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Objective To investigate the effect of different freezing thawing conditions on the stability of metronidazole sodium chloride injection in extreme cold environment. Methods The freezing process of metronidazole sodium chloride injection in extremely cold environment was simulated and appropriate conditions were given to melt. The effects of room temperature, 60 ℃ water bath thawing and freeze-thaw times on the content of metronidazole were investigated by HPLC, and the changes were analyzed by quality control chart. Results The linear range of metronidazole was 0.01～1.00 mg/ml and the relationship was acceptable, r=1.000, the average recovery was 101.03% (RSD=1.17%), which met the requirements of methodology. The samples were frozen at −20 ℃ and thawed in 60 ℃ water bath for 18 times with good stability. However, when thawed at room temperature, acicular crystals formed and the content decreased. Conclusion In extreme cold environment, the stability of metronidazole sodium chloride injection could be affected by freezing and thawing conditions. Therefore, in the use of Metronidazole and Sodium Chloride Injection, the number of freeze-thaw cycles should be minimized, and try to avoid thaw at room temperature. [ABSTRACT FROM AUTHOR]

Objective　To understand the current situation of pharmaceutical research development in China and provide a constructive thinking for universities to serve the national innovation strategy through the statistical analysis of pharmaceutical papers and highly cited papers from Double First-rate universities. Methods　CNKI, Wanfang, VIP and Chinese Biomedical Literature Database were searched for Chinese publications, and Scopus database was searched for English publications. Duplicates and non-research literatures were excluded. Excel 2016 software was used for statistical data analysis. Results　By comparing the data from 2017 to 2019 with that from 2014 to 2016, it was found that the number of papers in Q1 area from international journals and Q2 area from domestic journals increased significantly. The popularity of publishing papers in international journals by university authors was increasing. The number of publications in domestic journals slightly decreased. From 2014 to 2020, 850 papers were published in domestic journals, among which 223 papers were highly cited, with a total cited times of 2 410 and an average cited times per publication of 10.81. Conclusion　In spite of the government’s encouragement to publish the scientific and technological achievements in domestic journals, no such trend was formed from our analysis. Therefore, it is necessary to further build the corresponding academic ecology and enhance the international influence of domestic journals. The science and technology circles and technology publication circles in China should be deeply integrated to promote mutual development. [ABSTRACT FROM AUTHOR]

Objective　To understand the development status in the subject of pharmacy and provide recommendations for the construction of universities and the development of pharmacy by the bibliometric analysis of pharmaceutical papers from Double First-rate universities in China. Methods　China National Knowledge Network (CNKI), Wanfang and VIP databases were searched for Chinese literature, and Scopus database was searched for English literature. Duplicates and non-research literatures were deleted. 12 028 literatures were included. Excel 2016 software was used for statistical analysis. Results　From 2014 to 2019, the total number of papers published by Double First-rate universities increased year by year, with the highest increase rate of 14%. From 2014 to 2020, 11 178 papers were published in international journals, while only 850 were published in domestic journals. Nearly 93% of pharmaceutical papers flowed to foreign journals. Peking Union Medical College published the most papers in international journals. Sun Yat-sen University published the most SCI papers. Peking University published the most papers in domestic journals, while Fudan University published the highest number of papers in Q1 area. Only a few papers published with international coauthors from colleges or universities. The cooperation works were limited in the same province or municipality directly under the central government. Conclusion　Double First-rate universities should focus on strengthening international cooperation and inter-provincial cooperation, improving industry-university collaboration, and accelerating the transformation from scholar research to productions. [ABSTRACT FROM AUTHOR]

Objective To reduce the unreasonable medical expenditure and improve the level of clinical rational drug by strengthening the supervision of adjuvant drug use. Methods The regionally integrated medical database and standardized basic drug information database were used. The market share of adjuvant drugs varieties and their clinical consumption of multi-center hospital in certain region were collected and analyzed. The data of 2015 and 2018 after the implementation of supervision were compared. Results The monitoring results of clinical application adjuvant drugs in nearly 200 hospitals of the region were obtained. The selection method of key monitoring drug litt based on the medical big data was discussed after expett review. The firtt batch of 80 drugs in the key monitoring of regional medical institutions was confirmed. Improper use of key clinical monitoring drugs had been improved. Conclusion Through the introduction of relevant policies by the state and the implementation of rectification measures in various regions? the unreasonable use of key monitoring drugs had been improved to some extent. [ABSTRACT FROM AUTHOR]

Objective: To plan a better program, solicit high quality scientific papers, and enhance the influence of periodicals. Methods: The DOI resolution data of the periodical Pharmaceutical Care and Research from Oct.2010 to Jan.2015 were collected and sorted. The top 50 articles ranking in the DOI resolution number were retrieved and the information of these articles was analyzed and summed up. Results and Conclusion: The popularity of the periodical was rising among the readers abroad. In the past more than 4 years, the number of DOI resolution hit 17 285, and it was still in the rising trend. Statistics revealed the best received authors and their related research fields, the distribution of corporate authors, and so on. To facilitate the publication and technical transfer of scientific research achievements, it is recommended that first priority should be given to the Chinese and English periodicals in China for the publication of those high-quality scientific research achievements. [ABSTRACT FROM AUTHOR]

In order to meet our country strategic needs of “ The Belt and Road”, it was proposed to use the existing overseas warehouses from domestic companies as prepositioning locations. The situation and functionality were clarified. A comprehensive evaluation for the existing overseas warehouses in the Indian Ocean was conducted. The authors screened out several countries suitable for prepositioning medicinal supplies. Meanwhile, the potential problems were discussed in order to provide a theoretical basis for the future research on overseas medicinal supplies. [ABSTRACT FROM AUTHOR]

Objective To predict the target of Atractylodes-Panxia-Poria in the treatment of pancreatic cancer, and to explore its potential molecular mechanism by using network pharmacology and molecular docking. Methods Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), PharmMapper, OMIM, GeneCards, STRING, DAVID and Cytoscape software were used to construct a series of network diagrams. The core targets and conduct GO analysis and KEGG pathway enrichment analyses of the target genes were selected. Finally, molecular docking verification of key active ingredients and potential targets were conducted by AutoDock software. Results A total of 35 active ingredients, 190 related targets, 1566 targets of pancreatic cancer and 76 intersection targets were screened for the treatment of pancreatic cancer with Atractylodes-Panxia-Poria. These intersection targets were mainly involved in several biological processes, including positive regulation of gene expression, cytokine-mediated signaling pathway and regulation of apoptotic process, etc, which were also related to pathways in cancer, hepatitis B, colorectal cancer, chemical carcinogenesis-receptor activation, pancreatic cancer, and MAPK signaling pathway, etc. Molecular docking results showed that the main active components of Atractylodes-Panxia-Poria had certain affinity with the potential targets of pancreatic cancer. Conclusion Atractylodes-Panxia-Poria mainly exerts a therapeutic effect on pancreatic cancer through multi-component, multi-target and multi-pathway, which provides a certain theoretical basis for the clinical application of Atractylodes -Panxia-Poria in the treatment of pancreatic cancer. [ABSTRACT FROM AUTHOR]

Objective: To establish the quality evaluation criteria for the writing case reports of clinical pharmaceutical care. Methods: First, investigations and analyses were performed to find out the problems in the writing case reports of clinical pharmaceutical care, then the quality evaluation score system was preliminarily developed through the access of group discussion, and finally the scores and their related weights were established in combination with the Delphi method and expert panel consultation. Results and Conclusion: The quality evaluation criteria established through the research could be used for the evaluation of the writing case reports concerning clinical pharmaceutical care, and were beneficial to the promotion of standardization, integrity and scientific standards in the writing such scientific papers. [ABSTRACT FROM AUTHOR]

Objective ： To find out the problems related to the writing of the case reports of clinical pharmaceutical care and provide advice for writing，so as to provide reference for clinical pharmacists. Methods ： With "pharmaceutical care"，"clinical pharmacy，，and "clinical pharmacist，，as both Chinese and English key words，the Chinese Journal Full-text Database in China National Knowledge Infrastructure (CNKI),VIP China Science and Technology Journal Database，Wanfang Data-Digitalization Journals and PubMed from 2011-01-01 to 2014-12-31 were retrieved. The case reports of clinical pharmaceutical care were collected • The evaluation items were established on the basis of CARE guidelines and evaluations were made on the retrieved liter - ature. Results and conclusion ： Totally，1 187 papers were retrieved and the number of papers published in domestic medical journals increased year by year. The top three defects of such reports were ： summary of personal experience and recommendations ，past medical histories of patients and analyses of related medical literature • In addition，there were insufficient communication and cooperation with other clinical departments in the writing of such reports. More importantly，further efforts should be made on the scientific quality and integrity when writing such papers. [ABSTRACT FROM AUTHOR]

Osteoporosis (OP) is a systemic osteopathy with low bone mineral density and bone quality. It seriously endangered human physical and mental health due to its destructive and widespread characteristics. In clinic, drugs for OP, such as bisphosphonates and estrogens, have potential side effects. Contrarily, traditional Chinese medicine (TCM) has less adverse reactions and significant therapeutic effects. It becomes one of the remarkable complementary and alternative OP therapies. According to TCM theory, kidney is in charge of bone. The bone loss is attributed to the deficiencies of kidney. Therefore, herbs tonifying kidney had been used in the treatment of OP. Based on the different effects, herbs tonifying kidney are divided into tonifying kidney-yang and kidney-yin herbs. This paper reviews the effects and mechanisms of the herbs tonifying kidney-yang and kidney-yin in the OP treatment with the intention of exploring the similarities and differences of their treatment characteristics and providing reference for the development of kidney tonifying herbs in OP prevention and therapy. [ABSTRACT FROM AUTHOR]

Objective: To compare the scholarly treatise outputs of pharmaceutical sciences between top 10 universities in China and the USA，so as to provide reference for domestic pharmaceutical researchers. Methods: All the scholarly publications in pharmaceutical sciences produced by top 10 universities in China and the USA from 2005 to 2015 were retrieved from Scopus database，and then analyzed on the platform of SciVal. Results: Publication counts were not significantly different between China and USA. However, publications percentage in top 1% and 10% most cited papers, in top 10% and 25% journals, field-weighted citation impact, citations per publication, academic-corporate collaboration ratio and patent-cited publication ratio were significantly different（P<0.01）. Conclusion: The quantity of pharmaceutical scholarly treatise outputs of China was not significantly different from that of the USA, while the quality bibliometric indexes of China still lagged behind. It was suggested that pharmaceutical researchers in universities in China should further expand their academic-corporate, inter-institutional and international collaborations. [ABSTRACT FROM AUTHOR]

Objective To introduce the process and experience of construction of medical supplies support practice training platform under informatization. Methods To review and comment the structure composition, functions implemented, applications and experience of medical supplies support practice training platform. Results The medical supplies support practice training platform achieved four functions which are indoor deduction, simulation training, drill outdoor, participate in military health service exercise. Conclusion The medical supplies support practice training platform has achieved good effects in teaching and training, which has effectively promoted the teaching and training mode reform aimed at combat requirements. [ABSTRACT FROM AUTHOR]