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将快速非支配排序遗传算法和粗粒度-主从式并行遗传算法相结合，提出一种多目标并行遗传算法。该算法在同步优化消能减震结构上阻尼器的布置数量和布置位置时，既能多目标优化，又能并行运算，提高计算效率。采用该算法，以最大层间位移角和最大楼层加速度为多目标函数，优化一个14层钢框架结构上阻尼器的布置数量和布置位置。优化结果表明：该算法是逐渐收敛，具备较强收敛性；该算法优化结果适用于不同地震波，层间位移角减震系数最小为20.66%，加速度减震系数最小为18.35%；对于消能减震结构，综合考虑最大层间位移角和最大楼层加速度的影响时，建议阻尼器主要布置在结构中下部，且中部布置得要较多。

Copyright of Journal of Shaanxi University of Science & Technology is the property of Journal of Shaanxi University of Science & Technology Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Nonalcoholic fatty liver disease （NAFLD） has become the most common liver disease in the world and is an important risk factor for the progression to hepatocellular carcinoma. However, the pathogenesis of NAFLD remains unclear, and there is still a lack of specific treatment measures. Sterol regulatory element-binding proteins （SREBP） are an important nuclear transcription factor, which mainly maintains the balance of lipid metabolism inside the body by activating the genes associated with the synthesis and uptake of cholesterol, fatty acids, and triglycerides, and therefore, SREBP are a target for the treatment of metabolic diseases. This article reviews the latest advances in SREBP in the pathogenesis of NAFLD and the latest evidence of SREBP-targeted therapy for NAFLD. It is worth noting that recent studies have shown that SREBP inhibition can cause liver injury together with autophagy damage. Therefore, excessive inhibition of lipogenesis may exert a counterproductive effect on the treatment of NAFLD. In conclusion, SREBP is a promising therapeutic target for NAFLD； the molecular mechanism of SREBP in lipid metabolism is regulated by many factors, and these factors are being deeply explored and analyzed, which has an important clinical significance for the treatment of NAFLD. [ABSTRACT FROM AUTHOR]

Copyright of China Pulp & Paper is the property of China Pulp & Paper Magazines Publisher and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Educational Science of Hunan Normal University is the property of Hunan Normal University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Metabolic associated fatty liver disease (MAFLD) is considered a multisystem disease that can lead to multiple extrahepatic complications, among which cardiovascular disease (CVD) is the most common cause of death in MAFLD patients. MAFLD and its complications share many common metabolic risk factors, which increase the susceptibility to diabetes, hypertension, atherosclerosis, and venous thrombosis through the mechanisms such as inflammation, endothelial dysfunction, oxidative stress, insulin resistance, and abnormal lipid metabolism, and there is a complex interaction between such factors and the pathology of MAFLD, thereby promoting the occurrence of each other. During the progression of MAFLD, there might be changes in various parts of the liver microvasculature, resulting in hepatic microcirculation disturbance, and intrahepatic microvascular disturbance and microcirculation dysfunction are the key to the progression of extrahepatic complications, but MAFLD has not yet been taken seriously like other traditional risk factors. An in-depth understanding of the association between pathological changes of the microvasculature and microcirculation disturbance in MAFLD will help with the mechanism research and treatment of the extrahepatic complications of MAFLD, and more importantly, help MAFLD patients pay more attention to healthcare outside the liver. [ABSTRACT FROM AUTHOR]

Based on the GlobeLand30 data in 2000, 2010 and 2020, the artificial surface expansion of South Asian countries during 2000-2010 and 2010-2020 was analyzed by using the spatial scanning statistics, landscape expansion index as well as Lorenz curve. By combining the spatial distribution pattern of the artificial surface with evolution process, we investigated the spatio-temporal variation and spatial structure of artificial surface in South Asia. Results showed that: 1) The overall artificial surface area of South Asia continues to expand, with the expansion rate increasing from 0. 42% in 2000-2010 to 2. 59% in 2010-2020. 2) India has seen the largest increase in artificial surface area over the past 20 years, with Bhutan expanding at the fastest rate. In the process of artificial surface expansion in South Asia, there are significant spatial hot spots, and the spatial hot spots migrate at different time periods. 3) In western Pakistan, central Sri Lanka, northwestern Bangladesh, and eastern and southern India, enclave type patches have increased, and the artificial surface shows the characteristics of scattered and disordered diffusion expansion. The new patch types in northern India, eastern Sri Lanka and southeastern Bangladesh shift from enclave type to infilling and edge-expansion type, showing a pattern of change from diffusion to dense aggregation type. 4) The expansion of artificial surface in South Asian countries differs greatly on the scales of cities, which leads to obvious imbalances in the expansion of artificial surface. [ABSTRACT FROM AUTHOR]

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Evaluation & Analysis of Drug-Use in Hospitals of China is the property of Evaluation & Analysis of Drug-Use in Hospitals of China Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)