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目的应用集成磁共振成像技术（SyMRI）评估COVID-19康复患者脑灰质微结构的改变。方法29例COVID-19康复患者分为重症患者组（SG=11例）和普通患者组（OG=18例），选取年龄、性别、体质指数（BMI）和教育年限相匹配的健康志愿者作为健康对照组（HC=23例）。所有受试者均行SyMRI扫描，生成T1、T2定量图谱，利用自动解剖标记（AAL）模板将T1和T2图谱分割成90个感兴趣区（ROIs）。通过对ROI内的所有体素进行平均得到每个ROI的T1、T2弛豫值。分析比较三组间90个脑区的T1、T2值。结果HC相比，SG在双侧眶内额上回、双侧海马旁回、双侧豆状壳核、双侧颞中回、双侧颞下回、左侧眶部额上回、左侧眶部额下回、左侧直回、左侧前扣带与旁扣带脑回、右侧内侧和旁扣带脑回、左侧后扣带回、左侧缘上回的T2值显著升高（P < 0.05）；与OG相比，SG在左侧直回、左侧海马旁回、双侧颞中回、双侧颞下回的T2值显著升高（P < 0.05）。与HC相比SG在双侧眶内额上回、左侧直回、左侧前扣带和旁扣带脑回、右侧后扣带回、左侧海马旁回、左侧舌回、左侧豆状壳核、左侧丘脑的T1值显著升高（P < 0.05）；与OG相比，SG在右侧后扣带回、右侧距状裂周围皮层、左侧豆状壳核的T1值显著升高（P < 0.05）。结论COVID-19患者即使在康复后脑灰质微结构仍可能存在持续性或迟发性损伤，且损伤程度与病情严重程度相关；SyMRI可作为一项敏感的工具评估中枢神经系统（CNS）微结构损伤情况，有助于早期临床诊断。

目的探讨低强度聚焦超声能否触发聚乳酸-羟基乙酸共聚物（PLGA）包裹阿霉素在细胞内的空化作用以增加4T1肿瘤细胞的死亡。方法采用双乳化溶剂蒸发法制备了负载阿霉素的聚乳酸-羟基乙酸共聚物（PLGA）纳米气泡。设立细胞内释药组，细胞外释药组，传统给药组，单独超声组和对照组。用流式细胞仪检测各组细胞的死亡情况，用细胞活力检测试剂盒（CCK8）检测各组的细胞增殖，细胞划痕检测各组的侵袭情况。结果超声组细胞核的红色荧光平均强度高于对照组，差异具有统计学意义（t=16.627，PPP

从脂质立方液晶的形成结构特点及在药物载体领域中的应用进行归纳总结,分析其作为药物载体的优势、前景及 存在的问题,重点讨论脂质立方液晶在不同给药途径作为药物载体的应用,为进一步研究脂质立方液晶载药系统提供参考. [ABSTRACT FROM AUTHOR]

Objective To explore the diagnostic value of 1H proton MRS and in-phase and out-phase MRI for bone marrow fat deposition (BMFD), and to compare the consistency of two methods. Methods Thirsty-eight patients who were diagnosed with osteoporosis using DXA and 30 people with normal bone mass were enrolled in this study. All the 68 subjects underwent MRI regular examination, MRS, and in-phase and out-phase MRI. SIR, LRW, and FF of L2 vertebra were measured. SIR, LRW, and FF between the two groups were compared using Student t test. Diagnostic accuracy of SIR, LRW, and FF for osteoporosis were analyzed using ROC curve, and the diagnostic threshold of these indicators for osteoporosis was determined. By the use of Kolmogorov-Snimov normality test, the data were proved to be normally distributed. The correlations among SIR, LRW, and FF were assessed with Pearson analysis. Results Sixty-eight axial and sagittal MRI in-phase and out-phase MR images of the lumbar spine and 68 single voxel MRS images were obtained. SIR, LWR, and FF in osteoporosis group were 0.498 ±0.160, 3.677 ± 3.093, and 0.732 ±0.176, respectively. SIR, LWR, and FF in normal bone mass group were 0.350 ±0.971, 2.094 ±1.892, and 0.573 ±0.211, respectively. There were statistically significant differences in SIR, LWR, and FF between the two groups (t values were 6.404, 2.035, and 2.738 respectively, P ＜0.05). The area (measured with the SIR deferential point) under ROC curve was 0.784. Using the SIR value of 0.3850 as the ROC cut off point, the diagnostic sensitivity and specificity were 78.9% and 66.7%, respectively. In MRS, using the value 2.063 of LWR and 0.674 of FF as the cutting off points, the area under ROC curve was 0.706 and 0.740, the diagnostic sensitivity was 75.0% and 79.2%, and the diagnostic specificity was 71.4% and 72.4%, respectively. The result of correlation analysis between SIR, LRW, and FF using Pearson correlation showed P ＜0.05. Conclusion Both 1H-MRS and in-phase and out-phase MRI can provide information of bone marrow fat deposition in the lumbar spine and help to achieve quick and non-invasive osteoporosis diagnosis. There is correlation between the indicators of the two methods. [ABSTRACT FROM AUTHOR]