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Aiming at the problem that the construction cost risk of feed plant is not easy to accurately define, starting from the 12 key influencing factors of cost risk at four levels of feed plant site selection, feed processing and production, feed logistics and transportation, and feed plant operation and maintenance, the fuzzy analytic hierarchy analysis method combining the analytic hierarchy method and the fuzzy comprehensive evaluation method is used to establish a fuzzy analytic hierarchy model to calculate the risk level, size and factor weight of the feed plant construction cost, and a cost risk analysis method combining qualitative analysis and quantitative analysis of the whole process is proposed. The results obtained are quantitative and intuitive, and the examples verify that the method is simple and feasible, and the conclusion is in line with reality, that is, it provides a more objective judgment idea for the cost control of feed plant construction. [ABSTRACT FROM AUTHOR]

目的　观察三阴性乳腺癌 (TNBC)组织微小 RNA-495 (miR-495)、高迁移率族蛋白 A2 (HMGA2)表达变 化, 并探讨二者表达变化与患者临床病理特征和预后的关系。方法　选择TNBC患者83例, 取术中切除的乳腺癌组 织及其配对的癌旁正常组织, 采用 RT-qPCR法检测 miR-495、HMGA2 mRNA 表达。比较乳腺癌组织与癌旁正常组 织miR-495、HMGA2 mRNA表达, 分析乳腺癌组织miR-495表达与HMGA2 mRNA表达的关系以及二者表达与患者临 床病理特征和预后的关系。结果　乳腺癌组织miR-495相对表达量低于癌旁正常组织, HMGA2 mRNA相对表达量高 于癌旁正常组织 (t分别为17. 103、－5. 428, P均<0. 05)。乳腺癌组织miR-495相对表达量与HMGA2 mRNA相对表 达量呈负相关关系 (r=－0. 503, P<0. 01)。乳腺癌组织miR-495、HMGA2 mRNA表达与肿瘤直径、临床分期、淋巴结 转移有关 (P 均<0. 05), 而与年龄、月经状态、病理类型、组织分化程度无关 (P 均>0. 05)。以乳腺癌组织 miR-495、 HMGA2 mRNA 相对表达量的均值为临界值, 将患者分为 miR-495高表达者 44例与低表达者 39例, HMGA2 mRNA 高表达者38例与低表达者45例。生存分析发现, miR-495低表达者与高表达者术后3年累积生存率分别为69. 2%、 88. 6%, miR-495低表达者术后3年累积生存率低于其高表达者 (Log-rank χ² =4. 780, P<0. 05)；HMGA2 mRNA低表达 者与高表达者术后3年累积生存率分别为91. 1%、65. 8%, HMGA2 mRNA低表达者术后3年累积生存率高于其高表 达者 (Log-rank χ2 =8. 111, P<0. 05)。结论 TNBC组织miR-495低表达、HMGA2高表达, 二者表达变化与肿瘤直径、 临床分期、淋巴结转移等临床病理特征以及患者预后密切相关。 [ABSTRACT FROM AUTHOR]

With the increasing penetration of new energy, the role of microgrids in the operation control of distributed energy resources (DERs) has become increasingly prominent, but the access of distributed energy will also bring disturbance to the operation of microgrids. Therefore, a two-level decentralized coordinated control scheme based on multi-agent system (MAS) was proposed to ensure the high security and stability of microgrid. The upper agent was based on Petri-net (PN). According to the different working modes of various energy sources, the PN model of DERs was constructed, and the coordination logic control instruction set was designed based on the PN model. The optimal coordination logic control instruction was selected by mesh adaptive direct search filter algorithm (MADSFA). The lower agent was responsible for local continuous control, and different droop control strategies were adopted for inverters with different power characteristics DERs. In order to ensure the stability of the microgrid under transient and steady states, a preset performance controller was added between the inverter and the droop controller to ensure that the output power error of the inverter can be stabilized within the preset error range whether in transient or steady state. At the same time, in order to improve the stability of the microgrid system, the interaction between the two layers adopts the communication mode of master-slave and non-fixed master-slave combination. This interaction mechanism improves the timeliness and flexibility of MAS in the real-time monitoring process of the system. Finally, the simulation results verify the effectiveness of the two-level decentralized coordinated control strategy based on MAS. [ABSTRACT FROM AUTHOR]

The content of key components（humic acid and fulvic acid） in river mud to a certain extent affects the quality of river mud used for the production of gambiered Guangdong silk, so it is necessary to determine the content of humic acid and fulvic acid in river mud. The commonly used quantitative methods for humic acid and fulvic acid are complex or have limitations, so this study attempts to use new methods for quantification.Under alkaline conditions, phenolic substances in the Folin-Ciocalten reagent will reduce Mo6+and W6+, resulting in a blue color. The depth of the color is proportional to the concentration of the reactive phenolic substances. Finally, its content can be indirectly determined by testing its absorbance. Therefore, this study first determined the testing wavelength through UV-VIS spectroscopy, and then explored the optimal process conditions for the reaction, including factors such as the amount of Folin-Ciocalten reagent and sodium carbonate solution, reaction temperature, reaction time, and the use of ultrasound. Then, under the optimal conditions, the standard curve of humic acid and fulvic acid purification product was determined, and finally, the stability, repeatability, and spiked recovery rate of this method were evaluated, in order to conduct a simple and rapid quantitative detection of the key components of river mud used in the production of gambiered Guangdong silk.According to the UV-VIS spectrum, under alkaline conditions, the Folin-Ciocalten reagent has a maximum absorption peak at 760 nm after reacting with river mud or standard solution, and there is no peak before the reaction. When the dosage of Folin-Ciocaltenl is below 1.0 mL, the absorbance increases significantly with the increase of Folin-Ciocalten dosage, while when the dosage of Folin-Ciocalten is above 1.0 mL, the absorbance remains stable and no longer increases. As the concentration of sodium carbonate increases, the absorbance shows a trend of first increasing and then decreasing. When the concentration of sodium carbonate in the total solution is 18 mg/mL, the absorbance value is the highest. Under ultrasonic treatment at 40 ℃ and 40 kHz, the reactants in the river mud are more completely extracted, and the absorbance value at stability is significantly increased. The reaction rate is accelerated, and the time required for absorbance to reach stability is one hour. When the standard concentration ranges from 0.12 to 0.30 mg/mL, the fitting equation is Y=1.304 76X+0.269 43, and the correlation coefficient R~2=0.998 34. After testing, the stability and repeatability of this method are good, with RSD values of 0.68% and 1.43%, respectively. The average spiked recovery rate is 102.96%, and RSD is 3.41%. With this method, the total content of humic acid and fulvic acid in the river mud of Shunde, Xiqiao, and Xiasha is measured to be 9.64%, 5.61%, and 1.88%, respectively. There are still a small amount of humic acid and fulvic acid in humin and other insoluble substances that cannot be removed, accounting for 1.97%, 1.76%, and 1.36%, respectively in the river mud of Shunde, Xiqiao, and Xiasha.This study explores the method and reaction conditions for quantitative detection of key components in river mud based on the Folin-Ciocalten method. The results show that the optimal reaction conditions for testing 10.0 mg of river mud are: 1.0 mL 1 mol/L Folin-Ciocalten, 0.6 mL 150 mg/mL sodium carbonate solution, 3.4 mL deionized water, 40 kHz ultrasound treatment at 40 ℃ for 60 minutes, and testing at 760 nm in the UV visible spectrum. Within a certain concentration range of standard substances, the correlation between concentration and absorbance is good. By testing the stability, repeatability, and spiked recovery rate of this method, it is determined that it is scientifically feasible. The total content of humic acid and fulvic acid in the mud of Shunde, Xiqiao, and Xiasha River in Foshan is measured by this method, and it is similar to the content of the actually extracted humic acid and fulvic acid. [ABSTRACT FROM AUTHOR]

目的:调查和分析免疫检查点抑制剂在儿童患者应用中的不良反应。 方法:回顾性调查 2019 年 1 月 1 日至 2022 年 9 月 15 日于该院接受程序性死亡受体 1(PD-1) / 程序性死亡受体配体 1(PD-L1)抑制剂治疗各类恶性实体肿瘤和血液系统肿瘤的 25 例儿童患者(<18 周岁)病历(共 137 次入院记录),记录患儿接受治疗期间发生的所有不良反应信息,并进行严重程度分级、相 关性评价和影响因素分析。 结果:25 例使用 PD-1/ PD-L1 抑制剂的患儿中,16 例患儿合计发生 20 次不良反应。 患儿发生的不良 反应主要为发热(8 例,发生率为 32%)、氨基转移酶升高(3 例,发生率为 12%)和凝血功能障碍(2 例,发生率为 8%),此外还有白 细胞计数降低、咳嗽、皮疹、腹泻、便潜血、乏力及食欲减退(各 1 例,发生率均为 4%)等;其中,1—2 级不良反应 19 次,3—5 级不良 反应共 1 次;相关性为“很可能”的不良反应共 15 次。 4 例患儿在发生不良反应后再次接受治疗,有 2 例出现了新的不良反应。 经分析,并发症涉及 3 个及以上系统对不良反应的发生率有显著影响。 结论:儿童患者使用 PD-1/ PD-L1 抑制剂时,其不良反应 发生情况与成人有所差异,较成人而言需要更多关注。 临床需注意用药监护,提高儿童用药的安全性。 [ABSTRACT FROM AUTHOR]

Grain is the foundation of survival. In order to improve the timeliness of crop production and transportation, a kind of screw conveyor with parabolic blade was designed. Discrete element method (DEM) particle system simulation was used to explore the motion law of rice seeds transported by screw conveyor. Improve the discharge rate of rice seeds and reduce the blade consumption. A Hertz-Mindlin contact model was established to analyze the transport and contact characteristics of rice seeds under three helical angles and different helical speeds by comparing the ordinary straight generatrix blades. The results show that the parabolic generatrix blades express the kinetic energy change of rice seeds into three working stages: accelerated feeding, stable conveying and high-speed discharging, and the rice seeds also have different frequency and amplitude of circumferential motion while advancing along the axial direction of the screw. At the same speed, the highest discharge rate of 82. 3 g / s is achieved for 0° inclined angle parabolic generatrix blades stabilized transport of rice seeds at 600 r/ min, but the phenomenon of rice seed reflux is more obvious at 90° inclined angle, and the average discharge rate is reduced by 77. 8%. At the same inclination angle, the normal overlap of rice seeds at 45° with a high speed parabolic generatrix blades at 1 800 r/ min is reduced by a maximum of 10. 2% compare to straight generatrix blades. The average contact number of rice seeds in parabolic generatrix blades is 1. 3% less than straight generatrix blades at 1 300 ~ 1 800 r/ min of 90° inclined angle, which reduces the degree of blade abrasion during transportation. The research reveal the transport law of rice seeds, which can provide a theoretical basis for the mechanized and efficient transportation of screw conveyor. [ABSTRACT FROM AUTHOR]

Accurate prediction of wind speed in extreme weather can provide important guidance for distribution network to enhance disaster prevention and resilience. This paper proposes a method based on Temporal Convolutional Network (TCN), Bi-directional Long Short-Term Memory(BiLSTM)and error correction for wind speed prediction in extreme weather. First, the time series characteristics of multi-feature weather data are extracted by TCN, and then input into BiLSTM for wind speed prediction. To further improve the prediction accuracy, Variational Mode Decomposition (VMD) is introduced to decompose the error sequence, and BiLSTM models are constructed to perform error prediction for the decomposed error subsequences respectively. Then the error prediction value is used to correct the wind speed prediction value. Finally, simulations are carried out for a place of Henan province, and the results show that compared with measured weather data, the proposed method can effectively predict wind speed with high accuracy when extreme weather occurs. [ABSTRACT FROM AUTHOR]

BACKGROUND: Regulating ferroptosis by targeting iron overload genes may be a fast and effective way to delay the degeneration of osteoarthritis. However, the molecular mechanisms and gene targets related to ferroptosis in osteoarthritis are still unclear. OBJECTIVE: To analyze the key genes and pathways of ferroptosis in osteoarthritis by bioinformatics analysis, verify the marker genes of ferroptosis in combination with in vitro experiments, and explore the potential role of ferroptosis in osteoarthritis. METHODS: “Osteoarthritis” was used as a keyword. Relevant public data from the GEO database between January 1, 2010 and January 1, 2021 were retrieved. A gene microarray dataset GSE55235 was yielded and differentially expressed genes were identified after data correction analysis of the GSE55235 data set. Ferroptosis-related genes retrieved by the FerrDb database were intersected with differentially expressed genes in the GSE55235 dataset, and th intersected genes were used for Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis and the protein-protein interaction network was mapped. Ferroptosis-related HUB genes in osteoarthritis were obtained and ferroptosis marker genes were then selected. Human chondrocytes were divided into control group (normal human chondrocytes) and experimental group (cellular osteoarthritic model). The mRNA expression of ferroptosis marker genes in the two groups was detected by quantitative real-time fluorescence PCR. RESULTS AND CONCLUSION: A total of 36 ferroptosis-related genes in osteoarthritis were obtained. Gene Ontology enrichment analysis showed that these differentially expressed genes were mainly involved in oxidative stress, corticosteroids response, steroid hormone response, glucocorticoid response, and reactive oxygen metabolism, and play a role in NAD(P)H oxidase and oxidoreductase activity, heme binding, and tetrapyrrole binding that produce superoxides. Kyoto Encyclopedia of Genes and Genomes enrichment analysis showed that ferroptosis-related genes in osteoarthritis were mainly involved in NOD-like receptor, interleukin-17, hypoxia-inducible factor-1, tumor necrosis factor, fork head box transcription factor class O. After constructing the protein-protein interaction network, ferroptosis-related HUB genes, including vascular endothelial growth factor A, interleukin-6, JUN, PTGS2, DUSP1, were identified. Four ferroptosis marker genes, including vascular endothelial growth factor A, interleukin-6, PTGS2, and DUSP1, were selected. In vitro experiments confirmed significant differences between the control and experimental groups (P < 0.05). The overall findings indicate that ferroptosis may act on osteoarthritis through oxidative stress, redox and induced inflammation, which may be related to NAD(P) H stimulation by signaling pathway such as hypoxia-inducible factor 1. Vascular endothelial growth factor A, interleukin-6, PTGS2, and DUSP1 can be used as biomarkers of ferroptosis in osteoarthritis. [ABSTRACT FROM AUTHOR]

Objective To observe the effect of proprioceptive neuromuscular promotion(PNF) technology combined with functional electrical stimulation treadmill(FES-cycling) on upper limb function in stroke patients. Methods A total of 60 stroke patients receiving treatment in the Rehabilitation Department of this hospital were selected and divided into PNF group(group A),FES-cycling group(group B) and PNF combined with FES-cycling group(group C) according to random number table method, with 20 cases in each group. The patients were treated for four weeks. The muscle tone, motor function and activities of daily living(ADL) of the upper limbs of the three groups were evaluated before treatment, after treatment and during follow-up. Results After treatment and at follow-up, the scores of modified Ashworth scale(MAS) in the three groups was significantly lower than those before treatment, and those in group C were significantly lower than those in group A and B,with statistical significance(P<0. 05). The scores of Fugl-Meyer motor function rating scale(FMA) and Modified Barbi index(MBI) in the three groups were significantly higher than those before treatment, and the scores of FMA and MBI in the group C were significantly higher than those in the group A and group B,with statistical significance(P<0. 05). Conclusion PNF combined with FES-cycling can significantly improve the spasticity of the upper limb in stroke patients and improve the limb motor function and ADL. [ABSTRACT FROM AUTHOR]

The pH of the environment where the fungus is located has been constantly changing, which exert important impacts on the growth and development of the fungi. In order to adapt the ever-changing environment, fungi have evolved a pH-response signal pathway (the Pal pathway), in which pacC acts as a key regulator. The function and application of TvPacC gene in Trichoderma viride Tv-1511 was analyzed, including alkaline stress resistance and alkaline protease production, by constructions of the deletion mutants (Tv-1511-△TvPacC) of TvPacC in Tv-1511 using fusion PCR technology combined with protoplast transformation method. The results show that compared with wild-type Tv-1511, Tv-1511-△TvPacC strains obtains the improved adaptability of Tv-1511 to alkaline environment. Moreover, the deletion of TvPacC resulted in the elevated production and activity of alkaline protease. In all, TvPacC gene plays important roles in the alkaline stress tolerance and alkaline protease production. [ABSTRACT FROM AUTHOR]

The abuse of pesticides and chemical fertilizers poses a great threat to human health and living environment. It is very necessary to develop new fertilizers that can reduce the amount of chemical fertilizers and meet the sustainable development of agricul-ture. Trichoderma as a conunon functional microorganism of new fertilizer, has a wide range of applications in the field of agriculture. Among many mechanisms of promoting growth and disease prevention, it is an important way for Trichoderma to promote plant growth by producing indole-3-actsic acid ( IAA ). In order to further enhance the growth promoting effect and disease resistance of Trichoderma wide, the TvTRPS gene encoding tryptophan synthase (TRPS) and the TvTDC gene encoding L-tryptophan decarboxylase (TDC) were identified and cloned in Trichoderma viride Tv-1511, constructed the engineering strain of Trichoderma viride ovenspressing TvTRPS and TvTDC, and evaluated their effects on stress tolerance, IAA pnaluetion and plant growth promotion. The results show that Tri-choderma viride engineering strains overezpressing TvTRPS and TvTDC have the improved ability to synthesize IAA, as well as have stronger stress tolerance and growth promotion ability, which lays a foundation for the further application of Trichoderma viride in agri-cultural production. [ABSTRACT FROM AUTHOR]

Ankylosing spondylitis is a common and frequent clinical disease, which is highly susceptible to progressive degeneration of the spinal joints and the occurrence of fragility fractures, causing serious impact on the physical and mental health and quality of life of the patients. As a major complication of ankylosing spondylitis, osteoporosis is essentially an imbalance of bone metabolism caused by disorders of the body's internal environment, with immune disorders and hormonal imbalances involved in its pathogenesis. Exploration of the mechanism of osteoporosis secondary to ankylosing spondylitis at the molecular biology level provides a theoretical basis for clinical treatment of ankylosing spondylitis with active anti-osteoporosis therapy. [ABSTRACT FROM AUTHOR]

Simple firework algorithms get local optimal solutions easily and converge slowly, this paper adjusts the algorithm accordingly. Firstly, redefine the explosion operator by the aid of μ-law where the fitness value is converted to the degree of fitness, and the aberrance scope can be adjusted by the value of μ and the scaling factor. At the same time, the mapping strategy based on information exchange is used to enhance the search efficiency. In this paper, 12 general benchmark functions are used to compare the μFWA algorithm with other four algorithms. The experimental results show that the μFWA algorithm can obtain ideal results in the optimization of unimodal function and multimodal function which means that the algorithm can balance global search and local search well, and the convergence speed of the algorithm is improved obviously. [ABSTRACT FROM AUTHOR]

Based on our in-house aluminum nitride ( AlN) crystal growth reactor, growth characteristics and material characterization of homoepitaxial AlN growth on Al-polar AlN seeds under four different growth conditions by PVT method were investigated in detail. The results show that small tensile stresses exist in all crystals grown under four growth conditions revealed by Raman spectroscopy. When the temperature of the crucible top is 2 210 ℃, the temperature difference between the crucible bottom and top is 42 ℃, the AlN crystal is grown under a low supersaturation condition with a step-flow growth mode. And the as-grown crystal has smooth surfaces with typical AlN growth habits. The initial expansion angle of the crystal growth is larger than 40°, which indicates that quick diameter expansion is possible for AlN crystal growth. The high quality of the obtained crystals is confirmed by the rocking curves of 0002, 1012 reflections with high-resolution X-ray diffraction and Raman spectroscopy. Finally, an AlN crystal up to 45 mm to 47 mm in diameter is homoepitaxially grown successfully under the optimized growth conditions, and characterization results confirm its excellent quality and crystallinity. [ABSTRACT FROM AUTHOR]

In view of the self-supplying problem of the real-time monitoring system of railway vehicle axle temperature, this study proposes a new type of double-degree-of-freedom vibration energy harvester of railway vehicle axle box with suspended magnet structure. The proposed harvester can be used to convert the vibration energy existing in the working environment of the vehicle axle box into electrical energy. Based on the mechanical lumped system model and the electromechanical coupling model, the finite element model of the double-degree-of-freedom vibration energy harvester is constructed through multi-physics coupling. A new type of suspension magnet structure is designed by adding the inner ring radiating magnetizing magnet, and the output characteristics of the vibration energy harvester under harmonic excitation are studied. Compared with the copper block-permanent magnet composite suspension magnet structure, the output performance of the proposed structure is increased by 165%. The peak output current of the energy harvester system is 63.0 mA and the peak power is 13.22 mW. This research provides theoretical guidance for improving the response characteristics and output performance of the magnetic levitation vibration energy harvester. [ABSTRACT FROM AUTHOR]

Introduced the application of beneficial bacteria in aquaculture water, which can effectively reduce the content of toxic substances such 血 ammonia nitrogen，nitrite rdtrogen and hydrogen sulfide in aquaculture water, improve the water environment, and benefit the growth of aquatic organisms・ Compared with other water purification methods, it has the advantages of long-term stability and high efficiency・ The combination of beneficial bacteria and immobilization technology or anaerobic aerobic process was introduced, which made up for the shortcomings of traditional bioremediation method, greatly improved its degradation efficiency and saved investment ・ The development advantages of several beneficial bacteria in aquaculture water were summarized，and the application of beneficial bacteria in future clean aquaculture water was prospected. [ABSTRACT FROM AUTHOR]

Tetrahydro-5-(2-hydroxyethyl) -1, 3, 5-triazine-2 (1H) -thione (THTT) was synthesized from thiourea, formaldehyde and ethanolamine・ THTT is compounded with zinc dihydrogen phosphate and PBTCA to obtain THTT・3，a good antioxidant and corrosion inhibitor. Use the static weight loss to study the corrosion inhibition performance of THTT and THTT-3 ・ The results showed that when the concentration of THTT and THTT-3 is 100 mg/L at 50 °C, the corrosion rate of Q235A steel in the corrosion solution are 0. 038 1 mm/a and 0. 020 1 mm/a, which shows that THTT, zinc dihydrogen phosphate and PBTCA have good corrosion inhibition synergistic effects・ The electrochemical workstation was used to analyze the polarization curve and impedance spectrum of THTT・3，and the polarization curve change rule indicated that the corrosion inhibitor is a mixed type corrosion inhibitor that mainly inhibits the anode・ EIS shows that as the concentration of corrosion inhibitor increases, the corrosion inhibitory effect gradually increases ・ The dissolved oxygen curve shows that the corrosion inhibitor slows down the consumption of dissolved oxygen in the system. [ABSTRACT FROM AUTHOR]

目的 探讨Treg细胞、Th17细胞在成人原发性免疫性血小板减少症（ITP）中的变化及其意义。方法 选 取80例成人原发性ITP患者为病例组，另选取同期入院体检的80例健康者作为对照组。病例组给予一线的糖皮质 激素治疗，4周后评估疗效（完全反应、有效、无效）。采用流式细胞仪测定两组外周血Treg细胞、Th17细胞百分比， 计算 Treg/Th17，通过绘制受试者工作特征（ROC）曲线分析其对成人原发性 ITP 的诊断效能。结果 与对照组相 比，病例组外周血Treg细胞百分比降低，Th17细胞百分比升高，Treg/Th17降低（P均<0. 05）。与治疗前相比，病例组 治疗后外周血Treg细胞百分比高，Th17细胞百分比低，Treg/Th17高（P均<0. 05）。治疗后，完全反应、有效、无效者 组间外周血 Treg、Th17 细胞百分比及 Treg/Th17 比较差异有统计学意义（P<0. 05）。当外周血 Treg 细胞百分比取 4. 740% 时，诊断 ITP 的 ROC 曲线下面积（AUC）为 0. 804，灵敏度为 76. 3%，特异度为 77. 5%；当 Th17 细胞百分比取 1. 775% 时，诊断 ITP的 AUC 为 0. 872，灵敏度为 87. 5%，特异度为 78. 7%；当 Treg/Th17取 2. 585时，诊断 ITP的 AUC 为0. 901，灵敏度为91. 3%，特异度为80. 0%。结论 成人原发性ITP患者外周血Treg细胞百分比降低、Th17细胞百 分比升高、Treg/Th17降低，且其水平变化与患者治疗效果有关，可辅助用于疾病诊断及疗效评估。 [ABSTRACT FROM AUTHOR]

A Venlo-type greenhouse has widely been introduced from Netherland for modern agriculture in China at present. This type of greenhouse is also the largest, most commonly-used, and state-of-the-art glass structure with advanced equipment and control systems for super greenhouses in the world. However, few national standards are released for the structure design of modern agricultural greenhouse, although most industry or group standards in China. Furthermore, the combination of earthquake load other than wind load cannot be usually considered for the structure design in most studies, due to the light-weight components and covering materials in the greenhouse structure. If the greenhouse that designed by the Netherlands was directly introduced to adopt the Dutch structural standards in China, there is a safety hazard of seismic action for the damage of main structure, particularly for nearly half of land areas in high-level zones of seismic intensity in China, even above 7 degrees. Taking a Venlo-type greenhousedesigned by a Dutch company in Shandong province as an example, this study aims to explore the impact of seismic action on structural safety according to the Dutch code, considering the stress diaphragm of covering material on the structural stiffness. A finite element software MIDAS Gen with the response spectrum modal was also selected to simulate the whole structure of the greenhouse with the seismic precautionary intensity of 7 (0.10g), 7 (0.15g), 8 (0.20g), and 8 degrees (0.30g). A systematic analysis was made on the mode periods, vibration patterns, the maximum stresses, and displacements for the structure. The results showed that the longest period of natural vibration was 1.75 s in the greenhouse structure, indicating a relatively flexible performance of the structural system. The first and second vibration patterns were the flat motion in Y and X -direction, especially a similar seismic performance in the 2 principal axes. Additionally, the maximum bearing capacity of the structure was 216.96 MPa for different seismic precautionary intensities under the wind load. The maximum stress was still less than the yield strength of components. When the seismic precautionary intensity exceeded 8 degrees (0.30g), the maximum tensile and compressive stresses of components were 211.95 and 196.02 MPa for the X-directional seismic action, respectively. In addition, the maximum displacement was 31.80 mm under the X-directional wind load without considering seismic action. The structural deformation was also mainly influenced by the seismic load. Specifically, the Y-directional seismic action was about 11.6% than that in the X-direction under the same load combination. Consequently, the greenhouse structure introduced from Netherland can always be expected to fully meet the code requirements within the elastic range of components, when the seismic intensity was lower than 8 degrees (0.30g). Nevertheless, the maximum deformation exceeded the standard requirement of 1/250 of the elastic inter-story displacement angle, according to the code for seismic design of buildings in China. [ABSTRACT FROM AUTHOR]

Objective: To investigate the role of NOK in the process of epithelial stromal transformation of lung adenocarcinoma cell line promoted by estrogen. Methods: The experiment was divided into four groups, the NOK gene was not down regulated in the first group without estrogen, the NOK gene was down regulated in the second group without estrogen, the NOK gene was not down regulated in the third group with estrogen, the NOK gene was down regulated in the fourth group with estrogen. The NOK gene in A549 cell line was down regulated by lentivirus, the cells were stimulated by estrogen at a concentration of 1× 10-8 mol/L, the expression of NOK and EMT markers in each group were detected by q-RT-PCR and Western blot, and the migration ability of cells in each group was detected by Transwell test. The expression of NOK and Vimentin in the second group decreased and the expression of E-cadherin increased compared with the first group, which were 0.09± 0.01, 0.16± 0.02 and 4.83± 0.61, which were statistically different from the first group. The expression of NOK and Vimentin in the third group increased significantly and the expression of E-cadherin decreased, which were 6.03 ± 0.92, 5.77 ± 0.86 and 0.33 ± 0.04, which were statistically different from the first group. In the fourth group, the expression of NOK and vimentin decreased and the expression of E-cadherin increased, which were 0.11 ± 0.01, 0.19 ± 0.03 and 4.92± 0.59, there were statistical differences with the first group and no statistical differences with the second group. The trend of protein expression of NOK and EMT markers was consistent with that of mRNA expression. The number of cell migration in the second group was significantly lower than that in the first group, and there was statistical difference between the two groups. The number of cell migration in the third group was significantly higher than that in the first group, and there was statistical difference between the two groups. The number of cell migration in the fourth group was significantly lower than that in the first group, and there was statistical difference between the two groups. Estrogen can promote the EMT process of lung adenocarcinoma cell lines, and down regulating the expression of NOK gene can block this process. Therefore, estrogen can regulate the EMT process of lung adenocarcinoma through NOK gene. [ABSTRACT FROM AUTHOR]

BACKGROUND: Increasing evidence suggests that N6-methyladenosine (m6A) regulators are closely associated with osteoarthritis and are considered to be a new direction in the prevention and treatment of osteoarthritis, but their specific mechanism of action is unknown. OBJECTIVE: To conduct a bioinformatics analysis of the osteoarthritis gene microarray dataset in order to explore the role of m6A in osteoarthritis and analyze the pathogenesis of osteoarthritis. METHODS: The m6A regulators associated with osteoarthritis and their expression were first extracted from the GSE1919 dataset in the GEO database using R software, and then the results were analyzed by gene difference analysis and GO and KEGG enrichment analyses. Subsequently, the results of protein-protein interaction network topology analysis and machine learning results were intersected to obtain the m6A Hub regulators, which were validated by in vitro cellular experiments. RESULTS AND CONCLUSION: A total of 16 osteoarthritis-related m6A regulators were extracted and 11 m6A differential regulators, including ZC3H13, YTHDC1, YTHDF3 and HNRNPC, were obtained by differential analysis. GO enrichment analysis showed that osteoarthritis-related m6A differential regulators played a role in the biological processes such as mRNA transport, RNA catabolism, and regulation of insulin-like growth factor receptor signaling pathway. (3) KEGG enrichment analysis showed that the differential regulators were mainly involved in the p53, interleukin-17 and AMPK signaling pathways. The combined protein-protein interaction network topology analysis and machine learning results obtained the m6A Hub regulator - YTHDC1. (5) The results of in vitro cellular experiments showed that there was a significant difference in the expression of m6A key regulator between the control and experimental groups (P < 0.05). To conclude, YTHDC1 is closely related to the development of osteoarthritis, which is expected to be a molecular target of m6A for the treatment of osteoarthritis. [ABSTRACT FROM AUTHOR]

A porous core index-guided terahertz micro-structure polymer fiber is designed based on back ground material of Topas. Its transmission characteristics such as the effective refractive index, confinement loss, effective material loss and dispersion are analyzed b y ad opting full- vector finite element method with the perfectly matched layers. The numerical results indicate that its near-zero low-flattened dispersion of 0. 24 7 ± 0. 0 1 ps/THz/ cm can be obtained in the frequency band of 1. 2 ± 0. 1 THz when the optimal structural parameters is selected as short half axis of a=8 µm and the long half axis of b=l 20 µm of elliptical holes in fiber core. Meanwhile, its confinement loss and effective material loss ( EML) are 1. 39 X 10- 6 cm- 1 and 0. 13 9 cm- 1, respectively at frequency of 1. 2 THz. The proposed waveguide with multiple characteristics, such as low loss and low flat dispersion, and simple structure for fabrication will provide a potential application for the development of terahertz band long-distance high-speed huge-capacity communication and 6G communication technology in the future. [ABSTRACT FROM AUTHOR]

[Objectives] Rice seeds carrying pathogens is an important way of spreading rice bakanae pathogens. The research aimed to reveal the situation of seed-borne rice bakanae pathogens in Jiangsu Province,China.[Methods] The seeds of 103 rice cultivars harvested from Jiangsu Province in 2017 were analyzed by loop-mediated isothermal amplification (LAMP) assays for specific detection of four known rice bakanae pathogen species,including Fusarium fujikuroi,F.proliferatum,F.verticilliodes and F.andiyazi.[Results] Among the 103 seed samples,89 seed samples were detected with rice bakanae pathogens. The most frequent species was F.fujikuroi,representing 83.5% of the total samples tested. The detection rates of F.proliferatum,F.verticillides,and F.andiyazi were low,i.e.,15.5%,1.9% and 1.9%,respectively.[Conclusions] Rice seeds carrying rice bakanae pathogens is common in Jiangsu Province,and F.fujikuroi is the most dominant pathogen,followed by F.proliferatum. Seed-borne of the two pathogens are an important primary infection source of rice bakanae. The results of this study provide important reference value for prevention and treatment of the rice bakanae in Jiangsu Province. [ABSTRACT FROM AUTHOR]

BACKGROUND: Cellular senescence is closely related to the development and progression of osteoarthritis, but the specific targets and regulatory mechanisms are not yet clear. OBJECTIVE: To mine key genes in cellular senescence-mediated osteoarthritis by integrating bioinformatics and machine learning approaches and validate them via experiments to explore the role of cellular senescence in osteoarthritis. METHODS: The osteoarthritis gene expression profiles obtained from the GEO database were intersected with cellular senescence-related genes obtained from the CellAge database and the expression of the intersected genes was extracted for differential analysis, followed by GO and KEGG analysis of the differential genes. The key osteoarthritis cellular senescence genes were then screened by protein-protein interaction network analysis and machine learning, and in vitro cellular experiments were performed. Finally, the expression of the key genes was detected by qPCR. RESULTS AND CONCLUSION: A total of 31 osteoarthritis cell senescence differential genes were identified. GO analysis showed that these genes were mainly involved in the biological processes, such as regulation of leukocyte differentiation, monocyte differentiation, regulation of T cell differentiation and exerted roles in DNA transcription factor binding, histone deacetylase binding, chromatin DNA binding, and chemokine binding. KEGG analysis showed that osteoarthritis cell senescence differential genes were mainly activated in the JAK/STAT signaling pathway, PI3K/Akt signaling pathway and FoxO signaling pathway. MYC, a key gene for osteoarthritis cellular senescence, was identified by protein-protein interaction network topology analysis and machine learning methods. The results of the in vitro cellular assay showed that the mRNA expression of MYC was significantly lower in the experimental group (osteoarthritis group) than the control group (normal group) (P < 0.05). To conclude, MYC can be a key gene in the senescence of osteoarthritic cells and may be a new target in the prevention and treatment of osteoarthritis by mediating immune response, inflammatory response and transcriptional regulation. [ABSTRACT FROM AUTHOR]

Objective To evaluate the clinical efficacy of Chinese patent drugs on primary osteoporosis. Methods The database of EMBASE, PubMed, CNKI, CBM, Wanfang, Weipu, etc., were retrieved by computer, and the randomized controlled trials (RCTs) on the treatment of primary osteoporosis by Chinese patent drug was manually retrieved. The inclusion and exclusion of literature and the extraction of data were all adopted. Uniform standard was applied. The quality of the literature included was evaluated. Rev. Man 5.3 version of meta analysis software was used. Overall efficacy, bone mineral density (BMD) of the lumbar spine and hip, osteocalcin (OC), serum calcium, alkaline phosphatase, type I collagen cross-linked C-terminal peptide (β-CTX), type I collagen N-anterior peptide (PINP), and other bone metabolic indicators were evaluated. BMD of the hip contained Ward triangle and the femoral neck. Results The system evaluation included 41 randomized controlled clinical trials. Among those, 3 were of high quality, 5 were of medium quality, and the rest were of low quality. The 4 084 patients involved were all primary osteoporosis patients, including 2 112 cases in treatment group and 1 970 cases in control group. A total of 31 Chinese patent drugs were used. The total effective rate of Chinese proprietary drug was higher than that of the control group (P<0.05). Some Chinese patent drugs or combined Chinese and Western medicine therapy had a certain effect on increasing BMD and increasing serum bone calcium and the levels of β-CTX and PINP. There was no statistical difference between the ALP level and the S-Ca level (P>0.05). The side effect of Chinese patent drug was not obvious during the treatment process. Conclusion Chinese patent drugs for primary osteoporosis have a certain effect, but the evidence of efficacy is limited. Therefore, more high-quality research is urgently needed to strengthen the evaluation evidence. [ABSTRACT FROM AUTHOR]

Aiming at the time-consuming and error-prone problem of the manually generated HEX file and the complexity of data management, the principle of compiling and linking was studied, and the method of updating variable address and the way of data management were summarized and analyzed. Designed and developed with m scripts, the HEX automatic generation tool completed data management of the control model and enabled HEX file and A2 L file to be generated automatically with one key. The generated HEX file could be downloaded directly to the microcontroller. At last by engine bench test, the correctness and reliability of the generated code was fully verified. The results show that the high-pressure common rail control strategy developed with this tool is accurate, and can realize the engine’s normal operation under various working conditions. The HEX automatic generation tool can greatly simplify model-based ECU development. Therefore, the tool improves development efficiency, and cuts down costs. [ABSTRACT FROM AUTHOR]

女性小阴唇外观的个体差异较大，随着生活水平的不断提高，越来越多的女性开始追求自已满意的小阴唇外观。 肥大的小阴唇不仅影响美观，而且还会导致运动、穿紧身衣、性生活时的不适感，以及会阴部的卫生问题，近年来使小阴唇肥大 的整形倍受关注。然而，目前小阴唇肥大无明确的解剖学标准，整形术式多样，缺乏确切的小阴唇肥大及手术方式的实践指南。 现对近10 年来小阴唇整形术式作一综述。 [ABSTRACT FROM AUTHOR]

Molten-salt reactor (MSR)，one of the most promising next generation reactors，has incomparable advantages ：inherent safety，fission fuel sustainable utilization，producing less long-lived wastes，excellent heat transfer characteristics and so on. Thorium-based molten salt reactor technology is an important way to supply long-term nuclear energy for the future. Hastelloy N alloy used as the structural material in M S R directly contacts with fluoride salts. Fission product Te leads to intergranular embrittlement of Hastelloy N alloy，which seriously affects the service life of Hastelloy N. There are many kinds of element in Hastelloy N alloy and the reaction products of Te and Hastelloy N are complicated. Therefore， it is difficult to analyze the intergranular embrittlement caused by Te. In the present study，the effect of diffusion time on the intergranular embrittlement of Te into nickel (Ni) was investigated to reveal the relations between Ni and Te. The electroplating method was used for preparing samples and the research was mainly concerned on varieties and stability of surface reaction products， tensile property，fracture morphology， trend of cracking and intergranular diffusion depth analysis. This study is helpful to improve Hastelloy N alloy to resist intergranular embrittlement. The results indicate that the main product was Ni3Te2 at 700 􀀀 C， which had good thermal stability. Compared with samples of nickel without Te，the ultimate tensile strength (UTS) of samples with Te dramatically decreased， whereas the elongation was not obviously changed in the diffusion time range from 24 h to 1000 h. Fracture of the alloy with T e exhibited brittle fracture with intergranular section near the surface and transgranular fracture in the center. The depth of diffusion of Te into nickel and intergranular fracture gradually increased with time extension. [ABSTRACT FROM AUTHOR]

In this paper, the PREMIS Data Dictionary is chosen as the evidence base to support risk check. The following four steps are used to check risk: (1) designing the check method; (2) implementing the mapping between the preservation metadata and preservation risks, and analyzing the related issues including the correlation between the both sides of the mapping, the coverage of core responsibility and the independence of the preservation system; (3) designing and testing the implementation, and analyzing the related issues including the level of risk check, encoding, preservation policies and preservation events; (4) testing and analyzing the results, including full risk check and single risk check. The research result shows that although the PREMIS Data Dictionary can he used to check the risks of the digital preservation, it does have some shortcomings. It is necessary to design the risk metadata for digital preservation. [ABSTRACT FROM AUTHOR]

In order to overcome the limitations that traditional Kalman filtering algorithm can only be used in linear system and reduce noise estimation accuracy, this paper used the optimal sampling point filtering algorithm to estimate remaining lithium iron phosphate battery power of electric cars in real time. By selecting the appropriate battery model and optimal sample points, this paper simulated the road conditions using ADVISOR 2002 electric vehicle simulation software, compared the traditional Kalman filter algorithm, and obtained the best sampling point Kalman filter method which can more accurately estimate the battery remaining power, and better optimized the estimation of noise influences. This algorithm has good robustness. [ABSTRACT FROM AUTHOR]

To determine the causes of the grouting method's unfavorable impact on the foundation reinforcement of an existing highrise building in the loess area and to serve as a guide for the building's additional reinforcement. Based on a building rectification project, the grouting method's applicability in a local unsaturated loess foundation was explored. On-site measurements were made of the building's tilt and settlement as well as the pore water pressure index of the foundation soil. The reasons for the rise in the foundation soil;s bearing capacity and the building's settlement rate after grouting were examined in conjunction with the geological circumstances and the earlier reinforcement plan. The results show that the building;s settlement rate clearly increases at the start of grouting and is higher on the south side than the north side. The settlement rate decreases and increases as construction is halted and resumed. The maximum settlement difference between the north and south sides is 40. 78 mm, and the maximum settlement rate is 2. 05 mm/ d. The maximum pore water pressure is 990. 21 kPa, and the variation trend of pore water pressure is similar to that of settlement rate. The pore water pressure on the south side of the foundation decreased by roughly 8. 85% ~ 45. 56% after grouting was stopped. The water in the uncondensed slurry gradually penetrates into the foundation soil with poor drainage conditions under the action of grouting pressure and higher pore water pressure, as well as the initial pore water pressure and initial drainage conditions in the foundation. This is the reason for the uneven settlement of the building caused by grouting. The difference has an uneven impact on the foundation, which ultimately manifests itself in the building's uneven settlement. As can be seen, measures like drilling drainage plates and pressure relief holes should be taken to relieve excessive pore water pressure before grouting reinforcement, and then grouting construction should be carried out, for similar local unsaturated loess foundations with poor drainage and excessive pore water pressure. [ABSTRACT FROM AUTHOR]

We present a wavelet packet and fractal technology to analyze the aero-engine hydraulic pipeline vibration signals with variable pressure. Firstly, we decompose aero-engine hydraulic pipeline vibration signals using the wavelet packet, and the fractal characteristics of pipeline vibration signals with variable pressure are validated by the reconstruction coefficients of the wavelet packet. Moreover, the fractal dimension changes of different frequency components are verified by analyzing and comparing the correlation dimensions of the main wavelet packets. The combination analysis shows that the wavelet packet and fractal combination technology can reflect fractal features of aero-engine hydraulic pipeline vibration signals under different pressure. [ABSTRACT FROM AUTHOR]

In medical computer assisted instruction and clinical diagnosis，3D visualization of medical CT data can heljD researchers to observe and detect the internal information. In view of this， in order to achieve better visual effect of medical CT images，we propose an development platform based on visualization toollcit and VC + +6.0，and analyze the basis composition and the principle of VTIK Marching Cubes algorithm of surface render and )ay Casting algorithm of volume render are used to realize 3D visualization of CT images. Experimental results show that this algorithm can effectively obtain the good 3D reconstruction effect of CT images. [ABSTRACT FROM AUTHOR]

In the light of the nonlinear characteristics of agricultural price volatility and the insufficient traditional method in time series forecasting of short-term fluctuations in agricultural prices, this paper has applied chaos theory and neural network technology to study short-term prediction of agricultural prices, and has designed dynamic chaotic neural time-series prediction model taking full advantage of relevant advanced technologies. On this basis, after studying, training and testing the constructed dynamic chaotic neural time-series prediction model, the authors have assessed and analyzed model performances by virtue of statistical analysis method, and finally conducted comparative study on the prediction results derived from the developed model and the traditional method, selecting China daily potato prices as research objects dated from January 21, 2008 to July 1, 2012. The results have manifested that the whole dynamic chaotic neural network structure is 27-12-1, and time-series potato prices prediction model based on dynamic chaotic neural network has demonstrated significant advantages on prediction accuracy and performances compared with ARMA model. This prediction model has a promising prospect of application in short-term time-series forecasting of agricultural prices. [ABSTRACT FROM AUTHOR]

阿尔茨海默病（AD）是一种进行性的、不可逆的中枢神经系统退行性疾病。β 淀粉样蛋白（Aβ）通过多种 机制影响AD 的发生发展。靶向Aβ 治疗AD 的机制包括通过调节γ-分泌酶、β-分泌酶减少Aβ 的生成；通过肌醇 类化合物、由Aβ 特异性配体及金属纳米颗粒组成的多价轭合物阻止Aβ 的聚集；通过Aβ 降解酶、Aβ 抗体、免疫疗 法促进Aβ 清除。 [ABSTRACT FROM AUTHOR]

Objective： To prepare oxaliplatin long circulating liposomes and study their pharmacodynamics in mice. Methods: The oxaliplatin long circulating liposomes were prepared by ethanol injection and morphology was observed, the grain size and entrapment efficiency were determined. Tumor inhibition rates, tumor growth situation, survival situation of mice administered with oxaliplatin solution and long circulating liposomes were investigated with S 180 tumor-bearing mouse as animal models and physiological saline as control. The count of white blood cells, spleen index and thymus index in mice were determined to evaluate the toxicity of oxaliplatin to immune organs. Results： The average grain size of oxaliplatin long circulating liposomes were (112.2 + 0.3) nm, and the entrapment efficiency was (59.93 ± 0.67)% (n--3). Compared with oxaliplatin solution, tumor inhibition rate of oxaliplatin long circulating liposomes was obviously increased [(30.4+1.9)% vs (85.8士2.3)%, P<0.05]. There were no significant differences in the count of white blood cells, spleen index and thymus index, as compared with those of the physiological saline group (P>0.05). Tumor volume in the mice administered with oxaliplatin long circulating liposomes increased rather slowly, and the mice all survived. Conclusion： Oxaliplatin long circulating liposomes seemed to have significant inhibitory effects on tumors and could reduce oxaliplatin toxicity to the immune system. [ABSTRACT FROM AUTHOR]

BACKGROUND: Osteoarthritis is closely related to chronic and low-grade inflammation. Necroptosis is a new cell death pathway with extensive inflammatory characteristics, which can affect the progression of osteoarthritis, but the related targets of necroptosis in osteoarthritis have not been found. OBJECTIVE: To explore the key genes of necroptosis in osteoarthritis based on bioinformatics and verify them with animal experiments, so as to provide new targets for the prevention and treatment of osteoarthritis from the perspective of necroptosis. METHODS: Osteoarthritis- and necroptosis-related genes were screened from GEO database and GeneCard database respectively, and then the intersection of them was taken to obtain osteoarthritic necroptosis genes. Gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were further carried out to construct a protein-protein interaction network. The key genes of osteoarthritic necroptosis (Hub genes) were identified through five calculation methods using Cytoscape software. Finally, male Sprague-Dawley rats were selected to metaphase models of osteoarthritis. The expression of Hub genes in the metaphase models of osteoarthritis of male Sprague-Dawley rats detected by RT-PCR. RESULTS AND CONCLUSION: A total of 38 osteoarthritic necroptosis genes were identified. Gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses showed that they were significantly enriched in leukocyte activity, T cell receptor and interleukin-17 signal pathway. Five Hub genes, CYBB, FADD, IL1B, MYC and EGFR, were screened by the five different algorithms of Cytoscape. RT-PCR showed that EGFR and IL1B were highly expressed in the metaphase models of osteoarthritis of male Sprague-Dawley rats (P < 0.05), while CYBB and MYC were lowly expressed (P < 0.05), but FADD had no significant changes (P > 0.05). To conclude, CYBB, IL1B, MYC, and EGFR, as the key genes of osteoarthritic necroptosis, are expected to become new targets for the prevention and treatment of osteoarthritis. [ABSTRACT FROM AUTHOR]

[Objective] The aims of this study are to reveal the time temporal changes and spatial differentiation in carbon reserves of terrestrial ecosystems on the Loess Plateau caused by land use changes and their mechanisms, and to provide theoretical guidance for maintaining ecological safety and land management on the Loess Plateau. [Methods] GIS (Geographic Information System）, statistical models and geographic probes were used to investigate the temporal changes and spatial variation of terrestrial ecosystem carbon storage due to LUCC on the Loess Plateau and the influencing factors of spatial differentiation from 1985 to 2019. [Results] (1) From 1985 to 2019, arable land on the Loess Plateau decreased by 2 771 400 hm², while forest land, grassland and construction land increased by 1 679 700 hm², 1 193 500 hm² and 1 284 700 hm², respectively, and other land decreased by 1 437 500 hm². (2) From 1985 to 2019, the carbon stock of terrestrial ecosystems on the Loess Plateau increased by a total of 52.255 1 million tons. After 2002, with the further promotion of ecological projects such as returning forests to grass, the carbon storage increased significantly, especially the carbon storage of vegetation. (3) The hot spot areas for carbon stock changes in terrestrial ecosystems on the Loess Plateau from 1985 to 2002 mainly concentrated in Shaanxi, Shanxi, Ningxia and parts of Inner Mongolia. The cold spot areas mainly concentrated in parts of Henan, Shanxi and Gansu. The hot spot areas from 2002 to 2019 mainly concentrated in Shaanxi, Gansu, Inner Mongolia and some cities in Shanxi. The cold spot areas mainly concentrated in Shaanxi, Henan, Shanxi, Inner Mongolia and some cities in Ningxia. (4) The spatial pattern of carbon storage in terrestrial ecosystems on the Loess Plateau was influenced by a combination of natural and human activities, with annual NDVI, actual evapotranspiration, intensity of human activity, annual precipitation and slope gradient being the main influencing factors, and the interaction between the combination of natural factors and human factors was higher than that between single-type factors. [Conclusion] The increase in forestland and grassland area caused by the ecological project of returning farmland to forestland and grassland has led to an increase in carbon storage in terrestrial ecosystems on the Loess Plateau. With respect to the premise of ensuring food security, the scientific formulation of the differentiated ecological management plans, the promotion of the enhanced ecological engineering in the study area and the restriction of land expansion for construction are conducive to increasing regional carbon storage. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To systematically review the efficacy and safety of Bufei Yishen method in the treatment of bronchial asthma in remission stage. METHODS: CNKI, Wanfang Data, VIP, PubMed and the Cochrane Library database were retrieved to collect the randomized controlled trials of Bufei Yishen method in the treatment of bronchial asthma in remission stage. The retrieval time was from the establishment of the database to Dec. 2021. Two evaluators screened the retrieved literature and extracted valid data respectively. Cochrane software was used to evaluate the literature quality, and RevMan 5. 3 software was used for Meta-analysis. RESULTS: Fifteen randomized controlled trials with a total of 1 305 patients were ultimately included. Meta-analysis results showed that Bufei Yishen method was better than conventional western medicine alone in improving the clinical efficiency, traditional Chinese medicine syndrome score, lung function, interleukin ( IL)-4 and IL-8 and other outcome indicators of bronchial asthma in remission stage, the differences were statistically significant(P< 0. 05). The incidence of adverse drug reactions of Bufei Yishen method was similar to that of conventional western medicine, and the incidence of adverse drug reactions of Bufei Yishen method was lower with higher safety. There was no definite evidence that Bufei Yishen method was superior to conventional western medicine in improving serum NO concentration and IL-5 level. CONCLUSIONS: The results suggest that the application of Bufei Yishen method in the treatment of bronchial asthma in remission stage is superior to conventional western medicine, and has certain feasibility and application value. However, due to the low quality of clinical evidence, it is necessary to perform high-quality randomized controlled trials for further verification. [ABSTRACT FROM AUTHOR]

口腔癌患者的临床治疗主要采取外科手术的方式,术后往往会留置引流装置。负压引流装置 是将引流管连接于减压器, 借助负压作用吸出伤口内液体,防止废液积蓄,抑制细菌增殖。当前,不同类型的负 压引流装置逐渐被用于口腔癌术后治疗中,取得了较好的临床效果,且以负压封闭引流装置效果最佳。因此, 该文对负压引流装置在口腔癌术后患者中的应用进行了综述。 [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of rhein on the proliferation, migration and invasion of hepatocellular carcinoma (HCC) cells by regulating rat sarcoma protein (Ras)/extracellular signal-regulated kinase (ERK) signaling pathway. Methods: HepG2 cells were treated with different concentrations (0, 12.50, 25, 50, 100, 150, 200 mol/L) of rhein to detect cell activity and screen the best concentration of rhein. The cells were divided into control group, low, medium and high concentration rhein group, high concentration rhein+Ras/ERK activator group (high concentration rhein+ML-099 group), the number of cell colony formation, scratch healing rate, the number of cell invasion and the expression of Ras, p-ERK and ERK protein were detected in each group. Results: Rhein reduced the activity of HepG2 cells in a concentration-and time-dependent manner (P＜0.05), HepG2 cells were treated with 25, 50, 100 mol/L for 24 h for subsequent experiments. Compared with control group, the number of cell colony formation, the proportion of G0/G1 cells, cell scratch healing rate, the number of cell invasion and the expression of proto-oncogene (c-Myc), cyclin D1 (CyclinD1), Ras and p-ERK/ERK protein in low, medium and high concentration groups of rhein decreased in a concentration-dependent manner, and the proportion of S phase and G2/M cells and the expression of p53 protein increased in a concentration-dependent manner (P＜0.05). Compared with rhein high concentration group, the number of cell colony formation, the proportion of G0/G1 cells, cell scratch healing rate, the number of cell invasion and the expression of c-Myc, CyclinD1, Ras and p-ERK/ERK protein in rhein high concentration+ML-099 group were significantly increased, and the proportion of S phase and G2/M cells and the expression of p53 protein were significantly decreased (P＜0.05). Conclusion: Rhein may inhibit the proliferation, migration and invasion of HCC cells by inhibiting the Ras/ERK signaling pathway. [ABSTRACT FROM AUTHOR]

Objective To explore the effect of platelet rich fibrin （PRF）in the promotion of wound healing. Methods From June 2015 to October 2019, 30 patients with wounds were selected. All patients were divided into PRF treatment group and conventional dressing change group. All patients were followed up for 6 to 12 months after discharge. The treatment time, pain degree, satisfaction, total hospitalization expenses and complications of patients were recorded. Results In the PRF treatment group, the average treatment time were（20.53±12.69）days, the average frequency of dressing change were (3.76±1.66), the average treatment expenses were（19035.29±3993.07）yuan and the scores of pain were（3.01±1.63）. In the conventional dressing change group, the average treatment time（32.85±11.47）days, the average frequency of dressing change were（15.29±4.32）and the average treatment expenses were（25946.3±9425.1）yuan. Compared with the conventional dressing change group, the application of PRF can promote wound healing, reduce the frequency of dressing change, decrease the expenses of treatment and alleviate the pain during the therapeutic process. Conclusion The application of PRF is superior to the conventional dressing change in preventing wounds infection, shortening the treatment time, alleviating the pain and decreasing the expenses. The PRF has better therapeutic effect in the treatment of complex wounds. [ABSTRACT FROM AUTHOR]

阿尔茨海双病(AD)是一种造行性神经進行性疾病, β 淀粉样蛋白 (Aβ) 沉积是AD主要滿因之一。Aβ 引引发神经 元損伤的最主要原因可能是通过与細胞膜上的入p受体站合进而引起下信号通路改交,直接描伤神經元或增加神经元的易感 性,目前,Aβ 受体和特运体主要包括, PirB,FeγR IIB.PrPc,NgR1,EphB2、p75NTR,LRP1 和 RAGE,该文对这些 Aβ 受体和转 追体的最新研究展进行综述,以期为 AD 创新药物开发提供可能线索和依据 [ABSTRACT FROM AUTHOR]

In order to study the effect of vertical cyclic load on the uplift bearing capacity of pile foundations, the influence of the number of cycles under cyclic load and the ratio of cyclic load on the cyclic displacement ratio was analyzed based on on-site experiments. The relationship between the uplift coefficient under cyclic load and the cyclic displacement ratio was summarized, and a calculation model for the uplift bearing capacity of pile foundations based on the cyclic displacement ratio was established. The results show the bearing capacity of pile foundation decays faster under cyclic loading than that under single pull-out load, and the calculation methods of bearing capacity of pile foundation are not equivalent in two cases. The cyclic load ratio and the number of cycles have a significant impact on the pile foundation's bearing capability, the bearing capacity of the pile foundation is significantly reduced when the cyclic pull-out cycle count exceeds 2 or the cyclic pull-out load ratio exceeds 5∶ 4. The attenuation of the pile foundation's bearing capacity is amplified by the cyclic displacement ratio. The attenuation rate of the pile foundation􀆳s bearing capacity is 50% when the cyclic displacement ratio is 0. 8, therefore, the cyclic displacement ratio should be reasonably managed in actual engineering. Calculation model of bearing capacity of pile foundation under cyclic loading in loess foundation is proposed, the case shows that the uplift carrying capacity calculated by the new model and the measured value only differ by a little amount, which verifies the accuracy and reliability of the model. The research results provide a valuable reference for the calculation of uplift bearing capacity of pile foundation under cyclic loading. [ABSTRACT FROM AUTHOR]

Combining with the domestic and international research progress, this paper systematically elaborated the formation mechanism and dynamic change of humic acid during composting, and the influence mechanisms of composting technology on the yield and structural characteristics of humic acid. In order to provide a scientific reference for improving the humic efficiency of agricultural solid waste, this paper analyzed the composting humic process and the driving mechanism of composting technology. This review is of great significance to optimize agricultural composting technology and strengthen the practical application of humic acids, and promote the sustainable development of agriculture and soil. [ABSTRACT FROM AUTHOR]

Under the combined action of long-term soil and water loads and aggressive materials, the reinforced concrete lining structure of shield tunnels will undergo a reinforcement corrosion-concrete damage-deterioration performance process and gradually fail, resulting in a significant reduction in service performance. The cohesive zone model (CZM) and the concrete damaged plasticity model (CDP) were introduced to establish a three-dimensional numerical model of shield tunnel lining corrosion considering the bond slip between reinforced concrete. The lining structure deformation, damage evolution law, and overall structural deterioration characteristics under the coupling effect of the surrounding rock, soil, and water load and reinforcement corrosion were analyzed, taking into account the factors such as mechanical deterioration caused by reinforcement corrosion, loss of effective concrete section and degradation of reinforced concrete bonding performance. The research results were concluded as follows. Reinforcement corrosion leads to a reduction in the stiffness of the lining structure and greatly deepens the degree of the lining structure deformation. The corrosion causes different stiffness losses in different parts of the lining structure, reflecting the variability of lining structure damage under the action of corrosion. The lining structure has a large difference between the damage on the perimeter rock side and the adjacent air side. With the same corrosion rate, the pressurized side of the lining is subject to extrusion, which limits the development of cracks and leads to little damage on the pressurized side. In the corrosion process, the tunnel lining structure vault moment decreases, the vault damage deepens and the damaged area gradually expands. The cross-sectional stiffness damage is the most significant. The performance of the lining structure is deteriorating continuously, and internal force redistribution occurs. The cracks of the lining structure are mostly found on the surrounding rock side. The research results can provide a reference for the evaluation of the service performance of the tunnel lining structure. [ABSTRACT FROM AUTHOR]

Osteoporosis (OP) as an elderly bone metabolic disease, the researches on its treatment is constantly updated. In recent years, CircRNA has been found to be involved in the pathogenesis of OP, anda large number of experiments have proved that cirRNA can promote or inhibit bone metabolism to some extent. Many Cerna networks have been shown to play a positive role in the evolution of OP, there is increasing evidence that cirRNA may be a new target for the treatment of OP. At present, the pathogenesis of OP has not been fully elucidated. In this paper, the role of circoRNA in the regulation of bone metabolism is taken as the starting point to explain the pathogenesis of OP. To increase the understanding of the pathogenesis of OP, for clinical multi-way, multi-target, multi-means to develop new treatment methods and provide ideas for the development of new drugs. [ABSTRACT FROM AUTHOR]

The aim of the experiment was to evaluate the nutritional value of 13 concentrate feeds of Yunshang black goats collected in the northern region (Qujing), southern region (Honghe), central region (Kunming) and western region (Chuxiong, Dali) of Yunnan Province by using the classification method of carbohydrate and protein proposed by CNCPS. The results showed that in the protein system, the PA content of soybean meal in southern region was the lowest, the PB1 content of extruded soybean in central region was the highest, PB2 content of soybean meal in southern region was the highest, and PC content of soybean meal in western region was the lowest. In terms of carbohydrate components, the content of CHO in corn in the western region was the highest, the content of CHO in soybean meal in the central region was the lowest, the content of corn CBl was the highest in the northern region, the content of CB2 in wheat bran was the highest in the northern region, and the content of CC in corn in the western region was the lowest. The study indicates that among the protein components of CNCPS, the nutritional value of soybean meal in the southern region is the highest; among carbohydrate components, the nutritional value of corn in the western region is the highest. [ABSTRACT FROM AUTHOR]

摘要:目的对比观察腰椎布鲁杆菌性脊柱炎(BS)后路病灶清除植骨融合内固定术术中椎间植入自体骨与同 种异体骨的临床疗效。方法 腰椎BS患者45例,均接受后路病灶清除植骨融合内固定术治疗,根据椎间植骨材料 的不同分为自体骨组(25例)和异体骨组(20例)。收集两组患者的手术时间、术中出血量、住院时间等围术期相关 指标。术前、术后3个月复查时,末次随访时检测感染相关指标,包括红细胞沉降率(ESR)、C-反应蛋白。术前,末次 随访时测算患者的腰椎功能恢复情况及整体生活质量,包括VAS评分、Oswestry 功能障碍指数(ODI)JOA评分。 术 后3个月、术后6个月,末次随访时,采用Bridwell分级评价患者植骨融合情况。结果异体骨组患者手术时间低于 自体骨组(P<0.05)。两组患者术后3个月和末次随访时ESR、C-反应蛋白水平均低于术前(P均<0.05),但同一时 间点两组间 ESR、C-反应蛋白水平差异无统计学意义(P均>0.05)。两组患者末次随访时VAS评分、ODI均低于术 前(P均<0.05),JOA评分均高于术前(P均<0.05);但同一时间点两组间VAS评分、ODIJOA评分差异无统计学意 义(P均>0.05)。术后3个月时,自体骨组患者植骨融合11例,异体骨组患者植骨融合3例,两组相比,P<0.05。术 后6个月时,自体骨组患者植骨融合20例,异体骨组患者植骨融合12例,两组相比,P>0.05。末次随访时,两组患者 植骨均融合。结论 腰椎BS后路病灶清除植骨融合内固定术术中椎间植入自体骨与同种异体骨的临床疗效相当, 同种异体骨可以作为自体骨理想的替代材料。 [ABSTRACT FROM AUTHOR]