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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 探讨高频振荡通气联合多巴酚丁胺治疗新生儿持续性肺动脉高压（PPHN)的临床疗效及其机制。 方法按照治疗方式不同，将94例PPHN患儿分为A组32例、B组32例和C组30例。三组性别、胎龄、日龄、体 质量、肺动脉压、生产方式、原发病比较差异均无统计学意义(P均>0. 05)。A组采用常频机械通气联合多巴酚丁 胺,B组采用单纯高频振荡通气，C组采用高频振荡通气联合多巴酚丁胺，观察三组临床疗效。同时,治疗前、治疗 12、24、48 h检测三组血氧饱和度（SpO2)、氧合指数（OI),治疗前、治疗48 h检测三组血清C反应蛋白（CRP)、脑钠 肽（BNP)、D-二聚体（D-D)水平变化。结果 C组治疗总有效率(93. 3% )高于A组（75. 0% )、B组(68.7% ) (P均 <0.05);治疗12、24、48 h，C组SpO2高于同期A组、B组，OI低于同期A组、B组，差异有统计学意义（户均< 0.05);治疗48 h，C组血清CRP、BNP、D-D水平低于A组、B组（P均<0.05)。结论 高频振荡通气联合多巴酚 丁胺能显著改善PPHN患儿的缺氧状态,提高临床疗效，其机制与降低血清CRP、BNP、D-D水平有关。 [ABSTRACT FROM AUTHOR]