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为探究加热时间、钢管宽厚比和型钢含钢率等参数对火灾后方钢管型钢混凝土短柱力学性能的影响,对9根未经加热和12根加热不同时间后的短柱进行轴向静力荷载试验。通过分析荷载-轴向应变曲线,讨论了高温后试件的剩余承载力、延性及刚度退化的变化规律,最后提出了常温下方钢管型钢混凝土短柱极限承载力的计算公式。结果表明:所有试件均为鼓曲破坏,鼓曲处混凝土局部发生破碎,但其核心混凝土仍保持为一个整体。试件高温后的剩余承载力随加热时间先小幅增加后稳步下降;其下降幅度随着型钢含钢率的增加而减小,当含钢率接近9%时基本保持不变。延长加热时间可以提高试件的延性,试件加热130 min后延性系数约提高71%。增加内外含钢率比及加热时间能够减缓试件刚度退化的速率。基于提出公式所得的计算承载力与试验结果较为一致,可应用于工程实践。

文章主要讨论了自动交换光网络（ASON）控制平面的两种不同结构:控制平面在网元外部的结构和控制平面部分集成在网元内部的结构,并对这两种结构进行了比较.

【目的】研究心肌缺血状态下HIF-1α的表达规律及其在死亡之后48h的动态变化。【方法】建立SD大鼠急性心肌缺血模型。随机将大鼠分为正常对照组、假手术组、急性心肌缺血试验组和窒息组。用免疫组化、RT-PCR和Western blot检测心肌缺血及死亡后HIF-1α的表达规律。【结果】术后30min缺血心肌中开始出现HIF-1α mRNA表达上调，4～6h达高峰，至术后48h仍维持此高水平；蛋白质的表达相对滞后，于术后2h开始被检测到，之后表达进行性上升，至12h达高峰后维持在高水平；其它各组HIF-1α检测均为阴性。大鼠术后48h处死，死亡后48h内均可检测到HIF-1α mRNA和蛋白质的表达，但表达呈进行性下降趋势；其他各组均未检测到HIF-1α表达。【结论】HIF-1α可作为一个早期心肌缺血的敏感的辅助诊断指标，并用于急性心肌缺血缺氧性死亡和其他原因（例如窒息）缺氧造成的死亡的鉴别。

Urothelial carcinoma (UC), as a common malignant tumor of the urinary system, has an increasing inumber of patients. Some patients have developed into inoperable locally advanced or distant metastatic UC (la/mUC) at the initial treatment. At present, the standard treatment scheme is platinum-based chemotherapy, but the adverse reactions and therapeutic effects are not ideal. In recent years, antibody-drug conjugate combined with immune checkpoint inhibitors has gradually become a new focus of cancer precision medicine research, bringing new treatment options for these patients. Currently, there are many clinical trials in this field, and the purpose of this article was to provide a comprehensive review of the recent research progress. [ABSTRACT FROM AUTHOR]

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肌少症是一种与年龄相关, 以骨骼肌肌量下降和肌力降低为主要特征的全身性疾病。合并肌少症与胰腺 癌患者不良预后密切相关，胰腺癌合并肌少症的发生由炎症反应, 治疗方式, 胰岛素抵抗等多因素综合作用所促 成。胰腺癌合并肌少症会对患者接受手术和化疗造成不良影响，可降低疗效，延长恢复时间。肌少症也是胰腺癌患 者术后复发的重要影响因素。对于合并肌少症的胰腺癌患者，及时诊断并予以营养治疗和运动治疗等对症治疗具 有重要意义。 [ABSTRACT FROM AUTHOR]

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In order to improve the mechanical properties of PBO fiber wet-laid forming mesh, the hot pressing process was used to strengthen it, and the Box-Behnken response surface method was used to establish a response surface model by taking three factors of hot pressing temperature, hot pressing pressure and hot pressing time as independent variables, and taking the fracture strength of PBO fiber wet-laid nonwoven materials as the response value. The results show that the established response surface model is significant and has good fit.The Box-Behnken response surface method can predict the fracture strength of PBO fiber wet-laid nonwoven materials, and conclude that the factors affecting the fracture strength of PBO fiber wet-laid nonwoven materials are hot pressing pressure ＞ hot pressing temperature ＞ hot pressing time.The optimize process parameters of hot pressing are hot pressing temperature 245.6 ℃, hot pressing pressure 8.4 MPa, and hot pressing time 9.3 min.The average breaking strength of PBO fiber wet-laid nonwoven material obtained under this process parameter is 393.9 N. [ABSTRACT FROM AUTHOR]

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