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【目的】探讨采用大剂量甲氨蝶呤(MTX)预防性治疗中枢神经系统白血病(CNSL)对急性淋巴细胞白血病 (ALL)儿童智力与行为的影响。【方法】①按“ 中国-比内智力测验手册” 方法对42 例ALL 患儿在治疗前后与40 例正常儿童 进行测试比较;②根据自制行为量表对ALL 患儿治疗前后进行行为比较。【结果】①ALL 患儿治疗前IQ 、行为与对照组无差 异(P >0.05), 而治疗后IQ 明显低于对照组, (P

【目的】探讨人巨细胞病毒(HCMV)对红系祖细胞(CFU-E)的分化和增殖的影响, 并初步探讨其作用机制。【方 法】取15 例脐血标本, 用红系祖细胞单向半固体培养技术, 观察3 种不同浓度的HCMV AD169 株对CFU-E 集落形成的影 响, 用PCR 和RT-PCR 检测集落中的HCM V DNA 与la te mRNA 。【结果】3 个感染组的CFU-E 均减少, 与正常对照组比较, 分别为11.46%、21.88 %、34.45 %(P

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循环游离ＤＮＡ（ｃｃｆＤＮＡ）是指存在于血液、游离于细胞之外的ＤＮＡ 片段。ｃｃｆＤＮＡ 检测正逐渐成为肿 瘤筛查、早期诊断、预后评估以及抗癌治疗有效性监测的重要方法。通过相对无创方法获得的ｃｃｆＤＮＡ 可代替通 过有创手段获得的结直肠癌（ＣＲＣ）活检标本。ｃｃｆＤＮＡ 作为一种无创潜在肿瘤标志物在ＣＲＣ 早期诊断、疾病进 展、疗效监测中有较高的应用价值。 [ABSTRACT FROM AUTHOR]

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