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Objective：To investigate probiotic supplementation on blood sugar and lipids in patients with polycystic ovary syndrome. Methods：A total of 60 PCOS patients visited our hospital from March 2015 to January 2016 were divided into observed group (probiotic supplementation) and control group (metformin), each group of 30 cases. Serum levels of Fasting blood sugar (FBS), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), fasting serum insulin (FSI), luteotropic hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), progesterone (P), estradiol (E2), testosterone (T) was detected in this study; HOMA-IR were calculated in all patients. Results：Serum FBS, FSI, HOMA-IR, TG and VLDL leves in observed group were significantly decreased compared with control group after treatment (P＜0.05). After treatment, serum LH and T levels in observed group were lower than those before treatment (P＜0.05). In addition, probiotic supplementation in PCOS patients resulted in a significant reduction in weight and BMI compared with those patients without treatment. Conclusions：PCOS patients with probiotic supplementation have favourable effects on blood sugar, blood lipids and weight loss, which could alleviate PCOS and its associated complications development. [ABSTRACT FROM AUTHOR]

目的：探讨脑出血、脑梗死急性发作期患者血压、血脂、凝血纤溶功能差异及其临床意义。方法选取脑出血急性发作期患者52例（脑出血组）、脑梗死急性发作期患者48例（脑梗死组），另选体检健康者40例（对照组），均测量SBP、DBP，检测血浆TC、TG、LDL-C、HDL-C、脂蛋白a[Lp（a）]及抗凝血酶Ⅲ（AT-Ⅲ）、纤维蛋白原（FIB）、蛋白C（PC）、D-二聚体（D-D）。结果脑出血组、脑梗死组SBP和DBP均高于对照组（P均＜0．05）。脑出血组血浆TG、LDL-C及Lp（ a）水平均高于对照组，血浆TC、HDL-C水平均低于对照组；脑梗死组血浆TC、TG、LDL-C及Lp（ a）水平均高于对照组，血浆HDL-C水平低于对照组；脑出血组血浆TC、TG、LDL-C水平均低于脑梗死组；组间比较P均＜0．05。脑出血组、脑梗死组血浆FIB和D-D水平均高于对照组，血浆AT-Ⅲ水平均低于对照组；脑出血组PC活性高于脑梗死组及对照组；组间比较P均＜0．05。结论脑出血及脑梗死急性发作期患者均存在血压、血脂、凝血纤溶功能异常；脑梗死患者TC、TG、LDL-C水平及凝血纤溶亢进程度更高。 [ABSTRACT FROM AUTHOR]

目的　观察小剂量艾司氯胺酮联合右美托咪定在阻塞性睡眠呼吸暂停低通气综合征 (OSAHS) 患者清醒 纤维支气管镜引导气管插管 (AFOI) 中的应用效果。方法　全麻下行悬雍垂腭咽成形术的OSAHS患者60例, 按随 机数字表法分为对照组和观察组各30例。对照组静脉注射舒芬太尼, 观察组静脉注射艾司氯胺酮, 两组均同时予 右美托咪定泵注, 右美负荷量泵注完毕即开始纤维支气管镜引导插管。分别于入室安静10 min时 (T0 ) 、纤维支气管 镜置入鼻腔时 (T1 ) 、纤维支气管镜置入声门时 (T2 ) 、气管导管置入声门时 (T3 ) 记录两组患者心率 (HR) 、平均动脉压 (MAP) 、呼吸频率 (RR) 、脉搏血氧饱和度 (SpO2 ) 、Ramsay镇静评分 (RSS) 及T3时点呼气末二氧化碳分压 (PETCO2 ), 记 录两组患者插管时间、插管条件评分、患者舒适度评分、操作医师满意度评分、不良反应发生情况。结果　与同组T0 时点比较, 对照组T1 、T2时点HR、MAP下降, T1 ～T3时点RR、SpO2下降; 观察组T2时点RR、SpO2下降 (P均<0. 05) 。与 对照组同时点比较, 观察组T1 、T2 时HR升高 (P均<0. 05), T1 ～T3时MAP、RR、SpO2升高 (P均<0. 05) 。观察组T3时点 PETCO2低于对照组; 与同组 T0 时点比较, 两组 T1 ～T3时点 RSS评分均升高 (P均<0. 05) ; 两组同时点 RSS评分比较差 异均无统计学意义。两组插管时间、插管条件、患者舒适度和操作医师满意度差异均无统计学意义, 观察组低血压、 低氧血症及插管知晓发生率低于对照组 (P均<0. 05) 。结论　小剂量艾司氯胺酮联合右美托咪定在OSAHS患者清 醒气管插管中镇静效果较好, 且应用安全。 [ABSTRACT FROM AUTHOR]