Objective: To study the expression changes of insulin-like growth factor binding protein-1(IGFBP-1) level in burn patient and its clinical significance. Methods: 70 cases of burn patients who treated in our hospital from January 2015 to January 2013 were selected as research group, total burn surface area (TBSA) was divided into 4 subgroups:group Ⅰ(1%~15%) 34 cases, group Ⅱ(16%~30%)9 cases,group Ⅲ(31%~50%) 17 cases, group Ⅳ(51%~95%) 10 cases;In the same period, 50 healthy persons were selected as the control group.IGFBP-1 and insulin like growth factor (IGF-1) levels were determined, analyzed of its correlation with TBSA. Results: In the 10 d during observation period, the level of IGF-1 in group Ⅲ and group Ⅳ was significantly lower than that in control group (P<0.05), while the IGF-1 levels were significant difference between group Ⅱ and control group at 1d after burn (P<0.05), and in burn 2 d, as the grade of increased, the plasma IGF-1 level has a downward trend, the difference was statistically significant (P<0.05); The levels of IGFBP-1 in the research group were significantly higher than those in the control group (P<0.05); As the grade of increased, the plasma IGFBP-1 level has a upward trend, the difference was statistically significant (P<0.05); Linear correlation analysis showed that the plasma level of IGF-1was negatively correlated with TBSA value in burn patients (r=-0.693, P<0.05); Plasma IGFBP-1 levels was positively correlated with TBSA (r=0.377, P<0.05). Conclusion: Plasma levels of IGF-1 were significantly decreased in burn patients, while IGFBP-1 levels were significantly increased, which were closely related to the severity of burn, and the two were important indicators of early warning for the prognosis of burn patients. [ABSTRACT FROM AUTHOR]