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目的探究壮通饮通过Nrf2-SCL7A11/xCT-Gpx4通路调控铁死亡对大脑中动脉栓塞模型小鼠脑缺血再灌注损伤的保护作用及其机制。方法将C57BL/6J小鼠随机分为假手术组（Sham）、模型组（MCAO）、低剂量壮通饮组（ZTY-L+MCAO），高剂量壮通饮组（ZTY-H+MCAO），每组5只。其中MCAO组采用硅胶线栓法进行造模，小鼠大脑中动脉栓塞1h，拔出线栓再灌注72h后进行心脏灌注取脑，Sham组除了不插入线栓其余操作同MCAO组。采用Zea-Longa法对小鼠神经功能进行评分；采用TTC染色评估小鼠脑梗死体积；采用HE染色、尼氏染色评估脑损伤程度；采用普鲁士蓝染色评价三价铁离子蓄积水平；qPCR检测铁离子转运相关载体受体TfR1和DMT1、脂质过氧化相关基因ACSL4以及铁死亡标志物PTGS2 mRNA表达；ELISA试剂盒检测4-HNE的含量评估小鼠大脑脂质过氧化水平；Western-blot、免疫荧光检测小鼠脑组织中Nrf2、SCL7A11/xCT、Gpx4蛋白水平。结果①壮通饮改善了MCAO/R后小鼠神经功能（P＜0.05）和大脑梗死体积（P＜0.05）及缓解MCAO/R后大脑皮层细胞病理损伤。②壮通饮减弱了MCAO/R后小鼠大脑组织的三价铁离子蓄积状态；减少MCAO/R后小鼠大脑中与铁离子转运入细胞内相关载体TfR1和DMT1 mRNA的表达（P＜0.001）；下调MCAO/R后小鼠大脑脂质过氧化物4-HNE含量和组织脂质过氧化物酶ACSL4 mRNA表达（P＜0.001）；降低MCAO/R后小鼠大脑铁死亡标志物PTGS2 mRNA表达（P＜0.001）。③壮通饮增加MCAO/R后Nrf2入核表达（P＜0.001），以及增加xCT和Gpx4在神经元中的表达（P＜0.001）。结论壮通饮能够改善MCAO/R小鼠神经功能和脑梗死体积，缓解大脑皮层细胞病理损伤，影响Nrf2-SCL7A11/xCT-Gpx4通路关键信号分子表达，所以壮通饮改善小鼠MCAO/R损伤的作用机制可能是通过Nrf2-SCL7A11/xCT-Gpx4通路调节铁死亡水平达到的。

随着智能交通系统领域大量移动终端设备的涌现，理解并准确预测移动目标轨迹有助于降低交通事故发生的概率，提高基于位置服务的智能交通应用的质量和水平。主要从数据驱动和行为驱动的角度对移动目标轨迹预测方法进行综述，首先对概率统计、神经网络、深度学习和混合建模等数据驱动方法进行比较；其次对动力学建模和目标意图识别等行为驱动方法的基本概念及研究现状进行概述；然后分别对目标轨迹重建、目标异常行为识别和导航路径规划等轨迹预测应用进行简要叙述；最后讨论了移动目标轨迹预测存在的主要问题以及未来的发展方向。

采用常规直流与柔性直流混合的特高压多端直流输电系统是昆柳龙直流工程技术方案之一，对采用全桥和半桥混合拓扑的特高压柔性直流输电换流器充电时的均压问题进行分析，提出了两种不同的充电策略。研究了混合三端直流系统的启停顺控流程和直流线路瞬时故障穿越、重启策略。在RT-LAB中搭建三端混合直流输电系统，连接外部阀控装置进行实时仿真实验，实验结果验证了提出的充电策略的正确性，表明所提出的直流线路故障穿越和重启策略可以很好地实现系统穿越故障，使系统重新进入稳态。此外，在±10.5 kV/60 MW柔性直流背靠背样机上进行了充电策略验证和直流双极短路故障穿越后重启策略验证，充分验证了采用全半桥混合拓扑柔直系统的故障穿越能力。

针对柔性直流输电系统直流侧故障快速清除的难题，结合南澳多端柔性直流输电工程的实际生产应用需求，提出了一种新型机械式高压直流断路器拓扑方案，研制出了160 kV超快速机械式高压直流断路器产品，提出了一种采用发电机源提供电流来模拟直流故障的开断试验方法，并完成了双向大电流开断试验，开断电流大于9 kA、开断时间小于5 ms。研究并提出了160 kV机械式高压直流断路器工程应用技术方案，并完成南澳加装高压直流断路器示范工程的现场系统调试，试验结果表明其圆满地解决了南澳多端柔性直流系统第三站在线投切和直流线路故障隔离清除的难题，有效地提高了南澳多端柔性直流输电系统的灵活性和可靠性。

为了从高速OTDM（光时分复用）信号中提取出支路时钟并实现解复用,实现高速光信号与相对低速电信号之间的接口,首次展示了一种基于商用的MZM（马赫-曾德调制器）和PolM（偏振调制器）级联的OEO（光电振荡器）实现从2×40GBaud/s OTDM信号中提取支路时钟并同时解复用的实验方案。利用这种改进的OEO,成功地从2×40GBaud/s的OTDM DQPSK（差分四相相移键控）调制格式的高速光信号中提取出了40GHz电时钟,该时钟的相位噪声在10kHz频偏处达到-98.62dBc/Hz,与微波源（Agilent Technologies,E8267D）的相位噪声质量几乎相同。这种OEO还同时实现了从OT-DM信号中解复用出两个支路信号的功能,即将160Gbit/s的PRBS（伪随机二进制序列）OTDM信号成功解复用为两路高质量的80Gbit/s支路信号。

文章介绍了3种十分常用的OFDM-PON（正交频分复用-无源光网络）结构:WDM（波分复用）-OFDM-PON、TDM（时分复用）-OFDM-PON和ECDM（码分复用）-OFDM-PON,并讨论了它们各自在传输速率、接收终端结构和频带利用率等方面的优势。

文章在差集合理论的基础上,给出了满足相关特性的最佳光正交码的约束条件,提出了一种最佳（n,w,1）光正交码的构造方法,并构造出码容量为2的最佳（n,w,1）光正交码码组,最后递归构造出码容量为60的最佳光正交码码组。结果表明,此方法构造的光正交码码组具有较大的码容量和良好的相关特性,有一定的实用性。

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Obinutuzumab is the first humanized, glycosylation-modified type II anti-CD20 monoclonal antibody in the world. Compared with rituximab (type I anti-CD20 monoclonal antibody), obinutuzumab is more effective in the treatment of follicular lymphoma. Clinical trial data have shown a higher incidence of adverse drug reactions related to infusion reactions, thrombocytopenia and neutropenia with the use of otuzumab in the Chinese population. This thesis systematically reviews the common types, mechanisms of related adverse drug reactions, preventive measures and black box warnings of obinutuzumab related adverse drug reactions, with the aim of providing relevant references for safe medication in the real world. [ABSTRACT FROM AUTHOR]

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Objective To investigate the population distribution of non-alcoholic fatty liver disease before and after renaming and the association between the types of metabolic risk factors (MRF) for metabolic dysfunction-associated steatotic liver disease (MASLD) and advanced liver fibrosis. Methods This study was conducted among 515 patients who were admitted to The Affiliated Hospital of Xuzhou Medical University and Wuxi Fifth People’s Hospital from January 2019 to January 2022 and had hepatocyte steatosis ≥5% by liver biopsy. Among these patients, 2 patients did not meet the diagnostic criteria for nonalcoholic fatty liver disease (NAFLD) and metabolic associated fatty liver disease (MAFLD), respectively, and were classified as steatotic liver disease (SLD) with other specific causes, and the other 513 patients were divided into MASLD group with 275 patients, comorbid group with 216 patients (MASLD comorbid with other liver diseases), and cryptogenic SLD group with 22 patients. The above groups were compared in terms of clinical features, laboratory markers, and advanced liver fibrosis. The MASLD patients with different types of MRF were compared in terms of clinical features, laboratory markers, and advanced liver fibrosis, and the risk factors for advanced liver fibrosis in patients with MASLD were analyzed. The Kruskal-Wallis H test was used for comparison of continuous data with skewed distribution between multiple groups and further comparison between two groups； the chi-square test was used for comparison of categorical data between multiple groups, and Bonferroni correction was used for further comparison between two groups. The logistic regression analysis was used to identify the risk factors for liver fibrosis. Results Among the 515 patients with SLD, 297 patients (57.7%) met the diagnostic criteria for NAFLD, among whom 22 were classified as cryptogenic SLD and 275 met the diagnostic criteria for MASLD, and 467 (90.7%) were diagnosed with MAFLD. There were significant differences between the three groups in sex, body mass index (BMI), gamma-glutamyl transpeptidase, triglyceride, cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, fasting plasma glucose, NAFLD fibrosis score (NFS), fibrosis-4 (FIB-4), and F3-4 (all P<0.05). Compared with the MASLD group and the cryptogenic SLD group, the comorbid group had the highest proportion of patients with advanced liver fibrosis (P<0.001) . With the increase in the type of MRF, the patients tended to have an older age, a significantly higher proportion of female patients, a higher possibility of hypertension and diabetes, and higher levels of metabolic parameters including BMI, blood lipids, and blood glucose (all P<0.05) . With the increase in the types of MRF in MASLD patients, they tended to have significantly higher noninvasive fibrosis scores (NFS and FIB-4) and a significantly higher proportion of patients with advanced liver fibrosis (P<0.05). The multivariate logistic regression analysis showed that age ≥50 years (odds ratio [OR] =2.622, 95% confidence interval [CI] : 1.091—6.300, P=0.031) and the increase in the type of MRF (OR=1.876, 95%CI: 1.194—2.947, P=0.006) were independent risk factors for MASLD with severe liver fibrosis. Conclusion The new definition of MASLD is based on the positive identification of MRF, and the reclassified population of MASLD is smaller than that of MAFLD, with little difference from that of NAFLD. In addition, age ≥50 years and the increase in the type of MRF are independent risk factors for MASLD with advanced liver fibrosis. [ABSTRACT FROM AUTHOR]

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Resolution is one of the most important methods for the preparation of optically active compounds. Classic physical resolution via crystallization assisted by chiral resolution reagents can usually provide one compound with highly optical purity. As an important asymmetric synthetic technology, kinetic resolution has become a powerful tool for the construction of multifunctional enantioenriched molecules and has been widely used in the synthesis of drugs and natural products. Therefore, we designed a kinetic resolution experiment based on alkene E→Z isomerization catalyzed by a photoexcited chiral copper complex. This experiment involves substrate synthesis, separation and purification, photocatalytic reaction, kinetic resolution curve drawing and condition verification. Many experimental skills are concerned in this experiment, including column chromatography separation, (preparative) thin layer chromatography (TLC), gas chromatography (GC) and chiral high-performance liquid chromatography (HPLC), which can not only exercise students' comprehensive experimental skills, but also let students feel the advantages of kinetic resolution, photocatalysis and excited transition metal catalysis technologies. The experiment is designed reasonably with strong operability and high safety. It lasts 24 hours in total, including three one-day individual experiments. It is very suitable for the courses of organic chemistry experiment or comprehensive chemistry experiment. [ABSTRACT FROM AUTHOR]

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