Search

Objective To investigate the impacts of cinobufotalin combined with docetaxel+cisplatin chemotherapy on the disease control and the level of vascular endothelial growth factor (VEGF) in serum of patients with non-small cell lung cancer. Methods Totally 70 patients with non-small cell lung cancer admitted to Zhejiang Veteran Hospital from March 2019 to March 2022 were included. They were randomly divided into combination group (cinobufotalin combined with docetaxel+cisplatin,n=35) and control group (docetaxel+cisplatin chemotherapy alone,n=35).The disease control rates of two groups, serum VEGF level, carcinoembryonic antigen (CEA), cytokeratin 19 (CK19) and carbohydrate antigen 125 (CA125) were measured using ELISA; life quality of patients was evaluated with the KPS score; The adverse events between two groups were compared. Results The disease control rate in the combination group (33/35, 94.29%) was higher than that that of control group (25/35, 71.43%) (P＜0.05). After treatment, the level of VEGF in both groups of patients decreased, and the KPS score increased (P＜0.05) especially in the combination group (P＜0.05). After treatment, the level of serum CEA, CA125, and CK19 of control group and combination group were obviously lower than those before treatment(P＜0.05), while those in the combination group were even lower (P＜0.05). The incidence of adverse events in the combination group (5/35, 14.29%) was lower than that in the control group (13/35, 37.14%) (P＜0.05). Conclusions Cinobufotalin combined with docetaxel+cisplatin chemotherapy as a potential new chemotherapy significantly reduces the level of VEGF and tumor biomarkers in serum factor, improves the life quality of patients.The combined therapy is proved tobe safe. [ABSTRACT FROM AUTHOR]

To screening out good edible Japonica rice varieties suitable for planting in Taihu Lake area, we comprehensively compared the yield, growth characters, tiller dynamics and quality of 5 edible Japonica rice varieties (lines) with local variety Nanjing 46 as the control. Results showed that Songxiangjing 1018 and Wuxiangjing 968 had relatively high yield, as well as better RVA spectrum characteristic valu, taste valuee, rice processing, appearance quality, nutrition and cooking quality. Thus, it could be concluded that Songxiangjing 1018,Wuxiangjing 968 had relatively stable yield and good rice quality, which were suitable to be extended in Taihu area. [ABSTRACT FROM AUTHOR]

Dabeiyu Gold Deposit is a typical gold deposit in the northern part of Taihang Mountains. The ore-forming fluid characteristics of Dabeiyu Gold Deposit are studied to analyze the genesis of the deposit. The ore body is mainly distributed in the glide-detachment faults between Neo-Archean Fuping Group and Meso-Proterozoic Changchangian Gaoyuzhuang Formation, and the Gaoyuzhuang Formation dolomite fracture alteration zone. The mineralization process can be divided into 4 stages, namely pyrite quartz, quartz pyrite, quartz polymetallic sulfide, and quartz carbonate. The ore-forming fluid inclusions mainly include CO2, inclusion and gas-liquid inclusion. The temperature during the main mineralization stage ranges from 262.8 °C to 346.4 °C, the salinity ranges from 8.6 % to 12.3 %, and the density ranges from 0.77 g/cm³ to 1.08 g/cm³. The ore-forming fluid is characterized by medium-low temperature and medium-low salinity CO2,H₂O NaCl and H2O NaCl systems. The C, H, and O isotope compositions show that ore-forming fluid mainly consists of magmatic water and mixes with atmospheric precipitation. Based on the metallogenic theory of mantle branch structure, Dabeiyu Gold Deposit belongs to the glide-detachment fault type gold deposit. [ABSTRACT FROM AUTHOR]

Polyaniline-silver chloride nanocomposites were prepared by in-situ chemical oxidation polymerization with polyaniline with good conductivity as substrate and photosensitive semiconductor material silver chloride as initiator, and their electrical and optical properties were systematically studied. The morphology, structure, optical properties, and conductivity of polyaniline monomer and polyaniline or silver chloride nanocomposites were characterized and compared by scanning the electron microscope, quaternary probe conductivity tester, and simulating sunlight illumination. The results show that polyaniline silver chloride nanocomposites have good thermal stability; nano-silver chloride particles are uniformly dispersed in polyaniline; the doping of silver chloride will have a positive effect on the conductivity of the composites. At the same time, silver chloride with surface metal plasma oscillation effect is doped in the composite material, which makes the composite material have excellent light absorption and catalytic performance. [ABSTRACT FROM AUTHOR]

报道1例在南通大学附属启东人民医院内分泌科就诊的胰岛素抗体阳性的2型糖尿病 患者，使用司美格鲁肽、德谷胰岛素及达格列净联合降糖治疗的诊疗过程。患者为 83岁男性，因“反 复口干多饮23年，加重1周”就诊我院，患者近5年采用重组赖脯胰岛素混合注射液（25R）治疗，开始 血糖控制良好，近期血糖波动大，入院后查胰岛素抗体阳性，胰岛功能减退，予司美格鲁肽（0.25 mg， 1次/周）、德谷胰岛素（8 U，1次/d）及达格列净（10 mg 1次/d）联合降糖治疗，效果良好。司美格鲁肽为 胰高糖素样肽‑1（GLP‑1）受体激动剂，适用于成人 2型糖尿病患者的血糖控制，可有效刺激内源性胰 岛素分泌，改善胰岛素抵抗，减少血糖波动，使血糖快速达标。 [ABSTRACT FROM AUTHOR]

This paper aims to study the characteristics of traditional residential buildings in Gaoyi Village— a kind of atypical village that flourished due to immigration—and to provide guidance for local building protection and repair. The general knowledge, construction practices, and building procedures of the traditional residential houses in Gaoyi Village are summarized based on field surveys and interviews with the carpenters. The regional technique of wearing buckets is a perfect combination of the timber structure technology of the southwest dry bar building and Han architecture. This paper is an important case study of the bucket frame, and may help promote comprehensive explorations of the development of the southern timber frame. [ABSTRACT FROM AUTHOR]

The Dulong Sn-Zn polymetallic deposit is located in the western margin of Cathaysia and is one of the largest cassiterite-sulfide deposits in China. Ore bodies mainly occur as strata-bound in skarns within Neoproterozoic Xinzhaiyan Formation, overlying Late Cretaceous granite. The skarn alteration and mineralization can be divided into five stages: garnet-pyroxene stage, actinolite-chlorite stage, magnetite-cassiterite stage, cassiterite-pyrrhotite-sphalerite stage, sphalerite-chalcopyrite stage. The skarn in Dulong deposit was chosen as research object, and the major and trace elements of garnet and pyroxene were analyzed by EPMA and LA-ICP-MS based on the identification of mineral assemblage and structure. The results show that garnets can be divided into three types and show certain generation characteristics. In the early stage（Grt Ⅰ）, garnet is andradite(And90-99Gr1-5), most of which is located in the nuclear part, and symbiosis with diopside; Grt Ⅱ belongs to andradite-grossular solid solution series(And50-80Gr20-50), it is formed late around Grt Ⅰ and symbiosis with hedenbergite; Grt Ⅲ is fine-grained grossular(And30-40Gr60-70) formed in the latest stage, and most of which is irregular. The change of mineral assemblages of garnet and pyroxene indicates that the oxidization of fluid decreases gradually. Trace element characteristics show that Grt Ⅰ displays LREE-enrichment and HREE-depletion, whereas Grt Ⅱ displays HREE-enrichment and LREE-depletion. It is suggested that REE distribution may be influenced by the crystal chemical structure of garnet and the solid solution endmember components. Contents of In and Sn in different generations of garnet are also divergent significantly. Contents of In and Sn in andradite（Grt Ⅰ） are（63.0-264.0）×10-6 with the average of 159.0×10-6, and（2 790-13 100）×10-6 with the average of 7 441×10-6, respectively. Contents of In and Sn in grossular（Grt Ⅱ） are（1.6-81.0）×10-6 with the average of 20.0×10-6, and（436-4 740）×10-6 with the average of 2 518×10-6, respectively. The positive correlation of contents of In and Sn in garnet implies the simultaneous and homologous relationship between them. There is a certain tendency of selective enrichment in the early stage of skarn formation. Thus, the systematic research of skarn mineralogy and mineral chemistry characteristics is of great significance to effectively constrain the evolution of ore-forming fluid in skarn alteration and mineralization process. [ABSTRACT FROM AUTHOR]

BACKGROUND: With the comprehensive promotion of spinal internal fixation technology, the remodeling of spinal mechanical stability has attracted more and more attention. Lateral internal fixation via axillary midline transthoracic approach for the treatment of upper thoracic vertebra lesion is a new surgical approach. Currently, the research on the biomechanics of upper thoracic v七rt七bra after fixation is relatively rare. OBJECTIVE: To evaluate whether the reconstruction of upper thoracic v七rt七brae via axillary midline transthoracic approach can achieve the requirements of biomechanical stability by biomechanical analysis of three-dimensional motion stability and load-bearing strength of upper thoracic vertebrae in lateral and anterior internal fixation models. METHODS: The C7-T6 spine and bilateral rib cage joint specimens were obtained from 12 human cadaveric bodies, and the three-dimensional motion stability test of the complete upper thoracic vertebrae model was 店rfom,ed and 芘cord刮as a complete vertebral body group. Subsequently, the specimens were randomly divided into two groups, and the traditional front plate internal fixation (front internal fixation group) and the axillary line into the thoracic cavity side plate internal fixation models (lateral internal fixation group) were established, respectively, with six specimens in each group. Three-dirnensional motion test, vertical pressure test and vertical pressure failure test were perfom,ed. This study was approved by the Ethics Committee of Second Affiliated Hospital of Guangxi Medical University (approval No. 2017(KY-0080)). RES UL TS AND CONCLUSION: (1) The load of left vertebral body group under left/right flexion, flexion/posterior extension and left/right rotational motion was smaller than that of lateral internal fixation group and anterior internal fixation group (P < 0.01). The load in the front internal fixation group under left/right rotational motion was smaller than that in the lateral internal fixation group (P < 0.05). There was no significant difference between the left/right flexion and the flexion/rear extension between the internal fixation group and the lateral internal fixation group (P > 0.05). (2) When the load reaches 600 N, the vertebral body sinking dispplacement of the front internal fixation group was smaller than in the lateral internal fixation group [(1.39±0.20), (2.15±0.17) mm, P < 0.01]. (3) There was no significant difference in the maximum intensity load between the anterior internal fixation group and the lateral internal fixation group [(1 839.70±122.45), (1 798.65±120.21) N, P=0.571]. (4) Results showed that the axillary midline translhoracic approach was in the lateral steal plate. The fixation is stable and meats the biomechanical needs of spinal reconstruction. [ABSTRACT FROM AUTHOR]

目的探讨下腔静脉呼吸变异指数(IVC-RVI汃血清脑钠肤(BNP)水平对脓毒症休克患者容量反应性的预测效能。方法根据容显负荷试验结果将50例脓毒症休克患者分为R组［心输出显增加呈(,0.CO ⩾ 15%] 和NR(,6.CO < 15%）组。 记录容量负荷试验前后的下腔静脉直径的最大值(Dmax)和最小值(Dmin)，计算IVC­RV! ，采用化学发光法消BNP。 比较两组上述各指标。 绘制受试者工作特征曲线(ROC)分析IVC-RVI和血清BNP水平预测脓毒症休克患者容噩反应性的灵敏度及特异度。 结果容昼负荷试验前，R组的IVC-RVI大于NR组(P<0.05)，两组血清BNP水平比较，P >0.05；试验后，与NR组比较，R组,6.BNP、Dmax、Dmin低，IVC-RVI高(P均<0. 05)。IVC-RVI、,6. BNP与,6.CO 呈正相关(r 分别为0. 701、0. 362)。 IVC-RVI预测脓毒症休克患者容旦反应性的ROC下面积(AUC)为 0. 965，最佳预测值42.85%、灵敏度为95.7%、特异度为88.9%,,6.BNP水平预测脓毒症休克患者容量反应性的AUC为 0. 75趴最佳预测值－ 120.45 pg/mL,灵敏度为65.2%、特异度为81.5%，联合IVC­RVI和,6.BNP预测脓毒症休克患者容噩反应性的AUC为0. 968、灵敏度为91.3%、特异度为92.6%。 结论IVC­RVI可 以作为脓毒症休克患者容呈反应性的预测指标。 BNP的基线值不能作为脓毒症休克患者容呈反应性的预涓指标，但是BNP的动态变化值对容呈反应性的预测有帮助。 两者联合预测容呈反应性的价值与单独使用IVC­RVI相比无优越性。 [ABSTRACT FROM AUTHOR]

A virtual microwave experiment system, antenna measurement in microwave anechoic chamber, was developed by applying virtual reality technology, using Unity3D development engine, C# script language and 3ds Max modeling tool. The development of the system is based on a typical actual antenna measurement system and according to the practical experiments, simulating operation process of antenna measurement in microwave anechoic chamber and the measurement results of several conventional kinds of antennas. The system has graphical interface and vivid models. It can be generated as an executable file in Windows environment and run on PC machine. Users can acquire intuitive knowledge of composition, layout and function of microwave anechoic chamber, and can understand antenna testing system and the process of antenna testing. By interacting with the system, users can virtually measure several conventional kinds of antennas and custom antennas. It can also aid teachers ' theoretical teaching and classroom demonstration. Taking horn antenna as an example, implementation technologies of 3D simulation animation of the process of antenna testing and the main interactive functions of the system are emphatically introduced after fully stating the functions of the system. [ABSTRACT FROM AUTHOR]

The development of cholestatic liver disease is closely associated with the enterohepatic circulation disorder of bile acid. This article elaborates on metabolism of bile acid, enterohepatic circulation-related mechanism of hereditary cholestasis, molecular regulation of related transporters, and association between current therapeutic regimens and enterohepatic circulation, in order to investigate the pathogenesis of cholestatic liver disease and provide a basis for the research on new drugs or therapies. [ABSTRACT FROM AUTHOR]

HUT model (Helsinki university of technology snow emission model) is a semi-empirical radiative transfer model of passive microwave remote sensing of snow- and it considered the impact of soil, forests and atmosphere on brightness temperature receiving by the sensor. HUT model was able to simulate brightness temperature receiving by the sensor. This paper validated HUT model based on MWR1 data mounted on FY-3B satellite. The results showed that there was a big difference between brightness temperature of HUT' model simulation and brightness temperature of MWRI for 18.7 GHz horizontal polarization and 36.5 GHz horizontal polarization. So this paper improved the extinction coefficient formula. The model that used the improved extinction coefficient formula calculating extinction coefficient was called improved HUT model (IMI'HUT model'. The validation result of IMI'HUT model indicated that: the bias of IMI'HUT model for 18.7 GHz horizontal polarization and 36.5 GHz horizontal polarization were -0.91 K and -4.19 K respectively. However the bias of HUT model for 18.7 GHz horizontal polarization and 36. 5 GHz horizontal polarization were 14.03 K and -16.33 K respectively. Simulation accuracy of IMPHUT model was greatly improved. Finally, genetic algorithm was used to inverse snow depth on January 20. 2013. The result showed that bias of inversion snow depth based on IMPHUT model was -6.79 cm. The inversion snow depth based on IMPHUT model which was superior to HUT model and Chang algorithm was in good agreement with the measured snow depth. [ABSTRACT FROM AUTHOR]

This article analyzed the diferences of the teaching condition between the independent colleges and the regular institutions, and investigated the personal training strategies for the independent colleges. It presented a new M One-Four-Three" principle, which mainly focused on nurturing studentsx practical ability and innovative spirit. This principle utilized the independent-college-fitted electrical teaching and practicing system to gradually improve the students'three-level abilities. A detailed analysis and practice were included in this article. Practical results showed that the system not only fits into studentsx cognitive process, but also eases the situation of the lack of funds and staffs in independent colleges. It also proved to be an effective way on cultivating the creativity of higher engineering technical application talent. [ABSTRACT FROM AUTHOR]

目的探讨腹腔镜胆总管切开取石Ⅰ期缝合术治疗高龄胆总管结石患者的有效性与安全性。方法选择老年胆总管结石患者267例,其中年龄≥80岁77例(高龄组)、<80岁190例(低龄组)。两组均行腹腔镜胆总管切开取石Ⅰ期缝合术,比较两组手术成功率、手术时间、住院时间、术后拔除腹腔引流管时间、术后并发症情况。出院3个月复查CT或MRI,此后每半年复查1次,至术后1～2年,统计术后胆总管结石复发和胆管狭窄情况。结果两组均顺利完成腹腔镜胆总管切开取石Ⅰ期缝合术,无中转开腹或胆总管取石后胆总管留置T管,手术成功率均为100%。高龄组与低龄组手术时间分别为(100. 79±24. 24)、(100. 68±22. 06) min,住院时间分别为(8. 66±3. 21)、(8. 29±2. 77)天,术后拔除腹腔引流管时间分别为(5. 28±0. 95)、(5. 25±1. 0)天,两组手术成功率、手术时间、住院时间、术后拔除腹腔引流管时间比较P均> 0. 05。高龄组与低龄组术后并发症发生率分别为7. 8%(6/77)、3. 7%(7/190),两组比较P> 0. 05。术后随访1～2年,两组均未见胆总管结石复发和胆管狭窄。结论腹腔镜胆总管切开取石Ⅰ缝合术治疗高龄胆总管结石患者临床效果较好,并发症较少,可作为首先术式。 [ABSTRACT FROM AUTHOR]

Dexing porphyry copper deposit in Jiangxi is one of the largest in the eastern of China. It is composed of Zhushahong, Tongchang and Fujiawu deposits. Based on the petrographic investigation of drill core samples, SHRIMP zircon U-Pb dating and ID-TIMS apatite U-Pb dating for ore-bearing granodiorite porphyry from Zhushahong porphyry copper deposit in Dexing area were presented. The results show that SHRIMP zircon U-Pb age of granodiorite porphyry is (171.3±1.7)Ma with the mean standard weighted deviation (MSWD) of 1.4; ID-TIMS apatite U-Pb age with hydrothermal alteration is (170.6±1.0)Ma with the MSWD of 0.49. The above ages indicate that the emplacement of ore-bearing porphyry from Zhushahong porphyry copper deposit and the mineralization of Cu-Mo develop in Middle Jurassic and are nearly contemporaneous; there is short magmatic-hydrothermal evolution process from magma emplacement to hydrothermal mineralization. [ABSTRACT FROM AUTHOR]

目的比较股骨近端防旋髓内钉(PFNA)、动力髋螺钉(DHS)内固定术治疗老年不稳定型股骨粗隆间骨折的效果。方法选择老年不稳定型股骨粗隆间骨折患者68例,随机分为观察组和对照组,各34例,分别采用PFNA、DHS内固定术治疗。记录两组手术时间、切口长度、术中失血量、住院时间、骨折临床愈合时间以及并发症(感染、压疮、髋内翻、内固定松动、股骨头切割)发生情况。术后第6个月按照髋关节功能Harris评分标准评定两组髋关节功能。结果 PFNA组手术时间、切口长度、术中失血量均低于DHS组,P均<0.05。两组患者住院时间差异无统计学意义,PFNA组患者骨折临床愈合时间短于DHS组(P<0.05)。术后第6个月PFNA组患者髋关节功能优21例、良10例、可3例、差0例,优良率91.2%;DHS组优17例、良11例、可5例、差1例,优良率82.4%。PFNA组优良率高于DHS组,P<0.05。PFNA组术后发生压疮1例,术后并发症发生率2.9%;DHS组术后发生感染1例、压疮2例、髋内翻1例,术后并发症发生率11.7%。PFNA组术后并发症发生率低于DHS组,P<0.05。结论PFNA和DHS均可用于治疗老年不稳定型股骨粗隆间骨折,但相比DHS,PFNA内固定术治疗效果更好更安全。 [ABSTRACT FROM AUTHOR]

目的 观察腹腔镜下 D2 根治术治疗局部进展期远端胃癌的临床效果。方法 将收治的局部进展期远端胃癌患者60例随机分为腹腔镜组和开腹组各30例。腹腔镜组实施腹腔镜辅助下胃癌 D2 根治术,开腹组实施常规开腹胃癌 D2 根治术,对比两组手术效果、术后恢复情况、肿瘤根治情况、并发症发生率、复发率及1年生存率。结果 腹腔镜组手术时间、手术切口长度、术中出血量均明显少于开腹组(P均<0.05);腹腔镜组术后肛门排气时间、首次下床活动时间、进食流质饮食时间、术后平均住院时间均明显短于对照组(P均<0.05);两组清扫淋巴结总数、近切缘距肿瘤距离及远切缘距肿瘤距离的差异无统计学意义(P均>0.05)。两组术后并发症发生率、复发率及病死率比较均无统计学差异(P均>0.05)。结论 腹腔镜下 D2 根治术治疗局部进展期远端胃癌的近期临床效果较好,患者术后恢复快,并发症发生率低。 [ABSTRACT FROM AUTHOR]

Objective: To explore the relationship between ERα-29 gene polymorphisms and HBV-related hepatocellular carcinoma. Methods: 100 patients with HBV-related hepatocellular carcinoma were selected as the research group,and another 100 healthy people were chosen to be the control group. Then the ERα-29 gene polymorphisms in the two groups were detected by the polymerase chain reaction-restriction fragment length polymorphism. Results: Compared with the control group, the distributions of TT and TC genotypes of ER α-29 gene in the research group were higher, and the distribution of CC genotype of ERα-29 gene was lower with statistically significant differences (P<0.05); Compared with the control group, the rate of T genotype of ERα-29 gene in the research group were higher, and the rate of C genotype of ER α-29 gene was lower with statistically significant differences (P<0.05); Compared with the C allele,the incidence of PHC of T allele carrier was higher (P<0.05). Conclusions: There is a relationship with ERα-29 and HBV-related hepatocellular carcinoma,and the T allele carrier can increase the risk. [ABSTRACT FROM AUTHOR]

Objective To investigate whether sarcopenia before concurrent chemoradiotherapy is prone to grade≥3 acute adverse reactions (AAR) and shorten survival in patients with advanced esophageal squamous cell carcinoma (ESCC). Methods Data of advanced patients with pathologically diagnosed ESCC and CCRT (FP regimen) from August 2018 to July 2022 were reviewed retrospectively. Skeletal muscle mass and body composition were measured using pre-treatment CT images, and patients were divided into sarcopenia and non-sarcopenia groups. Grade≥3 AAR was diagnosed based on CTCAE5.0 and acute radiation injury criteria of the US RTOG. Risk factors for developing grade≥3 AAR were analyzed, and survival rates were calculated by Kaplan-Meier method. Results Among 132 patients with ESCC (87 in the sarcopenia group and 45 in the non-sarcopenia group), 23(17.4%) experienced grade≥3 AAR. In multivariate regression analysis, independent risk factors for grade ≥3 AAR included the following: sarcopenia (OR: 6.034, 95%CI: 1.206-30.190, P=0.029), decreased SMD (OR: 0.693, 95%CI: 0.492-0.976, P=0.036), decreased SMI (OR: 0.841, 95%CI: 0.721-0.982, P=0.028), and increased FMI (OR: 2.433, 95%CI: 1.194-4.958; P=0.014). The OS rates were 16.01 months (95%CI: 14.89-17.13) in the sarcopenia group and 19.27 months (95%CI: 14.45-24.09) in the non-sarcopenia group (χ2 =5.326, P=0.021) as well as 14.86 months (95%CI: 11.30-18.42) for patients with grade≥3 AAR and 16.67 months (95%CI: 14.91-18.43) for patients with grade 0-2 AAR (χ2 =5.47, P=0.019). Among patients with grade≥3 AAR, the OS rates were 12.13 months (95%CI: 10.15-14.11) in the sarcopenia group and 18.69 months (95%CI: 12.85-21.88) in the non-sarcopenia group (χ2 =4.466, P=0.035). Conclusion Sarcopenia, decreased skeletal muscle density, and increased fat mass are important predictors of grade≥3 AAR. The OS of patients with sarcopenia and grade≥3 AAR may be reduced. [ABSTRACT FROM AUTHOR]

目的 分析晚期妊娠胎膜早破(PROM)患者的阴道微生态状况,探讨阴道微生态变化在PROM发生中的作用。方法 回顾性分析53例发生PROM的患者的产检资料,选取同期住院、未出现PROM的健康待产孕妇50例作为对照组,分析两组产前36周阴道分泌物检测结果,分析阴道微生态状况,比较两组阴道分泌物成分、阴道病原菌类型。结果 PROM组、对照组微生态失调的发生率分别为77.4%、16.0%,PROM组高于对照组(P<0.01)。PROM组p H>4.5、过氧化氢酶、白细胞酯酶、唾液酸苷酶、β-葡萄糖醛酸酶、乙酰氨基葡萄糖苷酶阳性比例均高于对照组(P0.05),阴道支原体、衣原体感染率均高于对照组(P<0.05)。结论发生PROM的晚期妊娠孕妇阴道微生态失调的发生率高,阴道分泌物成分异常,阴道支原体、衣原体感染率高,可能与PROM的发生有关。 [ABSTRACT FROM AUTHOR]

The spectrum of the image reflects the distribution of image energy in the frequency domain. The ratio of the high and low frequency components of the spectrum reflects the distribution of edge information and smooth information in the image. Through statistical analysis of the spectral distribution of dear and blurred images, this paper proposes an image clarity and fuzzy discrimination method based on sub-band spectral information. First, the spectrum energy outside the frequency radius is calculated, and the characteristic curve of the residual energy of the spectrum is obtained. Secondly, according to the residual energy curve, the normalized fuzzy judgment parameters are obtained. When the fuzzy parameter is less than a certain threshold, the image is judged to be a blurred image. The experimental results show that the parameter proposed in this paper can quantitatively measure the degree of image blur, and has the advantages of fast and simple judgment process and high classification discrimination. [ABSTRACT FROM AUTHOR]

【Objective】The study aimed to explore the physiological regulation mechanism of diapause of Clanis bilineata tsingtauica Mell, the changes of nutrients and diapause hormones of C. bilineata tsingtauica Mell before and after diapause were explored.【Method】The mature larvae of C. bilineata tsingtauica Mell population in Jiangsu province were used as the insect source of test and the experiment was conducted to measure content of soluble protein, carbohydrates, fatty acid and diapause-related hormone level in three different periods of pre-diapause, diapause and post-diapause termination respectively.【Result】With propulsion of diapause process, the content of glycogen decreased continuously and the difference reached significant level after diapause termination (P＜0.05). However, the content of monosaccharide, soluble protein and fatty acid all first decreased and then increased and reached the minimum at diapause stage. In addition, the content of soluble protein was significantly different in three different diapause periods(P＜0.05). The content of palmitic acid and myristic acid increased fastest and there was the highest content of linolenic acid and palmitic acid which exceeded 9000 μg/g after diapause termination. At the same time, there existed certain variation between Juvenile hormone (JH) and Molting hormone (MH) at different diapause stages of C. bilineata tsingtauica Mell. JH titer gradually decreased and MH titer which always remained high level first decreased and then increased with the advancement of diapause.【Conclusion】The nutrients were constantly consumed in the process of diapause formation of C. bilineata tsingtauica Mell. Furthermore, MH increased significantly but gradually decreased of JH synthesis. The nutrient content required for activities were all increased gradually after diapause termination of C. bilineata tsingtauica Mell. MH played an important role in the process of diapause termination, which provided a good foundation for completing molting and entering the next insect state smoothly. [ABSTRACT FROM AUTHOR]

Traditional machine learning and deep learning models ignore the strength of emotional feature words when processing sentiment classification tasks. As a result, the emotional semantic relationship is poor, and the accuracy of sentiment classification is low. To this end, an improved BiLSTM-CNN+Attention sentiment classification algorithm with a sentiment dictionary was proposed. Firstly, a feature extraction algorithm fused with sentiment dictionaries was used to optimize the weight of feature words. Secondly, a convolutional neural network (CNN) model was designed to extract local features, and a bidirectional long and short-term memory(BiLSTM) model was used to extract contextual semantic features and long-distance dependencies. Then, the attention mechanism was designed to add weights to sentiment features. Finally, a Softmax classifier was used to predict the sentiment category. The experimental results show that the proposed sentiment classification algorithm can achieve the best precision, recall, and F value. Compared with TextCNN, BiLSTM, long and short-term memory (LSTM), CNN, and random forest models, the F value of the proposed method is increased by 2.35%, 3.63%, 4.36%, 2.72%, and 6.35%, respectively. In short, the proposed method can fully integrate the weights of emotional feature words, utilize contextual semantic features, and improve the performance of sentiment classification. Therefore, the proposed method has specific educational value and application prospects. [ABSTRACT FROM AUTHOR]

【Objective】 To study the color wheat tissue culture regeneration system and provide a theoretical basis for establishing a high-frequency color wheat genetic transformation system. 【Methods】 The mature embryos of three color wheat varieties（lines）of Zhongheimai No.6,CM-Z2 and Zhonglanmai No.1 were used. The induction status was recorded at 8,14,and 20 days after callus induction. Growth regulator IAA+KT and IAA+6-BA combination were used to redifferentiate color wheat callus. The callus rate,differentiation rate and seedling rate of different treatments were evaluated. 【Results】 The explants of Zhongheimai No.6,CM-Z2 and Zhonglanmai No.1 had the best callus induction effect after cultured for 14 days,with callus rates ranging from 80.54% to 95.39%. The regeneration ability of color wheat mature embryo callus was related to genotype and culture medium. Zhongheimai No.6 had the best regeneration ability,with a differentiation rate of 87.68%-97.50%,and a seedling rate of 17.26%-61.73%. The seedling rate was higher in the differentiation medium containing 0.1 mg/L IAA and 0.5 mg/L 6-BA,0.5 mg/L IAA and 4 mg/L KT,with a rate of 61.73% and 56.25% respectively. CM-Z2 followed Zhongheimai No.6,had a differentiation rate of 60.23%-95.45% and seedling rate of 2.27%-34.09%. CM-Z2 had the highest seedling rate in the differentiation medium containing 0.5 mg/L IAA and 4 mg/L KT,reaching 34.09%. 【Conclusion】 Zhongheimai No.6 was an ideal material for color wheat genetic transformation. Regeneration medium containing 0.1 mg/L IAA and 0.5 mg/L 6-BA,0.5 mg/L IAA and 4 mg/L KT were suitable for Zhongheimai No.6 and CM-Z2. [ABSTRACT FROM AUTHOR]

Under the designed hydrological conditions of different guarantee rates and different time scales, the paper dynamically calculated the sewage capacity and annual distribution of the urban section of Anyang River in 2016. The calculation results were comparatively analyzed. The results show that the pollutant discharge in Anyang sewage control area is not exceeding the standard, the COD and NH3-N discharge of other water function areas exceed the upper limit of the capacity and the NH3-N is more serious. The monthly average water environmental capacity of the river in flood season is smaller than that in non-flood season, the water environmental capacity of the river in July to October is larger, the water environmental capacity of August is the maximum in the whole year and the water environmental capacity of November to May is gradually reduced, in May, the water environmental capacity is the lowest in the whole year. There is a negative correlation between the size of the capacity and the time scale and the annual capacity is the monthly scale > the water scale > the annual scale. [ABSTRACT FROM AUTHOR]

Objective: To investigate the relationship between serum procalcitonin (PCT), C-reactive protein (CRP), coagulation function, disease score and prognostic factors in patients with sepsis. Methods: A total of 150 patients with sepsis who were diagnosed and treated in our hospital from August 2017 to October 2019 were selected as the study subjects. According to the survival status of the patients in the sepsis group, they were divided into survival group (n=118) and death group (n=32). Serum levels of PCT, CRP and prothrombin time (PT), partial thromboplastin time (APTT) in each group were detected by latex enhanced immunoturbidimetry. Acute physiological function and chronic health status scoring systemⅡ (APACHEⅡ) and sequential organ failure assessment (SOFA) were used to evaluate the condition of the two groups. The clinical data of the two groups were compared. Pearson test was used for correlation analysis. The influencing factors of patients' prognosis were analyzed by logistic regression. Results: Compared with survival group, serum calcitonin original, PCT, CRP, PT, APTT, APACHE II and SOFA score in death group increased significantly (P<0.05). Serum PCT>7.32 ng/mL, CRP>86.73 ng/mL, PT>15.48s, APTT>36.74s, APACHE Ⅱ score >15.88 score and SOFA score >6.48 were the major risk factors of death in patients with sepsis OR=2.099, 1.747, 2.333, 1.596, 1.916, 2.208, P<0.05 . Serum PCT and CRP and APACHE Ⅱ score, SOFA score, PT and APTT were positively correlated (P<0.05). Conclusions: The increase of serum PCT and CRP levels are related to the death of patients with sepsis, and they are positively related to Apache Ⅱ score, SOFA score, PT and APTT of patients with sepsis, and they are the influencing factors of poor prognosis of patients. They have a certain clinical value in the evaluation of prognosis of patients with sepsis. [ABSTRACT FROM AUTHOR]

Objective: To investigate the relationship between the levels of serum oxidative stress factors, inflammatory factors, acute physiology and chronic health II (APACHE II) score and prognosis in patients with sepsis. Method: 76 patients with sepsis admitted to our hospital from January 2016 to October 2019 were selected as the research group, and 60 patients with non-sepsis patients with the same underlying disease admitted during the same period were selected as the control group, and the serum oxidative stress of the two groups were compared. Factors [malondialdehyde (MDA), superoxide dismutase (SOD), nitric oxide (NO)], inflammatory factors [procalcitonin (PCT), C-reactive protein (CRP), interleukin 27 (IL -27)] level and APACHE II score, according to the prognosis of sepsis patients, they were divided into 25 cases of death group and 51 cases of survival group. The above indicators were compared between the two groups, and the factors affecting the prognosis of sepsis patients and serum oxidative stress were analyzed. The correlation between the levels of cytokines and inflammatory factors and APACHEII score. Results: The serum MDA, PCT, CRP, IL-27 and APACHEII scores of the study group were significantly higher than those of the control group, and the serum SOD and NO were significantly lower than those of the control group (P<0.05). The serum MDA, PCT, CRP, IL-27 and APACHEII scores of the death group were significantly higher than those of the survival group, and the serum SOD and NO were significantly lower than those of the survival group (P<0.05). Multivariate logistic regression analysis showed that increased MDA, decreased SOD, decreased NO, increased PCT, increased CRP, and increased APACHE II score were all risk factors for death in patients with sepsis (OR=2.293, 1.872, 1.527, 2.472, 1.667, 1.926, P<0.05). Pearson correlation analysis showed that serum MDA, PCT, CRP, IL-27 levels in patients with sepsis were positively correlated with APACHE II score (r=0.563, 0.582, 0.441, 0.302, P<0.05), and serum NO and SOD levels were positively correlated with APACHE II score There was a negative correlation (r=-301, -0.386, P<0.05). Conclusion: In patients with sepsis, serum MDA, PCT, CRP, IL-27 and APACHEII scores are abnormally increased, and serum NO and SOD are abnormally decreased. It is possible to determine the patient's condition and evaluate its prognosis by testing the above indicators. [ABSTRACT FROM AUTHOR]

Because of the complicated environment, various types of users, random time of power consumption and so on, the low-voltage power line communication has interference, which causes communication failure seriously. In this paper, the characteristics and laws of load and interference in low voltage power lines are studied. A channel noise model is established, and an intelligent active anti-interference technique for low voltage power line carrier communication is proposed. This technique matches the impedance of the transceiver controller with the impedance of the low voltage power communication line to a maximum, and broadens the spread spectrum technology. We further propose a method of actively selecting a high reliability band to communicate on the basis of spread spectrum, so as to overcome the strong attenuation and strong interference defects of low voltage power line. The experimental environment is set up, and the communication experiments are carried out for low voltage power lines, such as white noise, periodic noise and impulsive noise. The results show that the method is feasible. [ABSTRACT FROM AUTHOR]

BACKGROUND: To mimic physiological and functional requirements of cartilage and subcondral bone, some recent studies have fabricated bilayered scaffolds for osteochondral tissue engineering in cartilage repair. However, in cartilage repair, and little is reported on the use of a single biomaterial instead of composite biomaterials to fabricate bilayered porous scaffolds. OBJECTIVE: To investigate the biocompatibility of an integrated bilayered porous scaffold fabricated with poly(lactic-co-glycolide) (PLGA), and then to discuss its feasibility of constructing tissue-engineered osteochondral graft. METHODS: The integrated bilayered porous scaffolds were fabricated with PLGA by changing the ultrastructure of scaffold. In vitro, bone marrow mesenchymal stem cells (BMSCs) isolated from rabbits were seeded into the bilayered porous PLGA scaffold, co-cultured for 1 week and then observed under scanning electron microscope. After co-culturing 48 hours, the cells were stained by LIVE/DEAD Kit. In vivo, the composite of Dil-labeled IBMSCsand the scaffold or the scaffold alone were implanted subcutaneously into the skin of nude mice, and the implants were taken out and stained by hematoxylin-eosin and DAPI staining at 4 and 8 weeks after implantation. RESULTS AND CONCLUSION: (1) We successfully obtained the bilayered porous scaffolds with different pore sizes (the upper layer: 100-200 pm and the lower layer: 300-450 pm) and 85% porosity. (2) In the in vitro experiment, the LINVE/DEAD staining showed that BMSCs survived well in the scaffold, and the cells adhered well to the wall of pores in all the scaffolds and extracellular matrix deposition was found under the scanning electron microscope. (3) In the in vivo experiment, shown by the hematoxylin-eosin staining, a small amount of chondrocytes formed in the fibrous tissue in the upper layer and a large amount of trabecular bones in the lower layer were found at 8 weeks after implantation in the experimental group. The close integration between the upper layer and the lower layer appeared. BMSCs could survive for 8 weeks in vivo shown by the DAPI staining. However, in the control group, a little fibrous tissue was found without chondrocytes and apparent trabecular bone, and the scaffold was partially degraded. To conclude, the integrated bilayered porous scaffold fabricated with PLGA alone has good biocompatibility, which is feasibly used in osteochondral tissue engineering. [ABSTRACT FROM AUTHOR]

Based on Matlab image acquisition toolbox, an image data processing software and hardware platform is proposed in this paper. With the help of Matlab image processing and acquisition functions, real-time image can be captured from the image sensor and processed at once. Compared with the state-of-art image processing platform, the proposed experimental platform can provide more experimental projects and experimental experience, improve the effect of students'on-the-spot experiment, and make students focus on the innovative ideas and algorithm design in processing experiment projects. [ABSTRACT FROM AUTHOR]

Objective To determine the expression of macrophage migration inhibitory factor (MIF) in different molecular subtypes of breast cancer and its clinical significance so as to detect the biological markers of different molecular subtypes of breast cancer. Methods We divided 100 breast cancer patients into four molecular subtypes by immunostaining: luminal subtype, HER-2(+) subtype, basal-like (BLs) subtype and normal breast-like (NBLs) subtype, and then compared the expression of MIF in the groups. We analyzed the associations of MIF-positive expression rate with age, menstruation, tumor size, auxiliary lymph node metastasis, histological type and grade, and clinical stage of the breast cancer patients. We also compared MVD level and 5-year overall survival rate between MIF-positive patients and MIF-negative ones. Results The positive expression of MIF was correlated with HER2(+) subtype breast cancer and auxiliary lymph node metastasis (P<0.05). The patients with MIF-positive expression had a significantly higher level of MVD than those with MIF-negative expression (P<0.05). Kaplan-Meier method showed that MIF-positive patients had a poor prognosis than MIF-negative ones (Log-rank=19.516, P=0.000). Conclusion Breast cancer patients with MIF-positive expression may be mostly of HER2 (+) subtype, and tend to develop auxiliary lymph node metastasis. These patients have a significantly higher level of MVD and poor prognosis than those with MIF-negative expression. [ABSTRACT FROM AUTHOR]