Search

Copyright of University Chemistry is the property of Peking University, College of Chemistry & Molecular Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This paper mainly introduces the inorganic and analytical chemistry laboratory project, the synthesis of the complex [Ni(Me3en)(acac)]BPh4 and the solvato/thermochromic behavior, designed by Nanjing University for "The 10th National Undergraduate Chemistry Laboratory Tournament". This paper mainly deals with the experiment implementation process, results and related issues of the solvato/thermochromic behavior in the experiment. In the paper, the detailed and intuitive experimental phenomena inspire students to explore and understand the mechanism. The law of solvato/thermochromic behavior is summarized, which allows students to intuitively understand that the structure of complexes determines their properties. In the process, students can develop the ability of analysis, judgment, induction, summarizing and critical thinking. [ABSTRACT FROM AUTHOR]

A strong electromagnetic protection antenna is designed for the strong electromagnetic protection requirements of navigation receiver. The microstrip navigation antenna with eccentric feeding and adding radial strip line has characteristic of circular polarization and well gain at low elevation. Switching characteristics of navigation antenna with PIN diode loaded are realized in the bandwidth of navigation signal. Comparing with the original navigation antenna, the S11 and gain of designed strong electromagnetic protection antenna are basically unchanged and the axial ratio is improved. When the PIN diode is in low resistance state, the channel of navigation signal is off and the strong electromagnetic energy are prohibited to enter the back circuit though antenna. The simulation results show that the strong electromagnetic protection antenna meets the requirement of navigation and strong electromagnetic defending. [ABSTRACT FROM AUTHOR]

Bile acids are synthesized and catabolized by the liver, and many factors can lead to disorders in the production, secretion, and reabsorption of bile acids, thereby causing abnormal bile acid metabolism in vivo. Common predisposing factors include hepatitis, viruses, alcohol, drugs, biliary obstruction, and inheritance. It has been reported that abnormal bile acid metabolism is associated with transporter gene mutation, and in-depth studies have been conducted in China and globally. This article reviews the mechanism of abnormal bile acid metabolism caused by gene mutations and related research advances, so as to provide a new basis and new ideas for the diagnosis and treatment of such diseases. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Frontiers of Computer Science & Technology is the property of Beijing Journal of Computer Engineering & Applications Journal Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Neurosurgery / Linchuang Shenjingwaike Zazhi is the property of Editorial Board of Journal of Clinical Neurosurgery and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the effect and mechanism of liraglutide on ectopic fat deposition in rats with diabetic nephropathies(DN). Methods Forty male SD rats were randomly divided into three groups: normal control rats group (n=10), DN vehicle control rats group (n=15) and DN rats with liraglutide group (n=15). DN rats received subcutaneous injection of liraglutide (0.4 mg · kg-1 · d-1) for 12 weeks. Body weight, 24 h urine volume, 24 h total urine protein, serum insulin level, blood glucose, serum triglyceride (TG), total cholesterol (TC), and other biochemical index were detected after 12 week treatment of liraglutide. The histopathological changes of rat kidney were evaluated by periodic acid⁃schiff staining. The protein expression, distribution of sterol regulatory element binding protein and adipose differentiation⁃related protein in rat kidney were detected with immunohistochemistry. Renal tissue adenosine monophosphate activated protein kinase (AMPK), sterol regulatory element binding protein 1 (SREBP⁃1), adipose differentiation related protein (ADRP), fatty acid synthase (FAS) and p⁃AMPK phosphorylation levels protein expression in rats kidney were examined using western blot. One⁃way ANOVA was used to compare groups, pairwise comparison was tested by the least significant difference method. Results Compared to normal control group, the blood glucose, 24 h urine volume, and 24 h total urinary protein levels were increased in the DN vehicle control group (t=8.630-28.251, all P<0.01). When treated with liraglutide for 12 weeks, the total urine protein content of the DN vehicle control rats group was significantly higher than that of the diabetic rats before modeling [(20.3±10.6)vs (5.9±2.0) g/24 h,t=3.965,P< 0.01]. Glomerular mesangial cell proliferation and matrix expansion, serum TG and TC was significantly increased (t=3.616, 2.363, all P<0.05). SREBP⁃1 and ADRP proteins were mainly distributed in tubular(t= 7.588, 6.160, all P<0.01), and proteins expression of SREBP⁃1, FAS and ADRP protein in kidney tissue increased significantly, while AMPK phosphorylation levels in kidney tissue decreased (t=6.122,8.78,11.16, - 12.78, all P<0.01). Compared to DN vehicle control group, the body weight of DN rats decreased significantly after 12 weeks of treatment with liraglutide, serum TG and TC decreased significantly (t= - 3.338, - 2.944, - 2.390, all P<0.05). SREBP⁃1, FAS, ADRP protein expression in rats kidney was significantly decreased, while the phosphorylation level of AMPK in renal tissue was increased (t=-2.833, -4.228, -11.850, 7.653, all P<0.05). Conclusion Liraglutide inhibits renal ectopic fat deposition in rats with DN, which may be related to the increase of AMPK phosphorylation activity, inhibition of SREBP⁃1 transcriptional activity, reduction of FAS expression and subsequent inhibition of fatty acid synthesis pathway by liraglutide. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Zhengzhou University (Natural Science Edition) is the property of Journal of Zhengzhou University (Natural Science Edition) Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Oncology is the property of Chinese Journal of Oncology / Zhonghua Zhongliu Zazhi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Oil Drilling & Production Technology / Shiyou Zuancai Gongyi is the property of Shiyou Zuancai Gongyi Bianjibu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)