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以往研究认为各种细胞死亡途径有其独特的调控机制，近年来随着对细胞死亡途径的进一步研究发现各种途径之间存在串扰和协调，进而有研究提出一种新的细胞死亡途径：PANoptosis，认为PANoptosis是由PANoptosome复合物调节的炎症性程序性细胞死亡途径，具有细胞焦亡、细胞凋亡和/或坏死性凋亡的关键特征，并不能被细胞焦亡、细胞凋亡、坏死性凋亡中任意一种死亡方式单独表征。特定的触发因素如病毒、细菌及真菌感染可以诱导宿主以PANoptosis的途径死亡。本文就PANoptosis的相关通路、调节剂以及在致盲性眼病中的潜在作用进行相关综述。

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Copyright of Journal of South China Agricultural University is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Objective: To study and analyze the drug resistance spectrum and molecular typing of Stenotrophomonas maltophilia in hospital infection, so as to provide basis for making reasonable infection control plan. Method: 42 strains of clinical isolates of Stenotrophomonas maltophilia were identified by mass spectrometer and their drug resistance phenotypes were analyzed. According to the different groups of drug sensitivity results of five antibiotics, ceftazidime, compound neoformamine, levofloxacin, minocycline and cefepime, the strains with the same drug sensitivity results were divided into one type and the strains with different drug sensitivity results were divided into another type; PFGE was used for molecular typing Analysis. Results: 42 strains of Stenotrophomonas maltophilia were divided into 6 types. 42 strains of Stenotrophomonas maltophilia were analyzed by PFGE and 4 genotypes of A-D were obtained. Conclusion: The characteristics of drug resistance spectrum and PFGE typing of Stenotrophomonas maltophilia are very useful for the selective treatment of antibiotics. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Spectral community detection algorithms generally divide the network via structure which is often limited by the number of divisions and it is difficult to control the degree of overlapping. This paper designs an overlapping multiway spectral community detection algorithm for attribute network which can divide the attribute network into any number of overlapping communities and effectively discover outliers. Firstly，the partition mapping method from maximization to node vectorization is designed based on the weighted modularity. Secondly the initial selection strategy of cluster center vectors is given and merged in the attributed network. Thirdly the node allocation strategy is designed to calculate the inner product of the node and clustering center vector and to assign the node to the community with the highest inner product. Finally，the tightly structured overlapping communities that have outliers are effectively detected. In addition applying the algorithm to multiple networks in the real world verifies the effectiveness and efficiency of the proposed algorithm. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Acanthopanax giraldii belongs to the Araliaceae plant, and most of the Araliaceae plants have a two-way regulation effect in regulating immunity. A. giraldii polysaccharide is a single component extracted from the traditional Chinese medicine A. giraldii. The anti-inflammatory effect of polysaccharides has rarely been reported. This study aimed to explore the protective effect and mechanism of polysaccharide AHP-II on LPS-induced hepatocyte injury in rats. This experiment was divided into five groups: blank group, model group (LPS, 40 μg·mL-1), AHP-II low, moderate, high-dose group (25, 50, 100 μg·mL-1). LPS (40 μg·mL-1) was used to prepare the rat hepatocyte immune injury model. The cytotoxic effect of AHP-II on hepatocytes was first examined by CCK-8 method to eliminate interference, and the secreted level of TNF-α by the cells and the level of ROS were measured by ELISA and flow cytometry respectively to establish the hepatocyte immune injury model. Then the inhibitory effect of different doses of AHP-II on inflammatory factors was explored, and the level of JNK2 protein and its phosphorylation were detected by western method to further explore the inhibitory mechanism of AHP-II. The results showed that the experimental dose of AHP-II had no damage to cells by CCK-8 method, which indicates that the reduction of inflammatory factors secreted by cells treated by AHP-II is not due to its cytotoxic effect. AHP-II groups (25, 50, 100 μg·mL-1) decreased TNF-α content durig hepatocyte injury. At the same time, the high-dose AHP-II group can reduce the secretion of ROS durig hepatocytes injury, and the high-dose AHP-II group has the strongest effect in inhibiting ehe conrent of ROS. After the addition of AHP-II, the phosphorylation level of JNK2 protein decreased in a dose-dependent manner, and the AHP-II high-dose group had the strongest inhibitory effect. This indicate that the polysaccharide AHP-II can play an immunoprotective role by reducing the protein content of P-JNK2 and inhibiting the levels of TNF-α and ROS. The results of this study provide a scientific reference for the hepatoprotective effect of A. giraldii, and promote the further development and utilization of the resources of A. giraldii. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)