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OBJECTIVE: To probe into the efficacy of Cai’ s endometriosis Ⅲ formula in the treatment of endometriosis syndrome of damp-heat and blood stasis. METHODS: Forty patients with endometriosis syndrome of damp-heat and blood stasis admitted into Shuguang Hospital of Shanghai University of Traditional Chinese Medicine from Jul. 2021 to Dec. 2022 were extracted and treated with Cai’s endometriosis Ⅲ formula for 2 courses of treatment (6 menstrual cycles). Visual analogue scale ( VAS), traditional Chinese medicine syndrome score, pelvic mass volume and serum CA125 level were compared before and after 2 courses of treatment. RESULTS: Before treatment, the VAS score of the patient was (6. 16±1. 44) points and traditional Chinese medicine syndrome score was (23. 78± 7. 80) points. After treatment, the VAS score of the patients was ( 5. 18 ± 1. 58) points, and traditional Chinese medicine syndrome score was (20. 15 ± 5. 94) points, both of which decreased compared to before treatment, with statistically significant differences (P<0. 05). After treatment, the CA125 level of the patients was lower than that before treatment, and the cysts of B-ultrasound were lower than that before treatment, with statistically significant difference (Z = -2. 401, -2. 514, P<0. 05). CONCLUSIONS: Cai’s endometriosis Ⅲ formula can reduce patients’ VAS score, alleviate pain symptoms, improve traditional Chinese medicine symptom, decrease blood CA125, and inhibit the growth of ovarian endometriosis cysts. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Computer-Aided Design & Computer Graphics / Jisuanji Fuzhu Sheji Yu Tuxingxue Xuebao is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Computer-Aided Design & Computer Graphics / Jisuanji Fuzhu Sheji Yu Tuxingxue Xuebao is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Computer-Aided Design & Computer Graphics / Jisuanji Fuzhu Sheji Yu Tuxingxue Xuebao is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

We u se the first - principles calculations to discuss the defect formation energy and electronic properties of chalcogen - doped single - layer Ag2S. The defect formation energies reflect that the energetic favorability of doping under Ag -rich condition is recommended. The electronic properties are embodied by the corresponding characters of the band gap, Mulliken populations and density of states. Compared to pure single - layer Ag2S, the band gaps of AfoS with Se/T e doping reflect that the electrical conductivity is ab out the same. The Mu l- liken atomic and bond populations are discussed to investigate the covalency of Ag2S after chalcogen doping. In addition, the shifts of energy levels and the electrons contributions are analyzed by discussing the density of states [ABSTRACT FROM AUTHOR]

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Computer-Aided Design & Computer Graphics / Jisuanji Fuzhu Sheji Yu Tuxingxue Xuebao is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Endometriosis (EMs) is a common and difficult disease in women of childbearing age with complex pathogenesis. It is extremely invasive, easy to metastasize and relapse, and the therapeutic effect is not satisfactory. The research on the mechanism of its occurrence and development and the search for effective treatment is the focus of gynecological research. In recent years, studies have found that the processes of epithelial-mesenchymal transition, adhesion invasion and angiogenesis of ectopic endometrial cells are important mechanisms in the occurrence and development of EMs. There are many signal pathways in this process, such as transforming growth factor β (TGF-β)/Smad, Notch, nuclear factor κB (NF-κB), Wnt/β-catenin, phosphatidyl inositol 3 kinase/ protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR). In this paper, the related signal pathways involved in the pathogenesis of EMs were described to provide a new idea for clinical prevention and treatment of EMs. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Earth Sciences & Environment is the property of Journal of Earth Sciences & Environment and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To observe the expression of silent information regulator 1 (SIRT1) in esophageal squamous cell carcinoma, and its relationship with invasion and metastasis of esophageal squamous cell carcinoma and its effect on survival and prognosis. Methods The clinical and pathological data of 104 patients with esophageal cancer who underwent radical esophagectomy at the Affiliated Tumor Hospital of Xinjiang Medical University from January to December 2009 were retrospectively reviewed. Immunohistochemical method (EnVision method) was used to detect the expression of SIRT1 in cancer tissues and adjacent tissues. The clinicopathological features of different SIRT1 expressions were compared. The factors affecting the prognosis of the patients with esophageal cancer were analyzed. Results The positive expression rate of SIRT1 protein was significantly higher in esophageal squamous cell carcinoma tissues than that in adjacent tissues (61.54% vs. 29.81%, χ2=21.100, P＜0.05). The expression of SIRT1 in esophageal squamous cell carcinoma was significantly correlated with vascular infiltration (VI), infiltration depth (pT), lymph node metastasis (pN) and clinical stage (pTNM) (P＜ 0.05). Univariate survival analysis showed that the overall survival time (OS) was significantly lower in patients with SIRT1 positive expression than that of patients with negative expression (Log-rank χ2=10.065，P＜0.05). SIRT1 positive expression, lymph node metastasis, deep tumor infiltration, late clinical stage and vascular infiltration showed poor prognosis (P＜0.05). Cox multivariate regression analysis showed that SIRT1 positive expression, lymph node metastasis, depth of invasion and clinical stage were independent prognostic factors for esophageal squamous cell carcinoma. The prognosis of patients with deep tumor invasion, lymph node metastasis, late clinical stage and high expression of SIRT1 was worse. Conclusion SIRT1 is highly expressed in esophageal squamous cell carcinoma, and which is closely related to the invasion and metastasis of esophageal squamous cell carcinoma and has an effect on the prognosis of patients. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect and mechanism of miR-34a-5p on the apoptosis of gastric adenocarcinoma. Methods (1)Bioinformatics tools were used to predict the potential target gene of miR-34a-5p. (2)Normal gastric mucosa epithelial cells RGM-1 and gastric adenocarcinoma cells SGG7901 were cultured, and qRT-PCR was performed to detect the expression of miR-34a-5p and Bcl-2 mRNA in these two cell lines. (3)SGC7901 cells were assigned into two groups: die observation group was transfected with miR-34a-5p mimic plasmid and the control group with scramble plamid for 48 h, and then qRT-PCR was performed to detect Bcl-2 mRNA, and Western blotting was used to detect the Bcl-2 protein. (4) SGC7901 cells were assigned into three groups: die negative control group was co-transfected with miR-34a-5p mimic and pRL-TK; the Bcl-2 WT group was co-transfected with miR-34a-5p mimic, Bcl-2 WT plasmid, and pRL-TK; the Bcl-2 MT group was co-transfected with miR-34a-5p mimic, Bcl-2 MT plasmid, and pRL-TK. The relative luciferase activity was measured by dual luciferase reporter assay at 48 h. (5)SGC7901 cells were assigned into four groups: die negative control group was co-transfected with miRNA scramble and pcDNA3. 1 empty vector, the miR-34a-5p mimic group was transfected with miR-34a-5p mimic, the pcDNA3. 1-Bcl-2 group was transfected with pcDNA3. 1-Bcl-2, and the miR-34a-5p mimic + pcDNA3. 1-Bcl-2 group was co-transfected with miR-34a-5p mimic and pcDNA3. 1-Bcl-2. The apoptotic rate of the four groups was measured by flow cytometry after 48 h of transfection. Results (1)Bcl-2 was predicted to be the potential target gene of miR-34a-5p. (2) Compared with RGM-1 cells, SGG7901 cells had relatively low expression of miR-34a-5p and high expression of Bcl-2 mRNA (both P <0. 01 ). (3) The relative expression of Bcl-2 mRNA and protein in the ob-servation group was lower than that in the control group (P <0. 01 ). (4)The relative luciferase activity of the Bcl-2 WT group was lower than that of the negative control group and Bcl-2 MT group (P <0. 01). (5)The apoptotic rate of the miR-34a-5p mimic group was higher than that of the negative control group, and the apoptotic rates of the pcDNA3. 1-Bcl-2 group and miR-34a-5p mimic + pcDNA3. 1-Bcl-2 group were lower than those of the negative control group and miR-34a-5p mimic (P <0. 01 ). Conclusion The miR-34a-5p can inhibit the apoptosis of gastric adenocarcinoma by up-regulating the expression of Bcl-2 and thus be involved in the occurrence and development of gastric adenocarcinoma. [ABSTRACT FROM AUTHOR]

Copyright of Transactions of the Chinese Society of Agricultural Engineering is the property of Chinese Society of Agricultural Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Transactions of Beijing Institute of Technology is the property of Beijing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的探讨mi-34a靶向调控去乙酰化酶1(Simn 1)表达对食管鳞癌细胞侵袭、转移的影响。 方法采用miRNAs耙标预测软件、TargetScanHuman5. 1生物在线工具预测Sirtuin 1可能是miR-34a的耙基因。将 体外培养的人食管鳞癌细胞 EC9706 分别转染 miR-34a mimic(EC9706/miR-34a 组)、miR-34a ?ramble(EC9706/ scramble组)$转染48 h后收集细胞，采用Western blotting法检测Sirtuin 1蛋白表达、Transwell侵袭试验检测穿膜细 胞数、细胞划痕实验检测细胞划痕愈合率。将裸鼠随机分为对照组和mi-34a组，分别经尾静脉注射转染mi-34a scramble和转染miR-34a agomir的EC9706细胞悬液，接种8周后处死裸鼠，取出双肺，计数肺转移瘤数量。 结果 EC9706/miR-34a组及EC9706/?ramble组细胞Sirtuin 1蛋白相对表达量分别为0.75 ±0.07、1.90 ±0.06,穿 膜细胞数分别为(123. 00 ±8. 89)、(203. 33 ±5. 86)个，细胞划痕愈合率分别为(33. 67 ±2.08)%、(64. 00 1 2.65)%，两组比较P均<0.01。miR-34a组和对照组裸鼠形成肺转移瘤分别为(4.67 ±0.82)、(8.83 ±1. 17)个， 两组比较P <0.01。结论Sirtuin1是miR-34a的耙基因。miR-34a通过耙向抑制Sirtuin1蛋白表达抑制食管鳞癌 EC970细胞的侵袭、转移。 [ABSTRACT FROM AUTHOR]

目的 观察食管鱗状细胞癌（以下简称食管鳞癌）组织中磷酸化表皮生长因子受体（P-EGFR) 的表达变 化，并探讨其意义。方法 100 例食管鳞癌患者，手术治疗中均留取癌组织（观察组）和癌旁正常组织（对照组）， 采用免疫组化 SP 法检测两组组织中磷酸化 EGFR( P-EGFR),分析 P-EGFR 的表达与食管鳞癌临床病理参数及患 者预后的关系。结果观察组癌组织中 P-EGFR 的表达髙于对照组(P <0.05)。P-EGFR 的表达与食管鳞癌患者 肿瘤分化程度、淋巴结转移、临床分期等临床病理参数无关 (P均 > 0.05)。P-EGFR 低表达者总生存期、无病生存 期均长于 P-EGFR 高表达者(P 均 <0.05)。多元 Cox 回归分析结果表明 P-EGFR 髙表达是影响食管鳞癌生存时间 的独立危险因素。结论食管鳞癌组织中 P-EGFR 高表达。P-EGFR 高表达是影响食管鱗癌生存时间的独立危险 因素,P-EGFR 可能是一个预测食管鳞癌患者预后的独立因素。 [ABSTRACT FROM AUTHOR]

Objective To study the current situation of chewing betel quid among Shenzhen residents and its influencing factors. Methods A self-designed questionnaire was used to perform the anonymity questionnaire investigation among Shenzhen residents and the health education of chewing betel quid hazard was carried out on the respondents. Results 1 260 residents participated in the questionnaire investigation with 1 228 effective questionnaires. The prevalence of betel quid chewing among the respondents was 11.81%( 145/1 228), among them, males was higher than females[ 17.80% (115/646) vs. 5.15%(30/582),P<0.05], the difference was statistically significant(P<0.05). Most of betel quid chewers were accompanied by smoking and drinking (OR = 8.741,95%CI-.5.476-13.952, P<0.05). Driver, service industrial workers, crowds with the education year less thanl2 years, friends or relatives around with betel chewing habit had higher betel quid chewing rate, the difference was statistically significant (P<0.05). Conclusion Shenzhen has large crowd with chewing betel quid. The health education of betel quid chewing hazard should be carried out for reducing chewing betel quid behavior. [ABSTRACT FROM AUTHOR]