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The dual-phase-lag thermoelasticity theory with the memory-dependent differential can perfectly describe the phenomenon of non-Fourier heat conduction, nevertheless, it has not been comprehensively considered: the mechanical responses of materials under the size-dependent effects and the multiphysics coupling effects such as magnetic, thermal and elastic fields. A modified dual-phase-lag thermoelasticity theory with memory-dependent effects and non-local effects was established. Based upon this theory, the magneto-thermoelastic coupling problem of narrow long thin plates subjected to cyclical heat sources was investigated. First, the governing equations for the problem were formulated. Then with the boundary conditions and initial conditions, the solution to the problem was obtained through the Laplace transform and the inverse transform techniques. Finally, the influences of the magnetic field, the phase lag, the time-delay, the kernel function, non-local effect and the time on the dimensionless quantities were investigated respectively. The work provides a powerful reference for the dynamic responses of micro-scale materials. [ABSTRACT FROM AUTHOR]

Objective To investigate the effects of metformin on the migration and invasion abilities of PC-3 human prostate cancer cells in vitro and its possible mechanism. Methods PC-3 prostate cancer cells were cultivated by metformin hydrochloride at different concentrations(0, 1.0, 2.0, 3.0, 4.0, 5.0, 6.0, 7.0, 8.0, 9.0 mg/mL) for 24 hours. MTT method was used to select the optimal drug dose. The 3.0 mg/mL metformin hydrochloride was used as the experimental drug dose(the observation group), and the control group that did not receive drug treatment was set up. MTT method was used to detect the proliferation of cells in each group at 24, 48, and 72 h. The other PC-3 prostate cancer cells were cultivated by cell culture medium contain 0, 3.0, 6.0, 3.0 mg/mL metformin hydrochloride(taken as the CK, MET1, MET2, MET3 groups) in 37 °C constant temperature box. The cell scratch test and Transwell test were used to test the cell migration and invasion;Western blotting was used to detect the expression of matrix metalloproteinase-2(MMP-2), matrix metalloproteinase-9(MMP-9), human glucose transporter 1(Glut1) and matrix metalloproteinase-14(MMP-14 or MT1-MMP) of cells in each group at 48 h after cell culture. Results PC-3 prostate cancer cells were cultivated by metformin hydrochloride at different concentrations for 24 h, and the proliferation of cells decreased with the increase of drug dose(P<0.05). Compared with the control group, the OD values of the cells in the observation group were low at 24, 48, and 72 h(P<0.05). At 0 h after scratch text, there was no obvious abnormality on comparison of the proportion of no cell region in the four groups(CK, MET1, MET2 and MET3)(P>0.05);at 24 and 48 h after scratch text, there was abnormality on comparison of the proportion of no cell region in the four groups(P<0.05). Significant difference was found in the proportion of no cells between the CK and MET1 groups at 24 and 48 h after scratch text(P<0.05). The migration index of the CK group was greater than that of MET1 and MET2 groups at 24 and 48 h after scratch text(P<0.05). At 48 h after scratch text, the migration index of the MET2 group was lower than that of MET1 group(P<0.05). The migration index of the MET3 group was negative. The number of invasive cells was in the following order:MET1

BACKGROUND: Although mesenchymal stem cells (MSCs) from different sources share many similar characteristics, they also exhibit individual properties. OBJECTIVE: To compare the biological characteristics of MSCs derived from umbilical cord and decidua parietalis. METHODS: Growth curve, cell doubling time, clone formation rate, immune phenotype, differentiation capacity and secreted cytokine levels were analyzed in MSCs derived from umbilical cord and decidua parietalis. RESULTS AND CONCLUSION: MSCs from umbilical cord and the decidua basalis exhibited similar morphology, spiral growth, S-shaped growth curve, immunophenotype, and differentiation potentials to osteogenesis and adipogenesis. For two kinds of MSCs, the positive rates of CD73, CD90 and CD105 were over 95% and the positive rates of CD34 and CD45 were below 1%. The growth rate, cell doubling time and clone formation rate of umbilical cord derived MSCs at passages 2 and 5 were significantly higher than those of decidua parietalis derived MSCs at passages 2 and 5 (P < 0.05). The level of epidermal growth factor secreted from umbilical cord MSCs was significantly higher that that from decidua basalis derived MSCs, while the levels of vascular endothelial growth factor and stem cell growth factor from umbilical cord derived MSCs was significantly lower those from decidua basalis derived MSCs (P < 0.05). These findings indicate that MSCs from both sources have similar biological properties, but umbilical cord derived MSCs are deemed to have better application prospects. [ABSTRACT FROM AUTHOR]

Aimed at the poor intelligence and low efficiency of STEP-NC-compliant micro-process planning， an intelligent STEP-NC-compliant micro-process planning method based on rules and hybrid algorithm was proposed. In this method， a rule-based algorithm for matching manufacturing resources is proposed to choose the corresponding machine tools and cutting tools for each workingstep. Then， taking the shortest tool exchanging time as the optimization target， the hybrid algorithm which combines chaos algorithm with the genetic algorithm is used to optimize the STEP-NC-compliant workingstep sequences. Finally， taking the shortest machining time and the lowest machining cost as optimization objectives， the hybrid algorithm is used to optimize the STEP-NC-compliant machining parameters， which results in obtaining the optimal STEP-NC-compliant micro-process planning. The effectiveness and feasibility of this method was verified by using cases. [ABSTRACT FROM AUTHOR]

Objective To explore the function of FAM92A1-289 in regulating the proliferation and migration of glioma cells U251 and its relationship with galectin-1. Methods We transfected the plasmid CMV-SP6-TALEN-GFP-289 into U251 cells, and used puromycin to get the stable cell line U25 1/289++ with over-expression of FAM92A1-289 gene. We took U251/289++ cells as the observation group, and U251 cells without transfection as the control group. The real-time cell analysis (RTCA) technology was used to detect the cell proliferation ability of the two groups (expressed by the optical density value) at 24, 48, 72, 96, and 120 h; Transwell test was used to detect the cell migration ability of the two groups (expressed by the number of cells crossing the trans-well chamber). We constructed the PCS2-3Flag-Galectin-l plasmid, and the L251 cells were randomly divided into FAM92A1-289 group, the Galectin-1 group, co-transfection group, and control group. In the FAM92A1-289 group and Galectin-1 group, we used the Lipofactamine 3000 transfection method to transfect CMV-SP6-TALEN-GFP-289 and PCS2-3Flag-Galectin-1 plasmids, respectively. The cells in the co-transfection group were transfected with the two plasmids, and in the control group we only added Lipofactamine 3000 transfection reagent. The interaction between FAM92A1-289 and Galectin-1 protein was verified by Co-Immunoprecipitation. Results There was no statistically significant difference between the two groups cells at 24 h ( P >0. 05). The optical density value at 48 , 72, 96 and 120 h was significantly higher than that in the control group (P < 0.05 or P < 0.01 ). The number of cells crossing the chamber in the observation group and the control group were 242. 0 ± 11.41 and 65. 40 ±7. 92, respectively (P

Objective Improve the recovery rate of natural gas light hydrocarbon and reduce production energy consumption in Nanpu combined station. Methods A model is established based on HYSYS simulation software. The key parameters such as pressurization unit, refrigeration separation unit and light hydrocarbon fractionation unit of light hydrocarbon recovery process are analyzed by single factor, and the value range of each single-factor is obtained. According to the value range of each single factor, the response surface analysis method is used to optimize the parameters with the minimum specific power consumption of the system recovery unit as the objective function, and determine the best combination of multi-factor key parameters. Results Compared with the actual production, the optimized process increases the propane yield by 5. 62%, the liquefied gas yield by 3. 53%, the product specific power consumption is reduced by 0. 91%, and the total energy consumption of the light hydrocarbon recovery unit is reduced by 2. 46%. Conclusions The response surface analysis method is used for multi-parameter optimization of natural gas light hydrocarbon recovery, which improves the propane yield and reduces the energy consumption of the unit, and has good economy and application prospect. [ABSTRACT FROM AUTHOR]

Objective To explore the effect of glutamate transporter(GT)on cardiac hypertrophy. Methods Fifty 7-weekold wild-type female Balb/c mice(group A)and fifty 7-week-old ISO-induced cardiac hypertrophic large female Balb/c mice(group B)were selected. After 1 month of feeding, the hearts of the mice were removed, and the heart weight/body weight, myocardial cell volume, ventricular wall thickness, and specific index levels of each heart chamber were measured by direct measurement and cardiac ultrasound. Primary mouse cardiomyocytes were cultured, and the expression of GT genes in cardiomyocytes of mice A and B was detected by real-time fluorescent quantitative polymerase chain reaction(qPCR)and Western blotting. Results The EAAT3 gene was expressed more in normal mice. Conclusion The expression of EAAT3 is decreased in cardiac hypertrophy. [ABSTRACT FROM AUTHOR]

BACKGROUND: Qinghai nephrites show different colors. In recent years, there have been a lot of studies on Qinghai nephrite mineralogy, but the studies on the mineral characteristics of Qinghai nephrite with different colors are lacking. OBJECTIVES: To study the relationship) between color and mineralogical features of Qinghai nepjhrites. METHODS: Polarizing Microscopy, Scanning Electron Microscopy, Electron Probe Microanslyzer and X-ray Powder Diffraction were used to analyze the microtopography, microstructure, mineral composition and crystallinity of tremolite. RESULTS; Tremolite in white, blue-violet and brown Qinghai nephrite are mainly fibrous and have micro-fiber blastic texture with crystallinity of 96. 12% -96. 88%. Tremolite in green-white and viridis Qinghai nephrite are mainly foliated, and has micro-foliated blastic texture with crystallinity of 97.32% and 97. 35% , respectively. Tremolite in green and azure-green Qinghai nephrite are mainly foliated, and have microscopic blade -cryptocrystalline blastic texture with crystallinity of 95. 29% and 95. 48% , respectively. Tremolite in yellow' Qinghai nephrite is mainly columnar, and has micro-columnar blastic texture and crystallinity of 97. 84%. The main mineral different color Qinghai nephrite is tremolite, with content of more than 95%. Some minor minerals only appear in the specific color Qinghai nephrite, such as titanite in viridis Qinghai nephrite, anorthite in yellow Qinghai nephrite, magnesite in green Qinghai nephrite, chromite in azure-green Qinghai nephrite, and clinozoisite in brown Qinghai nephrite. CONCLUSIONS: There are differences in mineral features of Qinghai nephrite in different colors, which provide scientific basis for the study of ore-forming environments and conditions of Qinghai nephrites in different colors. [ABSTRACT FROM AUTHOR]

目的 寻找一种高血压防控新型服务模式，对其防控效果进行评价。 方法 以重庆市九龙坡区第二人民医院心内科为技术支撑，以2013年7月至2014年2月在重庆市九龙坡区中梁山街道社区卫生服务中心建档的35岁以上11 428名居民中诊断为高血压的929例患者为研究对象，分为观察组479例，对照组450例。观察组给予基层高血压服务新模式进行综合防治，对照组给予高血压常规防治。随访1～2年，观察两组患者高血压控制率，总心脑血管事件、心肌梗死、脑出血、脑梗死、全因死亡发生率。 结果 观察组人群中高血压控制率为66.8%（320/479），总心脑血管事件、心肌梗死、脑出血、脑梗死和全因死亡事件发生率分别为2.92％（14/479）、0.21％（1/479）、0.42％（2/479）、1.04％（5/479）、0％。而对照组人群中高血压控制率为34.0%（153/450），总心脑血管事件、心肌梗死、脑出血、脑梗死和全因死亡事件发生率分别为6.44％（29/450）、0.67％（3/450）、1.78％（8/450）、3.33％（15/450）、0.89％（4/450）。两组总心脑血管事件、脑出血、脑梗死、全因死亡发生率比较，差异均有统计学意义（P＜0.05）。 结论 在基层高血压防治工作采用以区县级医院为技术支撑的综合防治明显优于常规高血压防治，对减少脑卒中、全因死亡事件的发生意义更大。 [ABSTRACT FROM AUTHOR]