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Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Research of Environmental Sciences is the property of Research of Environmental Sciences Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Research of Environmental Sciences is the property of Research of Environmental Sciences Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the association between ACTN3 gene R577X polymorphism and serum lipid levels in an elderly Chinese Han population. Methods This study was based on the ageing arm of The Rugao Longevity and Ageing Study (RuLAS). Genotyping was performed by Taqman MGB method. Lipids includedtotal cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). Cut points of dyslipidemia were based on that reported in the NCEP ATPIII. We explored the associations between R577X polymorphism loci and dyslipidemia by using analysis of covariance and logistic regression analysis. Results Overall 1 618 samples was included (741 males and 877 females) in this study. Covariance analysis found that TC level of RR, XX and RX genotype in the general population were 1.34, 1.37, 1.43 mmol/L with an increasing trend (P=0.024); TC and LDL-C levels of RR, XX and RX genotype (TC: 5.13, 5.29, 5.43 mmol/L, P=0.004; LDL-C: 2.76, 2.88, 3.00 mmol/L, P=0.004) were significantly different in females. Logistic regression analysis showed that the increased copies of X allele were significantly associated with increased TC and LDL-C levels in the general population and females. For the general population, TC: OR=1.184, 95%CI: 1.030-1.361, P=0.018; LDL-C:OR=1.334, 95%CI:1.101-1.588, P=0.003; For females, TC: OR=1.332, 95% CI: 1.102-1.616, P=0.003; LDL-C: OR=1.549, 95%CI: 1.208-1.986, P=0.001. After adjusting for other covariates, the above associations remained significant. Conclusions ACTN3 gene R577X polymorphism is associated with plasma TC and LDL-C levels in elderly woman of Han populations in Rugao, China. [ABSTRACT FROM AUTHOR]