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工字钢组合梁桥正朝着少主梁、精简横向联系的方向发展。与传统多主梁复杂横向联系组合梁桥相比，双主梁桥由于采用了开口截面的结构形式，极大地削弱了其抗扭能力，在偏载作用下会产生较大的变形及翘曲应力，使钢主梁处于弯扭耦合的受力状态。空心管状翼缘钢板组合梁采用空心钢管取代传统的平板上翼缘，提升了稳定性，改善了结构性能。本文通过理论分析和实体有限元法的计算，研究了单梁在自重与横向风荷载作用下的稳定性；对非组合截面的组合体系下的稳定性能进行了分析与比较，并分离出扭转翘曲应力和纵向正应力，研究了不同跨径下扭转效应的影响。最后，对横向联系、加劲肋的影响进行了分析。研究结果表明，空心管状翼缘钢板组合梁桥扭转刚度大于传统工字形截面组合梁扭转刚度，自身横向稳定性好，并且需要较少的横向联系与加劲肋，可实现单梁吊装，避免采用过多临时加固及支撑措施，提高施工效率。

基于泡沫混凝土和轻钢龙骨的优点，提出了一种由泡沫混凝土、钢丝网和轻钢龙骨组成的轻钢龙骨泡沫混凝土墙板。为研究该类墙板的抗弯性能，采用通用有限元分析软件建立了其数值分析模型，通过对比分析，验证了有限元分析模型参数选取的有效性。在此基础上，研究了钢丝直径、龙骨和泡沫混凝土等参数变化对该类墙板抗弯承载力的影响，并对比了风荷载下墙板的正常使用情况。推导出了该类墙板开裂弯矩、挠度和极限承载力的计算公式，并与有限元分析结果进行了对比。研究结果表明：该墙板具有良好的整体刚度和弹塑性变形能力，其开裂弯矩、挠度和极限承载力计算公式具有较高的计算精度，可为该类墙板的工程应用提供理论依据。

【目的】探讨IL-12 、LPS 对肾小管上皮细胞中lck 基因表达及活性改变的影响, 明确lck/P38信号传递途径在炎症过 程的作用。【方法】用原位杂交、放射自显影分别检测lck 基因表达及lck 活性, 用免疫印迹法对肾小管上皮细胞在IL-12、LPS 刺激下其P38磷酸化进行测定。【结果】肾小管上皮细胞经IL-12, LPS 刺激后lck mRNA 表达水平增高, lck 活性在刺激后5 min 时最强, 加入lck 抑制剂PP1 , IL-12 刺激lck 活性明显减弱。IL-12 及LPS 可以促进肾小管上皮细胞中P38活化、磷酸化, 在15 min 时最强, 加入lck 抑制剂后则抑制IL-12 刺激时的P38磷酸化, 而LPS 刺激组不明显。【结论】IL-12, LPS 可通过促进肾小管上皮 细胞中lck/P38活化, 参与炎症过程。

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Objective To compare the clinical efficacy and pregnancy outcomes of CO2 laser and loop electrosurgical excision procedure (LEEP) surgery in the treatment of cervical high-grade squamous intraepithelial lesion (HSIL）in women of childbearing age. Methods Patients with cervical HSIL of appropriate reproductive age (20-34 years old) who underwent satisfied colposcope, subsequently treated with laser or LEEP between Jan 2019 and Dec 2021 in Obstetrics and Gynecology Hospital, Fudan University were collected. All the patients were interpreted as transformation zone (TZ) type 1/2, and colposcopy biopsy diagnosed as cervical high-grade squamous intraepithelial lesion (HSIL) and received laser or LEEP according to the physician’s advice and the patient’s wishes.The effectiveness of the two surgeries was evaluated, and postoperative cytology, HPV result, and colposcopic pathology were compared. We monitored the surgical pregnancy rate, pregnancy complications, and pregnancy results after the surgery. Results A total of 566 cases, including 233 laser cases and 333 LEEP cases, were enrolled. There was no significant difference between the two groups in terms of preoperative cytology, HPV distribution, or the length of cervical canal. After 6 months of surgery, 91.5% of patients who underwent laser therapy and 86.9% of those who underwent LEEP had normal cytology. The histology cure rate was 91.5% and the HPV conversion rate was 74.6% in both groups. The results of cytology, HPV, and colposcopic pathology had no significant difference between the two groups. The length of postoperative cervical canal was significantly longer in laser group than that in LEEP group [(29.09±3.15) mm vs. (27.05±3.84) mm, P<0.001]. There was no statistically significant difference in postoperative pregnancy rate and pregnancy outcome between the two groups. Conclusion Laser ablation and LEEP produce comparable effects pregnancy outcomes in cervical HSIL patients with TZ types 1 and 2, while LEEP has pathologic feedback, so its misdiagnosis of invasive cancer reduce. [ABSTRACT FROM AUTHOR]

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Pyroptosis is an important link in the development of diabetes nephropathy (DKD). The inflammation and cell damage caused by it are closely related to renal fibrosis, glomerulosclerosis and tubular damage. In depth research on the potential molecular mechanisms of pyroptosis and inflammasome signaling pathways may become a new approach for the prevention and treatment of DKD. The clinical effect of traditional Chinese medicine in preventing and treating DKD is significant, as it exerts a protective effect by affecting the cell pyroptosis pathway. The article reviews the molecular mechanisms of cell pyroptosis and DKD,as well as the research progress in traditional Chinese medicine intervention, providing important guidance for further exploration of the pathogenic mechanism of cell pyroptosis and the treatment of DKD with traditional Chinese medicine. [ABSTRACT FROM AUTHOR]

Objective To study the sedative and hypnotic effects of Yening Capsules and investigate its bioactive mechanism in mice. Methods The mice were randomly divided into control group, estazolam group (0.8 mg/kg）, low, medium and high-dose Yening Capsules groups (400, 600 and 800 mg/kg) . The locomotor activity, latency to persistent sleep, sleep duration and sleep rate were determined respectively in mice via the open field test and injection of pentobarbital sodium in subthreshold and suprathreshold doses. The content of GABA, 5-HT, DA and NE in brain tissue of mice were detected by enzymelinked immunosorbent assay（ELISA）. Results Compared with the control group, Yening Capsules medium and high dose group (P<0.05, P<0.01）significantly decreased the locomotor activity of mice.The sleep latency in Yening Capsules medium and high dose group were significantly shorten (P<0.05, P<0.05）and the sleep duration (P<0.05, P<0.01）were extended. The sleep rate of Yening Capsules medium and high dose groups (P<0.05, P<0.01) was significantly increased. Compared with the control group, high dose of Yening Capsules can significantly increase GABA (P<0.05), 5-HT (P<0.05), DA (P<0.05), NE (P<0.01) in mouse brain tissue. Conclusion Yening Capsules had obvious sedative and hypnotic effects, and its mechanism may be related to the increasement of GABA, 5-HT, DA and NE level in brain tissue of mice. [ABSTRACT FROM AUTHOR]

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Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Automatic text summarization aims to extract the main statements from text information for the purpose of compressing information. Existing generative automatic summarization methods do not take full advantage of the pre-trained model to learn the semantics of the original text, resulting in the loss of important information in the generated content, when the data set with a small number of samples is often prone to overfitting. In order to solve such problems and obtain better fine-tuning performance, the pre-trained model mT5(multilingual T5) is used as a baseline to improve the learning ability of the model by combining R-drop(Regularized dropout) with reinforced regularity for model fine-tuning, and Sparse softmax is used to reduce the ambiguity of prediction generation to ensure the accuracy of the output. The model calculates BLEU(Bilingual Evaluation Understudy) for hyperparameter test on Chinese data sets LCSTS and CSL, and uses Rouge as evaluation index to evaluate data sets of different orders of magnitude. The experimental results show that the optimized pre-trained model can better learn the semantic representation of the original text, and the model can maintain a good fit in the small samples and generate more practical results. [ABSTRACT FROM AUTHOR]

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[Objective]The genetic variations of mitochondria genome usually lead to cytoplasmic male sterility(CMS)in plants. Biotechnology is an important measure to produce variations resulting in CMS lines. In order to establish an efficient expression vector system for the research on potato mitochondrial genes, the optimal potato mitochondrial targeting expression vector was explored by comparing the expression level of eGFP, which was promoted by different combinations of promoters and mitochondrial targeting signal peptides(MTS). [Method]Three promoters AtUBI10, StUBI10, 2×35S and two mitochondrial transport signal peptides ATPγ and Rf1b were tested. The expression level of the target vector was verified by tobacco leaf transient expression system and PEG-mediated potato protoplast transformation system.[Result]AtUBI10 :: ATPγ-eGFP among 6 expressing vectors had the best expression effect in tobacco and was accurately located in mitochondria. The second best ones were StUBI10 :: ATPγ-eGFP and 2×35S :: ATPγ-eGFP. The vector AtUBI10 :: ATPγ-eGFP also showed the best performance, followed by StUBI10 :: Rf1b-eGFP and AtUBI10 :: Rf1b-eGFP in the potato protoplast transformation system. The two vectors with 2×35S promoter were weakly expressed in protoplasts.[Conclusion]The comparative studies showed the mitochondrial vector constructed by the promoter AtUBI10 and the mitochondrial transport signal peptide ATPγ is the best combination, and this vectors will be of great benefit to the relative study on mitochondrial genes. [ABSTRACT FROM AUTHOR]

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