The bioclastic limestone of Cretaceous Mishrif Formation in M oildeld, Iraq, has strong heterogeneity, and the problem in the process of development is serious. Based on the core observation,cast thin section and experiment data,the heterogeneity genesis was analyzed. The results show that the reservoirs of Mishrif Formation in M oiltield are mainly controlled by sedimentation,bioturbation, diagenesis, and sea level cycles. Sedimentation controls the structural components and original physical properties of rocks, and affects the subsequent diagenetic evolution; bioturbation transforms the rock structure, causes the structure to loosen, and provides seepage channels for diagenetic fluids; diagenesis controls the transformation trend of rocks physical property; sea level cycles cause the change of sediment facies, and control the marine diagenetic environment and meteoric freshwater diagenetic environment. The rocks developed in high-energy sedimentary environment have high content of grain fraction, and the original physical properties are good. During the sea level decline, the upper part ofthe shoal is preferentially leached, while the lower part is strongly cemented, and the reservoir physical properties are polarized, thus high-quality reservoirs are usually associated with physical interlayers. The rocks developed in low-energy sedimentary environment have high content of argillaceous and poor physical properties. However, the bioturbation is widely developed, the physical properties of the burrow are usually higher than that of the substrate. The sea level decline causes the rocks to be in the meteoric freshwater diagenetic environment, and the dissolute fluid can infiltrate the burrows and effectively improve the physical properties. The Mishrif Formation has multiple stages of sea levll cycles, the sedimentary environment evolves rapidly, the diagenetic environment changes continuously, the distribution of biological burrow is random, and reservoirs with different genesis are stacked each ther,whichresultinstrongverticalheterogeneityofthickbioclasticlimestonereservoirs. [ABSTRACT FROM AUTHOR]