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【目的】通过生物信息学方法，分析在肝衰竭中高表达的载脂蛋白H（APOH）在疾病发生发展中的功能与机制。【方法】从GEO数据库下载多个芯片数据集（GSE14688、GSE38941和GSE96851），以5筛选出差异表达基因，通过Cytoscape及R对前10位关键基因中的APOH基因进行GO生物学功能富集分析和KEGG信号通路分析，并进一步在慢乙肝相关肝衰竭组织中进行表达验证。【结果】共筛选出2438个差异表达基因，其中，1162个上调基因，1276个下调基因。蛋白质相互作用网络分析发现10个枢纽基因分别为：KNG1、IGF1、SPARC、APOH、CLU、SERPING1、TGFB2、CDC37L1、PCYOX1L和APOOL。通过慢乙肝相关肝衰竭组织验证发现APOH在肝衰竭组织中高表达，GeneMANIA预测APOH和炎症反应有关。GO分析及KEGG分析显示，APOH与补体/凝血级联通路以及碳代谢通路密切相关，并且，与补体C3（complement C3）的表达水平呈明显的正相关性。【结论】APOH在肝衰竭组织中高表达，可能通过补体C3调控补体/凝血级联通路以及碳代谢通路参与肝衰竭的发生发展。

移动数据的爆炸性增长带来了基站负载过大等问题,再加上频谱资源的稀缺,传统的蜂窝网络已经不能满足需求,为了获得吞吐量和用户密度的提升,异构蜂窝组网成为LTE-A（改进的长期演进）的必然选择。文章在假设SeNB（小基站）同时在S-MeNB（源宏基站）和T-MeNB（目标宏基站）的覆盖范围内的基础上,基于异构网中的双连接技术,对S-MeNB切换到TMeNB的流程进行了设计。为了验证此双连接切换流程设计的成功与否,文章提出了一种结合TTCN-3的实现方案,通过仿真图验证了流程设计的合理性和可行性。

【目的】通过对原发性肝细胞癌（HCC）的MR三维容积插入屏气检查（3D-VIBE）多期动态增强扫描与多层螺旋 CT（MSCT）增强扫描的对照研究，探讨MR 3D-VIBE序列动态增强扫描在显示HCC的动态强化特点中的价值。【方法】收集 23例在我院行上腹部3.0T MR 3D-VIBE多期动态增强扫描及MSCT双期增强扫描的HCC的患者的临床及影像学资料，对比 3D-VIBE序列动态增强扫描及MSCT增强扫描显示肿瘤的强化特点。【结果】23例经手术证实共发现23个HCC，MRI 3D- VIBE序列检出全部23个病灶，CT检出21个病灶。MRI 3D-VIBE序列多期动态增强扫描中病灶显示为“快进快退”征象者 占78.3%（18/23），MSCT增强扫描具有此征象者占54.5%。直径 ≤ 3 cm的肿瘤更易在3D-VIBE序列多期动态增强扫描中观 察到明显强化征象（P=0.037）。【结论】MR 3D-VIBE序列肝脏进行多期动态增强扫描，提高了HCC尤其是小HCC诊断的 敏感性与准确性。

【目的】为了分析直肠上静脉及肠系膜下静脉的直径与直肠癌淋巴转移的相关性，在CT上测量直肠上静脉及 肠系膜下静脉的直径，探讨利用直肠上静脉预测直肠癌淋巴结转移的可行性。【方法】回顾性分析105例直肠癌患者的CT 及病理资料，在 CT 上测量直肠上静脉和肠系膜下静脉直径，比较两条静脉的直径在不同病理状态下（是否存在微血管 癌栓、印戒细胞、淋巴结转移以及远处转移）的差异，采用ROC 曲线分析利用直肠上静脉直径预测直肠癌淋巴结转移的 准确性。【结果】直肠上静脉及肠系膜下静脉的直径在淋巴结转移组（分别为4.34 mm、5.00 mm）与无淋巴结转移组（分别为 3.56 mm、4.81 mm）间的差异有统计学意义（P < 0.001，P = 0.023）。直肠上静脉在是否存在微血管癌栓、印戒细胞间的差异 有统计学意义（P = 0.019，0.044），而肠系膜下静脉在是否存在微血管癌栓、印戒细胞间的差异无统计学意义（P值分别为 0.605，0.663）。直肠上静脉与肠系膜下静脉的直径在是否伴远处转移间的差异均无统计学意义（P > 0.05）。以直肠上静脉 直径3.75 mm、肠系膜下静脉直径4.65 mm为分界值，预测淋巴结转移的灵敏度分别为90.9%、87.3%，特异度分别为82.0%、 38%。【结论】利用CT测量直肠上静脉的直径预测直肠癌的淋巴结转移是完全可行的，具有很高的敏感度、准确性和较高的 特异度。

山东鄄城黄河公路大桥是目前规模最大的波形钢腹板PC组合结构桥梁,也是国内首次大规模使用波形钢腹板的工程。在考察日本等国家波形钢腹板制造技术的基础上,分析了以往采用传统冷成型方法生产中厚钢波形钢腹板产生的各种缺陷及原因,在山东鄄城黄河公路大桥的波形钢腹板制作中,将传统工艺中多点同时受压改为仅在钢板的波峰或波谷的中央处用上模和底模将钢板夹紧,而从夹紧处用小半径辊轮向两侧碾压的方法,使钢板在非设计折角处不产生塑性变形,并且与传统加工方法相比在设计折角区域也仅产生很微小量的拉伸和压缩变形。该工艺避免了钢板因受拉引起的损伤和微裂纹等各种缺陷的产生,提升了产品各项质量指标,提高了生产效率,并延长了产品使用寿命。在制作山东鄄城黄河公路大桥波形钢腹板过程中,制定的产品质量控制指标对钢板矫正、喷砂、喷铝、喷漆这4个工序作了补充。按照该方法浙江中隧桥波形钢腹板有限公司已成功建造了拥有自主知识产权的冲压加工机组,并获得了18项专利。

利用模糊数学理论对光网络中的多故障定位问题进行分析,得到了光网络中多故障定位的模糊聚类模型。根据由模糊聚类算法得到的专家系统和由此确定的告警和故障之间的隶属函数公式进行故障定位。在格状光网络拓扑下进行多故障定位仿真实验,得出故障定位成功率的对比图和时间性能的对比图。实验结果表明,模糊聚类算法可以高效快速地定位故障。

本研究目的在探討不同族群背景、學習風格與STS （ Science / Technology / Society）教學對國中生在自然與生活科技學習成效之影響，並評估其影響效果的關聯強度（ω2）。本研究採問卷調查法，樣本來源以立意抽樣方式取得國中一年級學生354人（中國籍和外國籍新住民子女169人，本國籍185人），同時選取擔任樣本學生班級之自然與生活科技教師44人。研究發現：一、中國籍新住民子女國中生的自然與生活科技學習成績高於本國籍國中生，也高於外國籍新住民子女國中生；族群與自然與生活科技成績僅有微弱的關聯強度；二、學習風格、STS教學與不同族群背景間皆沒有交互作用；三、學習風格與自然與生活科技成績間具有中等關聯強度。 The purpose of this study was to examine with a focus on children of new immigrants, the effects of ethnicity, learning styles, and STS (Science /Technology / Society) instruction on middle school students’ academic performance in natural sciences and technology, and to examine the strength of association (ω2) between the independent and dependent variables. The result revealed that there was no interaction among learning styles, STS instruction and ethnicity. However, there was a significant main effect for learning styles and ethnicity. Interestingly, students with Chinese nationality scored higher on the test of natural science and technology than the native Taiwanese students and foreign students. The strength of association between ethnicity and scores in natural science and technology was low.

本研究旨在探討榮獲教育部教學卓越獎之個案學校⎯⎯大一國小，其整體教師文化的內涵與特質，並深入了解教學卓越獲獎團隊表現與整體學校教師文化及領導人之間的脈絡，從而提出形塑優質學校教師文化之建議。本研究採質性研究方法，以參與觀察、訪談等方法蒐集資料。分析結果發現大一國小教師一向重視校園倫理；而教學卓越獲獎團隊，是以年級教師組成的學年團隊為基礎，多年經營發展而成；學校領導人對學校教師文化的發展有關鍵性的影響；學校中資深老師可發揮典範功能，在形塑優質學校文化上具有重要的地位；教學卓越獲獎團隊的運作，有利帶動學校教師專業合作與教學創新；社區家長的關注與教師間的情誼，均會對學校教師文化發展 產生重要影響。 The main purposes of the study are (1) to explore the factors, patterns, and functions of a distinguished instruction team at Ta-I elementary school, (2) to analyze its teachers’ learning behavior, common values, and interactions, (3) to describe the culture of teaching and learning at the school, (4) to examine the leadership style and related actions of the principal, and (5) to understand the impact of the team spirit on the school culture of teaching and learning. The results show that the principal and senior teachers of the school have been the key to the development of such exceptional school culture. To some extent, the help from parents and the friendship among colleagues have also exerted important influence on the team performance of the teachers.

曹娥江与钱塘江交汇处的曹娥江大闸枢纽工程中的挡潮泄洪闸工作闸门为弧形钢管桁架平面钢闸门,该闸门的构造形式为国内在强涌潮河口地区首次使用,具有自重轻、刚度好、节约钢材等优点,同时容易从潮水带来的泥沙中提升,能有效减弱潮涌冲击力对闸门的影响,闸门外形尺寸大、构件复杂,制作难度大。结合施工难点,介绍了难点解决办法、整个施工流程及质量控制措施,保证了施工质量。

文章用OptiSystem模拟出了利用闲频光实现的全光波长变换。通过调整半导体光放大器（SOA）注入电流、SOA腔长、泵浦光与信号波的频率差、偏振、耦合器信号衰减与泵浦衰减等参数的值,获得了12 dB的变换效率。研究发现,利用闲频光实现的全光波长变换比利用变换光实现的全光波长变换有更好的稳定性。

文章从 ASTN/ASON控制平面的角度 ,重点讨论了层网络 （ LNCP）的基本结构以及各层网络之间客户 /服务的交互通信方式 ,最后 ,还介绍了具有交换能力的 LNCP的连接类型

文章介绍了一款基于国产集成电路的1.25 Gbit/s光收发一体模块的研制。对发光功率的自动控制和消光比自动控制原理进行了计算推理,同时对接收灵敏度的设计进行了讨论。设计出的样品模块经过全面测试,其性能参数完全符合光纤通信的要求,产品可靠性满足工程使用要求。

偏振模色散仿真器是研究偏振模色散的重要工具。文章提出了一种新型的偏振模色散仿真器,并对该仿真器作了理论分析和仿真。理论分析和仿真结果表明:这种新型的偏振模色散仿真器能够产生可调的差分群延时和实现偏振态的各态遍历。

介绍了一种引入超声波研磨光纤连接器的新型研磨方式。对这种实验装置进行了简单的介绍,并将这种研磨的结果和普通研磨的结果进行了对比和分析,结果表明这种研磨方式的研磨效率比普通研磨提高了48倍,平均表面粗糙度

即将商用化的IP多媒体子系统（IMS）的体系结构是基于全IP核心网络架构的,商用化的IMS需要向用户提供高等级的服务质量（QoS）保证。而IMS的QoS很大程度上依赖于IP骨干网。集成模型的通用多协议标签交换（GMPLS）是下一代骨干网的核心技术,它使用流量工程技术可以提供高的QoS。文章主要对IMS利用GMPLS实现高QoS作出了阐述,并对实现方法进行了分析。

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【Objective】In the early stage of the study, the high-efficient and low-fishmeal compound feed developed by our research group showed good application effects in the aquaculture of small-sized Trachinotus ovatus. The study was conducted to further evaluate the application effect of this feed in the aquaculture of large-sized T. ovatus, to provide some references for practical production.【Method】Based on the formula of commercial feed (CK) and high-efficient and low-fishmeal compound feed (test feed), two groups of feed were prepared by feed processing technology and equipment of the enterprise, and large-sized Trachinotus ovatus (125.8 ± 0.70 g) were fed for 95 d. The growth performance, serum biochemical indicators, digestive enzyme activity and muscle quality of each group were compared and analyzed.【Result】There was no significant difference in the growth performance, morphological indicators, serum and liver antioxidant performance indicators, and intestinal digestive enzyme activities between the two groups (P > 0.05). However, the daily feed intake, specific growth rate, daily weight gain rate and weight gain rate of the test group T. ovatus were 2.64%, 1.35%, 2.73%, 247.34%, which were 0.21, 0.03, 0.07, 2.25 percentage point higher than those of the control group, respectively, while the feed coefficient that was 0.03 percentage point lower. The levels of total cholesterol (T-CHO), serum triglyceride(TG), low-density lipoprotein cholesterol(LDL-C) in the test group were 0.88, 0.18, 0.30 mmol/L, which were significantly reduced when compared with the control group, while the HDL-C/LDL-C ratio (102.20%) was significantly increased (P < 0.05). In terms of muscle quality, there was no significant difference in muscle protein and fat content as well as amino acid composition (total amino acids, essential amino acids and flavor amino acids) between the two groups (P > 0.05). However, the test feed significantly improved the texture characteristics of the muscle and increased the EPA level in the muscle. Furthermore, compared with the commercial feed, the cost of the test feed was reduced by 8.65%, and the aquaculture benefit was increased by 17.76%.【Conclusion】In the aquaculture of large-sized T. ovatus, the high-efficient and low-fishmeal compound feed exhibits similar growth-promoting effects as commercial feed, and it helps to reduce blood lipids, lower aquaculture costs, and improve aquaculture benefits. The above results indicate that the high-efficient and low-fishmeal compound feed can be applied in the entire aquaculture cycle of T. ovatus. [ABSTRACT FROM AUTHOR]

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