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Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Platelet-rich plasma can promote the repair and regeneration of intervertebral disc tissue. Percutaneous transforaminal endoscopic discectomy is widely used in the treatment of lumbar disc herniation. In recent years, more and more scholars have focused on the combined treatment of lumbar disc herniation with the two techniques in order to achieve a better patient prognosis. OBJECTIVE: To investigate the clinical safety and effectiveness of percutaneous transforaminal endoscopic discectomy combined with platelet-rich plasma in the treatment of lumbar disc herniation. METHODS: The clinical data of 58 patients with lumbar disc herniation who met the inclusion and exclusion criteria at Sixth Medical Center of PLA General Hospital from June 2017 to May 2018 were retrospectively analyzed. Among them, 29 patients underwent percutaneous transforaminal endoscopic discectomy combined with platelet-rich plasma (observation group), and the remaining 29 patients underwent percutaneous transforaminal endoscopic discectomy only (control group). Visual Analogue Scale score for back and leg pain, lumbar JOA score, and Oswestry Disability Index were evaluated preoperatively, at 3, 6, and 12 months postoperatively, and at the last follow-up. Intervertebral space height, nucleus pulposus to cerebrospinal fluid signal strength ratio, and intervertebral disc Pfirrmann grading were measured preoperatively, at 6 and 12 months postoperatively, and at the last follow-up. The modified MacNab criteria were used to assess excellent and good rate of curative effect at the last follow-up. RESULTS AND CONCLUSION: (1) The Visual Analogue Scale score for back and leg pain, JOA score, and Oswestry Disability Index of the two groups postoperatively were significantly improved compared with those preoperatively (P < 0.05). Visual Analogue Scale score and Oswestry Disability Index were lower in the observation group than those in the control group at 3 and 6 months postoperatively (P < 0.05). The JOA score was higher in the observation group than that in the control group at 3 and 6 months postoperatively (P < 0.05). (2) The nucleus pulposus to cerebrospinal fluid signal strength ratio was higher in the observation group than that in the control group at the last follow-up (P < 0.05). Pfirrmann grading of the intervertebral discs was better in the observation group than that in the control group (P < 0.05). The excellent and good rate was 93% in the observation group and 83% in the control group, and the difference was not statistically significant (P > 0.05). (3) These findings indicate that percutaneous transforaminal endoscopic discectomy combined with platelet-rich plasma in the treatment of lumbar disc herniation has satisfactory clinical efficacy and can delay the degeneration of the intervertebral disc to a certain extent. [ABSTRACT FROM AUTHOR]

Copyright of Science Technology & Engineering is the property of Chinese Society of Technology Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Immune mechanism plays an important role in the occurrence and development of lumbar discogenic neuralgia. Platelet-rich plasma is one of the effective means for the treatment of lumbar degenerative diseases such as lumbar discogenic neuralgia. Exploring the expression of immune complex of lumbar discogenic neuralgia and the therapeutic mechanism of platelet-rich plasma can provide new ideas for the prevention and timely treatment of neuralgia secondary to disc degeneration. OBJECTIVE: To review the immune mechanism of lumbar discogenic neuralgia and the therapeutic mechanism of platelet-rich plasma, and make a prospect. METHODS: PubMed database, CNKI database and VIP database were searched. The English and Chinese search terms were “disc degeneration, lumbar discogenic neuralgia, lumbar discogenic sciatica, sciatica, PRP, platelet rich plasma, immunological response”. After preliminary screening of all articles according to inclusion and exclusion criteria, 86 articles were finally included for review. RESULTS AND CONCLUSION: The role of immune mechanism in lumbar intervertebral disc degeneration has been extensively studied, and it plays a key role in the generation and development of lumbar discogenic neuralgia. Various immune inflammatory factors are the key mediators leading to nerve root pain. The treatment of lumbar discogenic neuralgia by platelet-rich plasma is mainly based on its rich growth factors, including anti-inflammatory and neuroprotection, immunomodulation, Schwann cell activation and axon regeneration, intervertebral disc degeneration repairing and angiogenesis. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)