMD, compares the advantages and dis- advantages of commonly used AMD treatment technologies, and focuses on the research progress of using SRB to treat AMD. This article summarizes the mechanism, influencing factors, and methods and current status of SRB fixation for AMD treatment, and summarizes and prospects the future research trends of SRB treatment for AMD. [ABSTRACT FROM AUTHOR]

Copyright of Coal Science & Technology (0253-2336) is the property of Coal Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Water Conservancy & Electric Power Technology & Application is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Electronic Communication & Computer Science is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

By constructing the XGBoost model, this paper takes the output of planting, fishery, animal husbandry and forestry in Zhongshan over the years as the independent variable and the total output of agricultural economy as the dependent variable for regression analysis. The research shows that the average growth rate of planting industry output value over the years is 3. 45%, the average growth rate of forestry output value is 2. 16%, the average growth rate of animal husbandry output value is 0. 46%, and the average growth rate of fishery output value is 9. 69%. The model fitting curve shows that all agricultural industries have promoted the positive growth of Zhongshan's total agricultural economy. From the analysis of the characteristic correlation parameters of the XGBoost model, it is concluded that the fishery industry has the largest contribution to the total agricultural output value of Zhongshan City, accounting for about 59. 8%, the planting industry accounts for about 35. 5%, the animal husbandry industry accounts for 4. 2%, and the forestry industry accounts for 0. 5%. It shows that fishery and planting industry are the pillar industries of agricultural economy in Zhongshan City. Through comparative analysis with other models, the evaluation indicators proposed in this paper are 0. 715 5, 0. 999 9, 6. 499 1×10-6 through root mean square error, R², and mean Poisson deviation regression Loss, respectively. This method is superior to other models, which verifies that the proposed XGBoost model has high fitting accuracy and robustness for the fitting and feature correlation analysis of the output value data of various industries in Zhongshan over the years. This method can provide a good regression fitting analysis model for the agricultural industry. [ABSTRACT FROM AUTHOR]

The "Practical Chemistry Laboratory" course is carried out using the platform of National Demonstration Center for Chemistry and Chemical Engineering Education, and is a general education course of chemistry laboratory for all undergraduates. The experimental projects of the course are interesting, moderately difficult and close to life. The experimental reports are not limited to a specific form. It can reflect students' creativity, and diversify electronic reports. Labor education runs through the entire teaching process to cultivate students' labor quality. This course is deeply loved by students, awarded as the outstanding school-level project, making general education achieve a high level. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To observe the effects of Yangzheng Touxie Qudu compound traditional Chinese medicine on the immune microenvironment in patients after triple negative breast cancer (TNBC) surgery, and to probe into the therapeutic regimen for the patients after TNBC surgery. METHODS: This study was a prospective randomized controlled trial (RCT), a total of 90 patients underwent TNBC surgery admitted into the hospital from Mar. 2019 to Feb. 2021 were selected to be divided into treatment group and control group via completely randomization method, with 45 cases in each group. The control group received adjuvant chemoradiotherapy, and the treatment group received adjuvant chemoradiotherapy+Yangzheng Touxie Qudu compound traditional Chinese medicine, 30 days as 1 treatment cycle and 4 cycles as the node for efficacy evaluation. Evaluation indicators included tumor markers [serum carcinoembryonic antigen ( CEA), carbohydrate ( CA) 125 and CA153 ], tumor immune microenvironment [ serum interleukin (IL) 6, IL-2, soluble interleukin-2 receptor (sIL-2R) and tumor necrosis factor α (TNF-α)], incidences and tolerability of adverse reactions of chemotherapy. RESULTS: A total of 5 patients in both groups met the exclusion criteria during treatment, including 3 cases in the treatment group and 2 cases in the control group, so that 42 cases in the treatment group and 43 cases in the control group were set as the actual research objects. After both groups had finished 4 cycles of treatment, the serum CEA, CA125 and CA153 levels decreased, and those of the treatment group were lower than the control group, with statistically significant differences (P<0. 05); the serum IL-6, IL-2, sIL-2R and TNF-α levels of both groups had been decreased, and those of the treatment group were lower than the control group, with statistically significant differences (P<0. 05). The severity degree of adverse reactions of chemotherapy in the treatment group was lower than that in the control group, with statistically significant difference (P<0. 05); the differences of incidences of myelosuppression, hepatorenal function impairment, gastrointestinal reaction and neurovirulence between two groups were not statistically significant (P>0. 05); there were no statistical significance in differences of recurrence rate and trasfer rate between two groups (P > 0. 05). CONCLUSIONS: The application of Yangzheng Touxie Qudu compound traditional Chinese medicine on patients receive chemoradiotherapy after TNBC surgery can promote anti-tumor effect, improve tumor immune microenvironment and reduce adverse reactions of chemotherapy. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To study the mechanism of Jianpi Tongluo Jiedu recipe in the treatment of chronic atrophic gastritis ( CAG) based on network pharmacology. METHODS: Active components and targets of Jianpi Tongluo Jiedu recipe were obtained by traditional Chinese medicine systems pharmacology database and analysis platform and UniProt database. GeneCards, OMIM and DrugBank were searched for CAG targets. The target of drug and disease interaction was obtained by intersection of the two. After that, STRING database was imported to construct protein-protein interaction network and drug-active ingredient target-disease network map by Cytoscape 3. 7. 2 software. Gene ontology (GO) functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed. AutoDock Vina software was used for molecular docking. RESULTS: A total of 206 effective components, 232 targets, 783 CAG targets and 91 co-action targets of Jianpi Tongluo Jiedu recipe were obtained. The key targets involved tumor protein p53 ( TP53), protein kinase B1 ( Akt1), Jun proto-oncogene (JUN), interleukin (IL) 6, vascular endothelial growth factor A, tumor necrosis factor, signaling and transcriptional activator 3, prostaglandin peroxidase synthase 2, caspase 3, IL-1β, HIF1A and epI Skin growth factor. GO function enrichment analysis showed that there were 2 024 biological processes, 34 cell components and 120 molecular functions. By KEGG analysis, 161 signal pathways were obtained. Molecular docking results showed good binding force. CONCLUSIONS: Jianpi Tongluo Jiedu recipe can affect CAG mainly through TP53, Akt1, JUN, IL-6 and other proteins, PI3K/ Akt, MAPK, p53, JAK/ STAT and other signaling pathways. [ABSTRACT FROM AUTHOR]

Copyright of Acta Agronomica Sinica is the property of Crop Science Society of China and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Surfactant Detergent & Cosmetics (2097-2806) is the property of China Surfactant Detergent & Cosmetics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Geodesy & Geodynamics (1671-5942) is the property of Editorial Board Journal of Geodesy & Geodynamics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Bulletin of the Chinese Ceramic Society is the property of Bulletin of the Chinese Ceramic Society Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Advances in Water Science / Shuikexue Jinzhan is the property of Editorial Board of Advances in Water Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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