Search

BACKGROUND: Spinal cord injury involves mechanisms such as oxidative stress, inflammation, apoptosis and autophagy. Activation of autophagy can improve neuromotor function after spinal cord injury and play a protective role in the spinal cord. OBJECTIVE: To investigate the effects of Periplaneta americana powder on hindlimb motor function and the autophagy protein Beclin-1 in the injured site of rats after spinal cord hemisection. METHODS: Thirty Sprague-Dawley rats, 6-8 weeks of age, were randomly divided into three groups (n=10 per group). In the sham-operated group, the lamina was just opened to exposure the spinal cord followed by suturing. Normal saline group and Periplaneta americana powder group both underwent left hemisection of the spinal cord to prepare animal models of spinal cord hemisection. The normal saline group was continuously gavaged with normal saline for 14 days, and the Periplaneta americana powder group was continuously gavaged with Periplaneta americana powder for 14 days. The Basso Beattie Bresnahan scale score was performed at the 6th hour, 1st day, 3rd day, 7th day and 14th day after operation to observe the hindlimb motor function. After 14 days of administration, the rats were sacrificed and sampled. Immunohistochemistry, western blot and immunofluorescence were used to detect the expression of Beclin-1 in the injured site of the spinal cord after hemisection. RESULTS AND CONCLUSION: After operation, the Basso Beattie Bresnahan scale scores were gradually increased in the normal saline group and Periplaneta americana powder group. Compared with the sham-operated group, the Basso Beattie Bresnahan scale scores were significantly reduced in the normal saline group and Periplaneta americana powder group at the 6th hour, 1st day, 3rd day, 7th day and 14th day after operation (P < 0.05). The Basso Beattie Bresnahan scale scores in the Periplaneta americana powder group were significantly higher than those in the normal saline group at the 7th and 14th days after operation (P < 0.05). Immunohistochemical staining showed that Beclin-1 was weakly positive in the sham-operated group, mainly expressed in the cytoplasm; in the normal saline group, Beclin-1 was mainly expressed in the cytoplasm and partially expressed in the nuclear membrane; in the Periplaneta americana powder group, Beclin-1 was mainly expressed in the cytoplasm and partially expressed in the nuclear membrane. The proportion of Beclin-1 positive cells was higher in the normal saline and Periplaneta americana powder groups than in the sham-operated group (P < 0.05), while the proportion of Beclin-1 positive cells was higher in the Periplaneta americana powder group than in the normal saline group (P < 0.05). Western blot assay and immunofluorescence staining showed that the Beclin-1 protein expression was higher in the normal saline and Periplaneta americana powder groups than in the sham-operated group (P < 0.05), and moreover, the Beclin-1 protein expression was higher in the Periplaneta americana powder group than in the normal saline group (P < 0.05). To conclude, Periplaneta americana powder could improve the hindlimb motor function of rats with spinal cord hemisection injury, and the mechanism may be that polysaccharides in the Periplaneta americana powder increase the expression of Beclin-1. [ABSTRACT FROM AUTHOR]

Objective To observe the presence of ferroptosis in acute pancreatitis (AP) and the effect of iron ions on the NLRP3 pathway so as to explore the possible mechanisms for the protection of pancreatic alveolar cells. Methods A total of 45 male C57BL/6 mice were randomly divided into three groups (control, AP, and AP+2'2-bipyridyl). A total of 12 injections (caerulein, 50 μg/kg) were given at one-hour intervals. The AP+2'2-bipyridyl group was pretreated with 2'2-bipyridyl(20 mg/kg)for 1 hour, and then injected with caerulein. The control group was injected with an equal volume of normal saline. All of the mice were killed one hour after the last injection. Their pancreases were harvested for histopathological evaluation, immunohistochemistry analyses, and Western blotting. Results The ferroptosis inhibitor 2'2-bipyridyl could prevent the accumulation of iron ions, reduce the formation of lipid peroxides and the injury in the process of AP, and it also reduced pancreatic inflammation through NLRP3 pathway. Conclusion This experiment confirmed the real existence of ferroptosis, a form of cell death, in AP, and revealed that inhibition of ferroptosis can reduce pancreatic inflammatory damage in AP. [ABSTRACT FROM AUTHOR]

Preeclampsia (PE) is one of the main causes of increased perinatal mortality, and its pathogenesis remains unclear. The present study has found that the levels of multivitamins during pregnancy were correlated with incidence of PE. It has been proved that vitamin D is involved in placental formation, inflammatory reaction, oxidative stress and immune activation in the pathogenesis of PE. Vitamin D deficiency can lead to PE through the above mechanisms. In addition, the levels of vitamin E in patients with PE are lower than those in normal pregnant women, suggesting that the lack of vitamin E may increase the risk of PE, but the specific mechanism is still under investigation, it may be related to its antioxidant activity. The relationship between vitamin A levels and PE is controversial. PE is also associated with homocysteine, folic acid (vitamin B9), vitamin B12 and vitamin B6, also known as carbon metabolism. The deficiency of related vitamins leads to homocysteine metabolism disorder, thus causing PE. Vitamin B3 primarily protects against PE by preserving the endothelium and regulating redox reactions. Vitamin C deficiency is associated with PE, and the use of vitamin C during fluid replacement therapy can partially reduce the incidence of pulmonary edema. [ABSTRACT FROM AUTHOR]

In order to preferably select the prospecting prediction target area in Baixingtu area of Alxa Right Banner, 1 ∶ 10 000 soil geochemical measurements were carried out on the basis of identifying the geological conditions of mineralization in the area. Elemental variation coefficients, ILR transform and ILR-PCA multivariate statistical analyses were used to analyze the seven elements : Au, Ag, Co, Cu, Pb, Zn and As in the study area. The results show that : (1) ore-forming elements mainly occure at the intersection of the fracture and mineralized alteration zone. Au and Ag show very strong differentiation and enrichment characteristics with the highest mineralization potential, while Pb, Zn, As, Co and Cu show low differentiation and enrichment characteristics, and low mineralization potential. (2) ILR transformation eliminates the closure effect of the original data and makes the elements show standard normal distribution; the first principal component of ILR-PCA can extract the comprehensive information of the elements of the original data to the maximum extent, i. e., the positive end-load of PC1 (Au-Ag-As) is the mineralization indicator, and the intensity and morphology of elemental anomalies are controlled by the fracture and mineralization alteration zone, and the negative end-load (Co-Cu-Pb-Zn) is caused by the enrichment of elements in multi-phase magmatic hydrothermal activity. (3) Engineering verification of the mineralization target area No.Ⅰ has identified several gold (silver) ore (mineralization) bodies, and the gold and silver contents have reached the minimum industrial grade or above, indicating that the Baxingtu area has a large potential for gold and silver prospecting. [ABSTRACT FROM AUTHOR]

To explore the clinical efficacy of armillariella oral solution in treating patients with chronic hepatitis and its impact on liver function and liver fibrosis. A total of 96 patients with chronic hepatitis admitted to the Sino Japanese Friendship Hospital of Jilin University from June 2018 to January 2021 were selected as the study subjects. They were randomly divided into an observation group and a control group with 48 patients each. The control group was treated with conventional drugs, while the observation group was treated with armillariella oral solution on the basis of the control group. The clinical efficacy, liver function, liver fibrosis indicators, and adverse reactions of the two groups of patients were compared. The total clinical effective rate in the observation group was higher than that in the control group (P<0.05); After treatment, the glutamic-pyruvic transaminase (ALT), glutamic-oxalacetic transaminase(AST), γ-glutamyl-transferase (γ-GT) in the observation group were significantly lower than that of the control group (P<0. 05); After treatment, the hyaluronidase (HA), laminin (LN), type III procollagen (PC III) and type IV collagen (IV-C) in the observation group were significantly lower than those in the control group(P<0.05); There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). The efficacy of armillariella oral solution in treating patients with chronic hepatitis is significant, it can significantly improve the liver function of patients, alleviate the degree of liver fibrosis, and has no significant adverse reactions. [ABSTRACT FROM AUTHOR]

Objective To explore the changes of fatty acids levels in peripheral blood erythrocyte membrane and their relationships with the risk of endometrial cancer (EC). Methods Peripheral blood of fasting 91 EC patients (EC group) and 203 healthy volunteer women (control group) were collected. After erythrocyte cells were isolated, the levels of erythrocyte membrane fatty acids were detected by gas chromatograph-mass spectrum. The effect of changes of fatty acid levels on the risk of EC was analyzed. Results The compositions of fatty acids ranged from high level to low level in erythrocyte membrane of the EC group and control group were total saturated fatty acids (SFA), total polyunsaturated fatty acids (PUFA) and total monounsaturated Fatty Acids (MUFA). Compared with the control group, the total SFA level was higher and the total MUFA level was lower than those of the EC group (both P<0. 05), but there was no significant difference in the PUFA level between these two groups (P>0. 05). In SFA of the erythrocyte membrane, the levels of myristic acid C14：0, stearic acid C18：0, behenic acid C22：0 and lignoceric acid C24：0 in the EC group were higher than those of the control group, but the level of arachidic acid C20：0 was lower than that of the control group (all P<0. 05). In MUFA of the erythrocyte membrane, the levels of palmitoleic acid C16：1n7 and nervonic acid C24：1n9 were higher, but the level of oleic acid C18：1n9 was lower than those of the control group (all P<0. 05). In ω-6 PUFA of the erythrocyte membrane, the level of linoleic acid (LA) C18：2n6 was lower, but the levels of gamma-linoleic acid (GLA) C18：3n6, C20：2n6 and C20：3n6 were higher than those of the control group (all P<0. 05). In ω-3 PUFA of erythrocyte membrane, the level of α -linolenic acid (ALA) C18：3n3 was lower, but the ratio of arachidonic acid (AA)/docosahexaenoic acid (DHA) was higher than those of the control group (both P<0. 05). As shown by binary Logistic regression analysis, the increased levels of total SFA, myristic acid C14：0, behenic acid C22：0, lignoceric acid C24：0, palmitoleic acid C16：1n7, nervonic acid C24：1n9, and GLA increased the risk of EC (OR= 2. 14，2. 36，2. 60，3. 21，3. 25，4. 81 and 2. 74, respectively； all P<0. 05). Decreased levels of C20：0, C18：1n9, LA and ALA increased the risk of EC (OR=0. 38，0. 34，0. 21 and 0. 51, respectively； all P<0. 05). Conclusions The proportions of total SFA, myristic acid, behenic acid, lignoceric acid, palmitoleic acid C16：1n7, nervonic acid C24：1n9 and GLA increased in the EC patients, the proportions of arachidic acid C20：0, oleic acid C18：1n9, LA, and ALA decreased, and the changes in the above fatty acid proportions were related to the incidence of EC [ABSTRACT FROM AUTHOR]

To compare the effects of sevoflurane and propofol maintenance anesthesia on cardiac function, oxidative stress and postoperative cognitive function in patients with coronary heart disease undergoing laparoscopic cholecystectomy (LC).Methods: 98 patients with coronary heart disease who were underwent general anesthesia LC in the department of Anesthesiology,Lequn Campus of Jilin University First Hospital from March 2020 to April 2022 were selected, and patients were divided into Group A (n=49, propofol maintained anesthesia) and Group B (n=49, sevoflurane maintained anesthesia) according to the random number table method. The anesthetic effects, hemodynamic related indicators [heart rate (HR), mean arterial pressure (MAP), oxygen saturation (SpO2)], cognitive function [mini-mental state examination (MMSE) scores], cardiac function indicators [cardiac output (CO), cardiac index (CI), left ventricular ejection fraction (LVEF)], oxidative stress indicators [superoxide dismutase (SOD), malondialdehyde (MDA), total antioxidant capacity (T-AOC)] and incidence of adverse reactions were compared between two groups. Results: The recovery spontaneous breathing time, eye opening time, extubation time, and directional recovery time in Group B were shorter than those in Group A (P<0.05). The SpO2, HR, and MAP in Group B at 5 minutes after pneumoperitoneum and at the end of surgery were higher than those in Group A (P<0.05). The MMSE scores in Group B at the 1d after surgery and 3d after surgery were higher than those in Group A (P<0.05). The CO, CI, and LVEF in Group B were higher than those in Group A at the 1d after surgery (P<0.05). The SOD in Group B was higher than that in Group A, while MDA and T-AOC were lower than those in Group A at the 1d after surgery (P<0.05). There were no statistically significant differences in the incidence of adverse reactions between two groups (P>0.05). Conclusion: Compared with propofol for maintaining anesthesia, sevoflurane used to in patients with coronary heart disease undergoing LC is beneficial for maintaining hemodynamic stability and reducing cardiac function, oxidative stress damage, and postoperative cognitive impairment. [ABSTRACT FROM AUTHOR]

As a major participant in the construction of "China-Myanmar Economic Corridor" and the "One Belt and One Road" Initiative, Myanmar has an important strategic position, but the research on its population and socio-economic situation is relatively weak. Based on the summary of Myanmar's population distribution from the provincial scale, this paper used panel data of population, socio-economic and natural environment of Myanmar from 2005 to 2017, and spatial econometric model, explored the influencing factors of population distribution in Myanmar. The results show that: ① There are significant differences in the spatial distribution of population in Myanmar. The population density in Myanmar is "high in the central part and low in the eastern part and low in the western part". Yangon, Mandalay and Naypyidaw are the national population agglomeration areas, and the population in the three provinces and regions accounts for 28. 5% of the total population in the country. ② social and public services have a significant positive direct effect on the population distribution, and natural environment on the population distribution has significant positive effect and negative spillover effects space direct‐ ly, with the urban development and the employment quality has significant positive direct effect on the population distribution and positive spatial spillover effects, political conflict on the popu‐ lation distribution has significant negative spatial spillover effect, and no significant effect on the population distribution statistics of economic development. [ABSTRACT FROM AUTHOR]

BACKGROUND: Polyetheretherketone rod is a new material for semi-rigid fixation; however, its biomechanical properties in posterior lumbar interbody fusion remain unclear. OBJECTIVE: To compare the biomechanical properties of polyetheretherketone rods and titanium rods in posterior lumbar interbody fusion, and try to answer whether polyetheretherketone rods have the potential to be a substitute for titanium rods, especially when the anterior column of the spine is not adequately supported. METHODS: An intact L3-5 lumbar model was constructed using the finite element method. The four posterior lumbar interbody fusion constructs were developed: (1) polyetheretherketone rods with cage; (2) titanium rods with cage; (3) polyetheretherketone rods with bone grafts alone; and (4) titanium rods with bone grafts alone. The range of motion, stress and strain of the related structures were compared among the four posterior lumbar interbody fusion constructs. RESULTS AND CONCLUSION: (1) There was no significant difference in the L4/5 range of motion among all surgical models. (2) Compared to titanium rods, polyetheretherketone rods increased the average strain of interbody bone grafts and the peak stresses of endplates and cages and reduced the peak stresses of the screws and bone-screw interfaces. The ratio of peak stress to yield stress for the polyetheretherketone rods (6%–26%) was higher than that for the titanium rods (3%–12%). (3) Polyetheretherketone rods only slightly reduced the range of motion and disc stress at the L3/4 segment. (4) Compared to titanium rods, polyetheretherketone rods maybe reduce the risks of pseudoarthroses, screw breaking, and loosening but lead to the higher risks of endplate collapse, cage failure, and rod fracture. Polyetheretherketone rods may have a weak advantage over titanium rods in retarding adjacent segment degeneration. Polyetheretherketone rods may be an alternative when interbody fusion is performed with bone grafts alone instead of cages. [ABSTRACT FROM AUTHOR]

The carbon rods of waste Zn-Manganese batteries were recycled with high added value, and the improved Hummers method was used to prepare Graphene Oxide (GO).The effects of reaction times at low, medium and high temperatures, potassium manganese acid dosage, concentrated sulfuric acid dosage and different drying methods on the preparation of graphene oxide were investigated. The results show that it is feasible to prepare graphene oxide with carbon rod as raw material. When the amount of graphite powder is 1 g, potassium permanganate is 5 g, concentrated sulfuric acid dosage is 20 mL, low temperature reaction time 2 h, medium temperature reaction time 4 h, high temperature reaction time 30 min, GO can be prepared with high oxidation degree. [ABSTRACT FROM AUTHOR]

Brachytherapy is an essential part of radical radiotherapy of cervical cancer. However, traditional brachytherapy applicators are difficult to be placed, cannot be adapted to individualized local lesions, and have unsatisfactory dose distribution for some patients with recurrent postoperative stumps or eccentric or large cervical cancer, which then affects the efficacy and prognosis. Personalized radiotherapy products can be designed for each patient by utilizing 3D printing technology. Combination of 3D printing technology and brachytherapy can effectively improve accuracy of radiotherapy. The application of 3D printing technology in cervical cancer brachytherapy mainly includes the construction of cervical cancer model to preoperative planning and display tumor shape as well as anatomic relationship between tumor and surrounding tissues. It also includes the production of personalized applicator to reduce the occurrence of air gaps to achieve precise dose distribution. In addition, the design of parallel/oblique needle channel applicator and the optimization of needle channel and target dose distribution are also included. Applications of 3D printing technology in brachytherapy of cervical cancer have been summarized in the afore-mentioned areas. At the same time, the challenges in the development of 3D printing materials, system establishment and image guidance have been discussed. [ABSTRACT FROM AUTHOR]

The no-idle flow shop problem (NIFSP) is a typical NP-hard problem with constraints in the flowshop problem. In most real-world scenarios, the no-idle constraint is the basic requirement for the machine. However, the current proposed algorithms on the NIFSP problem have poor flexibility in comprehensive performance and parameter adjustment, for large-scale instances. To this end, this paper proposed an variable block internal iteration algorithm named VIIA with the goal of minimizing the maximum make span. In the initialization phase of VIIA, used the improved FRB5 produced the initial solutions, which improved the efficiency of FRB5, and greatly reduced the CPU consumption time while ensuring the algorithm performance. In the destruction reconstruction phase, it increased the internal iteration of the number of removed variable blocks, thus flexibly adjusted the parameter values. VIIA increased the neigh borhood search to adapted to different size of instances. In order to verify the performance of VIIA, the algorithm was compared with several algorithms that perform well in the flowshop scheduling problem. The experimental results demonstrate the superiority of VIIA in solving the NIFSP problem, and the performance of VIIA is obviously better than that of the comparison algorithms in the search of the optimal solution. [ABSTRACT FROM AUTHOR]

Objective: To investigate the relationship between serum osteopontin (OPN), thymidine kinase 1 (TK1), fibroblasts growth factor receptor 4 (FGFR4) and neoadjuvant chemotherapy in patients with locally advanced cervical cancer (LACC). Methods: 160 patients with LACC who were treated in the Affiliated Tumor Hospital of Guizhou Medical University from August 2011 to July 2019 were selected. They all received three cycles of paclitaxel and carboplatin neoadjuvant chemotherapy. According to the curative effect, the patients were divided into effective group and ineffective group. The levels of serum OPN, TK1 and FGFR4 were detected before chemotherapy, and the differences of the above indexes between the two groups were compared. The related data were collected, and the influencing factors of neoadjuvant chemotherapy in patients with LACC were analyzed by multivariate Logistic regression. The predictive value of OPN, TK1 and FGFR4 on the efficacy of neoadjuvant chemotherapy was analyzed by receiver operating characteristic (ROC) curve. Results: All 160 patients successfully completed neoadjuvant chemotherapy, with effective treatment in 129 cases (effective group), and ineffective treatment in 31 cases (ineffective group). The levels of serum OPN, TK1 and FGFR4 in ineffective group were higher than those in effective group (P<0.05). Multivariate Logistic regression analysis showed that FIGO stage Ⅲ, IVA and the high levels of serum OPN, TK1 and FGFR4 were the risk factors affecting the efficacy of neoadjuvant chemotherapy in patients with LACC (P<0.05). The areas under the ROC curve of serum OPN, TK1 and FGFR4 in predicting the efficacy of neoadjuvant chemotherapy in patients with LACC were 0.831, 0.695 and 0.767 respectively, and the areas under the curve predicted by the combination of three items were 0.893, which was higher than that detected by each index alone. Conclusion:The efficacy of neoadjuvant chemotherapy in patients with LACC is affected by FIGO stage and the levels of serum OPN, TK1 and FGFR4. Combined detection of the levels of serum OPN, TK1 and FGFR4 has a certain predictive value for the efficacy of neoadjuvant chemotherapy in patients with LACC. [ABSTRACT FROM AUTHOR]

The experiment was to study the effect of Angelica sinensis extract on production performance, milk quality and economic benefits of dairy cows. A total of 48 Holstein cows were selected and randomly divided into four groups, with six replicates in each group and two cows in each replicate. The TMR mixed diet was supplemented with 0 (group A, control group), 0.5% (group B), 1.0% (group C) and 1.5% (group D) Angelica sinensis extract, respectively. The pre-trial period was 7 d, and the formal test period was 60 d. The results showed that compared with control group, the average daily feed intake of dairy cows in group C was significantly increased (P<0.05), and the average daily milk production of dairy cows in each test group was significantly increased (P<0.05). Compared with control group, the milk fat content of fresh milk in group C and group D was significantly increased (P<0.05). With the increase of the addition of Angelica sinensis extract, the serum T-AOC of dairy cows showed an upward trend (P<0.05). Compared with control group, the activity of serum GSH-Px and SOD of dairy cows in each experimental group were significantly increased (P<0.05), and the content of serum MDA was significantly decreased (P<0.05). Compared with control group, the content of IgA in group D was significantly increased (P<0.05), the content of serum IL-6 in each test group was significantly decreased (P<0.05), the content of serum IL-10 in test group was significantly increased (P<0.05), and the serum TNF-α content of dairy cows in group C and group D decreased significantly (P<0.05). The economic benefit of a each cow in group B was 94.33 yuan higher than that in control group. The study indicates that Angelica sinensis extract can significantly improve the production performance, milk quality and health of dairy cows. Combined with the calculation results of economic benefits, the 0.5% of Angelica sinensis extract is the suitable addition amount in dairy cow diets. [ABSTRACT FROM AUTHOR]

To analyze the influence of in-wheel motors’ eccentricity on the ride comfort of electric vehicles, a four degree-of-freedom vibration model of electric vehicles was established to consider the mass and excitation of in-wheel motors. The corresponding state equation and output vector expression were derived, and the ride comfort evaluation index was determined. The random road excitation of the front wheel was established by using the filtered white noise method. The random road excitation relationship between the rear wheel and the front wheel was obtained by combining the Laplace transformation and the fourth-order symmetric Pade approximation. The whole vertical excitation of a typical four-phase 8/6-pole switched reluctance motor was presented. The simulation of random road excitation and in-wheel motor excitation was realized, and the ride comfort simulation and comparison of four working conditions were carried out on a B-grade road. The results showed that in-wheel motors’ eccentricity has an important influence on the ride comfort of electric vehicles on random roads, and the negative effect of in-wheel motors’ eccentricity should be considered in the design of electric vehicles. [ABSTRACT FROM AUTHOR]

To study the efficacy of hysteroscopic electroresection in the treatment of endometrial polyps and the related factors affecting postoperative recurrence of patients. The clinical data of 90 cases of patients with endometrial polyps who were treated in the department of Gynecology of The Second People's Hospital of Anhui Province from January 2016 to December 2019 were retrospectively analyzed. According to different surgical methods, they were divided into observation group (n=45, hysteroscopic electric resection) and control group (n=45, hysteroscopic location diagnosis and curettage). The operative efficacy, perioperative indicators and differences of complications were compared between the two groups, and the influencing factors of postoperative recurrence were analyzed. The effective rate of observation group and control group were 91.11% and 75.56%, respectively, the difference was statistically significant (掊2 =3.921, P=0.048). Compared with the control group, the hospital stay of the observation group was shortened, and the operation time was prolonged (P<0.05). The amount of intraoperative bleeding in the observation group was less than that in the control group, but there was no difference between the two groups ( P>0.05). There was no significant difference in complications between the two groups ( P>0.05). The recurrence rate of observation group and control group were 6.67% and 28.89%, respectively, with statistical significance ( 掊2 =4.441, P=0.035). Multi-factor Logistics regression analysis shows that: body mass index [OR=1.251, 95%CI(1.013-1.537)], age [OR=1.117, 95%CI(1.033-1.449)], number of abortions [OR=1.219, 95%CI (1.011-1.449)], number of polyps [OR=1.320, 95%CI (1.090-1.670)] and complicating endometritis [OR=1.344, 95%CI (1.110-1.902)] were risk factors for recurrence of patients (P<0.05). Hysteroscopic resection of endometrial polyps has a significant effect on the postoperative recovery of patients. In the treatment of patients, timely follow-up is recommended for patients with older age, obesity, high number of abortions, excessive number of polyps and complicating endometritis, so as to reduce the risk of postoperative recurrence. [ABSTRACT FROM AUTHOR]

At present, although gait recognition methods based on deep learning have made some progress, data collection and changes in gait appearance are still challenges to achieving accurate gait recognition. In order to improve the network ' s ability to capture temporal and spatial gait information, this paper proposed a two-stream network architecture based on gait contour flow and gait feature differential flow. The gait contour stream toke the gait contour map as input to extract the spatial gait information contained in the gait contour sequence, and the gait feature difference stream used the gait feature difference map as input to capture the dynamic information between adjacent gait frames . At the same time, to make full use of the global and local information in the gait sequence, this paper proposed a multi-scale pyramid mapping ( MPM) module and inserted it into each single-stream network to enhance the network ' s ability to extract global and local gait information. The average recognition accuracy of this method on the gait datasets CASIA-B and OU-MVLP reaches 87. 0% and 85 . 5%, respectively, which shows that the two-stream network architecture and MPM module can effectively capture the spatiotemporal gait information in the gait sequence. [ABSTRACT FROM AUTHOR]

BACKGROUND: Anterior cruciate ligament rupture is one of the important causes of knee instability. There are few reports on the relationship between anterior cruciate ligament rupture and patellofemoral joint stability. OBJECTIVE: To discuss the relationship between anterior cruciate ligament rupture and patellofemoral stability. METHODS: This was a retrospective case-control study. A total of 65 cases of complete rupture of the anterior cruciate ligament confirmed by knee arthroscopy were set as the study group; 65 healthy persons participating in physical examination were set as the normal group. The parameters related to patellofemoral joint instability were measured in sagittal and axial MRI of the knee and compared between the two groups. The implementation of the study scheme was in accordance with the relevant ethical requirements of the First Affiliated Hospital of Guangzhou University of Chinese Medicine, and the subjects and their families gave full informed consent to the study process. RESULTS AND CONCLUSION: (1) The results tibial tubercle-femoral block spacing was shorter in the study group than that in the normal group (P < 0.05). Patellar tilt angle was significantly larger in the study group than that in the normal group (P < 0.05). (2) There was no statistically significant difference in baseline patella between the two groups (P > 0.05). The baseline value of trochlear and patella trochlear index was significantly lower in the study group than those in the normal group (P < 0.05). (3) It is concluded that completely anterior cruciate ligament rupture can decrease tibial tubercle-trochlear groove distance, increase the patellar tilt angle, rise patellar alta, and change the stability of the patellofemoral joint. It may be the potential risk factor for the patellofemoral arthritis. [ABSTRACT FROM AUTHOR]

Objective To investigate the effects of one-stage additional posterior pedicle screws (PPS) internal fixation on early Cage subsidence after oblique lateral interbody fusion (OLIF). Methods We made a retrospective analysis of 118 patients with lumbar degenerative diseases treated with OLIF at the Department of Orthopedics, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, from January 2016 to December 2019. We divided the patients into OLIF stand-alone group(58 ones)and OLIF with PPS fixation group(60 ones)according to the surgical procedure. All the patients had preoperative frontal and lateral radiographs of the lumbar spine, and CT and MR scans were performed. The clinical outcomes and reoperation rates of the two groups were compared at immediate postoperative follow-up and at 1, 3, 6 and 12 months. X-ray and CT examinations were performed to assess Cage subsidence in both groups at each postoperative follow-up. Results There was no statistical difference between the two groups in baseline data and surgical segmentation. Of the 118 patients with 141 discs who underwent OLIF surgery, 58 patients with 68 discs received OLIF stand-alone surgery and 60 ones with 73 discs received OLIF with PPS fixation. There were no significant differences in intraoperative bleeding, complications, or postoperative clinical outcomes between the two groups(P> 0. 05), and the Cage subsidence rate was 22. 4% in OLIF stand-alone group and 5% in OLIF with PPS fixation group, with significant difference between the two groups(P<0. 01). Conclusion Both OLIF stand-alone and OLIF additional PPS fixation can achieve good early clinical outcomes, and first-stage additional PPS fixation can significantly reduce the occurrence of Cage subsidence in the early postoperative period after OLIF. [ABSTRACT FROM AUTHOR]

The experiment selected Lactococcus lactis 17, Saccharomyces ceratosus Sa and Bacillus pumilus SE5 as fermentation strains, to analyze the nutritional values of the fermented soybean meals. The results showed that the inhibitory factors of pancreatic protein were almost all removed in all fermentation groups, and the content of soybean antigen protein was significantly decreased (P<0.05). The degradation rates of soybean globulin and β-associated soybean globulin were 88.83% and 58.03% in Bacillus pumilus SE5, respectively. The number of viable bacteria in all fermentation groups increased exponentially, the digestibility of crude protein, acid-soluble protein, soybean peptide and crude protein were significantly increased compared with that before fermentation (P<0.05), and the soybean peptide in soybean meal fermented by Bacillus pumilus SE5 was increased by 869.83%. The experiment indicates that the various indicators of Bacillus pumilus SE5 fermented soybean meal are better. [ABSTRACT FROM AUTHOR]

BACKGROUND: miR-124 plays an important role in the proliferation of neural stem cells and changes in brain tissue and blood expression after cerebral infarction, suggesting that it is one of the core regulators of endogenous nerve regeneration after cerebral infarction. Radial extracorporeal shock wave therapy can promote neural stem cell proliferation, but whether it is related to miR-124 is currently unclear. OBJECTIVE: To investigate the effect of radial extracorporeal shock wave therapy on the expression of miR-124 in the hippocampus after cerebral infarction and whether the promotion of neural stem cell proliferation is related to miR-124. METHODS: A model of middle cerebral artery occlusion in rats was established. Rats were randomly divided into radial extracorporeal shock wave group and control group. The radial extracorporeal shock wave group was subjected to radial extracorporeal shock wave therapy intervention, with the ischemic head 72 hours after the cerebral infarction, once every 3 days. At 11, 20, 29, and 38 days after model establishment, modified neurological function scores were assessed in rats. Then RT-qPCR was used to detect the expressions of miR-124 and Nestin mRNA in the hippocampus of cerebral infarction rats. Western blot assay and immunofluorescence were used to detect the expression of Nestin protein in the hippocampus of the ischemic side. RESULTS AND CONCLUSION: (1) After cerebral infarction in rats, the expression of miR-124 gradually increased in the hippocampus of the ischemic side. (2) At 11, 20, 29, and 38 days after middle cerebral artery occlusion, the neurological scores of the rats were lower in the radial extracorporeal shock wave group than those in the control group (P < 0.05). The expression of Nestin was higher on the ischemic side of the hippocampus than that in the control group (P < 0.05). (3) At 11, 20 and 29 days after middle cerebral artery occlusion, the expression of miR-124 in hippocampus of cerebral infarction rats on the affected side in the radial extracorporeal shock wave group was lower than that of the control group (P < 0.05). (4) Results suggest that expression of miR-124 in the hippocampus of cerebral infarction rats is increased. Radial extracorporeal shock wave therapy directly interfering with the head of the affected side can reduce the expression of miR-124, increase the number of neural stem cells, and improve impaired nerve function. [ABSTRACT FROM AUTHOR]

In order to bring the ecological protection and high-quality development of the Yellow River Basin into the track of the rule of law, and realize the good law and good governance of the Yellow River, it is an inevitable requirement to carry out the legislation work of the Yellow River Law scientifically and orderly. At present, the legislative work of the Yellow River Law has an urgent need for the systematization of institutional norms, and the basic theoretical discussion of the system design of the Yellow River Law is at the right time. Taking the ideal picture of the Yellow River Law institutional system design as a starting point, it explored the logical approach and frame structure of the Yellow River Law institutional system design. The design of the system of the Yellow River Law should need to follow the logical approach of “starting from basic concepts, to clear basic goals, then to clear basic principles, and finally to the determination of basic rules”. The system design of the Yellow River Law should focus on the whole the development of seven partial systems, including the river basin supervision and management system group, the development and utilization protection system group, the ecological environment restoration system group, the flood and drought disaster prevention system group, the high-quality development system group, the water pollution prevention system group, and the legal responsibility system group. [ABSTRACT FROM AUTHOR]

Objective : To investigate the clinical effect of Baofukang suppository combined with low dose estrogen in the treatment of senile vaginitis, and the effect on serum hormone level and quality of life. Method : 96 cases of senile vaginitis admitted in our hospital from January 2017 to March 2019 were selected, which were divided into research group (n=48) and control group(n=48) according to the method of random number table. The control group was treated with potassium permanganate and diethylstilbestrol, and the research group was treated with Baofukang suppository. The therapeutic effect, progesterone (P), estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH) and SF-36 quality of life were observed before and after treatment. Results : The disappearance time of abnormal vaginal secretion, pruritus or burning of vulva, atrophy of vaginal mucosa in the research group was shorter than that in the control group, and the total effective rate of the research group was higher than that of the control group (P<0.05). After treatment, the level of serum estrogen and the scores of SF-36 were improved, P, LH and FSH in the research group were significantly lower than those in the control group （P<0.05）, the scores of overall health, social function, physiological function, physical pain, mental health and vitality in SF-36 were higher than those in the control group (P<0.05). Conclusion : Combined with Baofukang suppository on the basis of small dose of estrogen, which can effectively improve the clinical efficiency of senile vaginitis, improve the estrogen level of patients, rapidly relieve the symptoms of abnormal vaginal secretion, pruritus or scorching of vulva, atrophy of vaginal mucosa, and improve the quality of life of patients. The curative effect is satisfactory and has better clinical value. [ABSTRACT FROM AUTHOR]

Objective　To establish a method for simultaneous determination of chlorogenic acid, luteolin-7-O-β-Dglucoside, 3,5-dicaffeoylquinic acid, linarin and pogostone in Fangshu Qingre mixture by RP-HPLC. Methods　ZORBAX-SB-C18 column(4.6 mm×250 mm, 5 μm) was used as the chromatographic column.The mobile phase was 0.2% formic acid water solution(A) and acetonitrile solution (B)with a gradient elution mode. The flow rate was 1.0 ml/min.The detective wavelength was 327 nm. The column temperature was 30 ℃. Results　There were good linear relationships in the determination of chlorogenic acid, luteolin-7-O-β-D-glucoside, 3,5-dicaffeoylquinic acid, linarin and pogostone (r≥0.999 6), with the average recovery rate of 102.03%(1.63%), 102.38%(1.51%), 102.39%(1.23%), 103.14%(1.87%) and 104.01%(2.33%). Conclusion　The method was simple and stable with a good reproducibility, which could be used as a quality control method for active compotents in Fangshu Qingre mixture. [ABSTRACT FROM AUTHOR]

Objective To investigate the efficacy and safety of programmed cell death protein-1 (PD-1) monoclonal antibody on the treatment of malignant tumor after solid organ transplantation (SOT). Methods The relevant literatures in 7 databases were searched. The data on 54 cases of recipients with malignant tumors treated with PD-1 monoclonal antibody after SOT were collected, and the clinical effects and rejection of SOT recipients treated with PD-1 monoclonal antibody were analyzed. Results Total 32 acceptable articles including 54 SOT recipients were incorporated, including 43 males and 11 females aged 14-79 years old. There are 29 renal transplant recipients, 19 liver transplant recipients and 6 heart transplant recipients. The types of PD-1 monoclonal antibody agent used by SOT recipients included pembrolizumab for 28 patients and nivolumab for 26 patients. The overall remission rate, disease progression rate and fatality rate of PD-1 monoclonal antibody for postoperative malignant tumors of SOT recipients were 32% (17/54), 44% (24/54) and 36% (19/54), respectively. After treatment with PD-1 monoclonal antibody for postoperative malignant tumors of SOT recipients, the incidence of rejection was 39% (21/54), indicating no significant correlation between rejection and type of PD-1 monoclonal antibody (P>0.05). Conclusions PD-1 monoclonal antibody can effectively treat postoperative malignant tumors of SOT recipients, and may induce rejection during the treatment. But rejection is not the most common cause for death of recipients. [ABSTRACT FROM AUTHOR]

To ensure the safety and efficacy of the military thermo-sensitive drugs, it is necessary to monitor the temperature changes through the whole process of production, transportation, storage, distribution and application. The characteristics of various commercial TTI were analyzed. The applications of TTI technology in the quality control for military thermo-sensitive drugs were reviewed in order to provide accurate quality assurance for those drugs. [ABSTRACT FROM AUTHOR]

Objective　To establish a method for content determination of total flavones and polysaccharides in Fangshu Qingre mixture by UV-Vis Spectrophotometry. Methods　The contents of total flavones and polysaccharides in Fangshu Qingre mixture were determined by UV-Vis spectroscopy with rutin and anhydrous glucose as reference substance, and the wavelength was set at 508 nm and 487 nm. Results　The contents were from 0.00 to 59.20 μg/ml for total flavones and from 10.92 to 109.20 μg/ml for total polysaccharides in Fangshu Qingre mixture. The recoveries of total flavones and total polysaccharides were 104.4% and 104.8% respectively. Conclusion　The method of using ultraviolet spectroscopy was simple, reproducible, accurate and reliable, which could be preferably used as the method for content determination of total flavones and polysaccharides in Fangshu Qingre mixture. [ABSTRACT FROM AUTHOR]

Objective To evaluate the effect of donor risk index (DRI) on the early prognosis of liver transplantation for acute-on-chronic liver failure (ACLF). Methods Clinical data of 159 ACLF recipients undergoing liver transplantation were retrospectively analyzed. According to the calculation formula of DRI, all recipients were divided into DRI<1.65 group (n=96) and DRI≥1.65 group (n=63). Based on the Chronic Liver Failure Consortium acute-onchronic liver failure score (CLIF-C ACLFs), all recipients were divided into CLIF-C ACLFs<48 group (n=78) and CLIF-C ACLFs≥48 group (n=81). The early prognosis indexes including the length of intensive care unit (ICU) stay and the length of postoperative hospital stay of the recipients in each group were observed after liver transplantation. The 90 d survival rate of the recipients after liver transplantation was analyzed by Kaplan-Meier survival curve. The risk factors affecting the early prognosis of ACLF recipients after liver transplantation were analyzed by Cox's hazards regression model. Results The length of ICU stay and the length of postoperative hospital stay did not significantly differ between the DRI<1.65 group and DRI≥1.65 group (both P>0.05). The length of postoperative hospital stay did not significantly differ between the CLIF-C ACLFs<48 group and CLIF-C ACLFs≥48 group (P>0.05). The length of ICU stay in the CLIF-C ACLFs<48 group was 4 (3-14) d, significantly shorter than 7 (1-33) d in the CLIF-C ACLFs≥48 group (P<0.05). The CLIF-C ACLFs was a risk factor of the early prognosis of ACLF recipients after liver transplantation (P<0.05). The postoperative 90 d survival rate did not significantly differ between the DRI<1.65 group and DRI≥1.65 group (P>0.05). The postoperative 90 d survival rate in the CLIF-C ACLFs<48 group was 94%, significantly higher than 79% in the CLIF-C ACLFs≥48 group (P<0.05). Conclusions The early prognosis of ACLF recipients after liver transplantation is correlated with the severity of the disease rather than the DRI. Liver transplantation should be performed early and promptly. [ABSTRACT FROM AUTHOR]

Objective To establish the transgenic mice-derived allografts (MDAs) so as to provide an appropriate experiment model of pancreatic cancer. Methods By using the tissue fragments derived from transgenic mice with pancreatic cancer named LSL-KrasG12D/+ ; Trp53fl/+ ; Pdx1-Cre (KPC) mice and subcutaneous transplant technique, we constructed the MDAs. We evaluated the histopathological characteristics of MDAs and infiltration of immune cells by H&E staining, Masson􀆳s staining and immunohistochemical method. Results MDAs could mimic the pathological morphology, proliferation and fibrosis of pancreatic cancer precisely. Besides, the infiltration of immune cells in MDAs tumor was the same as that of pancreatic cancer. Conclusion MDAs are an effective model to mimic the development of pancreatic cancer. [ABSTRACT FROM AUTHOR]

Since the first successful use of oocyte cryopreservation and resuscitation, to obtain twin pregnancies, in 1986, oocyte cryopreservation has gradually become an intervention measure for iatrogenic ovarian dysfunction. In recent years, the number of patients with diminished ovarian reserve (DOR) has shown an increasing trend, and the preservation of their fertility is receiving increasing attention. The iatrogenic influencing factors of DOR mainly include reproductive system surgery, tumor radiotherapy and chemotherapy, etc. Oocyte cryopreservation is a first-line treatment option for fertility preservation, and its safety, applicability, utilization rate, and egg donation treatment in the clinical application of iatrogenic DOR patients have been confirmed by clinical data and relevant literature. However, the issues related to the timing of oocyte cryopreservation, limitations of clinical application and ethical policies cannot be ignored. Oocyte cryopreservation is of great significance for improving the pregnancy outcomes of unmarried patients with iatrogenic DOR and the reproductive autonomy of married patients. After clarifying the iatrogenic influencing factors of DOR, it is recommended to seek consultation from multiple disciplines such as oncology, gynecology and reproductive health as soon as possible to develop the personalized oocyte cryopreservation plans. [ABSTRACT FROM AUTHOR]

Circular RNA (circRNA) is involved in tumor progression. CircPVT1 is an oncogene that is abnormally expressed and correlated with a variety of tumors. It can regulate tumors’ malignant behavior and affect the survival and prognosis of patients. This article reviews research on the regulatory roles of circPVT1 in tumors to provide references for accurate treatment. [ABSTRACT FROM AUTHOR]

The governing equation and solving algorithm of the probability density evolution method for stochastic dynamical systems were outlined. On this basis， some new advances in the solution of the generalized density evolution equation were discussed， including the ensemble evolution equation and its solution， the rational criterion for partitioning of the probability space, the densification technique of point set and the information reconstruction， etc. [ABSTRACT FROM AUTHOR]

The deployment of hadoop cluster is complicated, time-consuming and difficult, and is not conducive to the rapid expansion of the cluster. In order to solve these problems, the paper proposed a new solution of combining docker container based on fast, simple and flexible deployment of cluster. Docker images built with ambari and its operating environment and configuration. Write shell script with the multi-node container and process of hadoop deployment. With one command, it could realize the cross platform of arbitrary nodes Hadoop cluster’s automation installation and deployment. Experiments show that the proposed scheme is simple and reliable and can greatly improve the efficiency of cluster deployment. As a result, the proposed scheme has an important role in promoting the processing and analysis of mass data. [ABSTRACT FROM AUTHOR]

Objective To discuss the clinical therapeutic effect of tibia fracture treated by intramedullary nail using limited incision or close reduction. Methods We treated 54 tibia transverse fracture cases, 93 oblique fracture cases, 71 fragmental fracture cases by intramedullary nail using open with limited incision or close reduction. We then compared operation time, X-ray time, hospital stay duration, infection rate, nonunion rate, and postoperative function restoration between patients with different fractures. Results There was no different operation time in transverse fracture group, but longer for close reduction in oblique fracture group and for open reduction in fragmental fracture group. X-ray time did not differ for open or close reduction in transverse fracture group. Long X-ray time was used in close reduction in oblique and fragmental fracture groups. There was no significant difference in nonunion rate for open and close reduction in both transverse and fragmental fracture groups. The oblique fracture nonuinon rate was higher in close reduction group than in open reduction group. No difference was found in infection rate or function recovery whether for open or close reduction in all types of fractures. Conclusion Different therapy methods should be determined by different fracture types. Open reduction with minimal incision should be used for oblique fracture cases and fragmental fracture cases with reduction difficulty. [ABSTRACT FROM AUTHOR]

As Flame, Duqu, Stuxnet and other virus attacks have been reported in these years, the whole soceety has laid more emphasis on APT attacks. Compared with traditional attacks, APT attacks are more targeted, persistent, hidden and compeex; they are also destructive and can cause serious consequences. However, because APT attacks can happen in lots of ways and are deeply hidden, and traditional detecions, including firewall, antivirus, IDS and so on, can hardly discover APT attacks, or the attack goals have been reached long before the detection. To solve theses problems, we design an APT attack detection model based on the research of the features of APT attacks. Besides, with proper lin e threshold, we conduct association analysis of the attacks detected by various detection methods, and the attack paths can be matched with the attack detection model. Based on the matching degree of the intrusion paths, we can make a judgment about the existence of APT attacks. And experimental results show that with a relatively complete ATP attack detection model, the detection preasion of APT attacks is higher. [ABSTRACT FROM AUTHOR]

For understanding the relationship between microstructure characteristics and mechanical property of granite，nuclear magnetic resonance (NMR) measurement and rock mechanical test were conducted in this study. The relationship between NMR porosity，NMR T2 spectrum area and uniaxial compressive strength were analyzed respectively. The results show that the pore development has important influence on rock damage. There are exponential distribution between NMR porosity，NMR T2 spectrum area and uniaxial compressive strength. The pore distribution of rock has important effect on rock mechanical property and macro damage characteristics. The pore development characteristics of rock samples under freezing and thawing cycles were studied by using fractal theory and the fractal dimension values were obtained. The results indicate that the pore evolvement under freezing and thawing cycles was self-similar. The bigger the fractal dimension value，the more pore develops，and the smaller the uniaxial compressive strength. [ABSTRACT FROM AUTHOR]

目的 探讨中西医结合治疗女性复发性下尿路感染的临床疗效。 方法 选取该院2012年10月至2014年10月收治的女性下尿路感染患者96例，分为对照组和观察组各48例。对照组患者采用喹诺酮类药物或根据药敏试验选择抗生素抗感染治疗；观察组患者在对照组的基础上加用银翘八正散加减治疗，并在停用抗生素后使用知柏地黄汤加减治疗。比较两组患者治疗效果，尿频、尿痛、发热等临床症状缓解时间，菌尿消失时间，尿常规恢复正常时间及治疗6个月后的复发率等。 结果 观察组患者治疗总有效率（95.8%）高于对照组（75.0%），临床症状缓解时间、菌尿消失时间及尿常规恢复正常时间均短于对照组，且6个月后复发率低于对照组，差异均有统计学意义（P＜0.05）。 结论 中西医结合治疗复发性下尿路感染疗效优于单纯西医治疗，值得在临床推广。 [ABSTRACT FROM AUTHOR]

Linkable ring signatures could avoid double-spending attacks in the blockchain. Lattice-based signatures were quantum-resistant. However, as the number of ring members increased, the size of existing lattice-based linkable ring signatures increased. To solve this problem, a lattice-based linkable ring signatures scheme was proposed. This scheme used queues to implement a special conversion of vector number system, and used lattice-based accumulators to accumulate the public keys of ring members, so that the signature size didn’t increase with the number of ring members. And using the rejection sampling theorem, this scheme constructed signatures based on proofs of knowledge on lattices, prevented the signature private key from leaking, and improved the computational efficiency. In the random oracle model, the scheme was proved to be unforgeable, anonymous and linkable. Performance analysis and experimental evaluation show that, this scheme saves time and storage, and the signature size is constant with the increase of ring members. [ABSTRACT FROM AUTHOR]

Objective To explore the predictive value of the expression of CD44v6 and EGFR on the efficacy of neoadjuvant chemotherapy (NACT) in stageⅡ-Ⅲ cervical cancer. Methods A total of 53 patients with stageⅡ-Ⅲ cervical cancer diagnosed by pathology were selected. All patients received two cycles of paclitaxel+platinum NACT. The pathological tissue samples of cervical tumors before NACT treatment were collected. The expression of CD44v6 and EGFR were detected by the immunohistochemical SP method, and we analyzed their predictive value of NACT in stageⅡ-Ⅲ cervical cancer. Results Among the 53 patients, 38 were in the NACT effective group (CR+PR), and 15 were in the NACT ineffective group (SD+PD). The expression of CD44v6 in the ineffective group was significantly higher than that in the effective group (P<0.05). The expression of CD44v6 was significantly different in patients with CR, PR, and SD (P<0.05). The AUC of CD44v6 to NACT effect on stage Ⅱ-Ⅲ cervical cancer was 0.74 (P<0.05). The patients in the high expression group of CD44v6 had worse efficacy in NACT than those in the low expression group of CD44v6 (P<0.05). Pearson test showed that CD44v6 and EGFR expression were correlated (R=0.34, P<0.05). Conclusion High expression of CD44v6 may reduce the efficacy of NACT in stageⅡ-Ⅲ cervical cancer, suggesting that the expression of CD44v6 has a certain predictive value and clinical significance in the efficacy of paclitaxel+platinum NACT on cervical cancer. Moreover, CD44v6 is positively correlated with EGFR expression. [ABSTRACT FROM AUTHOR]

Objective To analyze the clinical characteristics and survival prognosis of patients with AIDSrelated malignant tumor. Methods We retrospectively analyzed the data of 354 patients with AIDS-related malignant tumor. Univariate analysis was conducted by Log rank test and multivariate analysis was conducted by Cox proportional risk regression model. Results The average age of the patients was 54.10±12.96 years old. The ratio of male to female patients was 2.1:1. The number of patients with AIDS complicated with lymphoma was the most, accounting for 28.25%. The 1-, 3- and 5-year survival rates were 78.48%, 62.13% and 55.31%, respectively. Univariate analysis showed that there were statistical differences in prognosis of patients with different types of malignant tumor, age, gender, medical insurance type, number of admissions after diagnosis of AIDS, average length of stay,radiotherapy or not, leaving hospital according to medical advice. Multivariate analysis showed that gender, number of admissions after diagnosis of AIDS, average length of stay, proportion of out-of-pocket and leaving hospital according to medical advice were independent risk factors affecting the survival and prognosis of patients. Conclusion AIDS is easily complicated with lymphoma, lung cancer and cervical cancer. The patients received insufficient anti-tumor courses in hospital. [ABSTRACT FROM AUTHOR]

BACKGROUND: The treatment of distal tibial comminuted fractures with soft tissue injury has always been challenging. The new retrograde tibial nailing and supercutaneous locking plate are important treatment methods, but their strain and stress shielding at the fracture end during different periods of fracture healing and different load conditions have not been reported. OBJECTIVE: To explore the biomechanical stability of retrograde tibial nailing and supercutaneous locking plate in different periods of fracture healing by finite element analysis to offer a scientific foundation for clinical application and rehabilitation exercise. METHODS: The finite element model of distal tibial comminuted fracture was established by utilizing the CT data of the tibia from a 40-year-old healthy male. Retrograde tibial nailing, supercutaneous locking plate, and callus models were assembled in accordance with the principle of fracture fixation. The finite element analysis was performed using ANSYS software to compare the displacement of the fracture end, the stress shielding of the tibia, the stress of the callus, and the stress distribution of the tibia and the fixation device during different periods of fracture healing. RESULTS AND CONCLUSION: (1) The relative displacement of the tibial fracture decreased gradually with the healing of the fracture, and the displacement decreased significantly after 3 months. At 0 and 1 months after operation, the vertical displacement and total displacement of the supercutaneous locking plate group were higher than those in the retrograde intramedullary nail group. The Z-axis displacement (horizontal medial and lateral displacement) of the two fixation methods was more obvious than the X-axis and Y-axis, and the Z-axis displacement of supercutaneous locking plate group was the most obvious. The maximum Z-axis displacement of the two fixation methods was located on the outside of the tibia, and the minimum displacement was located on the inside of the tibia. (2) The stress shielding rate at different periods of fracture healing gradually decreased with time. The stress shielding rate of the retrograde intramedullary nail was higher than that of the supercutaneous locking plate at different stages of fracture healing. After 3 months, the stress shielding rate of the supercutaneous locking plate was reduced to about 4%, and the stress shielding rate of the retrograde intramedullary nail was reduced to about 40%. (3) The stress of the stress concentration site of the callus in the two fixation methods increased with the increase of the load, and the stress of the callus in the supercutaneous locking plate group was always greater than that in the retrograde intramedullary nail group. The maximum stress distribution of the callus was approximately equally distributed among the two modes of fixation, both in the lateral portion of the tibia. (4) As the fracture healed, the maximum stress of the tibia in the two groups decreased gradually, and the stress in the supercutaneous locking plate group was always greater than that in the retrograde intramedullary nail group. The average stress of the maximum stress area of the tibia in the supercutaneous locking plate group under 1 500 N load was 285 MPa, while that in the retrograde intramedullary nail group was 26 MPa. (5) As the fracture healed, the stress of the fixation device in the two groups decreased gradually, and the stress in the supercutaneous locking plate group was significantly higher than that in the retrograde intramedullary nail group. After 3 months, the stress of the two fixation devices decreased significantly. (6) It is indicated that in the early stage of fracture healing, the strain on the fracture end in the retrograde intramedullary nail group is small, and the maximum stress of the tibia is moderate, allowing early loaded. The fractured ends in the supercutaneous locking plate group had too large strain and too large maximum stress of the tibia, which needed to be partially loaded under protection and could not be fully loaded. In the middle and late stages of fracture healing, the tibial retrograde intramedullary nail and the supercutaneous locking plate could be completely loaded, and the stress shielding rate of the supercutaneous locking plate was significantly lower than the tibial retrograde intramedullary nail. [ABSTRACT FROM AUTHOR]

Objective To explore the causal relationship between education level and pancreatitis risk through Mendelian randomization. Methods A two-sample Mendelian randomization analysis was conducted using genome-wide association study (GWAS) summary data. The GWAS data for education level and pancreatitis were obtained from SSGAC database and the FinnGen database (version R9). Causal relationship between education level and pancreatitis was explored using the inverse variance weighted (IVW), MR-Egger, and weighted median methods. Heterogeneity and directional pleiotropy were evaluated using Cochran's Q test and funnel plots. Results Totally 604 SNPs associated with education level were included. The results provided evidence that there was negative relationship between education level and pancreatitis risk. For acute pancreatitis, OR=0.52, 95% CI:0.44-0.62, P=2.43×10-14 while for chronic pancreatitis, OR=0.51, 95% CI:0.41-0.64, P=7.20×10-9. Results from MR-Egger and weighted median analyses obtained the same results. The results of sensitivity analysis indicated that this study did not violate the basic assumptions of Mendelian randomization. Conclusion There is a causal relationship between education level and the occurrence of pancreatitis. The educational level is negatively correlated with the risk of pancreatitis. [ABSTRACT FROM AUTHOR]

The purpose of this experiment was to study the effects of Chinese herbal medicine on the laying performance, egg quality, and serum indexes of Bashang long-tailed chickens in the late laying stage. A total of 240 Bashang long-tailed chickens aged 470 days were randomly divided into four groups with six replicates in each group and 10 chickens in each replicate. The control group was fed with basal diet, while the experimental groups were fed with 1.0%, 1.5%, and 2.0% Chinese herbal medicine additives, respectively. The pre-test period was seven days, and the formal test period was 56 days. The results showed that compared with the control group, the laying rate of the 1.5% dosage group increased significantly (/k0.05), and the average egg weight of the 1.0% and 2.0% dosage groups increased significantly (P<0.05). The Huff unit of the 1.0% and 1.5% dosage group tended to increase (jP>0.05), and the eggshell thickness of the 1.5% dosage group increased significantly (/kO.05). The activity of glutathione superoxide dismutase (GSH-Px) in serum of the 1.5% dosage group increased significantly (/k0.05). Serum levels of luteinizing hormone (LH), estradiol (E2) and progesterone (Prog) were significantly increased (P<0.01), and the serum levels of FSH were significantly increased in the 1.5% and 2.0% dosage groups (P<0.01). The serum levels of interferon-y (DFN-y) in the 1.5% and 2.0% dosage groups were significantly increased (PcO.Ol), and the serum levels of interleukin-2 (EL-2) in the 2.0% dosage group were significantly increased (fkO.Ol). The result shows that dietary Chinese herbal additives can increase laying rate, improve egg quality, enhance antioxidant capacity, promote the secretion of reproductive hormones, and improve the immune function of Bashang long-tail chickens in late laying period. The suitable supplemental level of Chinese herbal medicines is 1.5%. [ABSTRACT FROM AUTHOR]

Objective: To observe the effect of early electroacupuncture intervention on the expression of TARDNA binding protein 43 (TDP- 43) and HMGB1/RhoA signaling pathway in the cerebral cortex of amyotrophic lateral sclerosis (ALS) mice, and to explore the potential mechanism of early electroacupuncture intervention in improving motor function in ALS mice. Method: SOD1G93A gene phenotype mice were randomly divided into model group (SOD1G93A ), acupuncture intervention group (EA), riluzole group (Riluzole), and SOD1G93A negative mice in the same litter were blank control group (Control), with 15 mice in each group. The electroacupuncture group was given acupuncture of Baihui point, bilateral Tianzhu point, bilateral Tianshu point, 5 times/7 days, 7 days for a course of treatment, a total of 4 courses of treatment. The riluzole group was treated with riluzole 30 mg（/ kg·d) by gavage, once a day, five times a week for two weeks. The motor function of mice in each group was evaluated by hind limb functional neurological score and rotarod fatigue test, and the rate of TDP-43 positive cells in cerebral cortex was observed by immunofluorescence. The relative expression of Iba-1, HMGB1 or RhoA protein in cerebral cortex was detected by Western Blot. The levels of serum TNF-α and MCP-1 were detected by Elisa. The morphological changes of cerebral cortical neurons were observed by transmission electron microscopy. Result: Compared with the control group, the rotarod latency time was decreased and the neurological score was increased in the model group (P<0.01) . The contents of serum MCP-1 and TNF-α, the expression of Iba1, HMGB1 and RhoA protein in cerebral cortex and the rate of TDP-43 positive cells were increased in the model group (P<0.01) . Compared with the model group, the rotarod latency time of the electroacupuncture group and the riluzole group increased and the neurological score decreased (P<0.01, P<0.05), the serum MCP-1, TNF-α content and the cerebral cortex Iba-1, HMGB1, RhoA protein expression and TDP-43 positive cell rate decreased (P<0.01, P<0.05) . The results of electron microscopy showed that the structure of cortical neurons in the control group was normal, and the nerve cells in the model group exhibited obvious pathological changes. The damage of nerve cells in the electroacupuncture group and the riluzole group was reduced, the structure was relatively complete, and some normal organelles were detected. Conclusion: Electroacupuncture intervention can improve the motor function of ALS model mice. The mechanism may be related to the inhibition of HMGB1/RhoA signaling pathway and the reduction of microglia-induced neuroinflammation, and it is speculated that it has a positive effect on the reduction of ALS pathological substrate TDP-43 deposition. [ABSTRACT FROM AUTHOR]

Objective To establish a fast detection method of sodium aescinate by using near infrared (NIR) spectroscopy analysis method for the determination of the content of sodium aescinate for injection. Methods OPUS software was used to optimize the collected spectrum. PLS algorithm and factorization algorithm were used to establish quantitative model and qualitative model. Results The correlation coefficient of the quantitative model reached 0.992 6, the RMSECV deviation was 0.253. The deviation between the predicted value of the sample and the true measured value was less than 5%, which could accurately predict the content of sodium aescinate. Conclution The qualitative model can effectively distinguish the samples of other varieties that have not participated in the modeling, and provide a reference for the rapid screening of the drug. [ABSTRACT FROM AUTHOR]

Recent studies have shown that intestinal flora can play a role in the treatment of nonalcoholic fatty liver disease( NAFLD), and intestinal flora regulation can provide new thoughts for the treatment of NAFLD. This article reviews the research advances in the role of intestinal flora regulation in traditional Chinese and Western medicine therapy for NAFLD and explores the current situation of probiotics, fecal flora transplantation, antibiotics, and traditional Chinese medicine therapy in regulating intestinal flora and improving NAFLD, so as to provide a basis for clinical practice. [ABSTRACT FROM AUTHOR]

Based on the idea of fully differential amplification and the concept of impedance control, this paper introduces a set of controllable gain RF broadband amplification system with MSP430F6638 as the control core. To effectively suppress the noise interference and ensure the system performance while achieving the controllable gain adjustment, the system uses a cascade of a fixed-gain fully differential amplifier and a controllable gain fully differential amplifier. The final stage of the system uses an RF power amplifier to improve the system' s load capacity. In this paper, the working principle of the fully differential amplifier is discussed in detail, and the complete circuit and device selection of the key module are given. Finally, the system performance is analyzed experimentally, which provides a good guidance for undergraduate teaching, theoretical research and engineering practice. [ABSTRACT FROM AUTHOR]

Tn order to improve the performance of asphalt in pavement, basalt fiber, nano-ZnO and nano-TiO2 are used to composite the modified asphalt. The basic properties and rheological properties of composite modified asphalt were studied by three index of asphalt, Brookfield rotational viscosity and temperature sweep test, and the thin-film oven test (TFOT) and the pressurized aging vessel test (PAV) were used to simulate different aging states of asphalt to analyze the anti-aging performance of the composite modified asphalt. The results showed that with the increase of nano-ZnO and nano-TiO2 content, the penetration, softening point and viscosity of modified asphalt increased, and its high temperature performance was improved. The rutting factor G / sin§ and the fatigue factor G • sin§ of the composite modified asphalt were significantly improved, and its antirutting performance was improved, but its fatigue resistance was decreased. Compared the complex modulus, fatigue factor-temperature relationship curves of asphalt under different aging conditions, its anti-aging performance increased with the increase of nanocomposite modifier content. Through comprehensive comparison and selection, the optimal dosage of nanocomposite modifier was recommended to be 4%. [ABSTRACT FROM AUTHOR]

A novel charged iridium complex[Ir(mppy)2(Br2 bpy)]+PF6-was designed, synthesized and characterized by elemental analysis, NMR(1 H and 13 C), MS and FT-IR. Photophysical property of this complex was investigated. Single crystals of complex was prepared, via a solvent evaporation technique, and was subjected to X-ray diffraction analysis. The results show complex is in the triclinic system with a space group of P-1.A strong red-emission at 625 nm was observed in photoluminescence absorption spectra of the compound. [ABSTRACT FROM AUTHOR]