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To explore the role of RYBP in activating PARP-1 dependent Parthanatos and promoting response to YM155 in esophageal squamous cell carcinoma. Methods CCK-8 and flow cytometry were used to analyze the inhibition ratio and cell death percentage after YM155 treatment in both RYBP overexpression group and control group. Western blotting was used to detect the expression of Parthanatos-related proteins. Results Compared with control group, RYBP overexpression group showed higher inhibition ratio and cell death percentage after YM155 treatment. Overexpression of RYBP activated PARP-1 with or without YM155 treatment. Besides, after YM155 treatment, KYSE170-RYBP showed more PAR accumulation in the nucleus, AIF translocation from mitochondria to the nucleus than control cells. Conclusion RYBP can activate PARP-1/PAR/ AIF-dependent induced Parthanatos in esophageal squamous cell carcinoma and enhance response to YM155. [ABSTRACT FROM AUTHOR]

肾小球疾病是一组以血尿、蛋白尿、水肿、高血压和不同程度的肾功能损害等为临床表现的肾脏疾病，其 中以 IgA 肾病（IgAN)、特发性膜性肾病（IMN)、狼疮性肾炎（LN)、糖尿病肾病（DKD）多见。雷公藤多甙是从卫矛科 植物雷公藤根中提取精制而成的一种脂溶性混合物，具有抗炎、改善氧化应激、保护足细胞、减轻肾损伤等作用，被 称为“中草药激素”。在 IgA 肾病治疗中，雷公藤多甙能抑制体内 IgA 的生成及在肾组织的沉积，从而提高疾病缓解 率和改善肾功能。雷公藤多甙可以显著降低炎性细胞因子的产生，改善氧化应激，减轻炎症反应，在 IMN 治疗中联 合免疫抑制剂或激素治疗过程中获得较高的疾病缓解率。雷公藤还可以抑制雌激素发挥作用，在活动期或难治 性 LN 的治疗中常与激素和免疫抑制剂等联合使用，既可有效地改善患者的肾功能，又降低药物不良反应。另外雷 公藤多甙还能通过抑制炎症保护足细胞，减轻肾小球硬化，延缓肾损伤，在表现为大量蛋白尿的 DKD 患者治疗中应 用广泛。 [ABSTRACT FROM AUTHOR]