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Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: Relevant Meta-analyses have reported that there is a significant negative fixation pattern in depressed patients, but it is unclear about the magnitude of this pattern and the difference in gaze indicators under different stimuli. To this end, the article systematically evaluates the gaze characteristics of eye tracking in patients with depression under different emotional tasks, providing a reference for clinical outcome and prognostic evaluation. METHODS: PubMed, The Cochrane Library, EMbase, Web of science, CBM, CNKI, WanFang Database, and VIP database were electronically searched to collect case-control studies on eye tracking in depressive patients from their inception to September 5th, 2021. Two researchers independently screened literature, extracted data and the Newcastle-Ottawa Scale was used to evaluate the quality of the included studies. Meta-analysis was performed by using RevMan5.4 software. RESULTS: A total of 12 case-control studies were included, in which 231 subjects (depressed patients) were in the case group and 307 in the control group. The Newcastle-Ottawa Scale scores of the included studies were 5 and above, indicating a higher quality of the included studies. The results of Meta-analysis showed that: for different stimulus types, compared with the control group, the fixation duration of depressed patients was significantly reduced under the positive stimulus [Standardized mean difference (SMD)positive=-1.00, 95% confidence interval (CI) (-1.88, -0.12), P=0.03], and was significantly increased under the negative stimulus [SMDnegative=0.77, 95% CI (0.50, 1.04), P < 0.000 01]. There was no significant difference in fixation duration under the neutral stimulus [SMDneutral=-0.17, 95%CI (-0.48, 0.14), P=0.28]. There was no significant difference in the first fixation duration between the case and control groups [SMDpositive=0.18, 95% CI (-0.25, 0.61), P=0.42; SMDneutral=-0.19, 95% CI (-0.46, 0.08), P=0.17; SMDnegative=0.24, 95% CI (-0.04, 0.52), P=0.09]. Compared with the control group, depressed patients showed a significant reduction in the fixation counts under positive and neutral stimuli [SMDpositive=-3.65, 95% CI (-4.59, -2.71), P < 0.000 01; SMDneutral=-1.08, 95% CI (-1.61, -0.56), P < 0.000 1), while the fixation counts in depressed patients increased significantly under negative stimuli [SMDnegative=1.32, 95% CI (0.78, 1.86), P < 0.000 01]. CONCLUSION: There are significant differences in the fixation patterns between depression and healthy individuals, mainly in terms of fixation duration and fixation count. Future studies can explore more eye movement indicators and characteristics of fixation patterns in depressed patients. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: The current diagnosis and study of depression lacks objective biological indicators. As an emerging non-invasive brain functional imaging technology, functional near infrared spectroscopy (fNIRS) may be a potential biomarker for the identification and diagnosis of depression. OBJECTIVE: To review the application of fNIRS technique in depression research and provide guidance for clinical research. METHODS: The keywords were “functional near-infrared spectroscopy, oxyhemoglobins, prefrontal cortex, depressive disorder.” The first author searched CNKI, WanFang, VIP, PuMed and Web of Science database from 1996 to 2020 in Chinese and English. Finally, 50 literatures were selected for review. RESULTS AND CONCLUSION: fNIRS signal may be a potential biomarker for depression. fNIRS technology is mainly used to study the cognitive dysfunction of depression based on the frontal lobe hemodynamic changes, which can be used for the differential diagnosis of depression. However, the current research on fNIRS is still in the exploratory stage, and there are still some defects in the existing research, which need to be further optimized and deepened in the future research. It can increase the study sample size and monitoring indicators, and integrate fNIRS with other technologies to improve the temporal and spatial resolution, so as to study the neural mechanism of depression systematically, comprehensively and accurately [ABSTRACT FROM AUTHOR]